GNB1 | ENSG00000078369 | NCBI 2782

Details for: GNB1

Gene ID: 2782

Symbol: GNB1

Ensembl ID: ENSG00000078369

Description: G protein subunit beta 1

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Activation of the phototransduction cascade
(R-HSA-2485179)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Incretin synthesis, secretion, and inactivation
(R-HSA-400508)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Olfactory signaling pathway
(R-HSA-381753)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Peptide hormone metabolism
(R-HSA-2980736)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Sensory perception
(R-HSA-9709957)
Sensory perception of sweet, bitter, and umami (glutamate) taste
(R-HSA-9717207)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-HSA-381771)
The phototransduction cascade
(R-HSA-2514856)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Visual phototransduction
(R-HSA-2187338)
Adenylate cyclase-activating dopamine receptor signaling pathway
(GO:0007191)
Cell population proliferation
(GO:0008283)
Cellular response to catecholamine stimulus
(GO:0071870)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cytoplasm
(GO:0005737)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activity
(GO:0003924)
Gtpase binding
(GO:0051020)
Lysosomal membrane
(GO:0005765)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Retina development in camera-type eye
(GO:0060041)
Sensory perception of taste
(GO:0050909)
Signaling receptor complex adaptor activity
(GO:0030159)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 666.1728
Cell Significance Index: -103.6200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 394.9640
Cell Significance Index: -100.1800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 240.0548
Cell Significance Index: -98.8900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 230.4910
Cell Significance Index: -108.8200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 221.7192
Cell Significance Index: -90.0800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 200.2779
Cell Significance Index: -103.0200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 95.2351
Cell Significance Index: -90.9300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 86.1913
Cell Significance Index: -106.2700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 38.4697
Cell Significance Index: -103.0600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 27.9216
Cell Significance Index: -85.7600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.1943
Cell Significance Index: -107.3100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 25.6238
Cell Significance Index: -56.0800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 4.7166
Cell Significance Index: 297.2700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4690
Cell Significance Index: 495.2800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.2977
Cell Significance Index: 824.1400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2692
Cell Significance Index: 450.3400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.9960
Cell Significance Index: 122.6900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.8669
Cell Significance Index: 97.2500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7516
Cell Significance Index: 315.7700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.7156
Cell Significance Index: 96.2700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6939
Cell Significance Index: 208.2800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.5102
Cell Significance Index: 1044.5100
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2262
Cell Significance Index: 669.6800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1180
Cell Significance Index: 16.0800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0912
Cell Significance Index: 149.8500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0903
Cell Significance Index: 70.3400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8511
Cell Significance Index: 84.1900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8358
Cell Significance Index: 90.9100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8288
Cell Significance Index: 36.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7950
Cell Significance Index: 61.0100
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.7947
Cell Significance Index: 19.0600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7940
Cell Significance Index: 351.0600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6800
Cell Significance Index: 110.6000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6785
Cell Significance Index: 31.6400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6670
Cell Significance Index: 44.8500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6548
Cell Significance Index: 18.8700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6462
Cell Significance Index: 14.0000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4740
Cell Significance Index: 17.9500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4697
Cell Significance Index: 21.2900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4366
Cell Significance Index: 394.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3804
Cell Significance Index: 10.6300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3227
Cell Significance Index: 61.4100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2879
Cell Significance Index: 542.1200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2759
Cell Significance Index: 32.5400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2549
Cell Significance Index: 11.9800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1795
Cell Significance Index: 30.6500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1557
Cell Significance Index: 211.6800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1427
Cell Significance Index: 219.6800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1216
Cell Significance Index: 224.3000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0916
Cell Significance Index: 1.5700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0616
Cell Significance Index: 39.1400
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0260
Cell Significance Index: 0.3100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0014
Cell Significance Index: 0.6300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0045
Cell Significance Index: -0.1200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0275
Cell Significance Index: -17.2000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0552
Cell Significance Index: -7.0800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0582
Cell Significance Index: -3.0600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0583
Cell Significance Index: -43.2100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0652
Cell Significance Index: -47.8200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0889
