Details for: SAP30BP

Gene ID: 29115

Symbol: SAP30BP

Ensembl ID: ENSG00000161526

Description: SAP30 binding protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.82
    Marker Score: 3,836
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.7
    Marker Score: 1,558
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.53
    Marker Score: 3,736
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.45
    Marker Score: 2,133
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.43
    Marker Score: 498
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.36
    Marker Score: 5,260
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.32
    Marker Score: 15,290
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.3
    Marker Score: 1,025
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3
    Marker Score: 5,093
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.29
    Marker Score: 43,764
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.26
    Marker Score: 1,325
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.26
    Marker Score: 5,425
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.26
    Marker Score: 2,865
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.25
    Marker Score: 1,326
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.25
    Marker Score: 359
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.23
    Marker Score: 1,642
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.23
    Marker Score: 676
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.23
    Marker Score: 10,577
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.23
    Marker Score: 1,437
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.22
    Marker Score: 1,151
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.22
    Marker Score: 2,001
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2,544
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.21
    Marker Score: 290
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.2
    Marker Score: 1,503
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.2
    Marker Score: 1,278
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.2
    Marker Score: 1,543
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.19
    Marker Score: 486
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.19
    Marker Score: 15,721
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.19
    Marker Score: 2,016
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.18
    Marker Score: 801
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.18
    Marker Score: 2,350
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.14
    Marker Score: 834
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.14
    Marker Score: 1,646
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.13
    Marker Score: 1,195
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17,594
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.12
    Marker Score: 352
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.12
    Marker Score: 1,902
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.12
    Marker Score: 1,207
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.11
    Marker Score: 1,620
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.11
    Marker Score: 11,503
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.11
    Marker Score: 1,047
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.11
    Marker Score: 692
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3,008
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.1
    Marker Score: 752
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.1
    Marker Score: 1,521
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1
    Marker Score: 7,146
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.1
    Marker Score: 1,744
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1,181
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.09
    Marker Score: 1,098
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.09
    Marker Score: 3,426
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.08
    Marker Score: 523
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.08
    Marker Score: 2,026
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.08
    Marker Score: 962
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.08
    Marker Score: 3,988
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.07
    Marker Score: 3,173
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.06
    Marker Score: 3,344
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.06
    Marker Score: 1,072
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.06
    Marker Score: 952
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.06
    Marker Score: 10,684
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.06
    Marker Score: 430
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.06
    Marker Score: 5,213
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.06
    Marker Score: 391
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.06
    Marker Score: 1,130
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22,511
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.05
    Marker Score: 231
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.05
    Marker Score: 365
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.05
    Marker Score: 664
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.05
    Marker Score: 297
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.05
    Marker Score: 511
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Marker Score: 58,460
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.04
    Marker Score: 6,667
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.04
    Marker Score: 610
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.04
    Marker Score: 2,650
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.04
    Marker Score: 506
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.04
    Marker Score: 2,833
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.04
    Marker Score: 2,875
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.04
    Marker Score: 573
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.03
    Marker Score: 258
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.03
    Marker Score: 284
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.03
    Marker Score: 1,486
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.03
    Marker Score: 209
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.03
    Marker Score: 11,593
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.03
    Marker Score: 1,136
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.03
    Marker Score: 730
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.02
    Marker Score: 683
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.02
    Marker Score: 1,807
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 696
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.02
    Marker Score: 13,694
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.02
    Marker Score: 251
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.02
    Marker Score: 892
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.01
    Marker Score: 10,043
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.01
    Marker Score: 250
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.01
    Marker Score: 460
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.01
    Marker Score: 674
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.01
    Marker Score: 295
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.01
    Marker Score: 1,966
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1
    Marker Score: 1,092
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1
    Marker Score: 667
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1
    Marker Score: 1,544
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1
    Marker Score: 1,021

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Binding to SAP30:** SAP30BP interacts with the SAP30 protein, a histone-modifying enzyme, to regulate chromatin structure and gene expression. 2. **Tissue-specific expression:** SAP30BP is highly expressed in pancreatic acinar cells, choroid plexus epithelial cells, and blood cells, but its expression levels vary significantly across different tissues. 3. **Epigenetic regulation:** SAP30BP is involved in the regulation of gene expression through its interactions with chromatin-modifying enzymes and transcription factors. 4. **Response to viral infections:** SAP30BP has been shown to modulate the response to viral infections, suggesting its potential role in regulating the host-virus interaction. **Pathways and Functions:** 1. **Epigenetic regulation of gene expression:** SAP30BP interacts with chromatin-modifying enzymes to regulate the expression of genes involved in cell differentiation, proliferation, and survival. 2. **Gene expression (transcription):** SAP30BP modulates the expression of genes involved in transcriptional regulation, including the regulation of DNA-templated transcription. 3. **Intermediate filament cytoskeleton:** SAP30BP is involved in the regulation of the intermediate filament cytoskeleton, which is essential for maintaining cell shape and integrity. 4. **Modulation by host of symbiont transcription:** SAP30BP interacts with host transcription factors to regulate the expression of symbiont genes, highlighting its role in the host-symbiont interaction. **Clinical Significance:** 1. **Cancer:** SAP30BP has been implicated in the regulation of cancer cell proliferation and survival, suggesting its potential role in cancer pathogenesis. 2. **Neurodegenerative disorders:** SAP30BP has been shown to be involved in the regulation of gene expression in neurons, highlighting its potential role in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Viral infections:** SAP30BP's role in modulating the response to viral infections suggests its potential as a therapeutic target for viral diseases. 4. **Regulation of RNA expression:** SAP30BP's involvement in the regulation of RNA expression highlights its potential role in diseases characterized by altered RNA expression, such as cancer and neurodegenerative disorders. In conclusion, SAP30BP is a multifunctional protein that plays a crucial role in regulating gene expression and epigenetic processes. Its tissue-specific expression and involvement in various cellular processes make it an attractive target for future research and potential therapeutic applications.

Genular Protein ID: 2308440297

Symbol: S30BP_HUMAN

Name: SAP30-binding protein

UniProtKB Accession Codes:

Q9UHR5 B3KML7 Q8N1R5 Q8TDR8 Q96D27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15496587

Title: HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors.

PubMed ID: 15496587

DOI: 10.1093/jb/mvh108

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21221920

Title: Transcriptional regulation by HSV-1 induced HTRP via acetylation system.

PubMed ID: 21221920

DOI: 10.1007/s12250-010-3147-8

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 308
  • Mass: 33870
  • Checksum: C48CEFBD73CE82BC
  • Sequence:
    • MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD FSRLGGDEDG 
YEEEEDENSR QSEDDDSETE KPEADDPKDN TEAEKRDPQE LVASFSERVR NMSPDEIKIP 
PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN 
YPKDMFDPHG WSEDSYYEAL AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATSTTT 
TTASTAVADA QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG 
TIVKKAKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.