Details for: GRB14

Gene ID: 2888

Symbol: GRB14

Ensembl ID: ENSG00000115290

Description: growth factor receptor bound protein 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.3883
    Cell Significance Index: -10.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.1184
    Cell Significance Index: -11.5700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 5.9189
    Cell Significance Index: 4.2300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.6435
    Cell Significance Index: 17.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1024
    Cell Significance Index: 109.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.8388
    Cell Significance Index: 47.8200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.9295
    Cell Significance Index: 4.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7631
    Cell Significance Index: 349.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6341
    Cell Significance Index: 35.7800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.8978
    Cell Significance Index: 5.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8830
    Cell Significance Index: 7.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7420
    Cell Significance Index: 19.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7297
    Cell Significance Index: 72.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6656
    Cell Significance Index: 51.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5538
    Cell Significance Index: 111.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5015
    Cell Significance Index: 26.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4430
    Cell Significance Index: 400.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.4372
    Cell Significance Index: 45.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4100
    Cell Significance Index: 11.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3754
    Cell Significance Index: 61.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3689
    Cell Significance Index: 40.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3285
    Cell Significance Index: 117.8200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3266
    Cell Significance Index: 1.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3148
    Cell Significance Index: 217.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3078
    Cell Significance Index: 18.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2888
    Cell Significance Index: 33.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2528
    Cell Significance Index: 7.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2180
    Cell Significance Index: 41.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1875
    Cell Significance Index: 5.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1565
    Cell Significance Index: 2.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1506
    Cell Significance Index: 10.4200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1324
    Cell Significance Index: 1.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1212
    Cell Significance Index: 55.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0850
    Cell Significance Index: 2.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0632
    Cell Significance Index: 1.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0612
    Cell Significance Index: 2.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0444
    Cell Significance Index: 24.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0387
    Cell Significance Index: 1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0354
    Cell Significance Index: 25.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0342
    Cell Significance Index: 64.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0256
    Cell Significance Index: 4.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0235
    Cell Significance Index: 0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0207
    Cell Significance Index: 13.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0192
    Cell Significance Index: 0.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0183
    Cell Significance Index: 3.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0147
    Cell Significance Index: 0.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0088
    Cell Significance Index: 0.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0048
    Cell Significance Index: 0.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0034
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.2400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0127
    Cell Significance Index: -7.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0132
    Cell Significance Index: -0.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0148
    Cell Significance Index: -0.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0155
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0182
    Cell Significance Index: -11.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0183
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0207
    Cell Significance Index: -3.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0262
    Cell Significance Index: -3.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0268
    Cell Significance Index: -1.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0285
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0330
    Cell Significance Index: -3.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0390
    Cell Significance Index: -3.9800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0408
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0438
    Cell Significance Index: -6.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0517
    Cell Significance Index: -0.3500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0537
    Cell Significance Index: -2.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0576
    Cell Significance Index: -3.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0649
    Cell Significance Index: -4.0900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0704
    Cell Significance Index: -0.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0754
    Cell Significance Index: -9.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0832
    Cell Significance Index: -4.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0946
    Cell Significance Index: -3.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0972
    Cell Significance Index: -7.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1132
    Cell Significance Index: -1.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1161
    Cell Significance Index: -8.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1323
    Cell Significance Index: -1.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1383
    Cell Significance Index: -6.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1473
    Cell Significance Index: -5.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1484
    Cell Significance Index: -11.0600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1525
    Cell Significance Index: -1.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1646
    Cell Significance Index: -2.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1676
    Cell Significance Index: -2.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1768
    Cell Significance Index: -3.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1798
    Cell Significance Index: -9.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1816
    Cell Significance Index: -8.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1830
    Cell Significance Index: -4.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1838
    Cell Significance Index: -3.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1876
    Cell Significance Index: -4.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1895
    Cell Significance Index: -5.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1897
    Cell Significance Index: -12.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2062
    Cell Significance Index: -2.9700
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.2117
    Cell Significance Index: -1.6900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2176
    Cell Significance Index: -2.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GRB14 is a protein that functions as a molecular adaptor, binding to various growth factor receptors, including the insulin receptor. Its ability to interact with different signaling pathways underscores its versatility and importance in regulating cellular responses. GRB14's expression in multiple cell types, including hematopoietic stem cells and renal cells, highlights its widespread involvement in tissue development and maintenance. **Pathways and Functions:** GRB14's involvement in insulin receptor signaling pathways is well-documented, with evidence suggesting both positive and negative regulation of this pathway. On one hand, GRB14 can enhance insulin signaling by facilitating the recruitment of key signaling molecules, such as IRS-1 and PI3K. On the other hand, GRB14 can also inhibit insulin signaling by interacting with and inhibiting the activity of key signaling molecules, such as IRS-1 and AKT. Furthermore, GRB14's presence at the vascular wall and hemostatic sites suggests a role in maintaining vascular integrity and preventing thrombosis. In addition to its involvement in insulin receptor signaling, GRB14 has been implicated in other cellular processes, including cell surface interactions, cytoskeletal organization, and signal transduction. Its ability to bind to various growth factor receptors and interact with multiple signaling pathways underscores its importance in regulating cellular responses to changing environmental cues. **Clinical Significance:** Dysregulation of GRB14's insulin receptor signaling activity has been implicated in various metabolic disorders, including type 2 diabetes and insulin resistance. Mutations in the GRB14 gene have been associated with impaired insulin signaling and glucose homeostasis, highlighting the protein's importance in maintaining metabolic balance. Furthermore, GRB14's role in hemostasis and vascular integrity suggests that dysregulation of this protein may contribute to the development of cardiovascular diseases, such as atherosclerosis and thrombosis. Understanding the complex role of GRB14 in regulating insulin receptor signaling and hemostasis may provide insights into the development of novel therapeutic strategies for the treatment of metabolic and cardiovascular disorders. In conclusion, GRB14 is a multifunctional adaptor protein that plays a crucial role in regulating insulin receptor signaling and hemostasis. Its complex role in both positive and negative regulation of insulin receptor signaling pathways highlights its importance in maintaining metabolic balance and vascular integrity. Further research into the mechanisms underlying GRB14's function and dysregulation may provide valuable insights into the development of novel therapeutic strategies for the treatment of metabolic and cardiovascular disorders.

