RACGAP1 | ENSG00000161800 | NCBI 29127

Details for: RACGAP1

Gene ID: 29127

Symbol: RACGAP1

Ensembl ID: ENSG00000161800

Description: Rac GTPase activating protein 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Cdc42 gtpase cycle
(R-HSA-9013148)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Kinesins
(R-HSA-983189)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhob gtpase cycle
(R-HSA-9013026)
Rhoc gtpase cycle
(R-HSA-9013106)
Rhod gtpase cycle
(R-HSA-9013405)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Acrosomal vesicle
(GO:0001669)
Actomyosin contractile ring assembly
(GO:0000915)
Alpha-tubulin binding
(GO:0043014)
Beta-tubulin binding
(GO:0048487)
Centralspindlin complex
(GO:0097149)
Cleavage furrow
(GO:0032154)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Erythrocyte differentiation
(GO:0030218)
Extracellular exosome
(GO:0070062)
Flemming body
(GO:0090543)
Gamma-tubulin binding
(GO:0043015)
Gtpase activator activity
(GO:0005096)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Midbody
(GO:0030496)
Mitochondrion
(GO:0005739)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle
(GO:0072686)
Mitotic spindle midzone assembly
(GO:0051256)
Monoatomic ion transport
(GO:0006811)
Neuroblast proliferation
(GO:0007405)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Positive regulation of cytokinesis
(GO:0032467)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of attachment of spindle microtubules to kinetochore
(GO:0051988)
Regulation of embryonic development
(GO:0045995)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Rho protein signal transduction
(GO:0007266)
Spermatogenesis
(GO:0007283)
Spindle
(GO:0005819)
Spindle midzone
(GO:0051233)
Sulfate transmembrane transport
(GO:1902358)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 46.3249
Cell Significance Index: -11.7500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 31.2661
Cell Significance Index: -12.8800
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 27.7090
Cell Significance Index: -4.3100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 26.5185
Cell Significance Index: -12.5200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.5843
Cell Significance Index: -11.0600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.4975
Cell Significance Index: -11.7100
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 4.7073
Cell Significance Index: 77.5700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.2107
Cell Significance Index: -11.2800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.0740
Cell Significance Index: -12.1300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.8130
Cell Significance Index: -8.6400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.6495
Cell Significance Index: -3.6100
Cell Name: germ cell (CL0000586)
Fold Change: 1.3787
Cell Significance Index: 10.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8951
Cell Significance Index: 170.3400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7406
Cell Significance Index: 73.2600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7031
Cell Significance Index: 139.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6183
Cell Significance Index: 67.2600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6050
Cell Significance Index: 8.2600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5391
Cell Significance Index: 486.7300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5130
Cell Significance Index: 59.7800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4782
Cell Significance Index: 56.3900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4477
Cell Significance Index: 14.3400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4220
Cell Significance Index: 23.6800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3968
Cell Significance Index: 11.0900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3282
Cell Significance Index: 65.8300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.3247
Cell Significance Index: 3.5300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2190
Cell Significance Index: 15.1500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2150
Cell Significance Index: 9.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2107
Cell Significance Index: 7.9800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1984
Cell Significance Index: 5.3200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1878
Cell Significance Index: 3.9300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1777
Cell Significance Index: 28.9000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1736
Cell Significance Index: 62.2800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1468
Cell Significance Index: 3.1800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1338
Cell Significance Index: 8.0400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1312
Cell Significance Index: 4.5600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1265
Cell Significance Index: 69.0900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1055
Cell Significance Index: 3.0400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.0858
Cell Significance Index: 0.7000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0805
Cell Significance Index: 4.1800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0757
Cell Significance Index: 33.4600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0698
Cell Significance Index: 44.3200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0663
Cell Significance Index: 45.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0657
Cell Significance Index: 2.9800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0610
Cell Significance Index: 114.8900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0464
Cell Significance Index: 2.8500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0435
Cell Significance Index: 1.5300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0345
Cell Significance Index: 0.9200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0304
Cell Significance Index: 0.7600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0016
Cell Significance Index: 2.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0006
Cell Significance Index: 0.0700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0015
Cell Significance Index: -2.2700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0020
Cell Significance Index: -3.7100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0031
Cell Significance Index: -0.5500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0101
Cell Significance Index: -4.5900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0121
Cell Significance Index: -1.6600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0131
