Details for: MAT2B

Gene ID: 27430

Symbol: MAT2B

Ensembl ID: ENSG00000038274

Description: methionine adenosyltransferase 2 non-catalytic beta subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 175.2545
    Cell Significance Index: -27.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.4219
    Cell Significance Index: -25.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.3453
    Cell Significance Index: -33.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.3340
    Cell Significance Index: -32.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.0877
    Cell Significance Index: -33.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.5758
    Cell Significance Index: -34.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9254
    Cell Significance Index: -32.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7097
    Cell Significance Index: -28.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3958
    Cell Significance Index: -25.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0536
    Cell Significance Index: -31.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7813
    Cell Significance Index: -23.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8524
    Cell Significance Index: -10.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.4953
    Cell Significance Index: 241.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2085
    Cell Significance Index: 64.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4984
    Cell Significance Index: 243.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2974
    Cell Significance Index: 1171.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0622
    Cell Significance Index: 130.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8867
    Cell Significance Index: 159.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8332
    Cell Significance Index: 10.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8185
    Cell Significance Index: 22.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7967
    Cell Significance Index: 20.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7831
    Cell Significance Index: 92.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6559
    Cell Significance Index: 17.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5926
    Cell Significance Index: 58.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5230
    Cell Significance Index: 71.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5030
    Cell Significance Index: 100.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4279
    Cell Significance Index: 14.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4201
    Cell Significance Index: 185.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4072
    Cell Significance Index: 222.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3831
    Cell Significance Index: 8.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3743
    Cell Significance Index: 19.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3701
    Cell Significance Index: 6.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3523
    Cell Significance Index: 18.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3313
    Cell Significance Index: 9.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2454
    Cell Significance Index: 11.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2160
    Cell Significance Index: 13.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2018
    Cell Significance Index: 40.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1965
    Cell Significance Index: 25.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1945
    Cell Significance Index: 10.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1921
    Cell Significance Index: 36.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1919
    Cell Significance Index: 13.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1341
    Cell Significance Index: 8.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1290
    Cell Significance Index: 46.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1091
    Cell Significance Index: 4.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1043
    Cell Significance Index: 3.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0358
    Cell Significance Index: 3.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0193
    Cell Significance Index: 36.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0135
    Cell Significance Index: 2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0037
    Cell Significance Index: 0.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0102
    Cell Significance Index: -6.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0106
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -7.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0115
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0133
    Cell Significance Index: -1.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0145
    Cell Significance Index: -22.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0182
    Cell Significance Index: -12.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0208
    Cell Significance Index: -13.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0233
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0245
    Cell Significance Index: -33.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0290
    Cell Significance Index: -16.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0385
    Cell Significance Index: -0.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0398
    Cell Significance Index: -5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0470
    Cell Significance Index: -21.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0544
    Cell Significance Index: -0.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0725
    Cell Significance Index: -20.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0760
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0821
    Cell Significance Index: -17.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0902
    Cell Significance Index: -5.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0950
    Cell Significance Index: -13.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1108
    Cell Significance Index: -12.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1189
    Cell Significance Index: -3.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1265
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1421
    Cell Significance Index: -16.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1485
    Cell Significance Index: -4.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1682
    Cell Significance Index: -5.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1705
    Cell Significance Index: -1.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1776
    Cell Significance Index: -4.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1805
    Cell Significance Index: -2.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1932
    Cell Significance Index: -22.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1957
    Cell Significance Index: -2.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2011
    Cell Significance Index: -15.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2437
    Cell Significance Index: -5.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2614
    Cell Significance Index: -17.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2681
    Cell Significance Index: -6.8500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2715
    Cell Significance Index: -2.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2800
    Cell Significance Index: -4.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2819
    Cell Significance Index: -29.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2911
    Cell Significance Index: -17.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3408
    Cell Significance Index: -26.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4139
    Cell Significance Index: -25.3800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4839
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4960
    Cell Significance Index: -21.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5164
    Cell Significance Index: -3.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5621
    Cell Significance Index: -9.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5711
    Cell Significance Index: -8.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5823
    Cell Significance Index: -3.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAT2B is a non-catalytic subunit of the methionine adenosyltransferase complex, which consists of two catalytic subunits (MAT2A and MAT2B). Unlike its catalytic counterpart, MAT2B does not possess enzymatic activity but instead regulates the activity of the complex. This regulation is crucial for maintaining the balance of one-carbon metabolism, which is essential for various cellular processes, including gene expression, DNA synthesis, and immune response modulation. **Pathways and Functions:** MAT2B is involved in several key pathways, including: 1. **One-carbon metabolism:** MAT2B regulates the synthesis of SAMe, which is a crucial donor of one-carbon units in various cellular processes, including DNA synthesis, gene expression, and methylation. 2. **Immune regulation:** MAT2B is significantly expressed in immune cells, including T cells, B cells, and dendritic cells, suggesting its role in modulating immune responses. 3. **Deubiquitination:** MAT2B is involved in the deubiquitination of proteins, which is a process that regulates protein stability and activity. 4. **Protein binding:** MAT2B interacts with various proteins, including those involved in one-carbon metabolism, immune regulation, and cell signaling. **Clinical Significance:** The dysregulation of MAT2B has been implicated in various diseases, including: 1. **Autoimmune diseases:** MAT2B plays a crucial role in regulating immune responses, and its dysregulation can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** MAT2B is involved in the regulation of one-carbon metabolism, which is essential for cancer cell growth and proliferation. Its dysregulation can contribute to the development of cancer. 3. **Neurological disorders:** MAT2B has been implicated in the regulation of one-carbon metabolism in the brain, and its dysregulation can contribute to neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, MAT2B is a crucial gene that plays a vital role in regulating immune responses and metabolism. Its dysregulation can contribute to the development of various diseases, including autoimmune diseases, cancer, and neurological disorders. Further research is needed to fully understand the role of MAT2B in human health and disease.

