Details for: COMMD5

Gene ID: 28991

Symbol: COMMD5

Ensembl ID: ENSG00000170619

Description: COMM domain containing 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.5788
    Cell Significance Index: -17.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.2347
    Cell Significance Index: -16.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.6731
    Cell Significance Index: -17.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9591
    Cell Significance Index: -20.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.4923
    Cell Significance Index: -19.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.7380
    Cell Significance Index: -17.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.5318
    Cell Significance Index: -19.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0202
    Cell Significance Index: -19.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6662
    Cell Significance Index: -12.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1511
    Cell Significance Index: -12.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.1792
    Cell Significance Index: 46.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7161
    Cell Significance Index: 279.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4000
    Cell Significance Index: 1264.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3230
    Cell Significance Index: 79.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7747
    Cell Significance Index: 21.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6595
    Cell Significance Index: 5.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6286
    Cell Significance Index: 119.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6286
    Cell Significance Index: 43.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6098
    Cell Significance Index: 8.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5319
    Cell Significance Index: 15.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5284
    Cell Significance Index: 52.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4160
    Cell Significance Index: 19.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4012
    Cell Significance Index: 219.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3916
    Cell Significance Index: 18.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3885
    Cell Significance Index: 7.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3369
    Cell Significance Index: 39.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3104
    Cell Significance Index: 55.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3074
    Cell Significance Index: 37.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2996
    Cell Significance Index: 41.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2684
    Cell Significance Index: 13.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2604
    Cell Significance Index: 115.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2557
    Cell Significance Index: 19.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2382
    Cell Significance Index: 16.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2177
    Cell Significance Index: 7.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2159
    Cell Significance Index: 6.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1945
    Cell Significance Index: 39.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1913
    Cell Significance Index: 5.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1574
    Cell Significance Index: 3.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1566
    Cell Significance Index: 31.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1528
    Cell Significance Index: 4.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1523
    Cell Significance Index: 1.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1447
    Cell Significance Index: 18.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1421
    Cell Significance Index: 18.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1263
    Cell Significance Index: 1.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1046
    Cell Significance Index: 2.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1041
    Cell Significance Index: 6.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1040
    Cell Significance Index: 37.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0718
    Cell Significance Index: 4.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0601
    Cell Significance Index: 3.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0080
    Cell Significance Index: 6.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0071
    Cell Significance Index: 0.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0093
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0095
    Cell Significance Index: -14.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0149
    Cell Significance Index: -20.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0167
    Cell Significance Index: -10.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0173
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0180
    Cell Significance Index: -1.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0193
    Cell Significance Index: -13.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0215
    Cell Significance Index: -15.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0233
    Cell Significance Index: -0.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0265
    Cell Significance Index: -0.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0288
    Cell Significance Index: -8.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0306
    Cell Significance Index: -17.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0330
    Cell Significance Index: -5.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0336
    Cell Significance Index: -0.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0341
    Cell Significance Index: -15.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0418
    Cell Significance Index: -26.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0480
    Cell Significance Index: -1.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0618
    Cell Significance Index: -8.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0666
    Cell Significance Index: -7.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0698
    Cell Significance Index: -1.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0853
    Cell Significance Index: -1.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0921
    Cell Significance Index: -10.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0939
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1063
    Cell Significance Index: -22.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1095
    Cell Significance Index: -3.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1324
    Cell Significance Index: -3.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1357
    Cell Significance Index: -10.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1646
    Cell Significance Index: -10.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1885
    Cell Significance Index: -19.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2066
    Cell Significance Index: -16.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2238
    Cell Significance Index: -15.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2329
    Cell Significance Index: -3.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2538
    Cell Significance Index: -14.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3239
    Cell Significance Index: -19.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3383
    Cell Significance Index: -3.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3519
    Cell Significance Index: -6.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3731
    Cell Significance Index: -16.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3781
    Cell Significance Index: -4.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3949
    Cell Significance Index: -10.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4119
    Cell Significance Index: -4.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4221
    Cell Significance Index: -4.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4376
    Cell Significance Index: -16.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4407
    Cell Significance Index: -15.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4429
    Cell Significance Index: -16.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COMMD5 is a member of the COMM (Cullin-MD-5) domain-containing protein family, which is characterized by the presence of a unique COMM domain. This domain is crucial for the protein's interaction with other molecules, influencing its subcellular localization and function. COMMD5 is primarily expressed in various cell types, including germ cells, immune cells, and specialized epithelial cells. Its expression is also notable in the central nervous system, where it is found in GABAergic interneurons and radial glial cells. The gene's expression patterns suggest a broad range of cellular functions, from immune regulation to cellular differentiation and survival. **Pathways and Functions:** COMMD5 is involved in multiple cellular pathways, including: 1. **Neddylation:** COMMD5 interacts with the Cullin-RING E3 ubiquitin ligase (CRL) complex, which is responsible for the ubiquitination and subsequent degradation of target proteins. This process plays a critical role in regulating protein turnover, protein degradation, and cell signaling. 2. **Post-translational protein modification:** COMMD5 is also implicated in the regulation of post-translational modifications, including phosphorylation, ubiquitination, and acetylation. These modifications can significantly impact protein function, localization, and interactions. 3. **Protein binding:** COMMD5 exhibits a high degree of protein-binding affinity, interacting with various proteins involved in cellular processes, including immune responses, cell signaling, and cellular differentiation. **Clinical Significance:** The clinical significance of COMMD5 is multifaceted and far-reaching. As an immunologist, it is essential to recognize the gene's role in immune regulation, particularly in the context of: 1. **Autoimmune diseases:** COMMD5 has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. The gene's interaction with immune cells and its role in regulating immune responses make it a potential target for therapeutic interventions. 2. **Cancer:** COMMD5 has been associated with various types of cancer, including breast, ovarian, and lung cancer. The gene's involvement in cellular differentiation, survival, and apoptosis suggests its potential as a biomarker or therapeutic target. 3. **Neurological disorders:** COMMD5's expression in the central nervous system and its involvement in GABAergic interneuron function make it a potential candidate for the study of neurological disorders, such as Parkinson's disease, Alzheimer's disease, and schizophrenia. In conclusion, COMMD5 is a gene with a complex and multifaceted role in cellular biology, immune regulation, and disease. Further research is necessary to fully elucidate the gene's functions and its implications in human health and disease. As an immunologist, it is crucial to continue exploring the intricacies of COMMD5, with the ultimate goal of developing novel therapeutic strategies for the treatment of various diseases.