Cell Significance Index: -67.2900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1307
Cell Significance Index: -16.8900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1332
Cell Significance Index: -4.6800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1426
Cell Significance Index: -80.4200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1585
Cell Significance Index: -11.2100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2104
Cell Significance Index: -2.6100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2357
Cell Significance Index: -12.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2497
Cell Significance Index: -18.6100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2542
Cell Significance Index: -25.9700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2703
Cell Significance Index: -56.9400
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2987
Cell Significance Index: -6.5400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3341
Cell Significance Index: -38.9400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3360
Cell Significance Index: -96.6800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3906
Cell Significance Index: -2.3600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3932
Cell Significance Index: -57.1600
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5231
Cell Significance Index: -10.2100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5546
Cell Significance Index: -10.2500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5616
Cell Significance Index: -16.0300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6190
Cell Significance Index: -70.9200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6590
Cell Significance Index: -18.8900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7390
Cell Significance Index: -84.3600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7992
Cell Significance Index: -17.0200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8211
Cell Significance Index: -22.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8437
Cell Significance Index: -87.8500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8884
Cell Significance Index: -22.8400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0711
Cell Significance Index: -84.8300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.2170
Cell Significance Index: -32.6100
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.2854
Cell Significance Index: -33.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.4527
Cell Significance Index: -50.4800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4983
Cell Significance Index: -91.8600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.5181
Cell Significance Index: -13.9800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6748
Cell Significance Index: -22.8500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.7029
Cell Significance Index: -28.5000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.8802
Cell Significance Index: -40.1900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.1276
Cell Significance Index: -67.7600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.1280
Cell Significance Index: -69.6700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.1893
Cell Significance Index: -70.1200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -2.2677
Cell Significance Index: -38.2000
Cell Name: peg cell (CL4033014)
Fold Change: -2.3181
Cell Significance Index: -53.5600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.3601
Cell Significance Index: -82.6800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.3720
Cell Significance Index: -63.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The GNB1 gene is a single-copy gene located on chromosome 1q42.3. It encodes for a 273-amino acid protein, which is a subunit of the heterotrimeric G protein complex. The GNB1 protein is characterized by its ability to bind to guanine nucleotides and regulate the activity of G protein-coupled receptors (GPCRs). The GNB1 protein is also involved in the regulation of various signaling pathways, including those involved in neurotransmission, hormone secretion, and immune responses. **Pathways and Functions** The GNB1 protein plays a crucial role in various signaling pathways, including: 1. **Neurotransmission**: GNB1 is involved in the regulation of neurotransmitter release and synaptic transmission in neurons. 2. **Hormone Secretion**: GNB1 is involved in the regulation of hormone secretion from endocrine cells, including insulin, glucagon, and gastrin. 3. **Immune Response**: GNB1 is involved in the regulation of immune responses, including the production of anti-inflammatory cytokines and the activation of immune cells. 4. **Cell Proliferation**: GNB1 is involved in the regulation of cell proliferation and differentiation in various cell types. 5. **Energy Metabolism**: GNB1 is involved in the regulation of energy metabolism, including the regulation of glucose and lipid metabolism. The GNB1 protein also interacts with various other proteins and signaling molecules, including: 1. **G-protein-coupled receptors**: GNB1 interacts with GPCRs to regulate their activity and signaling. 2. **Adenylate cyclase**: GNB1 interacts with adenylate cyclase to regulate the production of cyclic AMP (cAMP), a key second messenger in cellular signaling. 3. **Phospholipase C**: GNB1 interacts with phospholipase C to regulate the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), two key second messengers in cellular signaling. **Clinical Significance** Alterations in the GNB1 gene have been implicated in various diseases, including: 1. **Neurological disorders**: GNB1 mutations have been implicated in neurological disorders, including Parkinson's disease, Huntington's disease, and schizophrenia. 2. **Metabolic disorders**: GNB1 mutations have been implicated in metabolic disorders, including type 2 diabetes and obesity. 3. **Cancer**: GNB1 mutations have been implicated in cancer, including breast cancer and colon cancer. 4. **Immune disorders**: GNB1 mutations have been implicated in immune disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, the GNB1 gene plays a crucial role in various cellular processes, including neurotransmission, hormone secretion, cell proliferation, and immune responses. Alterations in the GNB1 gene have been implicated in various diseases, including neurological disorders, metabolic disorders, and cancer. Further research is needed to fully understand the role of GNB1 in human disease and to develop effective therapeutic strategies for the treatment of GNB1-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
B3KVK2_HUMAN

Genular Protein ID: 2345404785

Symbol: GBB1_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

UniProtKB Accession Codes:

P62873 B1AJZ7 P04697 P04901 Q1RMY8

Database IDs:

Citations:

PubMed ID: 3095147

Title: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical.