Genular Protein ID: 2904949290

Symbol: MAT2B_HUMAN

Name: Methionine adenosyltransferase 2 subunit beta

UniProtKB Accession Codes:

Q9NZL9 B2R5Y6 Q1WAI7 Q27J92 Q3LIE8 Q567T7 Q6NYC7 Q9BS89 Q9H3E1 Q9UJ54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 7 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644686

Title: Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II).

PubMed ID: 10644686

DOI: 10.1074/jbc.275.4.2359

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12880961

Title: Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.

PubMed ID: 12880961

DOI: 10.1016/s0304-3835(03)00085-5

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11337507

Title: Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II.

PubMed ID: 11337507

DOI: 10.1074/jbc.m102816200

PubMed ID: 12671891

Title: Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.

PubMed ID: 12671891

DOI: 10.1053/gast.2003.50151

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23189196

Title: NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

PubMed ID: 23189196

DOI: 10.1371/journal.pone.0050329

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23425511

Title: Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

PubMed ID: 23425511

DOI: 10.1042/bj20121580

PubMed ID: 25075345

Title: Structure and function study of the complex that synthesizes S-adenosylmethionine.

PubMed ID: 25075345

DOI: 10.1107/s2052252514012585

Sequence Information:

  • Length: 334
  • Mass: 37552
  • Checksum: 6AAA5381BAF3F65F
  • Sequence:
    • MVGREKELSI HFVPGSCRLV EEEVNIPNRR VLVTGATGLL GRAVHKEFQQ NNWHAVGCGF 
RRARPKFEQV NLLDSNAVHH IIHDFQPHVI VHCAAERRPD VVENQPDAAS QLNVDASGNL 
AKEAAAVGAF LIYISSDYVF DGTNPPYREE DIPAPLNLYG KTKLDGEKAV LENNLGAAVL 
RIPILYGEVE KLEESAVTVM FDKVQFSNKS ANMDHWQQRF PTHVKDVATV CRQLAEKRML 
DPSIKGTFHW SGNEQMTKYE MACAIADAFN LPSSHLRPIT DSPVLGAQRP RNAQLDCSKL 
ETLGIGQRTP FRIGIKESLW PFLIDKRWRQ TVFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.