Details for: CHMP4A
Gene ID: 29082
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CHMP4A
Ensembl ID: ENSG00000254505
Description: charged multivesicular body protein 4A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 16.65rCSI 11.63%PRS 74.55
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CSI 16.57rCSI 17.32%PRS 69.21
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CSI 14.89rCSI 28.95%PRS 74.92
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CSI 14.69rCSI 13.38%PRS 84.8
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CSI 14.67rCSI 11.02%PRS 77.39
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CSI 8.7rCSI 7.64%PRS 76.9
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CSI 8.65rCSI 11.33%PRS 83.72
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CSI 8.63rCSI 9.98%PRS 62.58
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CSI 6.64rCSI 6.12%PRS 73.17
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CSI 6.3rCSI 7.4%PRS 73.64
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CSI 6.14rCSI 8.39%PRS 76.97
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CSI 5.72rCSI 5.52%PRS 63.36
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CSI 5.27rCSI 13.37%PRS 61.15
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CSI 5.25rCSI 17.03%PRS 70.56
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CSI 5.17rCSI 4.98%PRS 71.12
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CSI 5.07rCSI 11.17%PRS 75.58
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CSI 4.96rCSI 12.83%PRS 66.39
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CSI 4.85rCSI 5.09%PRS 74.94
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CSI 4.39rCSI 6.03%PRS 88.71
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CSI 4.28rCSI 21.48%PRS 83.82
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CSI 4.17rCSI 11.97%PRS 89.26
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CSI 4.16rCSI 12.06%PRS 71.99
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CSI 4.03rCSI 14.32%PRS 77.86
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CSI 3.99rCSI 3.35%PRS 86.27
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CSI 3.93rCSI 3.15%PRS 88.23
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CSI 3.41rCSI 2.37%PRS 82.91
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CSI 3.34rCSI 2.5%PRS 91.9
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CSI 3.13rCSI 2.59%PRS 71.67
-
CSI 3.04rCSI 3.82%PRS 91.32
-
CSI 3.01rCSI 8.19%PRS 92.85
-
CSI 2.99rCSI 3.12%PRS 88.55
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CSI 2.97rCSI 4.82%PRS 67.08
-
CSI 2.94rCSI 3.64%PRS 68.66
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CSI 2.91rCSI 5.97%PRS 60.12
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CSI 2.84rCSI 3.54%PRS 81.85
-
CSI 2.79rCSI 4.6%PRS 76.59
-
CSI 2.75rCSI 9.02%PRS 91
-
CSI 2.75rCSI 2.92%PRS 79.01
-
CSI 2.72rCSI 1.81%PRS 86.93
-
CSI 2.72rCSI 2.03%PRS 85.35
-
CSI 2.71rCSI 2.19%PRS 73.45
-
CSI 2.62rCSI 2.68%PRS 82.41
-
CSI 2.6rCSI 2.02%PRS 87.37
-
CSI 2.58rCSI 4.41%PRS 90.15
-
CSI 2.55rCSI 2.51%PRS 74.16
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CSI 2.52rCSI 2.88%PRS 86.02
-
CSI 2.46rCSI 1.45%PRS 87.58
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CSI 2.45rCSI 3.77%PRS 63.76
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CSI 2.45rCSI 1.93%PRS 77.95
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CSI 2.43rCSI 3.36%PRS 70.53
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CSI 2.39rCSI 2.5%PRS 68.48
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CSI 2.32rCSI 4.66%PRS 60.74