PubMed ID: 3095147

DOI: 10.1016/0014-5793(86)81486-7

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14512443

Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.

PubMed ID: 14512443

DOI: 10.1161/01.res.0000097607.14733.0c

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19255495

Title: The cationic region of Rhes mediates its interactions with specific Gbeta subunits.

PubMed ID: 19255495

DOI: 10.1159/000204075

PubMed ID: 19713215

Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.

PubMed ID: 19713215

DOI: 10.1074/jbc.m109.047282

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27108799

Title: Germline de novo mutations in GNB1 cause severe neurodevelopmental disability, hypotonia, and seizures.

PubMed ID: 27108799

DOI: 10.1016/j.ajhg.2016.03.011

PubMed ID: 34685729

Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.

PubMed ID: 34685729

DOI: 10.3390/cells10102749

PubMed ID: 18611381

Title: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.

PubMed ID: 18611381

DOI: 10.1016/j.str.2008.04.010

PubMed ID: 21827955

Title:

PubMed ID: 21827955

DOI: 10.1016/j.str.2011.07.010

PubMed ID: 29925951

Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.

PubMed ID: 29925951

DOI: 10.1038/s41586-018-0241-9

PubMed ID: 34239069

Title: Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex.

PubMed ID: 34239069

DOI: 10.1038/s41422-021-00527-4

PubMed ID: 33762731

Title: Structural insights into the lipid and ligand regulation of serotonin receptors.

PubMed ID: 33762731

DOI: 10.1038/s41586-021-03376-8

PubMed ID: 33828102

Title: Cryo-EM structure of the human histamine H1 receptor/Gq complex.

PubMed ID: 33828102

DOI: 10.1038/s41467-021-22427-2

PubMed ID: 35610220

Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.

PubMed ID: 35610220

DOI: 10.1038/s41421-022-00412-3

PubMed ID: 35714614

Title: GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

PubMed ID: 35714614

DOI: 10.1016/j.molcel.2022.05.031

PubMed ID: 36171289

Title: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity.

PubMed ID: 36171289

DOI: 10.1038/s41586-022-05258-z

PubMed ID: 35501348

Title: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.

PubMed ID: 35501348

DOI: 10.1038/s41467-022-30081-5

PubMed ID: 35835867

Title: Inactive and active state structures template selective tools for the human 5-HT5A receptor.

PubMed ID: 35835867

DOI: 10.1038/s41594-022-00796-6

PubMed ID: 36087581

Title: Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.

PubMed ID: 36087581

DOI: 10.1016/j.neuron.$2022.08.006

PubMed ID: 35061538

Title: Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.

PubMed ID: 35061538

DOI: 10.1126/sciadv.abl5442

PubMed ID: 37327704

Title: Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.

PubMed ID: 37327704

DOI: 10.1016/j.bbrc.2023.05.126

PubMed ID: 37963465

Title: Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.

PubMed ID: 37963465

DOI: 10.1016/j.cell.2023.10.014

PubMed ID: 37935377

Title: Recognition of methamphetamine and other amines by trace amine receptor TAAR1.

PubMed ID: 37935377

DOI: 10.1038/s41586-023-06775-1

PubMed ID: 37935376

Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.

PubMed ID: 37935376

DOI: 10.1038/s41586-023-06804-z

PubMed ID: 36989299

Title: Structural insights into constitutive activity of 5-HT6 receptor.

PubMed ID: 36989299

DOI: 10.1073/pnas.2209917120

PubMed ID: 37991948

Title: The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2 hydrolysis.

PubMed ID: 37991948

DOI: 10.1073/pnas.2315011120

PubMed ID: 38552625

Title: Flexible scaffold-based cheminformatics approach for polypharmacological drug design.