Cell Significance Index: -0.2800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0135
Cell Significance Index: -10.2000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0146
Cell Significance Index: -0.2500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0154
Cell Significance Index: -11.3000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0176
Cell Significance Index: -13.0100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0194
Cell Significance Index: -0.4900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0223
Cell Significance Index: -12.5800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0230
Cell Significance Index: -3.3500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0251
Cell Significance Index: -15.6600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0260
Cell Significance Index: -2.6600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0353
Cell Significance Index: -10.1500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0371
Cell Significance Index: -4.7600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0512
Cell Significance Index: -6.6200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0575
Cell Significance Index: -1.2600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0590
Cell Significance Index: -2.7500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0616
Cell Significance Index: -10.5200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0656
Cell Significance Index: -4.6400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0676
Cell Significance Index: -14.2400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0945
Cell Significance Index: -10.8300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0985
Cell Significance Index: -6.6200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0985
Cell Significance Index: -7.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1043
Cell Significance Index: -6.7300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1116
Cell Significance Index: -6.8400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1127
Cell Significance Index: -11.7300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1128
Cell Significance Index: -1.6200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1231
Cell Significance Index: -2.1100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1311
Cell Significance Index: -9.7700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1467
Cell Significance Index: -11.6200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1470
Cell Significance Index: -6.9100
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.1474
Cell Significance Index: -1.3400
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1500
Cell Significance Index: -0.8900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1693
Cell Significance Index: -4.0600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1698
Cell Significance Index: -5.0000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1750
Cell Significance Index: -5.1400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1821
Cell Significance Index: -11.4800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1922
Cell Significance Index: -5.1400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1965
Cell Significance Index: -5.0500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1967
Cell Significance Index: -4.0800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2084
Cell Significance Index: -10.9400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2091
Cell Significance Index: -10.8900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2158
Cell Significance Index: -5.6800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2412
Cell Significance Index: -8.4500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2469
Cell Significance Index: -5.2400
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.2531
Cell Significance Index: -1.8400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2537
Cell Significance Index: -8.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** RACGAP1 is a crucial regulator of Rac GTPases, which are essential for controlling cytoskeletal reorganization, cell migration, and cell cycle progression. The gene's expression is widespread, with significant levels found in cells involved in immune response, neural development, and tissue repair. RACGAP1's unique ability to interact with multiple signaling pathways, including those involving Rho GTPases, makes it an essential component of complex cellular processes. **Pathways and Functions:** RACGAP1 is involved in various signaling pathways, including: 1. **Immune System:** RACGAP1 regulates immune cell function, including antigen presentation, cytokine production, and cell migration. It interacts with MHC class II molecules and modulates the activity of immune cells, such as dendritic cells and T cells. 2. **Cytoskeletal Dynamics:** RACGAP1 controls cytoskeletal reorganization by regulating the activity of Rac GTPases, which are essential for cell migration, adhesion, and morphology. 3. **Cell Migration:** RACGAP1 is involved in cell migration, a process critical for immune cell trafficking, wound healing, and tissue repair. 4. **Cell Cycle Progression:** RACGAP1 regulates cell cycle progression by controlling the activity of Rac GTPases, which are essential for cell proliferation and differentiation. 5. **Signaling by Rho GTPases:** RACGAP1 interacts with Rho GTPases, modulating their activity and influencing cellular processes such as cell migration, adhesion, and morphology. **Clinical Significance:** RACGAP1's involvement in immune system regulation and cellular processes makes it a potential target for the treatment of various diseases, including: 1. **Immune Disorders:** RACGAP1's role in immune cell function and antigen presentation makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** RACGAP1's involvement in cell migration and proliferation makes it a potential target for the treatment of cancer, including metastatic disease. 3. **Neurological Disorders:** RACGAP1's role in neural development and function makes it a potential target for the treatment of neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, RACGAP1 is a multifaceted gene that plays a critical role in regulating immune system function, cellular processes, and tissue development. Its involvement in multiple signaling pathways underscores its significance in maintaining cellular homeostasis and responding to environmental cues. Further research on RACGAP1's functions and clinical significance is necessary to fully understand its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Rac GTPase-activating protein 1
B2RE34_HUMAN

