Details for: CDH20

Gene ID: 28316

Symbol: CDH20

Ensembl ID: ENSG00000101542

Description: cadherin 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 228.7069
    Cell Significance Index: -58.0100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 11.0781
    Cell Significance Index: 154.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 9.4469
    Cell Significance Index: 530.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8521
    Cell Significance Index: -17.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5385
    Cell Significance Index: 155.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8088
    Cell Significance Index: 648.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2317
    Cell Significance Index: 247.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6729
    Cell Significance Index: 465.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5849
    Cell Significance Index: 111.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.5072
    Cell Significance Index: 8.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4355
    Cell Significance Index: 820.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4260
    Cell Significance Index: 384.6800
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.3744
    Cell Significance Index: 4.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2271
    Cell Significance Index: 22.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1896
    Cell Significance Index: 291.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1597
    Cell Significance Index: 294.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1124
    Cell Significance Index: 3.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0784
    Cell Significance Index: 106.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0588
    Cell Significance Index: 37.3700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0556
    Cell Significance Index: 0.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0411
    Cell Significance Index: 6.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0094
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0706
    Cell Significance Index: -51.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0977
    Cell Significance Index: -72.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1084
    Cell Significance Index: -59.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1114
    Cell Significance Index: -69.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1166
    Cell Significance Index: -52.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1273
    Cell Significance Index: -71.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1559
    Cell Significance Index: -10.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1673
    Cell Significance Index: -48.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1753
    Cell Significance Index: -5.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2107
    Cell Significance Index: -37.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2142
    Cell Significance Index: -3.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2180
    Cell Significance Index: -9.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2282
    Cell Significance Index: -24.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2416
    Cell Significance Index: -6.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2884
    Cell Significance Index: -57.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2997
    Cell Significance Index: -43.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3387
    Cell Significance Index: -71.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3693
    Cell Significance Index: -3.9600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3818
    Cell Significance Index: -4.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3888
    Cell Significance Index: -47.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4034
    Cell Significance Index: -30.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4084
    Cell Significance Index: -69.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4106
    Cell Significance Index: -4.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4379
    Cell Significance Index: -60.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4585
    Cell Significance Index: -59.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4888
    Cell Significance Index: -50.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4978
    Cell Significance Index: -30.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5247
    Cell Significance Index: -53.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5329
    Cell Significance Index: -62.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5401
    Cell Significance Index: -62.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5491
    Cell Significance Index: -11.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6083
    Cell Significance Index: -42.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6339
    Cell Significance Index: -72.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6563
    Cell Significance Index: -51.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7945
    Cell Significance Index: -47.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7961
    Cell Significance Index: -59.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8228
    Cell Significance Index: -23.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8421
    Cell Significance Index: -21.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9067
    Cell Significance Index: -19.5900
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.9212
    Cell Significance Index: -11.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9355
    Cell Significance Index: -11.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9526
    Cell Significance Index: -33.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9677
    Cell Significance Index: -62.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9891
    Cell Significance Index: -51.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1229
    Cell Significance Index: -58.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1352
    Cell Significance Index: -22.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1384
    Cell Significance Index: -23.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1481
    Cell Significance Index: -72.3600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.1526
    Cell Significance Index: -8.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1576
    Cell Significance Index: -25.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1900
    Cell Significance Index: -62.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.2112
    Cell Significance Index: -33.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.2226
    Cell Significance Index: -57.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2413
    Cell Significance Index: -29.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3117
    Cell Significance Index: -58.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.3451
    Cell Significance Index: -12.7500
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -1.4429
    Cell Significance Index: -17.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4665
    Cell Significance Index: -50.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5451
    Cell Significance Index: -58.5100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.6150
    Cell Significance Index: -51.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6524
    Cell Significance Index: -54.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6759
    Cell Significance Index: -53.3800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -1.7084
    Cell Significance Index: -19.7800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -1.7456
    Cell Significance Index: -24.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.7827
    Cell Significance Index: -38.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7978
    Cell Significance Index: -66.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8021
    Cell Significance Index: -53.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.8058
    Cell Significance Index: -91.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.9068
    Cell Significance Index: -23.6500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -2.0041
    Cell Significance Index: -26.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.0565
    Cell Significance Index: -58.9500
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -2.0829
    Cell Significance Index: -25.4800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -2.1291
    Cell Significance Index: -13.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.1464
    Cell Significance Index: -53.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.1789
    Cell Significance Index: -46.4100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -2.1883
    Cell Significance Index: -23.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.1988
    Cell Significance Index: -102.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -2.2214
    Cell Significance Index: -65.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDH20 is a type of cadherin protein that belongs to the cadherin superfamily, which is characterized by its ability to mediate cell-cell adhesion. CDH20 is specifically expressed in mature astrocytes, macroglial cells, oligodendrocytes, and other glial cells in the central nervous system (CNS). It is also found in the cerebral cortex and other brain regions. CDH20 is a homophilic adhesion molecule, meaning that it interacts with itself to mediate cell-cell adhesion. **Pathways and Functions:** CDH20 is involved in several key pathways that regulate cell-cell adhesion and tissue structure. These include: 1. **Adherens junction organization**: CDH20 is essential for the formation and maintenance of adherens junctions, which are critical for cell-cell adhesion and tissue structure. 2. **Cadherin binding**: CDH20 binds to other cadherin molecules to mediate cell-cell adhesion. 3. **Calcium-dependent cell-cell adhesion**: CDH20 is sensitive to changes in calcium concentrations, which regulate its activity and cell-cell adhesion. 4. **Catenin complex formation**: CDH20 interacts with catenins, which are cytoskeletal proteins that regulate cell-cell adhesion and cell migration. **Clinical Significance:** CDH20 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: CDH20 has been found to be decreased in patients with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting a role in disease progression. 2. **Stroke and cerebral vasospasm**: CDH20 has been shown to play a role in the regulation of blood flow and blood pressure in the CNS, which is critical for stroke and cerebral vasospasm. 3. **Neuroinflammation**: CDH20 has been found to be decreased in patients with neuroinflammatory disorders, such as multiple sclerosis, suggesting a role in disease progression. In conclusion, CDH20 plays a critical role in maintaining cell-cell adhesion and tissue structure in the CNS. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the mechanisms of CDH20 and its potential therapeutic applications. **References:** * [Insert references to relevant studies on CDH20 and its functions] **Recommendations:** * Further research is needed to fully understand the mechanisms of CDH20 and its role in various neurological disorders. * CDH20 may serve as a potential therapeutic target for the treatment of neurodegenerative diseases and other neurological disorders. * Studies on the role of CDH20 in other tissues and diseases are warranted to fully appreciate its clinical significance. **Conflict of Interest:** None declared.

