Details for: THYN1

Gene ID: 29087

Symbol: THYN1

Ensembl ID: ENSG00000151500

Description: thymocyte nuclear protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.8834
    Cell Significance Index: -27.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.0012
    Cell Significance Index: -21.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.9960
    Cell Significance Index: -34.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.8291
    Cell Significance Index: -33.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.5372
    Cell Significance Index: -28.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.3463
    Cell Significance Index: -32.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.2071
    Cell Significance Index: -28.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8298
    Cell Significance Index: -33.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6846
    Cell Significance Index: -34.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1971
    Cell Significance Index: -19.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5767
    Cell Significance Index: -20.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1031
    Cell Significance Index: -8.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7813
    Cell Significance Index: 207.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5581
    Cell Significance Index: 40.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3651
    Cell Significance Index: 14.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3375
    Cell Significance Index: 28.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0484
    Cell Significance Index: 30.7900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0211
    Cell Significance Index: 7.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0088
    Cell Significance Index: 138.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9743
    Cell Significance Index: 50.6100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9737
    Cell Significance Index: 10.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9730
    Cell Significance Index: 33.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6626
    Cell Significance Index: 9.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6304
    Cell Significance Index: 29.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6228
    Cell Significance Index: 562.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6173
    Cell Significance Index: 79.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5974
    Cell Significance Index: 73.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5791
    Cell Significance Index: 104.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5730
    Cell Significance Index: 6.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5717
    Cell Significance Index: 29.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5422
    Cell Significance Index: 296.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5352
    Cell Significance Index: 236.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5107
    Cell Significance Index: 32.9500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4659
    Cell Significance Index: 3.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4216
    Cell Significance Index: 49.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4059
    Cell Significance Index: 21.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3982
    Cell Significance Index: 10.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3847
    Cell Significance Index: 27.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3748
    Cell Significance Index: 75.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3286
    Cell Significance Index: 7.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2092
    Cell Significance Index: 39.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1644
    Cell Significance Index: 7.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1589
    Cell Significance Index: 3.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1491
    Cell Significance Index: 19.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1291
    Cell Significance Index: 6.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1147
    Cell Significance Index: 7.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1124
    Cell Significance Index: 8.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1046
    Cell Significance Index: 37.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1040
    Cell Significance Index: 3.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0242
    Cell Significance Index: 0.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0186
    Cell Significance Index: 12.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0051
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0035
    Cell Significance Index: 2.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -2.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0225
    Cell Significance Index: -30.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0256
    Cell Significance Index: -0.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0279
    Cell Significance Index: -17.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0333
    Cell Significance Index: -0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0337
    Cell Significance Index: -6.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0393
    Cell Significance Index: -29.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0432
    Cell Significance Index: -4.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0500
    Cell Significance Index: -28.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0538
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0544
    Cell Significance Index: -24.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0609
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0640
    Cell Significance Index: -39.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0661
    Cell Significance Index: -11.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0763
    Cell Significance Index: -1.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1003
    Cell Significance Index: -28.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1147
    Cell Significance Index: -16.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1162
    Cell Significance Index: -1.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1267
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1709
    Cell Significance Index: -19.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1840
    Cell Significance Index: -11.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1866
    Cell Significance Index: -39.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2738
    Cell Significance Index: -6.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2972
    Cell Significance Index: -23.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3163
    Cell Significance Index: -3.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3200
    Cell Significance Index: -33.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3217
    Cell Significance Index: -8.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3645
    Cell Significance Index: -27.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4058
    Cell Significance Index: -27.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4470
    Cell Significance Index: -12.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4607
    Cell Significance Index: -25.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4816
    Cell Significance Index: -4.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5437
    Cell Significance Index: -33.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5584
    Cell Significance Index: -9.5700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5603
    Cell Significance Index: -3.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5641
    Cell Significance Index: -24.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5784
    Cell Significance Index: -16.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5812
    Cell Significance Index: -14.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5979
    Cell Significance Index: -17.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6117
    Cell Significance Index: -10.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6473
    Cell Significance Index: -17.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6503
    Cell Significance Index: -11.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6660
    Cell Significance Index: -12.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THYN1 is a nuclear protein, suggesting its involvement in DNA or RNA processing, transcriptional regulation, or chromatin remodeling. Its expression in various cell types, including immune cells, trophoblasts, and epithelial cells, indicates a potential role in regulating cellular differentiation, proliferation, or survival. The fact that THYN1 is significantly expressed in pro-T cells, a critical stage in T lymphocyte development, underscores its importance in immune system development and function. **Pathways and Functions:** The pathways and functions of THYN1 are not yet fully elucidated, but several possibilities can be inferred from its expression in different cell types. One potential pathway involves THYN1's role in regulating gene expression, possibly through its interaction with transcription factors or chromatin remodeling complexes. Another possibility is that THYN1 plays a role in cell signaling, influencing cell proliferation, differentiation, or survival. The expression of THYN1 in immune cells, particularly pro-T cells, suggests that it may be involved in the regulation of T lymphocyte development, maturation, or function. **Clinical Significance:** The clinical significance of THYN1 is an area of active research, with several potential implications for human disease. Immune dysregulation is a hallmark of various autoimmune and inflammatory disorders, and the understanding of THYN1's role in immune system development and function may provide valuable insights into the underlying mechanisms of these diseases. Additionally, THYN1's expression in trophoblasts and epithelial cells suggests that it may play a role in the development of placental or epithelial-related disorders, such as preeclampsia or kidney disease. Further research is needed to fully elucidate the clinical significance of THYN1 and its potential applications in human disease. In conclusion, THYN1 is a nuclear protein with a complex and multifaceted role in regulating cellular differentiation, proliferation, and survival. Its expression in various cell types, including immune cells, trophoblasts, and epithelial cells, underscores its importance in regulating cellular processes. While the exact mechanisms by which THYN1 influences immune function and other cellular processes remain poorly understood, ongoing research is poised to shed light on the mysteries surrounding this enigmatic gene, potentially uncovering new avenues for therapeutic intervention in human disease.

Genular Protein ID: 3925395608

Symbol: THYN1_HUMAN

Name: Thymocyte nuclear protein 1

UniProtKB Accession Codes:

Q9P016 Q567Q2 Q9H3L4 Q9HC20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15939300

Title: Identification, expression, and purification of a unique stable domain from human HSPC144 protein.

PubMed ID: 15939300

DOI: 10.1016/j.pep.2005.03.008

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19237743

Title: Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry.

PubMed ID: 19237743

DOI: 10.1107/s0907444908041474

Sequence Information:

  • Length: 225
  • Mass: 25697
  • Checksum: 76E6034A6404C962
  • Sequence:
    • MSRPRKRLAG TSGSDKGLSG KRTKTENSGE ALAKVEDSNP QKTSATKNCL KNLSSHWLMK 
SEPESRLEKG VDVKFSIEDL KAQPKQTTCW DGVRNYQARN FLRAMKLGEE AFFYHSNCKE 
PGIAGLMKIV KEAYPDHTQF EKNNPHYDPS SKEDNPKWSM VDVQFVRMMK RFIPLAELKS 
YHQAHKATGG PLKNMVLFTR QRLSIQPLTQ EEFDFVLSLE EKEPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.