Details for: CHMP4A

Gene ID: 29082

Symbol: CHMP4A

Ensembl ID: ENSG00000254505

Description: charged multivesicular body protein 4A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.1224
    Cell Significance Index: -27.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.1330
    Cell Significance Index: -29.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.2578
    Cell Significance Index: -39.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.2099
    Cell Significance Index: -40.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.7967
    Cell Significance Index: -35.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5754
    Cell Significance Index: -28.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5374
    Cell Significance Index: -37.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9925
    Cell Significance Index: -27.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3564
    Cell Significance Index: 63.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3186
    Cell Significance Index: 30.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3122
    Cell Significance Index: 84.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1870
    Cell Significance Index: 34.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1546
    Cell Significance Index: 208.1400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.1443
    Cell Significance Index: 17.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1079
    Cell Significance Index: 136.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0636
    Cell Significance Index: 580.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0623
    Cell Significance Index: 145.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0572
    Cell Significance Index: 12.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0278
    Cell Significance Index: 9.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0168
    Cell Significance Index: 75.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8363
    Cell Significance Index: 59.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7322
    Cell Significance Index: 323.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7171
    Cell Significance Index: 92.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6780
    Cell Significance Index: 86.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4991
    Cell Significance Index: 49.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4594
    Cell Significance Index: 92.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3953
    Cell Significance Index: 64.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3908
    Cell Significance Index: 3.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2643
    Cell Significance Index: 4.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2588
    Cell Significance Index: 29.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1962
    Cell Significance Index: 10.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1956
    Cell Significance Index: 9.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1903
    Cell Significance Index: 68.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1861
    Cell Significance Index: 1.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1539
    Cell Significance Index: 4.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1043
    Cell Significance Index: 2.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1040
    Cell Significance Index: 17.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1013
    Cell Significance Index: 4.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0906
    Cell Significance Index: 10.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0904
    Cell Significance Index: 56.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0318
    Cell Significance Index: 24.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0315
    Cell Significance Index: 0.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0139
    Cell Significance Index: 12.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0090
    Cell Significance Index: 0.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0084
    Cell Significance Index: 1.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0002
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0202
    Cell Significance Index: -37.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0205
    Cell Significance Index: -0.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0242
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0354
    Cell Significance Index: -19.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0357
    Cell Significance Index: -1.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0414
    Cell Significance Index: -11.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0562
    Cell Significance Index: -5.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0593
    Cell Significance Index: -3.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0600
    Cell Significance Index: -38.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0693
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0702
    Cell Significance Index: -14.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1068
    Cell Significance Index: -48.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1479
    Cell Significance Index: -29.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1485
    Cell Significance Index: -4.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1514
    Cell Significance Index: -17.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1644
    Cell Significance Index: -4.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2168
    Cell Significance Index: -3.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2680
    Cell Significance Index: -38.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2845
    Cell Significance Index: -32.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3066
    Cell Significance Index: -15.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3125
    Cell Significance Index: -14.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3251
    Cell Significance Index: -8.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3656
    Cell Significance Index: -38.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3692
    Cell Significance Index: -29.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3915
    Cell Significance Index: -17.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3920
    Cell Significance Index: -16.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4141
    Cell Significance Index: -10.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4375
    Cell Significance Index: -12.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4645
    Cell Significance Index: -5.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4875
    Cell Significance Index: -30.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5120
    Cell Significance Index: -5.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5260
    Cell Significance Index: -19.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5387
    Cell Significance Index: -33.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5579
    Cell Significance Index: -17.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5822
    Cell Significance Index: -4.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5876
    Cell Significance Index: -10.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6301
    Cell Significance Index: -17.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6393
    Cell Significance Index: -15.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7166
    Cell Significance Index: -23.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7240
    Cell Significance Index: -23.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7305
    Cell Significance Index: -25.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7603
    Cell Significance Index: -27.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7782
    Cell Significance Index: -11.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8074
    Cell Significance Index: -23.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9132
    Cell Significance Index: -12.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9946
    Cell Significance Index: -24.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0949
    Cell Significance Index: -23.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0983
    Cell Significance Index: -23.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1087
    Cell Significance Index: -19.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1305
    Cell Significance Index: -29.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.1350
    Cell Significance Index: -9.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1385
    Cell Significance Index: -30.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHMP4A is a charged protein with a molecular weight of approximately 40 kDa. It belongs to the CHMP family of proteins, which are characterized by their ability to interact with other ESCRT components and regulate the formation of MVBs. CHMP4A is known to interact with other ESCRT components, such as CHMP2A and CHMP3, to regulate the sorting and degradation of proteins within the cell. The protein is also involved in the regulation of autophagy, a process by which cells degrade and recycle damaged or dysfunctional cellular components. **Pathways and Functions** CHMP4A is involved in several cellular pathways, including: 1. **Autophagy**: CHMP4A plays a crucial role in the regulation of autophagy, a process by which cells degrade and recycle damaged or dysfunctional cellular components. 2. **Cell Cycle Progression**: CHMP4A is involved in the regulation of cell cycle progression, particularly during the G2/M phase, where it helps to regulate the sorting and degradation of proteins. 3. **Viral Budding**: CHMP4A is involved in the regulation of viral budding, particularly in the context of HIV and SARS-CoV-2 infections. 4. **Endosomal Sorting**: CHMP4A is involved in the regulation of endosomal sorting, where it helps to sort proteins and lipids within the endosomal system. **Clinical Significance** CHMP4A has been implicated in various diseases, including: 1. **Autoimmune Disorders**: CHMP4A has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus, where it is thought to contribute to the regulation of immune cell function. 2. **Cancer**: CHMP4A has been implicated in the regulation of cancer cell growth and survival, where it is thought to contribute to the development of cancer. 3. **Infectious Diseases**: CHMP4A has been implicated in the regulation of viral infections, particularly in the context of HIV and SARS-CoV-2 infections, where it is thought to contribute to the regulation of viral budding and replication. In conclusion, CHMP4A is a crucial protein involved in various cellular pathways, including autophagy, cell cycle progression, and viral budding. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is needed to fully understand the role of CHMP4A in human disease and to develop therapeutic strategies to target this protein in the treatment of various diseases.