Genular Protein ID: 3432935664

Symbol: COMD5_HUMAN

Name: COMM domain-containing protein 5

UniProtKB Accession Codes:

Q9GZQ3 D3DWN7 Q9NVN6 Q9UHX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 4 Ensembl 4 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10918053

Title: HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation.

PubMed ID: 10918053

DOI: 10.1074/jbc.m001352200

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15799966

Title: COMMD proteins, a novel family of structural and functional homologs of MURR1.

PubMed ID: 15799966

DOI: 10.1074/jbc.m501928200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21778237

Title: COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

PubMed ID: 21778237

DOI: 10.1074/jbc.m111.278408

PubMed ID: 23637203

Title: Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.

PubMed ID: 23637203

DOI: 10.1152/ajprenal.00158.2013

PubMed ID: 23563313

Title: CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.

PubMed ID: 23563313

DOI: 10.1172/jci66466

PubMed ID: 25355947

Title: COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

PubMed ID: 25355947

DOI: 10.1091/mbc.e14-06-1073

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 224
  • Mass: 24670
  • Checksum: C4CC0563B9FA3240
  • Sequence:
    • MSAVGAATPY LHHPGDSHSG RVSFLGAQLP PEVAAMARLL GDLDRSTFRK LLKFVVSSLQ 
GEDCREAVQR LGVSANLPEE QLGALLAGMH TLLQQALRLP PTSLKPDTFR DQLQELCIPQ 
DLVGDLASVV FGSQRPLLDS VAQQQGAWLP HVADFRWRVD VAISTSALAR SLQPSVLMQL 
KLSDGSAYRF EVPTAKFQEL RYSVALVLKE MADLEKRCER RLQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.