Details for: ORMDL2

Gene ID: 29095

Symbol: ORMDL2

Ensembl ID: ENSG00000123353

Description: ORMDL sphingolipid biosynthesis regulator 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.5023
    Cell Significance Index: -22.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.2555
    Cell Significance Index: -23.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.2409
    Cell Significance Index: -25.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.1673
    Cell Significance Index: -26.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.0318
    Cell Significance Index: -26.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.2222
    Cell Significance Index: -26.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0227
    Cell Significance Index: -25.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0162
    Cell Significance Index: -21.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8575
    Cell Significance Index: -27.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0465
    Cell Significance Index: -10.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.8865
    Cell Significance Index: 336.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2853
    Cell Significance Index: 62.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1176
    Cell Significance Index: 19.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8863
    Cell Significance Index: 97.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3814
    Cell Significance Index: 40.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3248
    Cell Significance Index: 61.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1852
    Cell Significance Index: 88.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1688
    Cell Significance Index: 210.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0728
    Cell Significance Index: 24.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8899
    Cell Significance Index: 10.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8868
    Cell Significance Index: 484.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8000
    Cell Significance Index: 130.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7924
    Cell Significance Index: 97.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7597
    Cell Significance Index: 35.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7538
    Cell Significance Index: 97.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6166
    Cell Significance Index: 117.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4897
    Cell Significance Index: 10.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4507
    Cell Significance Index: 53.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4280
    Cell Significance Index: 189.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3705
    Cell Significance Index: 26.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3359
    Cell Significance Index: 8.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2662
    Cell Significance Index: 36.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2611
    Cell Significance Index: 25.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2507
    Cell Significance Index: 15.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2443
    Cell Significance Index: 3.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2398
    Cell Significance Index: 15.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2340
    Cell Significance Index: 46.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1676
    Cell Significance Index: 4.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1407
    Cell Significance Index: 2.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1234
    Cell Significance Index: 2.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1216
    Cell Significance Index: 92.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0965
    Cell Significance Index: 12.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0819
    Cell Significance Index: 2.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0410
    Cell Significance Index: 1.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0256
    Cell Significance Index: 4.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0086
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0122
    Cell Significance Index: -22.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0188
    Cell Significance Index: -34.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0205
    Cell Significance Index: -31.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0259
    Cell Significance Index: -35.2700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0284
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0313
    Cell Significance Index: -17.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0344
    Cell Significance Index: -21.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0423
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0518
    Cell Significance Index: -5.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0559
    Cell Significance Index: -20.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0610
    Cell Significance Index: -27.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0636
    Cell Significance Index: -18.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0822
    Cell Significance Index: -16.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0943
    Cell Significance Index: -3.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0977
    Cell Significance Index: -2.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1165
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1238
    Cell Significance Index: -14.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1560
    Cell Significance Index: -22.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1566
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1640
    Cell Significance Index: -5.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1935
    Cell Significance Index: -1.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2243
    Cell Significance Index: -3.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2407
    Cell Significance Index: -6.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2470
    Cell Significance Index: -6.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2586
    Cell Significance Index: -26.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3030
    Cell Significance Index: -24.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3207
    Cell Significance Index: -18.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3456
    Cell Significance Index: -26.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3559
    Cell Significance Index: -17.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3644
    Cell Significance Index: -19.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3731
    Cell Significance Index: -15.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3755
    Cell Significance Index: -23.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3857
    Cell Significance Index: -23.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4008
    Cell Significance Index: -3.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4025
    Cell Significance Index: -27.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4056
    Cell Significance Index: -8.4900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4292
    Cell Significance Index: -6.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4358
    Cell Significance Index: -5.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4452
    Cell Significance Index: -11.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4709
    Cell Significance Index: -4.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4899
    Cell Significance Index: -14.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5843
    Cell Significance Index: -16.7500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5986
    Cell Significance Index: -10.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6034
    Cell Significance Index: -22.1500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6712
    Cell Significance Index: -9.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6923
    Cell Significance Index: -8.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7174
    Cell Significance Index: -18.4400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7419
    Cell Significance Index: -6.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7449
    Cell Significance Index: -32.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORMDL2 is a protein that belongs to the ORMDL family of sphingolipid biosynthesis regulators. It is primarily expressed in epithelial and immune cells, where it regulates the de novo biosynthesis of ceramide, a key sphingolipid species involved in various cellular functions. ORMDL2 is a negative regulator of ceramide biosynthesis, meaning that it inhibits the production of ceramide, which in turn modulates various cellular processes. **Pathways and Functions:** ORMDL2 regulates sphingolipid biosynthesis through its interaction with other proteins involved in the ceramide biosynthetic pathway. Specifically, ORMDL2 inhibits the activity of the enzyme ceramide synthase, which is responsible for producing ceramide from sphingosine. By regulating ceramide biosynthesis, ORMDL2 modulates various cellular processes, including: 1. Cell signaling: Ceramide is a key signaling molecule involved in various cellular processes, including cell proliferation, differentiation, and survival. 2. Cell differentiation: Ceramide regulates the differentiation of various cell types, including epithelial and immune cells. 3. Autophagy: Ceramide is involved in the regulation of autophagy, a process involved in the degradation and recycling of cellular components. 4. Apoptosis: Ceramide is involved in the regulation of apoptosis, or programmed cell death. **Clinical Significance:** Dysregulation of ORMDL2 has been implicated in various diseases, including: 1. Cancer: ORMDL2 is downregulated in various types of cancer, including breast, lung, and colon cancer. 2. Inflammatory disorders: ORMDL2 is downregulated in inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. 3. Neurodegenerative diseases: ORMDL2 is downregulated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. Atherosclerosis: ORMDL2 is downregulated in atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. In conclusion, ORMDL2 plays a crucial role in regulating sphingolipid biosynthesis, a process involved in various cellular functions. Dysregulation of ORMDL2 has been implicated in various diseases, highlighting the importance of this gene in human health. Further research is needed to fully understand the mechanisms by which ORMDL2 regulates sphingolipid biosynthesis and its implications in disease.

Genular Protein ID: 2342331363

Symbol: ORML2_HUMAN

Name: ORM1-like protein 2

UniProtKB Accession Codes:

Q53FV1 B2RA58 Q7Z4E5 Q8NFX0 Q9P004

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12093374

Title: ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins.

PubMed ID: 12093374

DOI: 10.1186/gb-2002-3-6-research0027

PubMed ID: 17928364

Title: A family of membrane proteins associated with presenilin expression and gamma-secretase function.

PubMed ID: 17928364

DOI: 10.1096/fj.07-9072com

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20182505

Title: Orm family proteins mediate sphingolipid homeostasis.

PubMed ID: 20182505

DOI: 10.1038/nature08787

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 153
  • Mass: 17363
  • Checksum: F4031EF81F8E8B71
  • Sequence:
    • MNVGVAHSEV NPNTRVMNSR GIWLAYIILV GLLHMVLLSI PFFSIPVVWT LTNVIHNLAT 
YVFLHTVKGT PFETPDQGKA RLLTHWEQMD YGLQFTSSRK FLSISPIVLY LLASFYTKYD 
AAHFLINTAS LLSVLLPKLP QFHGVRVFGI NKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.