Details for: GNB1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.94
Marker Score: 20,678 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.92
Marker Score: 132,233 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.8
Marker Score: 10,829 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.61
Marker Score: 5,074 - Cell Name: endocrine cell (CL0000163)
Fold Change: 3.24
Marker Score: 1,675 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.03
Marker Score: 53,783 - Cell Name: stellate neuron (CL0000122)
Fold Change: 3.01
Marker Score: 16,195 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.9
Marker Score: 9,731 - Cell Name: granule cell (CL0000120)
Fold Change: 2.77
Marker Score: 20,859 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.7
Marker Score: 805 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.68
Marker Score: 2,312 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.57
Marker Score: 3,740 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.48
Marker Score: 11,494 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.45
Marker Score: 2,825 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.43
Marker Score: 2,928 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.42
Marker Score: 5,790 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.42
Marker Score: 36,117 - Cell Name: macroglial cell (CL0000126)
Fold Change: 2.4
Marker Score: 5,522 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.37
Marker Score: 1,417 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.35
Marker Score: 18,022 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.34
Marker Score: 2,232 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.34
Marker Score: 88,795 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.33
Marker Score: 9,739 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.28
Marker Score: 45,316 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.24
Marker Score: 4,312 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.24
Marker Score: 9,320 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.22
Marker Score: 1,300 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.22
Marker Score: 1,256 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.22
Marker Score: 19,475 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.19
Marker Score: 9,124 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.15
Marker Score: 79,452 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.15
Marker Score: 2,263 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.13
Marker Score: 45,521 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.11
Marker Score: 8,762 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.09
Marker Score: 1,040 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.09
Marker Score: 2,254 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.09
Marker Score: 8,068 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.06
Marker Score: 865 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.06
Marker Score: 2,493 - Cell Name: podocyte (CL0000653)
Fold Change: 2.03
Marker Score: 749 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.02
Marker Score: 112,887 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.02
Marker Score: 2,154 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.01
Marker Score: 68,232 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2
Marker Score: 18,854 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.99
Marker Score: 122,303 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.98
Marker Score: 716 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.98
Marker Score: 2,661 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.94
Marker Score: 2,418 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.94
Marker Score: 463 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.93
Marker Score: 1,364 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.92
Marker Score: 19,499 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.92
Marker Score: 1,095 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.91
Marker Score: 3,389 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.9
Marker Score: 1,707 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.9
Marker Score: 683 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.89
Marker Score: 65,638 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.89
Marker Score: 19,534 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.87
Marker Score: 2,100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.87
Marker Score: 4,261 - Cell Name: basal cell (CL0000646)
Fold Change: 1.86
Marker Score: 2,400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.85
Marker Score: 2,048 - Cell Name: neuron (CL0000540)
Fold Change: 1.85
Marker Score: 7,546 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.85
Marker Score: 3,761 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.85
Marker Score: 2,116 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.84
Marker Score: 584 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.83
Marker Score: 4,020 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.83
Marker Score: 1,061 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.82
Marker Score: 2,685 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.82
Marker Score: 17,284 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.82
Marker Score: 4,382 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.81
Marker Score: 896 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.81
Marker Score: 2,563 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.79
Marker Score: 997 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.79
Marker Score: 868 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.79
Marker Score: 724 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.78
Marker Score: 45,629 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.78
Marker Score: 15,296 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.78
Marker Score: 348 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.77
Marker Score: 396 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.77
Marker Score: 1,366 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.77
Marker Score: 1,204 - Cell Name: erythroblast (CL0000765)
Fold Change: 1.76
Marker Score: 1,099 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.76
Marker Score: 1,615 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.75
Marker Score: 923 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.73
Marker Score: 707 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.73
Marker Score: 1,732 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.73
Marker Score: 572 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.72
Marker Score: 1,002 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.71
Marker Score: 19,253 - Cell Name: ependymal cell (CL0000065)
Fold Change: 1.71
Marker Score: 595 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.7
Marker Score: 8,183 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.7
Marker Score: 1,475 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.7
Marker Score: 1,988 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.7
Marker Score: 1,825 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.69
Marker Score: 986 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.68
Marker Score: 1,050 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.67
Marker Score: 1,675 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.67
Marker Score: 1,108 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.66
Marker Score: 26,711 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.66
Marker Score: 1,564
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2345404785
Symbol: GBB1_HUMAN
Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3095147
Title: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical.
PubMed ID: 3095147
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14512443
Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
PubMed ID: 14512443
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19255495
Title: The cationic region of Rhes mediates its interactions with specific Gbeta subunits.
PubMed ID: 19255495
DOI: 10.1159/000204075
PubMed ID: 19713215
Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
PubMed ID: 19713215
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27108799
Title: Germline de novo mutations in GNB1 cause severe neurodevelopmental disability, hypotonia, and seizures.
PubMed ID: 27108799
PubMed ID: 34685729
Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.
PubMed ID: 34685729
PubMed ID: 18611381
Title: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
PubMed ID: 18611381
PubMed ID: 21827955
PubMed ID: 36171289
Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.
PubMed ID: 36171289
PubMed ID: 35501348
Title: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
PubMed ID: 35501348
PubMed ID: 35061538
Title: Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.
PubMed ID: 35061538
PubMed ID: 25485910
Title: Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
PubMed ID: 25485910
DOI: 10.1038/nm.3751
PubMed ID: 27668284
Title: Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability.
PubMed ID: 27668284
PubMed ID: 28087732
Title: Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.
PubMed ID: 28087732
DOI: 10.1093/hmg/ddx018
Sequence Information:
- Length: 340
- Mass: 37377
- Checksum: 896CBD32D2686598
- Sequence:
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Genular Protein ID: 3055887314
Symbol: B3KVK2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 240
- Mass: 25935
- Checksum: 372B5998DF3B8414
- Sequence:
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.