Genular Protein ID: 562419567

Symbol: RGAP1_HUMAN

Name: Rac GTPase-activating protein 1

UniProtKB Accession Codes:

Q9H0H5 Q6PJ26 Q9NWN2 Q9P250 Q9P2W2

Database IDs:

Citations:

PubMed ID: 10979956

Title: MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells.

PubMed ID: 10979956

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 9497316

Title: MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells.

PubMed ID: 9497316

DOI: 10.1074/jbc.273.11.6019

PubMed ID: 11085985

Title: MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody.

PubMed ID: 11085985

DOI: 10.1074/jbc.m007252200

PubMed ID: 11278976

Title: Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.

PubMed ID: 11278976

DOI: 10.1074/jbc.m011740200

PubMed ID: 11782313

Title: Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.

PubMed ID: 11782313

DOI: 10.1016/s1534-5807(01)00110-1

PubMed ID: 12590651

Title: Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells.

PubMed ID: 12590651

DOI: 10.1042/bj20021652

PubMed ID: 12689593

Title: Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.

PubMed ID: 12689593

DOI: 10.1016/s1534-5807(03)00089-3

PubMed ID: 14729465

Title: MgcRacGAP regulates cortical activity through RhoA during cytokinesis.

PubMed ID: 14729465

DOI: 10.1016/j.yexcr.2003.10.015

PubMed ID: 14744859

Title: Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.

PubMed ID: 14744859

DOI: 10.1074/jbc.m313257200

PubMed ID: 16213214

Title: Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.

PubMed ID: 16213214

DOI: 10.1016/j.cell.2005.07.027

PubMed ID: 15642749

Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.

PubMed ID: 15642749

DOI: 10.1083/jcb.200408085

PubMed ID: 16103226

Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.

PubMed ID: 16103226

DOI: 10.1083/jcb.200501097

PubMed ID: 16129829

Title: MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.

PubMed ID: 16129829

DOI: 10.1073/pnas.0504145102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18511905

Title: Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.

PubMed ID: 18511905

DOI: 10.1038/emboj.2008.112

PubMed ID: 18445686

Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.

PubMed ID: 18445686

DOI: 10.1242/jcs.019174

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19468302

Title: Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

PubMed ID: 19468302

DOI: 10.1371/journal.pbio.1000111

PubMed ID: 19468300

Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.

PubMed ID: 19468300

DOI: 10.1371/journal.pbio.1000110

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25068414

Title: Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.

PubMed ID: 25068414

DOI: 10.1016/j.febslet.2014.07.019

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23235882

Title: Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.

PubMed ID: 23235882

DOI: 10.1038/nature11773

PubMed ID: 34818416

Title: RACGAP1 variants in a sporadic case of CDA III implicate the dysfunction of centralspindlin as the basis of the disease.

PubMed ID: 34818416

DOI: 10.1182/blood.2021012334

Sequence Information:

Length: 632
Mass: 71027
Checksum: 032B7DF9CEA8F39D
Sequence:

MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK 
AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE 
QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFDK TDESLDWDSS LVKTFKLKKR 
EKRRSTSRQF VDGPPGPVKK TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP 
YWTRSRRKTG TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC 
VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM LADFVSQTSP 
MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF LRVKTVPLLS KVDDIHAICS 
LLKDFLRNLK EPLLTFRLNR AFMEAAEITD EDNSIAAMYQ AVGELPQANR DTLAFLMIHL 
QRVAQSPHTK MDVANLAKVF GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS 
QFMMVEQENI DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS 
TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK

Genular Protein ID: 1821382532

Symbol: B2RE34_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RE34

Database IDs:

Sequence Information:

Length: 632
Mass: 70968
Checksum: 92F87DFACFE39F61
Sequence:

MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK 
AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE 
QKSALAFLNR GQPSSSNAGN KRLSTIDESG SILSDISFDK TDESLDWDSS LVKTFKLKKR 
EKRRSTSRQF VDGPPGPVKK TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP 
YWTRSRRKTG TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC 
VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM LADFVSQTSP 
MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF LRVKTVPLLS KVDDIHAICS 
LLKDFLRNLK EPLLTFRLNR AFMEAAEITD EGNSIAAMYQ AVGELPQANR DTLAFLMIHL 
QRVAQSPHTK MDVANLAKVF GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS 
QFMMVEQENI DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS 
TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RACGAP1

Associated with

Cells (max top 100)

Other Information

MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. PubMed ID: 10979956

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. PubMed ID: 9497316

MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. PubMed ID: 11085985

Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. PubMed ID: 11278976

Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. PubMed ID: 11782313

Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. PubMed ID: 12590651

Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. PubMed ID: 12689593

MgcRacGAP regulates cortical activity through RhoA during cytokinesis. PubMed ID: 14729465

Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. PubMed ID: 14744859

Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. PubMed ID: 16213214

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. PubMed ID: 15642749

An ECT2-centralspindlin complex regulates the localization and function of RhoA. PubMed ID: 16103226

MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. PubMed ID: 16129829

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Dissecting the role of Rho-mediated signaling in contractile ring formation. PubMed ID: 16236794

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. PubMed ID: 18511905

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. PubMed ID: 18445686

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PubMed ID: 19468302

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PubMed ID: 19468300

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4. PubMed ID: 25068414

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. PubMed ID: 23235882

RACGAP1 variants in a sporadic case of CDA III implicate the dysfunction of centralspindlin as the basis of the disease. PubMed ID: 34818416