Details for: GNB1
Gene ID: 2782
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GNB1
Ensembl ID: ENSG00000078369
Description: G protein subunit beta 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 79.39rCSI 100%PRS 17.65
-
CSI 51.1rCSI 85.77%PRS 10.61
-
CSI 47.31rCSI 76.09%PRS 11.54
-
CSI 43.67rCSI 77.13%PRS 10.56
-
CSI 43.16rCSI 95.35%PRS 12.89
-
CSI 38.55rCSI 46.05%PRS 10.4
-
CSI 38.2rCSI 40.01%PRS 19.23
-
CSI 34.84rCSI 43.34%PRS 9.89
-
CSI 33.32rCSI 50.9%PRS 18.1
-
CSI 33.25rCSI 50.17%PRS 18.14
-
CSI 33.11rCSI 80.46%PRS 10.42
-
CSI 30.58rCSI 35.31%PRS 15.78
-
CSI 30.08rCSI 38.78%PRS 11.12
-
CSI 27.59rCSI 86.21%PRS 11.33
-
CSI 27.21rCSI 59.92%PRS 27.37
-
CSI 25.78rCSI 33.09%PRS 17.43
-
CSI 25.61rCSI 56.09%PRS 24.1
-
CSI 24.98rCSI 34.03%PRS 15.97
-
CSI 23.33rCSI 83.95%PRS 9.98
-
CSI 22.59rCSI 70.65%PRS 12.19
-
CSI 21.73rCSI 42.27%PRS 18.41
-
CSI 21.62rCSI 16.66%PRS 16.62
-
CSI 20.66rCSI 39.01%PRS 22.67
-
CSI 20.62rCSI 35.66%PRS 13.7
-
CSI 19.31rCSI 73%PRS 10.93
-
CSI 18.96rCSI 64.93%PRS 15.52
-
CSI 18.44rCSI 22.94%PRS 19.09
-
CSI 16.22rCSI 43.19%PRS 14.83
-
CSI 15.23rCSI 18.84%PRS 15.76
-
CSI 14.93rCSI 21.63%PRS 26.95
-
CSI 14.76rCSI 39.79%PRS 23.27
-
CSI 13.39rCSI 65.98%PRS 24.33
-
CSI 12.91rCSI 28.01%PRS 11.81
-
CSI 12.69rCSI 74.73%PRS 11.14
-
CSI 12.04rCSI 17.77%PRS 28.12
-
CSI 11.97rCSI 31.98%PRS 14.96
-
CSI 11.71rCSI 27.3%PRS 41.59
-
CSI 11.4rCSI 18.21%PRS 19.71
-
CSI 11.27rCSI 43.86%PRS 29.62
-
CSI 10.9rCSI 43.38%PRS 31.11
-
CSI 10.33rCSI 51.35%PRS 19.23
-
CSI 10.32rCSI 48.32%PRS 36
-
CSI 9.72rCSI 34.5%PRS 29.25
-
CSI 9.53rCSI 9.18%PRS 18.64
-
CSI 9.52rCSI 22.63%PRS 26.98
-
CSI 9.03rCSI 66.38%PRS 10.2
-
CSI 9.02rCSI 11.31%PRS 23.31
-
CSI 8.92rCSI 25.01%PRS 27.85
-
CSI 8.79rCSI 56.31%PRS 27.2
-
CSI 8.67rCSI 38.07%PRS 33.33
-
CSI 8.49rCSI 24.59%PRS 20.34
-
CSI 8.23rCSI 19.79%PRS 26.62
-
CSI 8.18rCSI 92.03%PRS 43.07
-
CSI 7.81rCSI 5.91%PRS 24.79
-
CSI 7.6rCSI 44.23%PRS 26.85
-
CSI 7.57rCSI 19.67%PRS 23.25
-
CSI 7.53rCSI 6.91%PRS 21
-
CSI 7.26rCSI 33.52%PRS 37.19
-
CSI 7.08rCSI 9.67%PRS 20.37
-
CSI 6.88rCSI 59.3%PRS 8.22
-
CSI 6.69rCSI 16.98%PRS 13.64
-
