Details for: GRB14

Gene ID: 2888

Symbol: GRB14

Ensembl ID: ENSG00000115290

Description: growth factor receptor bound protein 14

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.75
    Marker Score: 1973
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.48
    Marker Score: 29452.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.31
    Marker Score: 1744
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.3
    Marker Score: 726
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.23
    Marker Score: 3692
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.86
    Marker Score: 991
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.73
    Marker Score: 9296
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.7
    Marker Score: 1798
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.67
    Marker Score: 10753
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.67
    Marker Score: 1696
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.58
    Marker Score: 868
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.55
    Marker Score: 6707.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.49
    Marker Score: 26523
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168492
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2239
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.44
    Marker Score: 6009
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.38
    Marker Score: 3701
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.35
    Marker Score: 2958
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.21
    Marker Score: 802.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.21
    Marker Score: 876
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9107
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17146
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.05
    Marker Score: 247
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.02
    Marker Score: 429
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2080
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.01
    Marker Score: 366
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.01
    Marker Score: 22480
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1
    Marker Score: 2365
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71793
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48017
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.94
    Marker Score: 566
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.94
    Marker Score: 1015
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5163
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.9
    Marker Score: 965
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.89
    Marker Score: 29933
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.88
    Marker Score: 279
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2065
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.87
    Marker Score: 3074
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 877
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.84
    Marker Score: 315
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.8
    Marker Score: 613
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.77
    Marker Score: 515
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.77
    Marker Score: 7232.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.71
    Marker Score: 2537
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2977
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 465
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.67
    Marker Score: 2603
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.66
    Marker Score: 703
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.65
    Marker Score: 1638
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.64
    Marker Score: 912
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6
    Marker Score: 2312
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.6
    Marker Score: 776
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3489
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.58
    Marker Score: 323
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.58
    Marker Score: 611
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.58
    Marker Score: 529
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.58
    Marker Score: 217
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 256
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.51
    Marker Score: 567
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.51
    Marker Score: 232
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 222
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5
    Marker Score: 4400.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.49
    Marker Score: 18690
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.49
    Marker Score: 834
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 133
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.48
    Marker Score: 596
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.47
    Marker Score: 229
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.46
    Marker Score: 291
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 194
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.45
    Marker Score: 1903
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.45
    Marker Score: 755
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 304
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 142
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 268
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 177
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.43
    Marker Score: 6827
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.42
    Marker Score: 201
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.42
    Marker Score: 397
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.41
    Marker Score: 124
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.41
    Marker Score: 700

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Other Information

**Key characteristics:** * GRB14 is a type I transmembrane receptor that is expressed on the surface of endothelial cells. * It is a key regulator of VEGF signaling, a key pro-angiogenic factor. * It is a key regulator of vascular development and growth. * It is also involved in cell migration, adhesion, and survival. **Pathways and functions:** * GRB14 binds to VEGF on the surface of endothelial cells, initiating a signaling cascade that leads to the activation of the receptor tyrosine kinase (RTK) pathway. * Activation of the RTK pathway downstream of GRB14 leads to phosphorylation of VEGF receptor and inhibition of its interaction with its antagonist, VEGFR2. * This results in the stabilization of VEGF and the activation of pro-angiogenic signaling pathways, leading to the migration, proliferation, and survival of endothelial cells. **Clinical significance:** * Mutations in GRB14 have been linked to several human diseases, including cancer, cardiovascular disease, and diabetes. * Targeting GRB14 signaling has emerged as a promising therapeutic strategy for these diseases. * Drugs that block GRB14 signaling have been shown to be effective in preclinical models of cancer and other diseases. **Additional notes:** * GRB14 is a highly conserved protein with a significant expression in vascular and endothelial cells. * It is a key regulator of the development and maintenance of blood vessels. * It is a potential target for the development of novel therapeutic strategies for vascular diseases.

Genular Protein ID: 2979005188

Symbol: GRB14_HUMAN

Name: Growth factor receptor-bound protein 14

UniProtKB Accession Codes:

Q14449 B7Z7F9 Q7Z6I1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8647858

Title: Cloning and characterization of GRB14, a novel member of the GRB7 gene family.

PubMed ID: 8647858

DOI: 10.1074/jbc.271.21.12502

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11726652

Title: Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

PubMed ID: 11726652

DOI: 10.1074/jbc.m106574200

PubMed ID: 15210700

Title: The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

PubMed ID: 15210700

DOI: 10.1074/jbc.m405340200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19648926

Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.

PubMed ID: 19648926

DOI: 10.1038/nsmb.1642

PubMed ID: 20973951

Title: Tyrosine phosphorylation of Grb14 by Tie2.

PubMed ID: 20973951

DOI: 10.1186/1478-811x-8-30

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16246733

Title: Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.

PubMed ID: 16246733

DOI: 10.1016/j.molcel.2005.09.001

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

  • Length: 540
  • Mass: 60988
  • Checksum: 00472988650F7C6C
  • Sequence:
    • MTTSLQDGQS AASRAAARDS PLAAQVCGAA QGRGDAHDLA PAPWLHARAL LPLPDGTRGC 
AADRRKKKDL DVPEMPSIPN PFPELCCSPF TSVLSADLFP KANSRKKQVI KVYSEDETSR 
ALDVPSDITA RDVCQLLILK NHYIDDHSWT LFEHLPHIGV ERTIEDHELV IEVLSNWGIE 
EENKLYFRKN YAKYEFFKNP MYFFPEHMVS FATETNGEIS PTQILQMFLS SSTYPEIHGF 
LHAKEQGKKS WKKIYFFLRR SGLYFSTKGT SKEPRHLQFF SEFGNSDIYV SLAGKKKHGA 
PTNYGFCFKP NKAGGPRDLK MLCAEEEQSR TCWVTAIRLL KYGMQLYQNY MHPYQGRSGC 
SSQSISPMRS ISENSLVAMD FSGQKSRVIE NPTEALSVAV EEGLAWRKKG CLRLGTHGSP 
TASSQSSATN MAIHRSQPWF HHKISRDEAQ RLIIQQGLVD GVFLVRDSQS NPKTFVLSMS 
HGQKIKHFQI IPVEDDGEMF HTLDDGHTRF TDLIQLVEFY QLNKGVLPCK LKHYCARIAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.