Details for: IGHV3 62

Gene ID: 28416

Symbol: IGHV3 62

Ensembl ID: ENSG00000253132

Description: immunoglobulin heavy variable 3-62 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 38.6080
    Cell Significance Index: 625.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 27.1156
    Cell Significance Index: 463.5100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 17.4301
    Cell Significance Index: 225.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 14.7708
    Cell Significance Index: 202.5600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 10.8171
    Cell Significance Index: 114.9100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.2626
    Cell Significance Index: 32.8500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.2123
    Cell Significance Index: 2.5200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.1893
    Cell Significance Index: 1.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0213
    Cell Significance Index: -0.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0243
    Cell Significance Index: -0.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0627
    Cell Significance Index: -0.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0755
    Cell Significance Index: -1.1000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0763
    Cell Significance Index: -0.8600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0792
    Cell Significance Index: -0.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0795
    Cell Significance Index: -1.1300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0799
    Cell Significance Index: -0.8700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0895
    Cell Significance Index: -1.1500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0915
    Cell Significance Index: -0.9700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0956
    Cell Significance Index: -1.2700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0975
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0977
    Cell Significance Index: -1.4800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0987
    Cell Significance Index: -0.9600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1035
    Cell Significance Index: -1.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1069
    Cell Significance Index: -1.3100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1073
    Cell Significance Index: -1.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1076
    Cell Significance Index: -1.2700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1081
    Cell Significance Index: -0.7200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1084
    Cell Significance Index: -0.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1099
    Cell Significance Index: -1.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1182
    Cell Significance Index: -2.9500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1217
    Cell Significance Index: -1.9600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1250
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1289
    Cell Significance Index: -1.2100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1342
    Cell Significance Index: -1.2500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1402
    Cell Significance Index: -0.9300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1429
    Cell Significance Index: -1.6400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1536
    Cell Significance Index: -1.8300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1573
    Cell Significance Index: -1.3900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1592
    Cell Significance Index: -1.9400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1639
    Cell Significance Index: -1.6600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1674
    Cell Significance Index: -1.6900
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1846
    Cell Significance Index: -0.8500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1893
    Cell Significance Index: -2.2400
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1920
    Cell Significance Index: -1.3600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1926
    Cell Significance Index: -2.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1930
    Cell Significance Index: -2.5200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1939
    Cell Significance Index: -0.9700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2004
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2020
    Cell Significance Index: -2.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2030
    Cell Significance Index: -2.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2051
    Cell Significance Index: -2.7900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2068
    Cell Significance Index: -2.4800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2082
    Cell Significance Index: -2.4600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2096
    Cell Significance Index: -2.1400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2175
    Cell Significance Index: -2.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2208
    Cell Significance Index: -1.7700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2349
    Cell Significance Index: -2.4000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2546
    Cell Significance Index: -2.9300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2684
    Cell Significance Index: -2.2700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2705
    Cell Significance Index: -2.5300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2734
    Cell Significance Index: -2.5000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2858
    Cell Significance Index: -1.5300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2874
    Cell Significance Index: -2.4800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2898
    Cell Significance Index: -2.4700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3442
    Cell Significance Index: -3.2100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3538
    Cell Significance Index: -2.4900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3681
    Cell Significance Index: -3.4900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3890
    Cell Significance Index: -3.4700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.5255
    Cell Significance Index: -4.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV3-62 is a non-functional, non-coding gene, resulting from a mutation that has rendered it unable to participate in the immunoglobulin gene rearrangement process. 2. **Widespread expression:** Despite its pseudogenous status, IGHV3-62 is significantly expressed in various hematopoietic cell types, including erythrocytes, megakaryocytes, and precursor B cells. 3. **Cell-type specificity:** IGHV3-62 expression is restricted to hematopoietic cells, with minimal or no expression in other cell types. **Pathways and Functions:** The mechanisms underlying IGHV3-62 expression and its functional implications remain unclear. However, several hypotheses can be proposed: 1. **Regulatory elements:** The presence of regulatory elements, such as enhancers or silencers, within the IGHV3-62 locus may contribute to its expression in specific cell types. 2. **Gene regulation networks:** IGHV3-62 may interact with other genes or transcription factors to modulate gene expression in hematopoietic cells. 3. **Epigenetic modifications:** Epigenetic modifications, such as DNA methylation or histone modifications, may influence IGHV3-62 expression in response to cellular cues. **Clinical Significance:** The discovery of IGHV3-62 as a pseudogene with significant expression in hematopoietic cells has important implications for our understanding of gene regulation and hematopoiesis. Further studies are needed to elucidate the functional significance of IGHV3-62 and its potential role in disease. Some potential clinical implications include: 1. **Hematopoietic disorders:** Abnormal expression of IGHV3-62 may contribute to the development of hematopoietic disorders, such as leukemia or lymphoma. 2. **Gene therapy:** Understanding the mechanisms underlying IGHV3-62 expression may inform the development of gene therapy strategies for hematopoietic disorders. 3. **Immunological insights:** The discovery of IGHV3-62 highlights the complexity of gene regulation and the need for further investigation into the mechanisms underlying immunoglobulin gene expression. In conclusion, the IGHV3-62 gene, a pseudogene with significant expression in hematopoietic cells, presents a fascinating example of gene regulation and its implications for our understanding of hematopoiesis. Further studies are necessary to elucidate the functional significance of IGHV3-62 and its potential role in disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.