Details for: RACGAP1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.72
Marker Score: 6,659 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.33
Marker Score: 702 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.22
Marker Score: 1,753 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.19
Marker Score: 1,497 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.14
Marker Score: 3,110 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.06
Marker Score: 847 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,777 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.03
Marker Score: 971 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.02
Marker Score: 546 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,795 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,019 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.99
Marker Score: 2,338 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,404 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,409 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,730 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5,090 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.88
Marker Score: 1,464 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.85
Marker Score: 244 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.83
Marker Score: 1,686 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.82
Marker Score: 264 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.81
Marker Score: 849 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.78
Marker Score: 1,479 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.78
Marker Score: 1,201 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,259 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.77
Marker Score: 11,998 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 577 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 386 - Cell Name: neural crest cell (CL0011012)
Fold Change: 0.74
Marker Score: 795 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 296 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.74
Marker Score: 501 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.73
Marker Score: 2,155 - Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 638 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.68
Marker Score: 509 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.68
Marker Score: 337 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.67
Marker Score: 2,819 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.67
Marker Score: 196 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.67
Marker Score: 886 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.64
Marker Score: 2,663 - Cell Name: oocyte (CL0000023)
Fold Change: 0.63
Marker Score: 155 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.62
Marker Score: 2,582 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.61
Marker Score: 366 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.6
Marker Score: 375 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.57
Marker Score: 20,982 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.55
Marker Score: 309 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.55
Marker Score: 4,692 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.54
Marker Score: 33,373 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.54
Marker Score: 5,101 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.53
Marker Score: 263 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.52
Marker Score: 2,045 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.5
Marker Score: 157 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.5
Marker Score: 500 - Cell Name: Unknown (CL0000548)
Fold Change: 0.5
Marker Score: 361 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.49
Marker Score: 833 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.48
Marker Score: 581 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.45
Marker Score: 149 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.45
Marker Score: 1,734 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.43
Marker Score: 1,011 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.42
Marker Score: 886 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.42
Marker Score: 120 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.42
Marker Score: 526 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.41
Marker Score: 398 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.41
Marker Score: 3,138 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.41
Marker Score: 15,445 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.41
Marker Score: 1,103 - Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.4
Marker Score: 200 - Cell Name: neural cell (CL0002319)
Fold Change: 0.4
Marker Score: 192 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.39
Marker Score: 124 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.39
Marker Score: 3,662 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.39
Marker Score: 262 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.39
Marker Score: 184 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.38
Marker Score: 102 - Cell Name: glial cell (CL0000125)
Fold Change: 0.37
Marker Score: 407 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.36
Marker Score: 224 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.36
Marker Score: 413 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.36
Marker Score: 2,185 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.36
Marker Score: 94 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.36
Marker Score: 226 - Cell Name: neuron (CL0000540)
Fold Change: 0.36
Marker Score: 1,464 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.36
Marker Score: 206 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.35
Marker Score: 1,471 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.35
Marker Score: 7,010 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.35
Marker Score: 144 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.34
Marker Score: 307 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.33
Marker Score: 148 - Cell Name: radial glial cell (CL0000681)
Fold Change: 0.33
Marker Score: 123 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.33
Marker Score: 237 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.33
Marker Score: 220 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.33
Marker Score: 164 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.33
Marker Score: 160 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.33
Marker Score: 113 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.33
Marker Score: 344 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.32
Marker Score: 204 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.32
Marker Score: 513 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.32
Marker Score: 187
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 562419567
Symbol: RGAP1_HUMAN
Name: Rac GTPase-activating protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10979956
Title: MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells.
PubMed ID: 10979956
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10819331
Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10819331
PubMed ID: 9497316
Title: MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells.
PubMed ID: 9497316
PubMed ID: 11085985
Title: MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody.
PubMed ID: 11085985
PubMed ID: 11278976
Title: Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.
PubMed ID: 11278976
PubMed ID: 11782313
Title: Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.
PubMed ID: 11782313
PubMed ID: 12590651
Title: Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells.
PubMed ID: 12590651
DOI: 10.1042/bj20021652
PubMed ID: 12689593
Title: Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
PubMed ID: 12689593
PubMed ID: 14729465
Title: MgcRacGAP regulates cortical activity through RhoA during cytokinesis.
PubMed ID: 14729465
PubMed ID: 14744859
Title: Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.
PubMed ID: 14744859
PubMed ID: 16213214
Title: Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.
PubMed ID: 16213214
PubMed ID: 15642749
Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
PubMed ID: 15642749
PubMed ID: 16103226
Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.
PubMed ID: 16103226
PubMed ID: 16129829
Title: MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.
PubMed ID: 16129829
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16236794
Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.
PubMed ID: 16236794
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18511905
Title: Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.
PubMed ID: 18511905
PubMed ID: 18445686
Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.
PubMed ID: 18445686
DOI: 10.1242/jcs.019174
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19468302
Title: Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
PubMed ID: 19468302
PubMed ID: 19468300
Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
PubMed ID: 19468300
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25068414
Title: Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.
PubMed ID: 25068414
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 23235882
Title: Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.
PubMed ID: 23235882
DOI: 10.1038/nature11773
PubMed ID: 34818416
Title: RACGAP1 variants in a sporadic case of CDA III implicate the dysfunction of centralspindlin as the basis of the disease.
PubMed ID: 34818416
Sequence Information:
- Length: 632
- Mass: 71027
- Checksum: 032B7DF9CEA8F39D
- Sequence:
MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFDK TDESLDWDSS LVKTFKLKKR EKRRSTSRQF VDGPPGPVKK TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP YWTRSRRKTG TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM LADFVSQTSP MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF LRVKTVPLLS KVDDIHAICS LLKDFLRNLK EPLLTFRLNR AFMEAAEITD EDNSIAAMYQ AVGELPQANR DTLAFLMIHL QRVAQSPHTK MDVANLAKVF GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS QFMMVEQENI DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK
Genular Protein ID: 1821382532
Symbol: B2RE34_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 632
- Mass: 70968
- Checksum: 92F87DFACFE39F61
- Sequence:
MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFDK TDESLDWDSS LVKTFKLKKR EKRRSTSRQF VDGPPGPVKK TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP YWTRSRRKTG TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM LADFVSQTSP MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF LRVKTVPLLS KVDDIHAICS LLKDFLRNLK EPLLTFRLNR AFMEAAEITD EGNSIAAMYQ AVGELPQANR DTLAFLMIHL QRVAQSPHTK MDVANLAKVF GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS QFMMVEQENI DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.