Genular Protein ID: 4198562863

Symbol: CHM4A_HUMAN

Name: Charged multivesicular body protein 4a

UniProtKB Accession Codes:

Q9BY43 Q14D22 Q32Q79 Q86SZ8 Q96QJ9 Q9P026

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12860994

Title: The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.

PubMed ID: 12860994

DOI: 10.1074/jbc.m301604200

PubMed ID: 14583093

Title: Structure and function of human Vps20 and Snf7 proteins.

PubMed ID: 14583093

DOI: 10.1042/bj20031347

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14505569

Title: AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.

PubMed ID: 14505569

DOI: 10.1016/s0092-8674(03)00653-6

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 14519844

Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PubMed ID: 14519844

DOI: 10.1073/pnas.2133846100

PubMed ID: 14678797

Title: CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms.

PubMed ID: 14678797

DOI: 10.1016/j.abb.2003.09.038

PubMed ID: 15632132

Title: Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.

PubMed ID: 15632132

DOI: 10.1074/jbc.m413968200

PubMed ID: 17853893

Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

PubMed ID: 17853893

DOI: 10.1038/sj.emboj.7601850

PubMed ID: 17547705

Title: Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain.

PubMed ID: 17547705

DOI: 10.1111/j.1600-0854.2007.00584.x

PubMed ID: 18209100

Title: Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.

PubMed ID: 18209100

DOI: 10.1083/jcb.200707031

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18511562

Title: ALIX-CHMP4 interactions in the human ESCRT pathway.

PubMed ID: 18511562

DOI: 10.1073/pnas.0801567105

Sequence Information:

  • Length: 222
  • Mass: 25098
  • Checksum: 6712BA6AAA1D7CB7
  • Sequence:
    • MSGLGRLFGK GKKEKGPTPE EAIQKLKETE KILIKKQEFL EQKIQQELQT AKKYGTKNKR 
AALQALRRKK RFEQQLAQTD GTLSTLEFQR EAIENATTNA EVLRTMELAA QSMKKAYQDM 
DIDKVDELMT DITEQQEVAQ QISDAISRPM GFGDDVDEDE LLEELEELEQ EELAQELLNV 
GDKEEEPSVK LPSVPSTHLP AGPAPKVDED EEALKQLAEW VS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.