CSI 6.69rCSI 19.84%PRS 25.41
-
CSI 6.48rCSI 17.05%PRS 34.85
-
CSI 6.47rCSI 39.13%PRS 39.74
-
CSI 6.44rCSI 8.56%PRS 19.71
-
CSI 6.35rCSI 8.83%PRS 18.47
-
CSI 6.05rCSI 4.21%PRS 21.43
-
CSI 5.72rCSI 13.57%PRS 22.32
-
CSI 5.69rCSI 80.7%PRS 13.32
-
CSI 5.43rCSI 14.17%PRS 16.53
-
CSI 5.43rCSI 13.97%PRS 23.64
-
CSI 5.41rCSI 8.63%PRS 15.44
-
CSI 5.27rCSI 12.29%PRS 36.21
-
CSI 5.21rCSI 5.13%PRS 19.55
-
CSI 5.07rCSI 14.51%PRS 31.63
-
CSI 5.03rCSI 25.96%PRS 34.97
-
CSI 5.02rCSI 40.81%PRS 18.24
-
CSI 4.86rCSI 7.42%PRS 23.17
-
CSI 4.85rCSI 7.81%PRS 27.97
-
CSI 4.8rCSI 6.42%PRS 23.6
-
CSI 4.75rCSI 8.47%PRS 30.04
-
CSI 4.66rCSI 8.48%PRS 60.24
-
CSI 4.54rCSI 4.18%PRS 18.6
-
CSI 4.53rCSI 27.17%PRS 29.95
-
CSI 4.49rCSI 9.94%PRS 16.68
-
CSI 4.38rCSI 3.56%PRS 19.02
-
CSI 4.3rCSI 23.86%PRS 47.61
-
CSI 4.29rCSI 10.23%PRS 20.9
-
CSI 4.29rCSI 33.6%PRS 36.85
-
CSI 4.27rCSI 12.61%PRS 16.52
-
CSI 4.27rCSI 86.98%PRS 14.19
-
CSI 4.24rCSI 3.4%PRS 32.18
-
CSI 4.21rCSI 5.75%PRS 19.96
-
CSI 4.18rCSI 7.48%PRS 16.63
-
CSI 4.13rCSI 6.05%PRS 66.84
-
CSI 4.1rCSI 83.48%PRS 15.23
-
CSI 4.03rCSI 5.39%PRS 34.21
-
CSI 3.99rCSI 6.84%PRS 24.47
-
CSI 3.97rCSI 4.95%PRS 25.48
-
CSI 3.85rCSI 2.87%PRS 30.34
-
CSI -2.6rCSI -4.0%PRS 41.8%
-
CSI -2.5rCSI -1.8%PRS 26.7%
-
CSI -1.9rCSI -5.7%PRS 41.9%
-
CSI -1.5rCSI -1.7%PRS 28.9%
-
CSI -1.2rCSI -10.1%PRS 11.4%
-
CSI -1.1rCSI -3.2%PRS 38.6%
-
CSI -1.0rCSI -5.5%PRS 9.3%
-
CSI -1.0rCSI -2.4%PRS 18.2%
-
CSI -0.9rCSI -2.4%PRS 26.6%
-
CSI -0.8rCSI -9.0%PRS 60.5%
-
CSI -0.7rCSI -11.7%PRS 59.2%
-
CSI -0.4rCSI -0.6%PRS 17.5%
-
CSI -0.4rCSI -1.0%PRS 27.4%
-
CSI -0.3rCSI -1.5%PRS 32.0%
-
CSI -0.2rCSI -0.2%PRS 33.3%
-
CSI 0.0rCSI -0.1%PRS 33.6%
-
CSI 0.0rCSI 0.1%PRS 53.2%
-
CSI 0.0rCSI 0.0%PRS 21.9%
-
CSI 0.1rCSI 0.3%PRS 27.4%
-
CSI 0.1rCSI 0.6%PRS 47.5%
-
CSI 0.1rCSI 0.5%PRS 14.0%
-
CSI 0.1rCSI 0.3%PRS 35.2%
-
CSI 0.1rCSI 1.5%PRS 20.3%
-
CSI 0.2rCSI 0.9%PRS 26.4%
-
CSI 0.2rCSI 0.1%PRS 25.6%
-
CSI 0.2rCSI 0.7%PRS 33.3%
-
CSI 0.2rCSI 0.1%PRS 28.7%
-
CSI 0.2rCSI 0.6%PRS 47.4%
-
CSI 0.2rCSI 0.4%PRS 38.1%
-
CSI 0.2rCSI 0.8%PRS 38.1%
-
CSI 0.2rCSI 0.4%PRS 47.5%
-
CSI 0.2rCSI 0.8%PRS 30.9%
-