Genular Protein ID: 2979005188

Symbol: GRB14_HUMAN

Name: Growth factor receptor-bound protein 14

UniProtKB Accession Codes:

Q14449 B7Z7F9 Q7Z6I1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8647858

Title: Cloning and characterization of GRB14, a novel member of the GRB7 gene family.

PubMed ID: 8647858

DOI: 10.1074/jbc.271.21.12502

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11726652

Title: Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

PubMed ID: 11726652

DOI: 10.1074/jbc.m106574200

PubMed ID: 15210700

Title: The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

PubMed ID: 15210700

DOI: 10.1074/jbc.m405340200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19648926

Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.

PubMed ID: 19648926

DOI: 10.1038/nsmb.1642

PubMed ID: 20973951

Title: Tyrosine phosphorylation of Grb14 by Tie2.

PubMed ID: 20973951

DOI: 10.1186/1478-811x-8-30

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16246733

Title: Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.

PubMed ID: 16246733

DOI: 10.1016/j.molcel.2005.09.001

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

  • Length: 540
  • Mass: 60988
  • Checksum: 00472988650F7C6C
  • Sequence:
    • MTTSLQDGQS AASRAAARDS PLAAQVCGAA QGRGDAHDLA PAPWLHARAL LPLPDGTRGC 
AADRRKKKDL DVPEMPSIPN PFPELCCSPF TSVLSADLFP KANSRKKQVI KVYSEDETSR 
ALDVPSDITA RDVCQLLILK NHYIDDHSWT LFEHLPHIGV ERTIEDHELV IEVLSNWGIE 
EENKLYFRKN YAKYEFFKNP MYFFPEHMVS FATETNGEIS PTQILQMFLS SSTYPEIHGF 
LHAKEQGKKS WKKIYFFLRR SGLYFSTKGT SKEPRHLQFF SEFGNSDIYV SLAGKKKHGA 
PTNYGFCFKP NKAGGPRDLK MLCAEEEQSR TCWVTAIRLL KYGMQLYQNY MHPYQGRSGC 
SSQSISPMRS ISENSLVAMD FSGQKSRVIE NPTEALSVAV EEGLAWRKKG CLRLGTHGSP 
TASSQSSATN MAIHRSQPWF HHKISRDEAQ RLIIQQGLVD GVFLVRDSQS NPKTFVLSMS 
HGQKIKHFQI IPVEDDGEMF HTLDDGHTRF TDLIQLVEFY QLNKGVLPCK LKHYCARIAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.