Details for: TRBV5 7

Gene ID: 28608

Symbol: TRBV5 7

Ensembl ID: ENSG00000211731

Description: T cell receptor beta variable 5-7 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.2028
    Cell Significance Index: 0.5400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0373
    Cell Significance Index: 0.1400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0016
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0070
    Cell Significance Index: -0.0600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0091
    Cell Significance Index: -0.1000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0092
    Cell Significance Index: -0.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0111
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0142
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0216
    Cell Significance Index: -0.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0245
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0278
    Cell Significance Index: -0.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0322
    Cell Significance Index: -0.6300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0329
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0382
    Cell Significance Index: -0.4300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0387
    Cell Significance Index: -0.4600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0402
    Cell Significance Index: -0.4400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0405
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0421
    Cell Significance Index: -0.4300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0450
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0465
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0487
    Cell Significance Index: -0.4500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0498
    Cell Significance Index: -0.4300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0515
    Cell Significance Index: -0.5200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0530
    Cell Significance Index: -0.6100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0530
    Cell Significance Index: -0.6100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0545
    Cell Significance Index: -0.5800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0546
    Cell Significance Index: -0.5500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0550
    Cell Significance Index: -0.4300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0556
    Cell Significance Index: -0.4500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0557
    Cell Significance Index: -0.4700
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.0557
    Cell Significance Index: -0.4200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0560
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0569
    Cell Significance Index: -0.5900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0570
    Cell Significance Index: -0.4900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0572
    Cell Significance Index: -0.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0575
    Cell Significance Index: -0.6200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0582
    Cell Significance Index: -0.4000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0582
    Cell Significance Index: -0.6500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0583
    Cell Significance Index: -0.6400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0585
    Cell Significance Index: -0.6200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0589
    Cell Significance Index: -0.6200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0595
    Cell Significance Index: -0.5200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0600
    Cell Significance Index: -0.6500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0603
    Cell Significance Index: -0.6200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0611
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0613
    Cell Significance Index: -0.2100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0621
    Cell Significance Index: -0.6300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0631
    Cell Significance Index: -0.7800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0658
    Cell Significance Index: -0.5500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0680
    Cell Significance Index: -0.5800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0694
    Cell Significance Index: -0.5600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0698
    Cell Significance Index: -0.6500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0702
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0704
    Cell Significance Index: -0.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0737
    Cell Significance Index: -0.7500
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0760
    Cell Significance Index: -0.6200
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0768
    Cell Significance Index: -0.6300
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: -0.0843
    Cell Significance Index: -0.4300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0860
    Cell Significance Index: -0.6400
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.0909
    Cell Significance Index: -0.6300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0930
    Cell Significance Index: -0.8400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1009
    Cell Significance Index: -0.5400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1066
    Cell Significance Index: -0.8100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1086
    Cell Significance Index: -1.2800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1145
    Cell Significance Index: -1.0500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1151
    Cell Significance Index: -1.1900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1707
    Cell Significance Index: -1.5600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1903
    Cell Significance Index: -0.5800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.2422
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional nature:** The TRBV5-7 gene is devoid of a functional coding sequence, implying that it does not encode a protein that can interact with other molecules to mediate immune responses. 2. **Significant expression across T cell subsets:** The gene is expressed in various T cell subsets, including effector, central memory, naive, and gamma-delta T cells, indicating its potential role in regulating or compensating for immune responses. 3. **Adaptive immune response pathways:** The TRBV5-7 gene is involved in adaptive immune response pathways, specifically in cell surface receptor signaling and the T cell receptor complex. **Pathways and Functions:** 1. **Adaptive immune response:** The TRBV5-7 gene is part of the adaptive immune response, which involves the activation of immune cells, such as T cells, to recognize and eliminate pathogens. 2. **Cell surface receptor signaling:** The gene is involved in cell surface receptor signaling pathways, which are critical for the activation and function of T cells. 3. **T cell receptor complex:** The TRBV5-7 gene is part of the T cell receptor complex, which recognizes and binds to antigens presented by MHC molecules on antigen-presenting cells. 4. **Regulatory and compensatory functions:** The limited function of the TRBV5-7 gene may suggest that it has regulatory or compensatory roles in the immune response, potentially modulating the activity of other T cell receptors or signaling pathways. **Clinical Significance:** 1. **Immunodysregulation:** The TRBV5-7 gene's limited function and significant expression across T cell subsets may contribute to immunodysregulation, leading to impaired immune responses or increased susceptibility to infections. 2. **Autoimmune diseases:** The gene's involvement in adaptive immune response pathways and cell surface receptor signaling may also contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. 3. **Cancer immunotherapy:** The TRBV5-7 gene's expression in T cells may also have implications for cancer immunotherapy, as it could influence the activity of T cells in recognizing and eliminating cancer cells. In conclusion, the TRBV5-7 gene is a non-functional component of the adaptive immune system, with significant expression across various T cell subsets. Its limited function and involvement in adaptive immune response pathways and cell surface receptor signaling suggest that it may have regulatory or compensatory roles in the immune response. Further research is needed to fully understand the clinical significance of the TRBV5-7 gene and its implications for immunodysregulation, autoimmune diseases, and cancer immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.