Details for: N6AMT1

Gene ID: 29104

Symbol: N6AMT1

Ensembl ID: ENSG00000156239

Description: N-6 adenine-specific DNA methyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.8400
    Cell Significance Index: -9.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.5598
    Cell Significance Index: -10.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.5259
    Cell Significance Index: -10.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.9054
    Cell Significance Index: -10.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4716
    Cell Significance Index: -9.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8801
    Cell Significance Index: -11.3700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.0361
    Cell Significance Index: 6.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8980
    Cell Significance Index: 46.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7549
    Cell Significance Index: 681.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6153
    Cell Significance Index: 36.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5208
    Cell Significance Index: 84.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4960
    Cell Significance Index: 13.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3706
    Cell Significance Index: 16.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3643
    Cell Significance Index: 4.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3545
    Cell Significance Index: 10.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3345
    Cell Significance Index: 21.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3032
    Cell Significance Index: 54.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2911
    Cell Significance Index: 20.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2856
    Cell Significance Index: 2.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2807
    Cell Significance Index: 32.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2460
    Cell Significance Index: 5.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2250
    Cell Significance Index: 3.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2198
    Cell Significance Index: 30.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2171
    Cell Significance Index: 26.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2164
    Cell Significance Index: 43.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2159
    Cell Significance Index: 42.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2033
    Cell Significance Index: 4.3500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1804
    Cell Significance Index: 2.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1646
    Cell Significance Index: 89.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1358
    Cell Significance Index: 25.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1236
    Cell Significance Index: 15.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1227
    Cell Significance Index: 9.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0884
    Cell Significance Index: 8.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0853
    Cell Significance Index: 12.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0794
    Cell Significance Index: 3.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0766
    Cell Significance Index: 27.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0654
    Cell Significance Index: 1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0640
    Cell Significance Index: 2.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0592
    Cell Significance Index: 1.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0478
    Cell Significance Index: 2.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0316
    Cell Significance Index: 0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0301
    Cell Significance Index: 0.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0254
    Cell Significance Index: 0.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0254
    Cell Significance Index: 11.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0120
    Cell Significance Index: 7.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0102
    Cell Significance Index: 0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0099
    Cell Significance Index: 15.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0086
    Cell Significance Index: 16.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0051
    Cell Significance Index: 9.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0009
    Cell Significance Index: 1.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0123
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0161
    Cell Significance Index: -1.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0167
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0201
    Cell Significance Index: -2.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0229
    Cell Significance Index: -2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0298
    Cell Significance Index: -8.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0305
    Cell Significance Index: -1.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0319
    Cell Significance Index: -4.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0347
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0424
    Cell Significance Index: -7.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0431
    Cell Significance Index: -2.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0506
    Cell Significance Index: -1.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0530
    Cell Significance Index: -1.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0541
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0549
    Cell Significance Index: -6.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0562
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0563
    Cell Significance Index: -11.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0815
    Cell Significance Index: -2.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0863
    Cell Significance Index: -6.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0881
    Cell Significance Index: -1.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0894
    Cell Significance Index: -0.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0908
    Cell Significance Index: -5.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0922
    Cell Significance Index: -2.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0995
    Cell Significance Index: -10.3600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1020
    Cell Significance Index: -0.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1026
    Cell Significance Index: -5.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1071
    Cell Significance Index: -8.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1218
    Cell Significance Index: -3.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1226
    Cell Significance Index: -1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1361
    Cell Significance Index: -6.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1363
    Cell Significance Index: -2.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1482
    Cell Significance Index: -2.5400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1536
    Cell Significance Index: -1.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1674
    Cell Significance Index: -6.3400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1732
    Cell Significance Index: -1.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1788
    Cell Significance Index: -5.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1902
    Cell Significance Index: -4.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1935
    Cell Significance Index: -4.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2173
    Cell Significance Index: -6.2300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2220
    Cell Significance Index: -3.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2269
    Cell Significance Index: -6.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** N6AMT1 is a DNA methyltransferase enzyme that specifically targets adenine residues in DNA, catalyzing the transfer of a methyl group from S-adenosylmethionine (SAM) to the N6 position of adenine. This process is essential for the regulation of gene expression, as it can alter the binding affinity of transcription factors to their target DNA sequences. N6AMT1 is also implicated in the maintenance of genomic stability, as aberrant methylation patterns can lead to mutations and chromosomal instability. **Pathways and Functions:** N6AMT1 is involved in various cellular processes, including: 1. **DNA Methylation and Gene Regulation:** N6AMT1 plays a crucial role in the regulation of gene expression by modifying the methylation status of adenine residues in DNA. This, in turn, can influence the binding affinity of transcription factors to their target DNA sequences, thereby modulating gene expression. 2. **Epigenetic Modifications:** N6AMT1 is involved in the regulation of epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA expression. These modifications can influence cellular behavior, including proliferation, differentiation, and survival. 3. **Transcriptional Regulation:** N6AMT1 has been shown to regulate transcriptional activity by modifying the methylation status of adenine residues in DNA. This can influence the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. 4. **Cancer and Disease Pathogenesis:** Aberrant methylation patterns, including those mediated by N6AMT1, have been implicated in the development and progression of various cancers. N6AMT1 has been shown to play a role in the regulation of tumor suppressor genes and oncogenes, highlighting its potential as a therapeutic target in cancer treatment. **Clinical Significance:** N6AMT1 has been implicated in various diseases, including: 1. **Cancer:** N6AMT1 has been shown to play a role in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Neurological Disorders:** N6AMT1 has been implicated in the regulation of gene expression in the central nervous system, and alterations in its activity have been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious Diseases:** N6AMT1 has been shown to play a role in the regulation of gene expression in response to infection, and alterations in its activity have been linked to the development of infectious diseases. In conclusion, N6AMT1 is a multifunctional enzyme that plays a critical role in maintaining genomic stability, regulating gene expression, and influencing cellular behavior. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target in disease treatment and prevention. Further research is needed to fully elucidate the mechanisms of N6AMT1 and its role in various cellular processes.

