Details for: GNB1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 666.1728
Cell Significance Index: -103.6200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 394.9640
Cell Significance Index: -100.1800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 240.0548
Cell Significance Index: -98.8900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 230.4910
Cell Significance Index: -108.8200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 221.7192
Cell Significance Index: -90.0800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 200.2779
Cell Significance Index: -103.0200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 95.2351
Cell Significance Index: -90.9300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 86.1913
Cell Significance Index: -106.2700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 38.4697
Cell Significance Index: -103.0600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 27.9216
Cell Significance Index: -85.7600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.1943
Cell Significance Index: -107.3100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 25.6238
Cell Significance Index: -56.0800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 4.7166
Cell Significance Index: 297.2700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4690
Cell Significance Index: 495.2800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.2977
Cell Significance Index: 824.1400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2692
Cell Significance Index: 450.3400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.9960
Cell Significance Index: 122.6900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.8669
Cell Significance Index: 97.2500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7516
Cell Significance Index: 315.7700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.7156
Cell Significance Index: 96.2700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6939
Cell Significance Index: 208.2800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.5102
Cell Significance Index: 1044.5100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2262
Cell Significance Index: 669.6800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1180
Cell Significance Index: 16.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0912
Cell Significance Index: 149.8500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0903
Cell Significance Index: 70.3400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8511
Cell Significance Index: 84.1900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8358
Cell Significance Index: 90.9100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8288
Cell Significance Index: 36.6600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7950
Cell Significance Index: 61.0100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.7947
Cell Significance Index: 19.0600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7940
Cell Significance Index: 351.0600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6800
Cell Significance Index: 110.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6785
Cell Significance Index: 31.6400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6670
Cell Significance Index: 44.8500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6548
Cell Significance Index: 18.8700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6462
Cell Significance Index: 14.0000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4740
Cell Significance Index: 17.9500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4697
Cell Significance Index: 21.2900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4366
Cell Significance Index: 394.2100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3804
Cell Significance Index: 10.6300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3227
Cell Significance Index: 61.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2879
Cell Significance Index: 542.1200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2759
Cell Significance Index: 32.5400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2549
Cell Significance Index: 11.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1795
Cell Significance Index: 30.6500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1557
Cell Significance Index: 211.6800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1427
Cell Significance Index: 219.6800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1216
Cell Significance Index: 224.3000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0916
Cell Significance Index: 1.5700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0616
Cell Significance Index: 39.1400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0260
Cell Significance Index: 0.3100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0014
Cell Significance Index: 0.6300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0045
Cell Significance Index: -0.1200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0275
Cell Significance Index: -17.2000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0552
Cell Significance Index: -7.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0582
Cell Significance Index: -3.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0583
Cell Significance Index: -43.2100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0652
Cell Significance Index: -47.8200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0889
Cell Significance Index: -67.2900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1307
Cell Significance Index: -16.8900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1332
Cell Significance Index: -4.6800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1426
Cell Significance Index: -80.4200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1585
Cell Significance Index: -11.2100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2104
Cell Significance Index: -2.6100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2357
Cell Significance Index: -12.2500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2497
Cell Significance Index: -18.6100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2542
Cell Significance Index: -25.9700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2703
Cell Significance Index: -56.9400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2987
Cell Significance Index: -6.5400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3341
Cell Significance Index: -38.9400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3360
Cell Significance Index: -96.6800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3906
Cell Significance Index: -2.3600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3932
Cell Significance Index: -57.1600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5231
Cell Significance Index: -10.2100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5546
Cell Significance Index: -10.2500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5616
Cell Significance Index: -16.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6190
Cell Significance Index: -70.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6590
Cell Significance Index: -18.8900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7390
Cell Significance Index: -84.3600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7992
Cell Significance Index: -17.0200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8211
Cell Significance Index: -22.3500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8437
Cell Significance Index: -87.8500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8884
Cell Significance Index: -22.8400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0711
Cell Significance Index: -84.8300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.2170
Cell Significance Index: -32.6100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.2854
Cell Significance Index: -33.8000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.4527
Cell Significance Index: -50.4800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4983
Cell Significance Index: -91.8600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.5181
Cell Significance Index: -13.9800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6748
Cell Significance Index: -22.8500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.7029
Cell Significance Index: -28.5000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.8802
Cell Significance Index: -40.1900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.1276
Cell Significance Index: -67.7600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.1280
Cell Significance Index: -69.6700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.1893
Cell Significance Index: -70.1200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -2.2677
Cell Significance Index: -38.2000 - Cell Name: peg cell (CL4033014)
Fold Change: -2.3181
Cell Significance Index: -53.5600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.3601
Cell Significance Index: -82.6800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.3720
Cell Significance Index: -63.4500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2345404785
Symbol: GBB1_HUMAN
Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3095147
Title: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical.
