Details for: BZW2

Gene ID: 28969

Symbol: BZW2

Ensembl ID: ENSG00000136261

Description: basic leucine zipper and W2 domains 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 254.8455
    Cell Significance Index: -39.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 101.7241
    Cell Significance Index: -41.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.4286
    Cell Significance Index: -46.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.0404
    Cell Significance Index: -24.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.8476
    Cell Significance Index: -37.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.4698
    Cell Significance Index: -43.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.6756
    Cell Significance Index: -37.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.2973
    Cell Significance Index: -43.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4543
    Cell Significance Index: -41.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3455
    Cell Significance Index: -44.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 8.5048
    Cell Significance Index: 227.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8120
    Cell Significance Index: -12.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.0226
    Cell Significance Index: 585.3300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.7682
    Cell Significance Index: 17.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7364
    Cell Significance Index: 142.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2602
    Cell Significance Index: 60.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9248
    Cell Significance Index: 147.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7462
    Cell Significance Index: 36.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7008
    Cell Significance Index: 18.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6623
    Cell Significance Index: 22.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6428
    Cell Significance Index: 329.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5246
    Cell Significance Index: 247.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4461
    Cell Significance Index: 91.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3517
    Cell Significance Index: 87.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2612
    Cell Significance Index: 34.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0696
    Cell Significance Index: 9.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0377
    Cell Significance Index: 187.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0149
    Cell Significance Index: 47.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9776
    Cell Significance Index: 69.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9208
    Cell Significance Index: 113.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8782
    Cell Significance Index: 479.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8053
    Cell Significance Index: 104.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7973
    Cell Significance Index: 352.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7584
    Cell Significance Index: 150.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.6699
    Cell Significance Index: 9.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6601
    Cell Significance Index: 29.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6366
    Cell Significance Index: 13.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6308
    Cell Significance Index: 47.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6236
    Cell Significance Index: 23.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6138
    Cell Significance Index: 37.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5911
    Cell Significance Index: 26.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5525
    Cell Significance Index: 11.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5446
    Cell Significance Index: 15.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5342
    Cell Significance Index: 191.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4804
    Cell Significance Index: 33.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4702
    Cell Significance Index: 16.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4447
    Cell Significance Index: 61.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3389
    Cell Significance Index: 8.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3103
    Cell Significance Index: 8.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2989
    Cell Significance Index: 35.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2818
    Cell Significance Index: 4.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2794
    Cell Significance Index: 193.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2394
    Cell Significance Index: 2.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2008
    Cell Significance Index: 91.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1769
    Cell Significance Index: 2.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1647
    Cell Significance Index: 5.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1120
    Cell Significance Index: 1.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1050
    Cell Significance Index: 5.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0920
    Cell Significance Index: 9.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0919
    Cell Significance Index: 4.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0883
    Cell Significance Index: 16.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0667
    Cell Significance Index: 1.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0413
    Cell Significance Index: 2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0290
    Cell Significance Index: 53.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0266
    Cell Significance Index: 0.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0213
    Cell Significance Index: 1.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0181
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0059
    Cell Significance Index: 1.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0096
    Cell Significance Index: -14.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0187
    Cell Significance Index: -13.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0207
    Cell Significance Index: -13.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0311
    Cell Significance Index: -42.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0403
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0565
    Cell Significance Index: -41.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0579
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0736
    Cell Significance Index: -41.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0818
    Cell Significance Index: -51.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0822
    Cell Significance Index: -0.9800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0882
    Cell Significance Index: -0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0956
    Cell Significance Index: -9.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1037
    Cell Significance Index: -3.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1296
    Cell Significance Index: -37.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1510
    Cell Significance Index: -21.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2147
    Cell Significance Index: -5.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2396
    Cell Significance Index: -50.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2688
    Cell Significance Index: -4.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2794
    Cell Significance Index: -6.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3023
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3388
    Cell Significance Index: -38.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3603
    Cell Significance Index: -37.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3996
    Cell Significance Index: -9.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4357
    Cell Significance Index: -34.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4514
    Cell Significance Index: -12.9400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4704
    Cell Significance Index: -3.0600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4864
    Cell Significance Index: -4.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5124
    Cell Significance Index: -13.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6184
    Cell Significance Index: -32.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6303
    Cell Significance Index: -5.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BZW2 is a gene that encodes a protein containing a basic leucine zipper (bZIP) and W2 domains. These domains are crucial for protein-protein interactions, which play a pivotal role in regulating various cellular processes. The expression of BZW2 is observed in a wide range of cell types, including cardiac myocytes, neural crest cells, and hematopoietic stem cells. This diverse expression pattern suggests that BZW2 may play a multifaceted role in maintaining tissue homeostasis and immune function. **Pathways and Functions:** BZW2 is involved in several key pathways, including: 1. **Cadherin binding**: BZW2 interacts with cadherins, which are cell adhesion molecules that regulate cell-cell interactions. This interaction is essential for maintaining tissue structure and organization. 2. **Cytoplasm and membrane**: BZW2 is localized to the cytoplasm and membrane, where it regulates protein-protein interactions and signaling pathways. 3. **Protein binding**: BZW2 binds to various proteins, including transcription factors, which modulate gene expression and cellular differentiation. 4. **Regulation of translational initiation**: BZW2 regulates the translation of specific mRNAs, influencing protein synthesis and cellular processes. **Clinical Significance:** BZW2 has been implicated in various diseases, including: 1. **Cardiovascular diseases**: BZW2 expression is altered in cardiac myocytes, suggesting a potential role in myocardial function and disease. 2. **Cancer**: BZW2 is overexpressed in various types of cancer, including neuroblastoma and leukemia, indicating a potential role in tumorigenesis. 3. **Immunological disorders**: BZW2 is expressed in hematopoietic stem cells, suggesting a potential role in immune function and disorders, such as autoimmune diseases. In conclusion, BZW2 is a multifunctional gene that plays a crucial role in regulating cellular processes, including cell adhesion, protein-protein interactions, and gene expression. Its diverse expression pattern and involvement in various diseases highlight the importance of BZW2 in maintaining tissue homeostasis and immune function. Further research is necessary to fully elucidate the immunological significance of BZW2 and its potential therapeutic applications. **Recommendations:** 1. **Further investigation**: Elucidate the specific mechanisms by which BZW2 regulates cellular processes and disease progression. 2. **Therapeutic targeting**: Explore the potential of BZW2 as a therapeutic target for various diseases, including cardiovascular and immunological disorders. 3. **Functional analysis**: Conduct in vitro and in vivo studies to investigate the role of BZW2 in maintaining tissue homeostasis and immune function. By exploring the immunological significance of BZW2, we can gain a deeper understanding of its role in regulating cellular processes and developing novel therapeutic strategies for various diseases.

Genular Protein ID: 894332688

Symbol: 5MP1_HUMAN

Name: Basic leucine zipper and W2 domain-containing protein 2

UniProtKB Accession Codes:

Q9Y6E2 A4D123 Q3B779 Q96JW5 Q9H3F7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21745818

Title: Mechanisms of translational regulation by a human eIF5-mimic protein.

PubMed ID: 21745818

DOI: 10.1093/nar/gkr339

PubMed ID: 25147208

Title: Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.

PubMed ID: 25147208

DOI: 10.1093/nar/gku670

PubMed ID: 28981728

Title: Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.

PubMed ID: 28981728

DOI: 10.1093/nar/gkx808

PubMed ID: 29470543

Title: Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.

PubMed ID: 29470543

DOI: 10.1371/journal.pone.0192648

PubMed ID: 34260931

Title: Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.

PubMed ID: 34260931

DOI: 10.1016/j.celrep.2021.109376

Sequence Information:

  • Length: 419
  • Mass: 48162
  • Checksum: 7ABFE7A51501E721
  • Sequence:
    • MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK FLDSTGSRLD 
YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS ANEDHETIRN YAQVFNKLIR 
RYKYLEKAFE DEMKKLLLFL KAFSETEQTK LAMLSGILLG NGTLPATILT SLFTDSLVKE 
GIAASFAVKL FKAWMAEKDA NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK 
ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC 
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC YDNIHFMKAF 
QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK FVEWLQNAEE ESESEGEEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.