Details for: SAP30BP

Gene ID: 29115

Symbol: SAP30BP

Ensembl ID: ENSG00000161526

Description: SAP30 binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 249.1237
    Cell Significance Index: -38.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.9203
    Cell Significance Index: -41.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.4535
    Cell Significance Index: -46.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.9307
    Cell Significance Index: -38.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.6957
    Cell Significance Index: -44.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.7161
    Cell Significance Index: -46.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.9380
    Cell Significance Index: -44.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8902
    Cell Significance Index: -37.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5913
    Cell Significance Index: -45.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8515
    Cell Significance Index: -33.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4569
    Cell Significance Index: -16.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9744
    Cell Significance Index: 136.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3812
    Cell Significance Index: 37.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1247
    Cell Significance Index: 32.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0196
    Cell Significance Index: 47.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9353
    Cell Significance Index: 152.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9224
    Cell Significance Index: 24.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7832
    Cell Significance Index: 155.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7719
    Cell Significance Index: 57.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7678
    Cell Significance Index: 94.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7452
    Cell Significance Index: 102.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7063
    Cell Significance Index: 141.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6844
    Cell Significance Index: 35.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6244
    Cell Significance Index: 28.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5881
    Cell Significance Index: 106.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5825
    Cell Significance Index: 257.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5787
    Cell Significance Index: 27.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5646
    Cell Significance Index: 66.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5349
    Cell Significance Index: 14.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4933
    Cell Significance Index: 63.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4805
    Cell Significance Index: 61.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4758
    Cell Significance Index: 7.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4157
    Cell Significance Index: 287.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3977
    Cell Significance Index: 25.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3703
    Cell Significance Index: 202.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3264
    Cell Significance Index: 117.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3183
    Cell Significance Index: 8.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3091
    Cell Significance Index: 30.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2899
    Cell Significance Index: 20.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2838
    Cell Significance Index: 5.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2329
    Cell Significance Index: 4.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1884
    Cell Significance Index: 5.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1878
    Cell Significance Index: 6.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1495
    Cell Significance Index: 28.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1273
    Cell Significance Index: 6.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0541
    Cell Significance Index: 101.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0230
    Cell Significance Index: 35.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0199
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0187
    Cell Significance Index: 3.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0134
    Cell Significance Index: 8.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0129
    Cell Significance Index: 17.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0060
    Cell Significance Index: 11.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0218
    Cell Significance Index: -1.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0238
    Cell Significance Index: -18.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0295
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0349
    Cell Significance Index: -25.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0508
    Cell Significance Index: -37.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0576
    Cell Significance Index: -3.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0772
    Cell Significance Index: -43.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0820
    Cell Significance Index: -51.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1025
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1205
    Cell Significance Index: -13.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1314
    Cell Significance Index: -37.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1338
    Cell Significance Index: -2.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1617
    Cell Significance Index: -23.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2096
    Cell Significance Index: -11.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2102
    Cell Significance Index: -3.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2146
    Cell Significance Index: -25.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2217
    Cell Significance Index: -13.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2438
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2442
    Cell Significance Index: -51.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2775
    Cell Significance Index: -2.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3306
    Cell Significance Index: -22.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3379
    Cell Significance Index: -4.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3565
    Cell Significance Index: -6.1100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3896
    Cell Significance Index: -2.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3924
    Cell Significance Index: -40.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4171
    Cell Significance Index: -2.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4440
    Cell Significance Index: -11.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4574
    Cell Significance Index: -9.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4861
    Cell Significance Index: -38.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4871
    Cell Significance Index: -15.6000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4976
    Cell Significance Index: -5.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5129
    Cell Significance Index: -10.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5550
    Cell Significance Index: -24.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5748
    Cell Significance Index: -15.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5995
    Cell Significance Index: -15.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6001
    Cell Significance Index: -15.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6522
    Cell Significance Index: -17.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6623
    Cell Significance Index: -25.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7255
    Cell Significance Index: -7.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7411
    Cell Significance Index: -45.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9338
    Cell Significance Index: -34.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9489
    Cell Significance Index: -10.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0019
    Cell Significance Index: -31.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0077
    Cell Significance Index: -29.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0104
    Cell Significance Index: -35.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0272
    Cell Significance Index: -33.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Binding to SAP30:** SAP30BP interacts with the SAP30 protein, a histone-modifying enzyme, to regulate chromatin structure and gene expression. 2. **Tissue-specific expression:** SAP30BP is highly expressed in pancreatic acinar cells, choroid plexus epithelial cells, and blood cells, but its expression levels vary significantly across different tissues. 3. **Epigenetic regulation:** SAP30BP is involved in the regulation of gene expression through its interactions with chromatin-modifying enzymes and transcription factors. 4. **Response to viral infections:** SAP30BP has been shown to modulate the response to viral infections, suggesting its potential role in regulating the host-virus interaction. **Pathways and Functions:** 1. **Epigenetic regulation of gene expression:** SAP30BP interacts with chromatin-modifying enzymes to regulate the expression of genes involved in cell differentiation, proliferation, and survival. 2. **Gene expression (transcription):** SAP30BP modulates the expression of genes involved in transcriptional regulation, including the regulation of DNA-templated transcription. 3. **Intermediate filament cytoskeleton:** SAP30BP is involved in the regulation of the intermediate filament cytoskeleton, which is essential for maintaining cell shape and integrity. 4. **Modulation by host of symbiont transcription:** SAP30BP interacts with host transcription factors to regulate the expression of symbiont genes, highlighting its role in the host-symbiont interaction. **Clinical Significance:** 1. **Cancer:** SAP30BP has been implicated in the regulation of cancer cell proliferation and survival, suggesting its potential role in cancer pathogenesis. 2. **Neurodegenerative disorders:** SAP30BP has been shown to be involved in the regulation of gene expression in neurons, highlighting its potential role in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Viral infections:** SAP30BP's role in modulating the response to viral infections suggests its potential as a therapeutic target for viral diseases. 4. **Regulation of RNA expression:** SAP30BP's involvement in the regulation of RNA expression highlights its potential role in diseases characterized by altered RNA expression, such as cancer and neurodegenerative disorders. In conclusion, SAP30BP is a multifunctional protein that plays a crucial role in regulating gene expression and epigenetic processes. Its tissue-specific expression and involvement in various cellular processes make it an attractive target for future research and potential therapeutic applications.

Genular Protein ID: 2308440297

Symbol: S30BP_HUMAN

Name: SAP30-binding protein

UniProtKB Accession Codes:

Q9UHR5 B3KML7 Q8N1R5 Q8TDR8 Q96D27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15496587

Title: HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors.

PubMed ID: 15496587

DOI: 10.1093/jb/mvh108

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21221920

Title: Transcriptional regulation by HSV-1 induced HTRP via acetylation system.

PubMed ID: 21221920

DOI: 10.1007/s12250-010-3147-8

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 308
  • Mass: 33870
  • Checksum: C48CEFBD73CE82BC
  • Sequence:
    • MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD FSRLGGDEDG 
YEEEEDENSR QSEDDDSETE KPEADDPKDN TEAEKRDPQE LVASFSERVR NMSPDEIKIP 
PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN 
YPKDMFDPHG WSEDSYYEAL AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATSTTT 
TTASTAVADA QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG 
TIVKKAKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.