Details for: NKIRAS2

Gene ID: 28511

Symbol: NKIRAS2

Ensembl ID: ENSG00000168256

Description: NFKB inhibitor interacting Ras like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.3649
    Cell Significance Index: -18.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.7563
    Cell Significance Index: -16.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.2258
    Cell Significance Index: -20.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.2239
    Cell Significance Index: -17.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.2507
    Cell Significance Index: -20.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.1763
    Cell Significance Index: -20.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.5495
    Cell Significance Index: -17.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.2536
    Cell Significance Index: -20.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7566
    Cell Significance Index: -18.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1925
    Cell Significance Index: -20.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6004
    Cell Significance Index: -14.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4672
    Cell Significance Index: 15.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2639
    Cell Significance Index: 43.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2035
    Cell Significance Index: 1086.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1829
    Cell Significance Index: 24.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1172
    Cell Significance Index: 8.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9860
    Cell Significance Index: 107.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8894
    Cell Significance Index: 12.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7855
    Cell Significance Index: 127.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7633
    Cell Significance Index: 19.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6019
    Cell Significance Index: 38.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5373
    Cell Significance Index: 9.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5345
    Cell Significance Index: 33.6900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4927
    Cell Significance Index: 6.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4633
    Cell Significance Index: 63.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4541
    Cell Significance Index: 23.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4103
    Cell Significance Index: 224.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3858
    Cell Significance Index: 10.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3807
    Cell Significance Index: 10.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3704
    Cell Significance Index: 73.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3643
    Cell Significance Index: 3.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3397
    Cell Significance Index: 23.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3368
    Cell Significance Index: 17.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3009
    Cell Significance Index: 29.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2910
    Cell Significance Index: 35.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2620
    Cell Significance Index: 7.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2518
    Cell Significance Index: 45.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2384
    Cell Significance Index: 28.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2281
    Cell Significance Index: 10.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2219
    Cell Significance Index: 28.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2098
    Cell Significance Index: 9.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2087
    Cell Significance Index: 9.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1971
    Cell Significance Index: 87.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1844
    Cell Significance Index: 13.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1796
    Cell Significance Index: 4.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1749
    Cell Significance Index: 3.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1653
    Cell Significance Index: 33.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1540
    Cell Significance Index: 1.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1529
    Cell Significance Index: 19.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1414
    Cell Significance Index: 26.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0905
    Cell Significance Index: 6.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0711
    Cell Significance Index: 12.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0546
    Cell Significance Index: 19.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0498
    Cell Significance Index: 1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0446
    Cell Significance Index: 2.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0373
    Cell Significance Index: 0.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0155
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0155
    Cell Significance Index: 1.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0045
    Cell Significance Index: 0.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0072
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0102
    Cell Significance Index: -18.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0134
    Cell Significance Index: -1.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0204
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0236
    Cell Significance Index: -2.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0346
    Cell Significance Index: -15.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0396
    Cell Significance Index: -8.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0510
    Cell Significance Index: -1.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0513
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0569
    Cell Significance Index: -1.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0623
    Cell Significance Index: -1.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0658
    Cell Significance Index: -4.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0728
    Cell Significance Index: -20.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0867
    Cell Significance Index: -10.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0886
    Cell Significance Index: -12.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1329
    Cell Significance Index: -7.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1357
    Cell Significance Index: -10.4200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1484
    Cell Significance Index: -4.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1869
    Cell Significance Index: -12.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1924
    Cell Significance Index: -20.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1958
    Cell Significance Index: -3.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2008
    Cell Significance Index: -15.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2202
    Cell Significance Index: -2.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2212
    Cell Significance Index: -3.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2388
    Cell Significance Index: -5.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2599
    Cell Significance Index: -3.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2679
    Cell Significance Index: -5.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2820
    Cell Significance Index: -17.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2940
    Cell Significance Index: -8.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3624
    Cell Significance Index: -16.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4067
    Cell Significance Index: -6.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Inhibitory function**: NKIRAS2 acts as an inhibitor of NF-κB, a transcription factor involved in immune responses, inflammation, and cellular development. 2. **Ras-like protein**: NKIRAS2 belongs to the Ras-like protein family, which plays a critical role in cellular signaling pathways. 3. **GTPase activity**: NKIRAS2 possesses GTPase activity, which is essential for regulating its function in cellular signaling pathways. 4. **Cellular localization**: NKIRAS2 is primarily localized to the cytosol, where it interacts with NF-κB to regulate its activity. 5. **Signaling pathways**: NKIRAS2 is involved in various signaling pathways, including canonical NF-κB signaling, cytokine signaling, and Toll-like receptor (TLR) signaling. **Pathways and Functions** NKIRAS2 is involved in several signaling pathways, including: 1. **Canonical NF-κB signaling**: NKIRAS2 inhibits the activity of NF-κB, thereby regulating the expression of genes involved in immune responses, inflammation, and cellular homeostasis. 2. **Cytokine signaling**: NKIRAS2 modulates the activity of cytokines, such as IL-1β, which play a crucial role in immune responses and inflammation. 3. **Toll-like receptor signaling**: NKIRAS2 interacts with TLRs, including TLR2, TLR3, TLR4, and TLR9, to regulate the activation of NF-κB and the expression of genes involved in immune responses. 4. **Rip-mediated NF-κB activation**: NKIRAS2 inhibits the activity of RIP, a kinase involved in NF-κB activation, thereby regulating the expression of genes involved in immune responses. 5. **Surfactant homeostasis**: NKIRAS2 plays a role in regulating surfactant homeostasis in the lung alveolus, which is essential for maintaining lung function. **Clinical Significance** 1. **Immune system disorders**: Alterations in NKIRAS2 expression or function may contribute to immune system disorders, such as autoimmune diseases or immunodeficiency. 2. **Inflammation**: Dysregulation of NKIRAS2 may lead to excessive inflammation, which is a hallmark of various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. 3. **Cancer**: NKIRAS2 may play a role in cancer development and progression, particularly in tumors that exhibit altered NF-κB signaling. 4. **Neurological disorders**: NKIRAS2 may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, NKIRAS2 is a critical regulator of immune responses, inflammation, and cellular development. Its dysregulation may contribute to various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 1227152167

Symbol: KBRS2_HUMAN

Name: NF-kappa-B inhibitor-interacting Ras-like protein 2

UniProtKB Accession Codes:

Q9NYR9 A6NCZ5 B3KNN0 B4DNM3 Q6PK52 Q96KC7 Q9NSX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 6 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 6 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10657303

Title: A subclass of Ras proteins that regulate the degradation of IkappaB.

PubMed ID: 10657303

DOI: 10.1126/science.287.5454.869

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 191
  • Mass: 21508
  • Checksum: 27429230DA563342
  • Sequence:
    • MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD RGVREQVRFY 
DTRGLRDGAE LPRHCFSCTD GYVLVYSTDS RESFQRVELL KKEIDKSKDK KEVTIVVLGN 
KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS VADRRSLLEP FVYLASKMTQ PQSKSAFPLS 
RKNKGSGSLD G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.