Genular Protein ID: 2767319349

Symbol: N6MT1_HUMAN

Name: Methylarsonite methyltransferase N6AMT1

UniProtKB Accession Codes:

Q9Y5N5 B2RA97 Q96F73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 31 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 9 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18539146

Title: HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.

PubMed ID: 18539146

DOI: 10.1016/j.febslet.2008.05.045

PubMed ID: 20606008

Title: Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality.

PubMed ID: 20606008

DOI: 10.1128/mcb.00218-10

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21193388

Title: Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.

PubMed ID: 21193388

DOI: 10.1289/ehp.1002733

PubMed ID: 25851604

Title: The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.

PubMed ID: 25851604

DOI: 10.1091/mbc.e15-02-0073

PubMed ID: 25997655

Title: Interactive effects of N6AMT1 and As3MT in arsenic biomethylation.

PubMed ID: 25997655

DOI: 10.1093/toxsci/kfv101

PubMed ID: 30392959

Title: N6-methyladenine DNA modification in glioblastoma.

PubMed ID: 30392959

DOI: 10.1016/j.cell.2018.10.006

PubMed ID: 30017583

Title: N6-methyladenine DNA modification in the human genome.

PubMed ID: 30017583

DOI: 10.1016/j.molcel.2018.06.015

PubMed ID: 31466382

Title: The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.

PubMed ID: 31466382

DOI: 10.3390/biom9090422

PubMed ID: 31632689

Title: Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112.

PubMed ID: 31632689

DOI: 10.1038/s41421-019-0119-5

PubMed ID: 32203414

Title: The origin of genomic N6-methyl-deoxyadenosine in mammalian cells.

PubMed ID: 32203414

DOI: 10.1038/s41589-020-0504-2

PubMed ID: 34948388

Title: Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.

PubMed ID: 34948388

DOI: 10.3390/ijms222413593

PubMed ID: 31636962

Title: Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase.

PubMed ID: 31636962

DOI: 10.1038/s41421-019-0121-y

PubMed ID: 31061526

Title: KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.

PubMed ID: 31061526

DOI: 10.1038/s41594-019-0219-9

PubMed ID: 32969463

Title: Structural insight into HEMK2-TRMT112-mediated glutamine methylation.

PubMed ID: 32969463

DOI: 10.1042/bcj20200594

Sequence Information:

  • Length: 214
  • Mass: 22957
  • Checksum: 65512C91DC85ADDB
  • Sequence:
    • MAGENFATPF HGHVGRGAFS DVYEPAEDTF LLLDALEAAA AELAGVEICL EVGSGSGVVS 
AFLASMIGPQ ALYMCTDINP EAAACTLETA RCNKVHIQPV ITDLVKGLLP RLTEKVDLLV 
FNPPYVVTPP QEVGSHGIEA AWAGGRNGRE VMDRFFPLVP DLLSPRGLFY LVTIKENNPE 
EILKIMKTKG LQGTTALSRQ AGQETLSVLK FTKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.