CSI 0.2rCSI 1.2%PRS 60.8%
-
CSI 0.3rCSI 1.9%PRS 18.4%
-
CSI 0.3rCSI 0.9%PRS 18.8%
-
CSI 0.3rCSI 1.7%PRS 32.0%
-
CSI 0.3rCSI 0.5%PRS 23.2%
-
CSI 0.3rCSI 1.1%PRS 61.4%
-
CSI 0.4rCSI 0.9%PRS 27.6%
-
CSI 0.4rCSI 1.0%PRS 33.8%
-
CSI 0.4rCSI 0.7%PRS 27.5%
-
CSI 0.4rCSI 3.1%PRS 61.5%
-
CSI 0.4rCSI 2.4%PRS 54.1%
-
CSI 0.4rCSI 0.6%PRS 17.9%
-
CSI 0.4rCSI 0.5%PRS 36.5%
-
CSI 0.4rCSI 2.1%PRS 23.8%
-
CSI 0.4rCSI 0.9%PRS 27.0%
-
CSI 0.5rCSI 0.9%PRS 44.1%
-
CSI 0.5rCSI 0.6%PRS 22.7%
-
CSI 0.5rCSI 0.8%PRS 23.7%
-
CSI 0.5rCSI 1.3%PRS 29.0%
-
CSI 0.5rCSI 7.4%PRS 50.3%
-
CSI 0.5rCSI 2.3%PRS 19.0%
-
CSI 0.5rCSI 2.2%PRS 10.3%
-
CSI 0.5rCSI 1.2%PRS 18.6%
-
CSI 0.5rCSI 3.0%PRS 56.2%
-
CSI 0.5rCSI 0.6%PRS 31.4%
-
CSI 0.5rCSI 1.7%PRS 13.9%
-
CSI 0.5rCSI 0.6%PRS 17.6%
-
CSI 0.5rCSI 3.5%PRS 45.1%
-
CSI 0.5rCSI 1.3%PRS 16.6%
-
CSI 0.5rCSI 1.9%PRS 53.4%
-
CSI 0.6rCSI 0.9%PRS 21.5%
-
CSI 0.6rCSI 1.1%PRS 35.2%
-
CSI 0.6rCSI 5.5%PRS 47.0%
-
CSI 0.6rCSI 1.9%PRS 29.1%
-
CSI 0.6rCSI 0.9%PRS 18.1%
-
CSI 0.6rCSI 0.9%PRS 16.6%
-
CSI 0.6rCSI 2.3%PRS 35.8%
-
CSI 0.6rCSI 6.6%PRS 32.1%
-
CSI 0.6rCSI 0.9%PRS 25.2%
-
CSI 0.6rCSI 0.9%PRS 13.9%
-
CSI 0.6rCSI 1.4%PRS 35.9%
-
CSI 0.6rCSI 2.1%PRS 25.9%
-
CSI 0.7rCSI 0.9%PRS 24.9%
-
CSI 0.7rCSI 0.6%PRS 16.2%
-
CSI 0.7rCSI 5.9%PRS 59.5%
-
CSI 0.7rCSI 1.9%PRS 30.8%
-
CSI 0.7rCSI 1.1%PRS 13.8%
-
CSI 0.7rCSI 2.9%PRS 24.9%
-
CSI 0.7rCSI 1.4%PRS 39.8%
-
CSI 0.7rCSI 1.4%PRS 40.1%
-
CSI 0.8rCSI 3.2%PRS 43.8%
-
CSI 0.8rCSI 5.1%PRS 18.6%
-
CSI 0.8rCSI 23.3%PRS 39.7%
-
CSI 0.8rCSI 1.2%PRS 29.1%
-
CSI 0.8rCSI 1.2%PRS 19.0%
-
CSI 0.8rCSI 4.9%PRS 12.1%
-
CSI 0.8rCSI 0.5%PRS 25.0%
-
CSI 0.8rCSI 2.5%PRS 52.4%
-
CSI 0.9rCSI 0.9%PRS 21.2%
-
CSI 0.9rCSI 0.9%PRS 18.4%
-
CSI 0.9rCSI 3.9%PRS 55.6%
-
CSI 0.9rCSI 2.3%PRS 21.5%
-
CSI 0.9rCSI 2.1%PRS 26.1%
-
CSI 0.9rCSI 1.9%PRS 29.0%
-
CSI 0.9rCSI 1.3%PRS 23.6%
-
CSI 0.9rCSI 1.3%PRS 28.5%
-
CSI 0.9rCSI 6.9%PRS 19.1%
-
CSI 0.9rCSI 1.1%PRS 31.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2345404785
Symbol: GBB1_HUMAN
Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3095147
Title: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical.
