Details for: LAMTOR2

Gene ID: 28956

Symbol: LAMTOR2

Ensembl ID: ENSG00000116586

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 284.7082
    Cell Significance Index: -44.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.8628
    Cell Significance Index: -42.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 135.6483
    Cell Significance Index: -55.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.5826
    Cell Significance Index: -46.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.4875
    Cell Significance Index: -53.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.2471
    Cell Significance Index: -52.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.8781
    Cell Significance Index: -53.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.4793
    Cell Significance Index: -47.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.7452
    Cell Significance Index: -51.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6212
    Cell Significance Index: -53.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5468
    Cell Significance Index: -36.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1506
    Cell Significance Index: -37.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2963
    Cell Significance Index: -13.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.8810
    Cell Significance Index: 631.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0960
    Cell Significance Index: 144.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0111
    Cell Significance Index: 18.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7533
    Cell Significance Index: 51.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6600
    Cell Significance Index: 906.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5061
    Cell Significance Index: 17.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4413
    Cell Significance Index: 33.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3910
    Cell Significance Index: 72.2600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2772
    Cell Significance Index: 7.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1831
    Cell Significance Index: 213.2800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1774
    Cell Significance Index: 9.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1394
    Cell Significance Index: 53.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1362
    Cell Significance Index: 21.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0874
    Cell Significance Index: 70.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0843
    Cell Significance Index: 133.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0599
    Cell Significance Index: 78.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0276
    Cell Significance Index: 121.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8980
    Cell Significance Index: 7.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7030
    Cell Significance Index: 310.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6419
    Cell Significance Index: 16.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6417
    Cell Significance Index: 88.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6188
    Cell Significance Index: 28.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5555
    Cell Significance Index: 71.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5519
    Cell Significance Index: 39.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5455
    Cell Significance Index: 93.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4592
    Cell Significance Index: 59.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1874
    Cell Significance Index: 35.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1835
    Cell Significance Index: 2.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1491
    Cell Significance Index: 3.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1409
    Cell Significance Index: 7.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1395
    Cell Significance Index: 27.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1049
    Cell Significance Index: 5.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1021
    Cell Significance Index: 77.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0768
    Cell Significance Index: 15.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0690
    Cell Significance Index: 6.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0669
    Cell Significance Index: 2.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0324
    Cell Significance Index: 23.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0255
    Cell Significance Index: 0.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0112
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0098
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0146
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0151
    Cell Significance Index: -9.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0213
    Cell Significance Index: -40.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0254
    Cell Significance Index: -0.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0257
    Cell Significance Index: -9.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0288
    Cell Significance Index: -19.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0330
    Cell Significance Index: -60.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0418
    Cell Significance Index: -64.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0434
    Cell Significance Index: -1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0491
    Cell Significance Index: -66.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0676
    Cell Significance Index: -42.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0685
    Cell Significance Index: -38.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1067
    Cell Significance Index: -12.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1124
    Cell Significance Index: -51.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1249
    Cell Significance Index: -14.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1256
    Cell Significance Index: -36.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1398
    Cell Significance Index: -29.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1420
    Cell Significance Index: -8.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1574
    Cell Significance Index: -4.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2010
    Cell Significance Index: -4.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2770
    Cell Significance Index: -7.7400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3200
    Cell Significance Index: -3.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3263
    Cell Significance Index: -7.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3319
    Cell Significance Index: -48.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3574
    Cell Significance Index: -28.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4280
    Cell Significance Index: -26.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4486
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4503
    Cell Significance Index: -51.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5117
    Cell Significance Index: -53.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5371
    Cell Significance Index: -3.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5731
    Cell Significance Index: -16.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6170
    Cell Significance Index: -16.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6517
    Cell Significance Index: -50.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6849
    Cell Significance Index: -7.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6912
    Cell Significance Index: -12.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7408
    Cell Significance Index: -49.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7599
    Cell Significance Index: -42.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8637
    Cell Significance Index: -9.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8647
    Cell Significance Index: -53.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9430
    Cell Significance Index: -25.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9849
    Cell Significance Index: -13.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0545
    Cell Significance Index: -12.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0801
    Cell Significance Index: -27.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.0878
    Cell Significance Index: -8.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0961
    Cell Significance Index: -31.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1472
    Cell Significance Index: -50.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LAMTOR2 is characterized by its ability to interact with a wide range of proteins and signaling pathways, including: 1. **MAPK and MTOR signaling**: LAMTOR2 is a key activator of the MAPK and MTOR signaling cascades, which are crucial for regulating cell growth, proliferation, and survival. 2. **Autophagy**: LAMTOR2 is involved in the regulation of autophagy, a cellular process that involves the degradation and recycling of cellular components. 3. **Immune system**: LAMTOR2 is predominantly expressed in cells of the immune system, where it plays a critical role in regulating immune responses to pathogens and stress. 4. **Cellular stress response**: LAMTOR2 is involved in the regulation of cellular responses to stress, including endoplasmic reticulum stress and nutrient deprivation. **Pathways and Functions** LAMTOR2 is involved in several signaling pathways, including: 1. **Amino acids regulate mTORc1**: LAMTOR2 interacts with amino acid sensors to regulate mTORc1 signaling, which is critical for regulating cell growth and metabolism. 2. **Autophagy**: LAMTOR2 is involved in the regulation of autophagy, which is essential for maintaining cellular homeostasis and responding to stress. 3. **Cellular responses to stimuli**: LAMTOR2 modulates cellular responses to various stimuli, including pathogens, stress, and nutrient availability. 4. **Immune system**: LAMTOR2 plays a critical role in regulating immune responses to pathogens and stress. **Clinical Significance** Dysregulation of LAMTOR2 has been implicated in various diseases, including: 1. **Cancer**: LAMTOR2 is overexpressed in certain types of cancer, including breast and lung cancer, where it promotes cell growth and metastasis. 2. **Autoimmune diseases**: LAMTOR2 is involved in the regulation of immune responses to pathogens and stress, and dysregulation of LAMTOR2 has been implicated in autoimmune diseases such as rheumatoid arthritis and lupus. 3. **Metabolic disorders**: LAMTOR2 is involved in the regulation of cellular metabolism, and dysregulation of LAMTOR2 has been implicated in metabolic disorders such as type 2 diabetes and obesity. In conclusion, LAMTOR2 is a multifunctional gene that plays a critical role in regulating various cellular processes, including autophagy, cell growth, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of LAMTOR2 and its potential therapeutic applications.

Genular Protein ID: 2940152293

Symbol: LTOR2_HUMAN

Name: Endosomal adaptor protein p14

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 17195838

Title: A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.

PubMed ID: 17195838

DOI: 10.1038/nm1528

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 30181260

Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

PubMed ID: 30181260

DOI: 10.1073/pnas.1811727115

PubMed ID: 29285400

Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.

PubMed ID: 29285400

DOI: 10.1038/celldisc.2017.49

PubMed ID: 29123114

Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.

PubMed ID: 29123114

DOI: 10.1038/s41467-017-01567-4

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 29107538

Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

PubMed ID: 29107538

DOI: 10.1016/j.molcel.2017.10.016

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

  • Length: 125
  • Mass: 13508
  • Checksum: 69599211C2CBC03D
  • Sequence:
  • MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWAAYDRNG 
    NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAQA LVQYLEEPLT 
    QVAAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.