Details for: GPR20

Gene ID: 2843

Symbol: GPR20

Ensembl ID: ENSG00000204882

Description: G protein-coupled receptor 20

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.81
    Marker Score: 4259
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170088
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.26
    Marker Score: 663
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.16
    Marker Score: 1102
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 629
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.92
    Marker Score: 1028
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.83
    Marker Score: 1425
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 462
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.79
    Marker Score: 10373.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 571.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.72
    Marker Score: 248
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.67
    Marker Score: 255
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 385
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.61
    Marker Score: 281
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 384
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 223
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.53
    Marker Score: 506
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 251
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.52
    Marker Score: 153
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.49
    Marker Score: 913
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.48
    Marker Score: 279
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.47
    Marker Score: 132
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 240.5
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.39
    Marker Score: 101
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 98
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.36
    Marker Score: 377.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.34
    Marker Score: 185
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 675.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.31
    Marker Score: 535
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.29
    Marker Score: 117
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.28
    Marker Score: 79
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.26
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.26
    Marker Score: 84
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 94
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.24
    Marker Score: 172
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.22
    Marker Score: 312
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 109.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 197
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 155
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 122
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 465
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.15
    Marker Score: 29
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.14
    Marker Score: 214
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.13
    Marker Score: 28.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.13
    Marker Score: 159
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.13
    Marker Score: 28.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 277
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.11
    Marker Score: 28.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.11
    Marker Score: 194.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1
    Marker Score: 124
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.09
    Marker Score: 28.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.09
    Marker Score: 86.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 53.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.07
    Marker Score: 21.5
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.07
    Marker Score: 26.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.07
    Marker Score: 19.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.07
    Marker Score: 453.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.07
    Marker Score: 26.5

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Other Information

**Key characteristics:** * GPR20 is a transmembrane protein that is expressed in the plasma membrane. * It is a G protein-coupled receptor that is activated by a variety of ligands, including growth factors and cytokines. * Once activated, GPR20 recruits the G protein Galpha to the plasma membrane, which leads to the activation of downstream signalling pathways. * GPR20 is a key regulator of the enteric smooth muscle cell phenotype. **Pathways and functions:** * GPR20 is involved in cell migration by promoting the migration of enteric smooth muscle cells. * It is also involved in cell proliferation by promoting the proliferation of enteric smooth muscle cells. * GPR20 is involved in differentiation by promoting the differentiation of enteric smooth muscle cells into myocytes. **Clinical significance:** * Mutations in GPR20 have been linked to a number of human diseases, including Crohn's disease, ulcerative colitis, and cancer. * This is because GPR20 is a key regulator of the enteric smooth muscle cell phenotype, and mutations in this gene can lead to the development of these diseases. **Additional information:** * The gene encoding GPR20 is located on chromosome 17q21.1. * The protein encoded by GPR20 is a transmembrane protein that is composed of 12 transmembrane domains. * GPR20 is a member of the GPCR family of G protein-coupled receptors. * It is a ligand-gated channel, which means that it opens or closes when a ligand binds to it.

Genular Protein ID: 1378764620

Symbol: GPR20_HUMAN

Name: G-protein coupled receptor 20

UniProtKB Accession Codes:

Q99678 Q17R96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9073069

Title: Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

PubMed ID: 9073069

DOI: 10.1016/s0378-1119(96)00722-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18347022

Title: Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins.

PubMed ID: 18347022

DOI: 10.1074/jbc.m709487200

Sequence Information:

  • Length: 358
  • Mass: 38650
  • Checksum: 5A34126C51BA732C
  • Sequence:
    • MPSVSPAGPS AGAVPNATAV TTVRTNASGL EVPLFHLFAR LDEELHGTFP GLWLALMAVH 
GAIFLAGLVL NGLALYVFCC RTRAKTPSVI YTINLVVTDL LVGLSLPTRF AVYYGARGCL 
RCAFPHVLGY FLNMHCSILF LTCICVDRYL AIVRPEGSRR CRQPACARAV CAFVWLAAGA 
VTLSVLGVTG SRPCCRVFAL TVLEFLLPLL VISVFTGRIM CALSRPGLLH QGRQRRVRAM 
QLLLTVLIIF LVCFTPFHAR QVAVALWPDM PHHTSLVVYH VAVTLSSLNS CMDPIVYCFV 
TSGFQATVRG LFGQHGEREP SSGDVVSMHR SSKGSGRHHI LSAGPHALTQ ALANGPEA

Genular Protein ID: 889771449

Symbol: Q59GP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GP3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 273
  • Mass: 29791
  • Checksum: 8571B8E21E685AB1
  • Sequence:
    • TPSVIYTINL VVTDLLVGLS LPTRFAVYYG ARGCLRCAFP HVLGYFLNMH CSILFLTCIC 
VDRYLAIVRP EGSRRCRQPA CARAVCAFVW LAAGAVTLSV LGVTGSRPCC RVFALTVLEF 
LLPLLVISVF TGRIMCALSR PGLLHQGRQR RVRAMQLLLT VLIIFLVCFT PFHARQVAVA 
LWPDMPHHTS LVVYHVAVTL SSLNSCMDPI VYCFVTSGFQ ATVRGLFGQH GEREPSSGDV 
VSMHRSSKGS GRHHILSAGP HALTQALANG PEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.