PubMed ID: 38552625

DOI: 10.1016/j.cell.2024.02.034

PubMed ID: 38168118

Title: Molecular basis of human trace amine-associated receptor 1 activation.

PubMed ID: 38168118

DOI: 10.1038/s41467-023-44601-4

PubMed ID: 25485910

Title: Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.

PubMed ID: 25485910

DOI: 10.1038/nm.3751

PubMed ID: 27668284

Title: Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability.

PubMed ID: 27668284

DOI: 10.1212/nxg.0000000000000106

PubMed ID: 28087732

Title: Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.

PubMed ID: 28087732

DOI: 10.1093/hmg/ddx018

Sequence Information:

Length: 340
Mass: 37377
Checksum: 896CBD32D2686598
Sequence:

MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA 
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 
CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF 
TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA 
FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL 
KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN

Genular Protein ID: 3055887314

Symbol: B3KVK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVK2

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 240
Mass: 25935
Checksum: 372B5998DF3B8414
Sequence:

MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS 
SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ 
TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK 
SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GNB1

Associated with

Cells (max top 100)

Other Information

Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. PubMed ID: 3095147

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. PubMed ID: 14512443

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The cationic region of Rhes mediates its interactions with specific Gbeta subunits. PubMed ID: 19255495

Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. PubMed ID: 19713215

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Germline de novo mutations in GNB1 cause severe neurodevelopmental disability, hypotonia, and seizures. PubMed ID: 27108799

Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease. PubMed ID: 34685729

Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. PubMed ID: 18611381

PubMed ID: 21827955

Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go. PubMed ID: 29925951

Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex. PubMed ID: 34239069

Structural insights into the lipid and ligand regulation of serotonin receptors. PubMed ID: 33762731

Cryo-EM structure of the human histamine H1 receptor/Gq complex. PubMed ID: 33828102

Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A. PubMed ID: 35610220

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. PubMed ID: 35714614

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity. PubMed ID: 36171289

Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. PubMed ID: 35501348

Inactive and active state structures template selective tools for the human 5-HT5A receptor. PubMed ID: 35835867

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. PubMed ID: 36087581

Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. PubMed ID: 35061538

Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6. PubMed ID: 37327704

Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. PubMed ID: 37963465

Recognition of methamphetamine and other amines by trace amine receptor TAAR1. PubMed ID: 37935377

Ligand recognition and G-protein coupling of trace amine receptor TAAR1. PubMed ID: 37935376

Structural insights into constitutive activity of 5-HT6 receptor. PubMed ID: 36989299

The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2 hydrolysis. PubMed ID: 37991948

Flexible scaffold-based cheminformatics approach for polypharmacological drug design. PubMed ID: 38552625

Molecular basis of human trace amine-associated receptor 1 activation. PubMed ID: 38168118

Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance. PubMed ID: 25485910

Novel GNB1 missense mutation in a patient with generalized dystonia, hypotonia, and intellectual disability. PubMed ID: 27668284

Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. PubMed ID: 28087732

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Database document:

PubMed ID: 3095147

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 14512443

PubMed ID: 19413330

PubMed ID: 19255495

PubMed ID: 19713215

PubMed ID: 21269460

PubMed ID: 22223895

PubMed ID: 23186163

PubMed ID: 25944712

PubMed ID: 27108799

PubMed ID: 34685729

PubMed ID: 18611381

PubMed ID: 29925951

PubMed ID: 34239069

PubMed ID: 33762731

PubMed ID: 33828102

PubMed ID: 35610220

PubMed ID: 35714614

PubMed ID: 36171289

PubMed ID: 35501348

PubMed ID: 35835867

PubMed ID: 36087581

PubMed ID: 35061538

PubMed ID: 37327704

PubMed ID: 37963465

PubMed ID: 37935377

PubMed ID: 37935376

PubMed ID: 36989299

PubMed ID: 37991948

PubMed ID: 38552625

PubMed ID: 38168118

PubMed ID: 25485910

PubMed ID: 27668284

PubMed ID: 28087732

PubMed ID: 11237011

PubMed ID: 14702039

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 21269460

PubMed ID: 25944712