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CSI 2.29rCSI 6.52%PRS 68.19
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CSI 2.28rCSI 2.24%PRS 88.19
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CSI 2.28rCSI 1.7%PRS 85.95
-
CSI 2.26rCSI 2.79%PRS 80.09
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CSI 2.26rCSI 1.96%PRS 76.15
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CSI 2.24rCSI 1.78%PRS 90.22
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CSI 2.23rCSI 2.59%PRS 76.95
-
CSI 2.22rCSI 1.69%PRS 84.15
-
CSI 2.2rCSI 2.88%PRS 89.75
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CSI 2.19rCSI 12.88%PRS 53.78
-
CSI 2.18rCSI 2.62%PRS 85.11
-
CSI 2.14rCSI 1.62%PRS 84.61
-
CSI 2.14rCSI 4.19%PRS 92.94
-
CSI 2.12rCSI 2.39%PRS 86.22
-
CSI 2.11rCSI 6.24%PRS 73.42
-
CSI 2.11rCSI 2%PRS 70.73
-
CSI 2.11rCSI 2.07%PRS 85.96
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CSI 2.06rCSI 1.8%PRS 79.88
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CSI 2.03rCSI 2.09%PRS 85.56
-
CSI 2.01rCSI 2.58%PRS 67.99
-
CSI 2rCSI 3.46%PRS 61.99
-
CSI 1.99rCSI 2.72%PRS 91.39
-
CSI 1.96rCSI 1.77%PRS 68.78
-
CSI 1.94rCSI 3.53%PRS 83.23
-
CSI 1.92rCSI 2.06%PRS 72
-
CSI 1.92rCSI 4.86%PRS 78.19
-
CSI 1.91rCSI 2.77%PRS 85.87
-
CSI 1.91rCSI 2.73%PRS 73.56
-
CSI 1.9rCSI 3.06%PRS 72.6
-
CSI 1.9rCSI 1.28%PRS 84.57
-
CSI 1.89rCSI 8.4%PRS 71.76
-
CSI 1.87rCSI 1.86%PRS 65.02
-
CSI 1.84rCSI 1.62%PRS 59.63
-
CSI 1.79rCSI 1.41%PRS 58.81
-
CSI 1.77rCSI 1.32%PRS 83.86
-
CSI 1.77rCSI 1.48%PRS 76.7
-
CSI 1.76rCSI 4.03%PRS 62.77
-
CSI 1.72rCSI 2.29%PRS 77.81
-
CSI 1.71rCSI 3.21%PRS 82.36
-
CSI 1.71rCSI 1.32%PRS 73.46
-
CSI 1.71rCSI 1.41%PRS 73.85
-
CSI 1.7rCSI 1.74%PRS 82.59
-
CSI 1.7rCSI 2.72%PRS 87.23
-
CSI 1.69rCSI 2.59%PRS 82.52
-
CSI 1.69rCSI 3.05%PRS 89.25
-
CSI 1.69rCSI 1.47%PRS 81.88
-
CSI 1.68rCSI 3.76%PRS 53.26
-
CSI 1.67rCSI 9.73%PRS 77.97
-
CSI 0.2rCSI 2.3%PRS 92.0%
-
CSI 0.2rCSI 1.8%PRS 84.4%
-
CSI 0.2rCSI 1.1%PRS 78.4%
-
CSI 0.2rCSI 2.3%PRS 83.0%
-
CSI 0.3rCSI 2.1%PRS 79.5%
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CSI 0.3rCSI 2.5%PRS 65.0%
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CSI 0.4rCSI 2.1%PRS 79.0%
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CSI 0.4rCSI 2.5%PRS 81.5%
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CSI 0.4rCSI 5.7%PRS 83.9%
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CSI 0.4rCSI 1.6%PRS 89.1%
-
CSI 0.5rCSI 2.0%PRS 80.5%
-
CSI 0.7rCSI 1.6%PRS 78.9%
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CSI 0.7rCSI 2.2%PRS 72.0%
-
CSI 0.7rCSI 2.1%PRS 84.6%
-
CSI 0.8rCSI 3.9%PRS 89.5%
-
CSI 0.8rCSI 3.0%PRS 81.4%
-
CSI 0.8rCSI 2.7%PRS 81.6%
-
CSI 0.8rCSI 1.2%PRS 60.8%
-
CSI 0.9rCSI 2.1%PRS 86.7%
-
CSI 0.9rCSI 3.1%PRS 88.3%
-
CSI 0.9rCSI 1.4%PRS 76.7%
-
CSI 0.9rCSI 1.5%PRS 79.2%
-
CSI 0.9rCSI 2.9%PRS 74.9%
-
CSI 1.0rCSI 4.4%PRS 83.9%
-
CSI 1.0rCSI 5.4%PRS 80.7%
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CSI 1.1rCSI 1.6%PRS 77.6%
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CSI 1.1rCSI 1.4%PRS 62.8%
-
CSI 1.1rCSI 1.8%PRS 80.8%
-
CSI 1.2rCSI 2.4%PRS 70.7%
-
CSI 1.2rCSI 2.2%PRS 81.4%
-
CSI 1.2rCSI 1.9%PRS 85.2%
-
CSI 1.2rCSI 1.8%PRS 66.3%
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CSI 1.2rCSI 3.1%PRS 65.1%
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CSI 1.2rCSI 3.3%PRS 86.2%
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CSI 1.3rCSI 3.1%PRS 70.4%
-
CSI 1.3rCSI 2.4%PRS 87.6%
-
CSI 1.3rCSI 1.8%PRS 79.2%
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CSI 1.3rCSI 3.5%PRS 81.1%
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CSI 1.3rCSI 1.6%PRS 73.1%
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CSI 1.3rCSI 1.6%PRS 54.7%