Genular Protein ID: 1559922542

Symbol: CAD20_HUMAN

Name: Cadherin-20

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10995570

Title: Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.

PubMed ID: 10995570

DOI: 10.1006/geno.2000.6305

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 801
  • Mass: 88993
  • Checksum: 6B8B226519F49C5E
  • Sequence:
  • MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK PQSHQRTKRS 
    WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ 
    RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY VATVPEMSPV 
    GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV 
    IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD 
    LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT LKVEGANPHL 
    EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVAIGTTIQI ISAKDPDVTN 
    NSIRYSIDRS SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVPV 
    TIKVLDVNDN APEFPRFYEA FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN 
    PNFTIRDNQD NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD 
    GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDEENIHE 
    NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVNS 
    TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW 
    GPRFRKLAEL YGASEGPAPL W

Genular Protein ID: 3854316136

Symbol: A8K2C5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 801
  • Mass: 88933
  • Checksum: 6285D962F9E173A4
  • Sequence:
  • MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK PQSHQRTKRS 
    WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ 
    RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY VATVPEMSPV 
    GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV 
    IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD 
    LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT LKVEGANPHL 
    EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVAIGTTIQI ISAKDPDVTN 
    NSIRYSIDRS SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVPV 
    TIKVLDVNDN APEFPRFYEA FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN 
    PNFTIRDNQD NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD 
    GHVMSCSPEA CMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDEENIHE 
    NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVNS 
    TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW 
    GPRFRKLAEL YGASEGPAPL W

Genular Protein ID: 849810076

Symbol: Q8N9J3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 335
  • Mass: 37141
  • Checksum: AD9BD604DE4CE1A0
  • Sequence:
  • MEMNNPSQVG SVPVTIKVLD VNDNAPEFPR FYEAFVCENA KAGQLIQTVS AVDQDDPRNG 
    QHFYYSLAPE AANNPNFTIR DNQDNTARIL TRRSGFRQQE QSVFHLPILI ADSGQPVLSS 
    TGTLTIQVCS CDDDGHVMSC SPEAYMLPVS LSRGALIAIL ACIFVLLVLV LLILSMRRHR 
    KQPYIIDDEE NIHENIVRYD DEGGGEEDTE AFDIAAMWNP REAQAGAAPK TRQDMLPEIE 
    SLSRYVPQTC AVNSTVHSYV LAKLYEADMD LWAPPFDSLQ TYMFEGDGSV AGSLSSLQSA 
    TSDSEQSFDF LTDWGPRFRK LAELYGASEG PAPLW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.