PubMed ID: 3095147
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14512443
Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
PubMed ID: 14512443
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19255495
Title: The cationic region of Rhes mediates its interactions with specific Gbeta subunits.
PubMed ID: 19255495
DOI: 10.1159/000204075
PubMed ID: 19713215
Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
PubMed ID: 19713215
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27108799
Title: Germline de novo mutations in GNB1 cause severe neurodevelopmental disability, hypotonia, and seizures.
PubMed ID: 27108799
PubMed ID: 34685729
Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.
PubMed ID: 34685729
PubMed ID: 18611381
Title: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
PubMed ID: 18611381
PubMed ID: 21827955
PubMed ID: 29925951
Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.
PubMed ID: 29925951
PubMed ID: 34239069
Title: Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex.
PubMed ID: 34239069
PubMed ID: 33762731
Title: Structural insights into the lipid and ligand regulation of serotonin receptors.
PubMed ID: 33762731
PubMed ID: 33828102
Title: Cryo-EM structure of the human histamine H1 receptor/Gq complex.
PubMed ID: 33828102
PubMed ID: 35610220
Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.
PubMed ID: 35610220
PubMed ID: 35714614
Title: GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
PubMed ID: 35714614
PubMed ID: 36171289
Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
PubMed ID: 36171289
PubMed ID: 35501348
Title: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
PubMed ID: 35501348
PubMed ID: 35835867
Title: Inactive and active state structures template selective tools for the human 5-HT5A receptor.
PubMed ID: 35835867
PubMed ID: 36087581
Title: Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
PubMed ID: 36087581
PubMed ID: 35061538
Title: Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.
PubMed ID: 35061538
PubMed ID: 37327704
Title: Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.
PubMed ID: 37327704
PubMed ID: 37963465
Title: Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
PubMed ID: 37963465
PubMed ID: 37935377
Title: Recognition of methamphetamine and other amines by trace amine receptor TAAR1.
PubMed ID: 37935377
PubMed ID: 37935376
Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
PubMed ID: 37935376
PubMed ID: 36989299
Title: Structural insights into constitutive activity of 5-HT6 receptor.
PubMed ID: 36989299
PubMed ID: 37991948
Title: The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2 hydrolysis.
PubMed ID: 37991948
PubMed ID: 38552625
Title: Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
PubMed ID: 38552625
PubMed ID: 38168118
Title: Molecular basis of human trace amine-associated receptor 1 activation.
PubMed ID: 38168118
PubMed ID: 25485910
Title: Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
PubMed ID: 25485910
DOI: 10.1038/nm.3751
PubMed ID: 27668284
Title: Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability.
PubMed ID: 27668284
PubMed ID: 28087732
Title: Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.
PubMed ID: 28087732
DOI: 10.1093/hmg/ddx018
Sequence Information:
- Length: 340
- Mass: 37377
- Checksum: 896CBD32D2686598
- Sequence:
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Genular Protein ID: 3055887314
Symbol: B3KVK2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 240
- Mass: 25935
- Checksum: 372B5998DF3B8414
- Sequence:
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.