Details for: LAMTOR2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 284.7082
Cell Significance Index: -44.2900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 165.8628
Cell Significance Index: -42.0700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 135.6483
Cell Significance Index: -55.8800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 114.5826
Cell Significance Index: -46.5500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 113.4875
Cell Significance Index: -53.5800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.2471
Cell Significance Index: -52.0800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 79.8781
Cell Significance Index: -53.6000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 49.4793
Cell Significance Index: -47.2400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.7452
Cell Significance Index: -51.4700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.6212
Cell Significance Index: -53.7500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.5468
Cell Significance Index: -36.2900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.1506
Cell Significance Index: -37.3200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.2963
Cell Significance Index: -13.7800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.8810
Cell Significance Index: 631.2100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.0960
Cell Significance Index: 144.3500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.0111
Cell Significance Index: 18.5200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.7533
Cell Significance Index: 51.4900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.6600
Cell Significance Index: 906.5500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.5061
Cell Significance Index: 17.1100 - Cell Name: peg cell (CL4033014)
Fold Change: 1.4413
Cell Significance Index: 33.3000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.3910
Cell Significance Index: 72.2600 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.2772
Cell Significance Index: 7.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1831
Cell Significance Index: 213.2800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.1774
Cell Significance Index: 9.8900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1394
Cell Significance Index: 53.5500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.1362
Cell Significance Index: 21.0000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0874
Cell Significance Index: 70.1600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0843
Cell Significance Index: 133.3300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.0599
Cell Significance Index: 78.9900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0276
Cell Significance Index: 121.1900 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.8980
Cell Significance Index: 7.1700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7030
Cell Significance Index: 310.8100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.6419
Cell Significance Index: 16.8800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6417
Cell Significance Index: 88.1300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6188
Cell Significance Index: 28.0500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5555
Cell Significance Index: 71.2100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5519
Cell Significance Index: 39.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5455
Cell Significance Index: 93.1400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4592
Cell Significance Index: 59.3200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1874
Cell Significance Index: 35.6700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1835
Cell Significance Index: 2.7500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1491
Cell Significance Index: 3.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1409
Cell Significance Index: 7.3400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1395
Cell Significance Index: 27.6900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1049
Cell Significance Index: 5.5100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1021
Cell Significance Index: 77.2700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0768
Cell Significance Index: 15.4100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0690
Cell Significance Index: 6.8300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0669
Cell Significance Index: 2.3500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0324
Cell Significance Index: 23.7400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0255
Cell Significance Index: 0.6800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0112
Cell Significance Index: 0.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0059
Cell Significance Index: -4.3600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0098
Cell Significance Index: -1.0000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0146
Cell Significance Index: -0.2500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0151
Cell Significance Index: -9.4200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0213
Cell Significance Index: -40.0800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0254
Cell Significance Index: -0.8200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0257
Cell Significance Index: -9.2200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0288
Cell Significance Index: -19.9500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0330
Cell Significance Index: -60.8900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0418
Cell Significance Index: -64.3400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0434
Cell Significance Index: -1.1800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0491
Cell Significance Index: -66.7900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0676
Cell Significance Index: -42.9300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0685
Cell Significance Index: -38.6100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1067
Cell Significance Index: -12.2200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1124
Cell Significance Index: -51.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1249
Cell Significance Index: -14.5500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1256
Cell Significance Index: -36.1300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1398
Cell Significance Index: -29.4500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1420
Cell Significance Index: -8.9500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1574
Cell Significance Index: -4.0200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2010
Cell Significance Index: -4.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2770
Cell Significance Index: -7.7400 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.3200
Cell Significance Index: -3.4000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3263
Cell Significance Index: -7.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3319
Cell Significance Index: -48.2500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3574
Cell Significance Index: -28.3100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4280
Cell Significance Index: -26.3100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4486
Cell Significance Index: -6.1200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4503
Cell Significance Index: -51.4100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5117
Cell Significance Index: -53.2800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5371
Cell Significance Index: -3.2500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5731
Cell Significance Index: -16.8800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6170
Cell Significance Index: -16.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6517
Cell Significance Index: -50.0100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6849
Cell Significance Index: -7.0900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6912
Cell Significance Index: -12.2200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7408
Cell Significance Index: -49.8100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7599
Cell Significance Index: -42.6400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.8637
Cell Significance Index: -9.3900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8647
Cell Significance Index: -53.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9430
Cell Significance Index: -25.2700 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.9849
Cell Significance Index: -13.8100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.0545
Cell Significance Index: -12.5700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.0801
Cell Significance Index: -27.0000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.0878
Cell Significance Index: -8.8700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0961
Cell Significance Index: -31.4200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.1472
Cell Significance Index: -50.7500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2940152293
Symbol: LTOR2_HUMAN
Name: Endosomal adaptor protein p14
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17897319
Title: Integral and associated lysosomal membrane proteins.
PubMed ID: 17897319
PubMed ID: 17195838
Title: A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
PubMed ID: 17195838
DOI: 10.1038/nm1528
PubMed ID: 20381137
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
PubMed ID: 20381137
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22980980
Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.
PubMed ID: 22980980
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25561175
Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
PubMed ID: 25561175
DOI: 10.1038/nature14107
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 25567906
Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
PubMed ID: 25567906
PubMed ID: 30181260
Title: Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
PubMed ID: 30181260
PubMed ID: 29285400
Title: Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.
PubMed ID: 29285400
PubMed ID: 29123114
Title: Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
PubMed ID: 29123114
PubMed ID: 29158492
Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.
PubMed ID: 29158492
PubMed ID: 29107538
Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
PubMed ID: 29107538
PubMed ID: 28935770
Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
PubMed ID: 28935770
PubMed ID: 31704029
Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.
PubMed ID: 31704029
PubMed ID: 31601708
Title: Structural basis for the docking of mTORC1 on the lysosomal surface.
PubMed ID: 31601708
PubMed ID: 31672913
Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
PubMed ID: 31672913
PubMed ID: 32868926
Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
PubMed ID: 32868926
PubMed ID: 35338845
Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
PubMed ID: 35338845
PubMed ID: 36103527
Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.
PubMed ID: 36103527
PubMed ID: 36697823
Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
PubMed ID: 36697823
Sequence Information:
- Length: 125
- Mass: 13508
- Checksum: 69599211C2CBC03D
- Sequence:
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWAAYDRNG NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAQA LVQYLEEPLT QVAAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.