PubMed ID: 3095147
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14512443
Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
PubMed ID: 14512443
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19255495
Title: The cationic region of Rhes mediates its interactions with specific Gbeta subunits.
PubMed ID: 19255495
DOI: 10.1159/000204075
PubMed ID: 19713215
Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
PubMed ID: 19713215
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27108799
Title: Germline de novo mutations in GNB1 cause severe neurodevelopmental disability, hypotonia, and seizures.
PubMed ID: 27108799
PubMed ID: 34685729
Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.
PubMed ID: 34685729
PubMed ID: 18611381
Title: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
PubMed ID: 18611381
PubMed ID: 21827955
PubMed ID: 29925951
Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.
PubMed ID: 29925951
PubMed ID: 34239069
Title: Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex.
PubMed ID: 34239069
PubMed ID: 33762731
Title: Structural insights into the lipid and ligand regulation of serotonin receptors.
PubMed ID: 33762731
PubMed ID: 33828102
Title: Cryo-EM structure of the human histamine H1 receptor/Gq complex.
PubMed ID: 33828102
PubMed ID: 35610220
Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.
PubMed ID: 35610220
PubMed ID: 35714614
Title: GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
PubMed ID: 35714614
PubMed ID: 36171289
Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
PubMed ID: 36171289
PubMed ID: 35501348
Title: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
PubMed ID: 35501348
PubMed ID: 35835867
Title: Inactive and active state structures template selective tools for the human 5-HT5A receptor.
PubMed ID: 35835867
PubMed ID: 36087581
Title: Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
PubMed ID: 36087581
PubMed ID: 35061538
Title: Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.
PubMed ID: 35061538
PubMed ID: 37327704
Title: Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.
PubMed ID: 37327704
PubMed ID: 37963465
Title: Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
PubMed ID: 37963465
PubMed ID: 37935377
Title: Recognition of methamphetamine and other amines by trace amine receptor TAAR1.
PubMed ID: 37935377
PubMed ID: 37935376
Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
PubMed ID: 37935376
PubMed ID: 36989299
Title: Structural insights into constitutive activity of 5-HT6 receptor.
PubMed ID: 36989299
PubMed ID: 37991948
Title: The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2 hydrolysis.
PubMed ID: 37991948
PubMed ID: 38552625
Title: Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
PubMed ID: 38552625
PubMed ID: 38168118
Title: Molecular basis of human trace amine-associated receptor 1 activation.
PubMed ID: 38168118
PubMed ID: 25485910
Title: Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
PubMed ID: 25485910
DOI: 10.1038/nm.3751
PubMed ID: 27668284
Title: Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability.
PubMed ID: 27668284
PubMed ID: 28087732
Title: Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.
PubMed ID: 28087732
DOI: 10.1093/hmg/ddx018
Sequence Information:
- Length: 340
- Mass: 37377
- Checksum: 896CBD32D2686598
- Sequence:
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Genular Protein ID: 3055887314
Symbol: B3KVK2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 240
- Mass: 25935
- Checksum: 372B5998DF3B8414
- Sequence:
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN