Details for: IFT81

Gene ID: 28981

Symbol: IFT81

Ensembl ID: ENSG00000122970

Description: intraflagellar transport 81

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.7768
    Cell Significance Index: -33.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 128.3692
    Cell Significance Index: -32.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.8494
    Cell Significance Index: -32.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.5572
    Cell Significance Index: -26.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.5395
    Cell Significance Index: -33.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6416
    Cell Significance Index: -34.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5287
    Cell Significance Index: -12.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2801
    Cell Significance Index: 36.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5338
    Cell Significance Index: 96.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2481
    Cell Significance Index: 250.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1054
    Cell Significance Index: 179.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0865
    Cell Significance Index: 60.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9402
    Cell Significance Index: 848.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9308
    Cell Significance Index: 57.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8974
    Cell Significance Index: 178.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5867
    Cell Significance Index: 63.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5278
    Cell Significance Index: 288.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5224
    Cell Significance Index: 187.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5129
    Cell Significance Index: 12.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4962
    Cell Significance Index: 38.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4773
    Cell Significance Index: 5.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4684
    Cell Significance Index: 64.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4296
    Cell Significance Index: 297.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4143
    Cell Significance Index: 10.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4128
    Cell Significance Index: 24.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3760
    Cell Significance Index: 16.6300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3354
    Cell Significance Index: 4.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3317
    Cell Significance Index: 12.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2931
    Cell Significance Index: 5.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2336
    Cell Significance Index: 42.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2208
    Cell Significance Index: 15.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2098
    Cell Significance Index: 395.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1660
    Cell Significance Index: 75.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1621
    Cell Significance Index: 19.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1522
    Cell Significance Index: 28.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1325
    Cell Significance Index: 58.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1177
    Cell Significance Index: 3.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1046
    Cell Significance Index: 4.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1017
    Cell Significance Index: 5.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0980
    Cell Significance Index: 12.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0894
    Cell Significance Index: 3.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0875
    Cell Significance Index: 119.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0668
    Cell Significance Index: 42.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0665
    Cell Significance Index: 102.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0602
    Cell Significance Index: 5.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0545
    Cell Significance Index: 100.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0506
    Cell Significance Index: 1.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0498
    Cell Significance Index: 0.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0446
    Cell Significance Index: 3.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0397
    Cell Significance Index: 0.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0186
    Cell Significance Index: -13.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0206
    Cell Significance Index: -12.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0270
    Cell Significance Index: -1.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0330
    Cell Significance Index: -18.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0374
    Cell Significance Index: -28.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0622
    Cell Significance Index: -1.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0637
    Cell Significance Index: -0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0694
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0841
    Cell Significance Index: -17.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0894
    Cell Significance Index: -15.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0996
    Cell Significance Index: -28.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1140
    Cell Significance Index: -11.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1207
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1411
    Cell Significance Index: -16.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1454
    Cell Significance Index: -10.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1613
    Cell Significance Index: -19.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1707
    Cell Significance Index: -17.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1841
    Cell Significance Index: -23.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1916
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2048
    Cell Significance Index: -23.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2066
    Cell Significance Index: -13.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2307
    Cell Significance Index: -6.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2491
    Cell Significance Index: -6.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2709
    Cell Significance Index: -5.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2823
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2928
    Cell Significance Index: -33.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2952
    Cell Significance Index: -2.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3120
    Cell Significance Index: -23.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3322
    Cell Significance Index: -26.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3368
    Cell Significance Index: -7.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3455
    Cell Significance Index: -21.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3709
    Cell Significance Index: -10.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3755
    Cell Significance Index: -7.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3902
    Cell Significance Index: -18.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3945
    Cell Significance Index: -10.5700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4338
    Cell Significance Index: -6.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4393
    Cell Significance Index: -22.8800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4443
    Cell Significance Index: -2.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5002
    Cell Significance Index: -16.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5190
    Cell Significance Index: -16.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5195
    Cell Significance Index: -17.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5299
    Cell Significance Index: -13.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5614
    Cell Significance Index: -12.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5745
    Cell Significance Index: -12.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6226
    Cell Significance Index: -21.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6387
    Cell Significance Index: -12.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6414
    Cell Significance Index: -15.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6543
    Cell Significance Index: -9.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFT81 is a protein encoded by the IFT81 gene, which is significantly expressed in various cell types, including ciliary muscle cells, ciliated columnar cells of the tracheobronchial tree, and oogonial cells. The protein is predicted to be a member of the IFT complex, which is responsible for the transport of proteins and other cargo along the length of cilia. IFT81 exhibits a high degree of sequence similarity to other IFT proteins, suggesting a conserved functional role. **Pathways and Functions:** IFT81 is involved in several key pathways, including: 1. **Intraflagellar transport (IFT):** IFT81 is a critical component of the IFT complex, responsible for the transport of proteins and other cargo along the length of cilia. 2. **Ciliary assembly:** IFT81 plays a role in the assembly of cilia, ensuring the proper formation and maintenance of cilia. 3. **Smoothened signaling pathway:** IFT81 is involved in the regulation of the Smoothened signaling pathway, which is critical for various cellular processes, including development and cell growth. 4. **Spermatogenesis:** IFT81 is required for the proper formation and function of sperm flagella, highlighting its importance in male fertility. 5. **Regulation of cilium length:** IFT81 is involved in the regulation of cilium length, ensuring that cilia are properly formed and maintained. **Clinical Significance:** Dysfunction of the IFT complex, including IFT81, has been implicated in various human diseases, including: 1. **Primary ciliary dyskinesia (PCD):** A genetic disorder characterized by defective cilia function, leading to respiratory and reproductive problems. 2. **Ciliary dyskinesia:** A condition characterized by defective cilia function, leading to respiratory and other problems. 3. **Polycystic kidney disease (PKD):** A genetic disorder characterized by the formation of cysts in the kidneys, which can lead to kidney failure. 4. **Spermatogenesis disorders:** IFT81 dysfunction has been implicated in various spermatogenesis disorders, including infertility and male infertility. In conclusion, IFT81 is a critical protein involved in the assembly and maintenance of cilia, with significant implications for various cellular processes. Understanding the role of IFT81 in ciliary function and disease will provide valuable insights into the development of novel therapeutic strategies for diseases associated with ciliary dysfunction.

Genular Protein ID: 363408565

Symbol: IFT81_HUMAN

Name: Intraflagellar transport protein 81 homolog

UniProtKB Accession Codes:

Q8WYA0 Q2YDY1 Q8NB51 Q9BSV2 Q9UNY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11130971

Title: Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene.

PubMed ID: 11130971

DOI: 10.1007/s003350010207

PubMed ID: 12549821

Title: Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation.

PubMed ID: 12549821

DOI: 10.1023/a:1021232518628

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15955805

Title: Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits.

PubMed ID: 15955805

DOI: 10.1074/jbc.m505062200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23990561

Title: Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

PubMed ID: 23990561

DOI: 10.1126/science.1240985

PubMed ID: 27666822

Title: Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a spectrum of short-rib polydactyly syndrome.

PubMed ID: 27666822

DOI: 10.1038/srep34232

PubMed ID: 28625565

Title: The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base.

PubMed ID: 28625565

DOI: 10.1016/j.devcel.2017.05.016

PubMed ID: 28428259

Title: RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.

PubMed ID: 28428259

DOI: 10.1091/mbc.e17-01-0017

Sequence Information:

  • Length: 676
  • Mass: 79746
  • Checksum: E5EBD887A6BF953E
  • Sequence:
    • MSDQIKFIMD SLNKEPFRKN YNLITFDSLE PMQLLQVLSD VLAEIDPKQL VDIREEMPEQ 
TAKRMLSLLG ILKYKPSGNA TDMSTFRQGL VIGSKPVIYP VLHWLLQRTN ELKKRAYLAR 
FLIKLEVPSE FLQDETVADT NKQYEELMEA FKTLHKEYEQ LKISGFSTAE IRKDISAMEE 
EKDQLIKRVE HLKKRVETAQ NHQWMLKIAR QLRVEKEREE YLAQQKQEQK NQLFHAVQRL 
QRVQNQLKSM RQAAADAKPE SLMKRLEEEI KFNLYMVTEK FPKELENKKK ELHFLQKVVS 
EPAMGHSDLL ELESKINEIN TEINQLIEKK MMRNEPIEGK LSLYRQQASI ISRKKEAKAE 
ELQEAKEKLA SLEREASVKR NQTREFDGTE VLKGDEFKRY VNKLRSKSTV FKKKHQIIAE 
LKAEFGLLQR TEELLKQRHE NIQQQLQTME EKKGISGYSY TQEELERVSA LKSEVDEMKG 
RTLDDMSEMV KKLYSLVSEK KSALASVIKE LRQLRQKYQE LTQECDEKKS QYDSCAAGLE 
SNRSKLEQEV RRLREECLQE ESRYHYTNCM IKNLEVQLRR ATDEMKAYIS SDQQEKRKAI 
REQYTKNTAE QENLGKKLRE KQKVIRESHG PNMKQAKMWR DLEQLMECKK QCFLKQQSQT 
SIGQVIQEGG EDRLIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.