-
CSI 1.3rCSI 7.9%PRS 86.3%
-
CSI 1.3rCSI 2.9%PRS 82.0%
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CSI 1.3rCSI 3.2%PRS 64.5%
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CSI 1.3rCSI 0.9%PRS 74.3%
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CSI 1.4rCSI 1.1%PRS 74.9%
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CSI 1.4rCSI 1.6%PRS 63.8%
-
CSI 1.4rCSI 1.7%PRS 80.4%
-
CSI 1.4rCSI 2.0%PRS 70.0%
-
CSI 1.5rCSI 1.4%PRS 69.4%
-
CSI 1.6rCSI 2.1%PRS 71.2%
-
CSI 1.6rCSI 2.2%PRS 73.6%
-
CSI 1.6rCSI 2.4%PRS 80.2%
-
CSI 1.6rCSI 2.0%PRS 81.4%
-
CSI 1.6rCSI 1.9%PRS 69.6%
-
CSI 1.6rCSI 2.6%PRS 63.1%
-
CSI 1.6rCSI 3.6%PRS 70.2%
-
CSI 1.6rCSI 1.6%PRS 88.9%
-
CSI 1.6rCSI 4.1%PRS 89.5%
-
CSI 1.7rCSI 3.0%PRS 84.5%
-
CSI 1.7rCSI 2.6%PRS 70.4%
-
CSI 1.7rCSI 1.5%PRS 88.2%
-
CSI 1.7rCSI 2.3%PRS 72.3%
-
CSI 1.7rCSI 9.7%PRS 78.0%
-
CSI 1.7rCSI 3.8%PRS 53.3%
-
CSI 1.7rCSI 1.5%PRS 81.9%
-
CSI 1.7rCSI 3.1%PRS 89.3%
-
CSI 1.7rCSI 2.6%PRS 82.5%
-
CSI 1.7rCSI 2.7%PRS 87.2%
-
CSI 1.7rCSI 1.7%PRS 82.6%
-
CSI 1.7rCSI 1.4%PRS 73.9%
-
CSI 1.7rCSI 1.3%PRS 73.5%
-
CSI 1.7rCSI 3.2%PRS 82.4%
-
CSI 1.7rCSI 2.3%PRS 77.8%
-
CSI 1.8rCSI 4.0%PRS 62.8%
-
CSI 1.8rCSI 1.5%PRS 76.7%
-
CSI 1.8rCSI 1.3%PRS 83.9%
-
CSI 1.8rCSI 1.4%PRS 58.8%
-
CSI 1.8rCSI 1.6%PRS 59.6%
-
CSI 1.9rCSI 1.9%PRS 65.0%
-
CSI 1.9rCSI 8.4%PRS 71.8%
-
CSI 1.9rCSI 1.3%PRS 84.6%
-
CSI 1.9rCSI 3.1%PRS 72.6%
-
CSI 1.9rCSI 2.7%PRS 73.6%
-
CSI 1.9rCSI 2.8%PRS 85.9%
-
CSI 1.9rCSI 4.9%PRS 78.2%
-
CSI 1.9rCSI 2.1%PRS 72.0%
-
CSI 1.9rCSI 3.5%PRS 83.2%
-
CSI 2.0rCSI 1.8%PRS 68.8%
-
CSI 2.0rCSI 2.7%PRS 91.4%
-
CSI 2.0rCSI 3.5%PRS 62.0%
-
CSI 2.0rCSI 2.6%PRS 68.0%
-
CSI 2.0rCSI 2.1%PRS 85.6%
-
CSI 2.1rCSI 1.8%PRS 79.9%
-
CSI 2.1rCSI 2.1%PRS 86.0%
-
CSI 2.1rCSI 2.0%PRS 70.7%
-
CSI 2.1rCSI 6.2%PRS 73.4%
-
CSI 2.1rCSI 2.4%PRS 86.2%
-
CSI 2.1rCSI 4.2%PRS 92.9%
-
CSI 2.1rCSI 1.6%PRS 84.6%
-
CSI 2.2rCSI 2.6%PRS 85.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4198562863
Symbol: CHM4A_HUMAN
Name: Charged multivesicular body protein 4a
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12860994
Title: The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.
PubMed ID: 12860994
PubMed ID: 14583093
Title: Structure and function of human Vps20 and Snf7 proteins.
PubMed ID: 14583093
DOI: 10.1042/bj20031347
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14505569
Title: AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.
PubMed ID: 14505569
PubMed ID: 14505570
PubMed ID: 14519844
Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
PubMed ID: 14519844
PubMed ID: 14678797
Title: CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms.
PubMed ID: 14678797
PubMed ID: 15632132
Title: Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.
PubMed ID: 15632132
PubMed ID: 17853893
Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
PubMed ID: 17853893
PubMed ID: 17547705
Title: Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain.
PubMed ID: 17547705
PubMed ID: 18209100
Title: Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.
PubMed ID: 18209100
PubMed ID: 22660413
Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
PubMed ID: 22660413
DOI: 10.1038/ncb2502
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 18511562
Title: ALIX-CHMP4 interactions in the human ESCRT pathway.
PubMed ID: 18511562
Sequence Information:
- Length: 222
- Mass: 25098
- Checksum: 6712BA6AAA1D7CB7
- Sequence:
MSGLGRLFGK GKKEKGPTPE EAIQKLKETE KILIKKQEFL EQKIQQELQT AKKYGTKNKR AALQALRRKK RFEQQLAQTD GTLSTLEFQR EAIENATTNA EVLRTMELAA QSMKKAYQDM DIDKVDELMT DITEQQEVAQ QISDAISRPM GFGDDVDEDE LLEELEELEQ EELAQELLNV GDKEEEPSVK LPSVPSTHLP AGPAPKVDED EEALKQLAEW VS