Details for: TRBJ2 5

Gene ID: 28624

Symbol: TRBJ2 5

Ensembl ID: ENSG00000211769

Description: T cell receptor beta joining 2-5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6617
    Cell Significance Index: 40.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4425
    Cell Significance Index: 6.4500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3825
    Cell Significance Index: 5.0200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1137
    Cell Significance Index: 0.6200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0716
    Cell Significance Index: 0.9000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0508
    Cell Significance Index: 0.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0054
    Cell Significance Index: -0.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0100
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0118
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0136
    Cell Significance Index: -0.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0184
    Cell Significance Index: -0.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0200
    Cell Significance Index: -0.5100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0204
    Cell Significance Index: -0.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0239
    Cell Significance Index: -0.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0260
    Cell Significance Index: -0.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0260
    Cell Significance Index: -0.5200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0330
    Cell Significance Index: -0.3100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0336
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0346
    Cell Significance Index: -0.3500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0352
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0363
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0365
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0383
    Cell Significance Index: -0.5000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0406
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0414
    Cell Significance Index: -0.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0421
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0424
    Cell Significance Index: -0.4100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0427
    Cell Significance Index: -0.3600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0429
    Cell Significance Index: -0.4400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0431
    Cell Significance Index: -0.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0437
    Cell Significance Index: -0.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0439
    Cell Significance Index: -0.4900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0442
    Cell Significance Index: -0.4500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0452
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0460
    Cell Significance Index: -0.4300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0461
    Cell Significance Index: -0.4900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0463
    Cell Significance Index: -0.3800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0464
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0465
    Cell Significance Index: -0.5100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0471
    Cell Significance Index: -0.3900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0472
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0474
    Cell Significance Index: -0.5000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0475
    Cell Significance Index: -0.5000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0490
    Cell Significance Index: -0.5200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0496
    Cell Significance Index: -0.5100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0497
    Cell Significance Index: -0.4600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0501
    Cell Significance Index: -0.4700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0511
    Cell Significance Index: -0.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0529
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0537
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0562
    Cell Significance Index: -0.4600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0569
    Cell Significance Index: -0.5300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0574
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0574
    Cell Significance Index: -0.5300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0583
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0594
    Cell Significance Index: -0.4900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0595
    Cell Significance Index: -0.5300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0604
    Cell Significance Index: -0.4700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0605
    Cell Significance Index: -0.5200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0618
    Cell Significance Index: -0.4300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0629
    Cell Significance Index: -0.5200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0651
    Cell Significance Index: -0.5700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0663
    Cell Significance Index: -0.5300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0677
    Cell Significance Index: -0.4700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0685
    Cell Significance Index: -0.5100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0925
    Cell Significance Index: -0.5000
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.1476
    Cell Significance Index: -0.3800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1509
    Cell Significance Index: -0.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBJ2-5 gene is a member of the TCR beta chain family, which consists of genes that encode the beta subunits of the TCR complex. These genes are responsible for generating the diversity of the TCR repertoire, allowing T cells to recognize a wide range of antigens. The TRBJ2-5 gene is specifically involved in the joining of the TCR beta chain with the TCR alpha chain, resulting in the formation of a functional TCR complex. This gene is part of the larger TRB family, which includes 30-40 genes that encode the beta chain subunits. **Pathways and Functions:** The TRBJ2-5 gene is integral to the adaptive immune response, which is mediated by T cells. The TCR complex recognizes antigens presented by major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells. Upon recognition, the TCR complex triggers a signaling cascade that activates T cells, leading to their proliferation, differentiation, and effector functions. The TRBJ2-5 gene is highly expressed in various immune cells, including CD4+ and CD8+ T cells, B cells, natural killer cells, and thymocytes. This suggests that TRBJ2-5 plays a critical role in the development, maturation, and function of these immune cells. **Clinical Significance:** Dysregulation of the TRBJ2-5 gene has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, alterations in the TRBJ2-5 gene have been associated with the development of multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. Additionally, TRBJ2-5 has been shown to play a role in the regulation of immune responses in cancer, where it may contribute to the development of tumor-infiltrating T cells. In conclusion, the TRBJ2-5 gene is a crucial component of the TCR complex, playing a pivotal role in the regulation of immune responses. Its dysregulation has been implicated in various immune-related disorders, highlighting its importance in the development of therapeutic strategies aimed at modulating the adaptive immune system. Further research is needed to fully elucidate the mechanisms by which TRBJ2-5 regulates immune responses and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.