Details for: GRSF1

Gene ID: 2926

Symbol: GRSF1

Ensembl ID: ENSG00000132463

Description: G-rich RNA sequence binding factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.04
    Marker Score: 2883
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.99
    Marker Score: 2859
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.7
    Marker Score: 6967
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.64
    Marker Score: 6436
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.63
    Marker Score: 1641
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.6
    Marker Score: 1702
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.59
    Marker Score: 4329
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.59
    Marker Score: 3612
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.53
    Marker Score: 378
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.53
    Marker Score: 52899
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.53
    Marker Score: 1645
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.51
    Marker Score: 2638
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.51
    Marker Score: 2220
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.49
    Marker Score: 9663
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.48
    Marker Score: 14936
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.44
    Marker Score: 461
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.44
    Marker Score: 791
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.43
    Marker Score: 577
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.43
    Marker Score: 412
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.43
    Marker Score: 9128
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4
    Marker Score: 4153
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.4
    Marker Score: 520
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.39
    Marker Score: 3309.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.39
    Marker Score: 1011
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.38
    Marker Score: 483
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.37
    Marker Score: 389
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.37
    Marker Score: 672
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.36
    Marker Score: 2228
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.36
    Marker Score: 473
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.35
    Marker Score: 1687
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.32
    Marker Score: 685
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.31
    Marker Score: 5615
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.31
    Marker Score: 69235.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.3
    Marker Score: 938
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.27
    Marker Score: 874
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.27
    Marker Score: 1421.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.26
    Marker Score: 858
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.26
    Marker Score: 1159
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.26
    Marker Score: 10848
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.24
    Marker Score: 1302
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.24
    Marker Score: 3901
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.24
    Marker Score: 1492
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.24
    Marker Score: 10644
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.24
    Marker Score: 1968
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.23
    Marker Score: 1080
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.23
    Marker Score: 68745
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.22
    Marker Score: 2184
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.22
    Marker Score: 75169
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.22
    Marker Score: 1240.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.21
    Marker Score: 2951
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.21
    Marker Score: 1867
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.21
    Marker Score: 11450
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.2
    Marker Score: 1279
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.19
    Marker Score: 995
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.19
    Marker Score: 2801
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.19
    Marker Score: 282
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.18
    Marker Score: 901
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.18
    Marker Score: 805
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.18
    Marker Score: 8787
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.18
    Marker Score: 2086
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.17
    Marker Score: 802
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.17
    Marker Score: 5637
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.17
    Marker Score: 12061
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.16
    Marker Score: 573
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.16
    Marker Score: 1087
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.16
    Marker Score: 2877.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.15
    Marker Score: 275
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.15
    Marker Score: 11648
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.15
    Marker Score: 6816
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.15
    Marker Score: 432
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.15
    Marker Score: 3622.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.15
    Marker Score: 1022
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.13
    Marker Score: 15249
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.13
    Marker Score: 4197
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.13
    Marker Score: 14918
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.13
    Marker Score: 1087
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.12
    Marker Score: 452
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 521
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.11
    Marker Score: 741
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.11
    Marker Score: 4796
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.11
    Marker Score: 696
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.11
    Marker Score: 919
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.1
    Marker Score: 40705
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.1
    Marker Score: 449
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.09
    Marker Score: 1155
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.09
    Marker Score: 2304
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.08
    Marker Score: 1125
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.08
    Marker Score: 2107
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.08
    Marker Score: 538
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.08
    Marker Score: 1390
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.07
    Marker Score: 235
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 251.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.07
    Marker Score: 6809
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.07
    Marker Score: 9264
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.07
    Marker Score: 1768
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.06
    Marker Score: 27246
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.06
    Marker Score: 2400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.06
    Marker Score: 1557
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.05
    Marker Score: 9905
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.05
    Marker Score: 1242

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Other Information

**Key characteristics:** - GRSF1 is a protein of approximately 130 kDa. - It is expressed in a variety of cell types, including CD8-alpha-alpha-positive cells, alpha-beta intraepithelial T cells, oogonial cells, pro-T cells, placental villous trophoblast, fraction A pre-pro B cell, unknown cells, ovarian surface epithelial cells, acinar cells of the salivary gland, oocyte, and cells in vitro. - It is a G-rich RNA sequence binding factor. - It is involved in the anterior/posterior pattern specification of the developing embryo. - It is involved in disease, G-quadruplex rna binding, infectious disease, influenza infection, influenza viral rna transcription and replication, metabolism of rna, mitochondrial rna catabolic process, mitochondrial rna degradation, morphogenesis of embryonic epithelium, mrna binding, mrna polyadenylation, positive regulation of mitochondrial rna catabolic process, protein binding, rna binding, trna processing, viral infection pathways, and viral mrna translation. **Pathways and functions:** - GRSF1 is involved in the anterior/posterior pattern specification of the developing embryo by binding to a G-rich RNA sequence in the regulatory region of the Hox11 gene. This binding is essential for the proper development of the neural tube and other posterior tissues. - It is involved in disease by binding to G-quadruplex rna molecules in the genome and regulating the expression of genes involved in disease processes. - It is involved in infectious disease by binding to G-quadruplex rna molecules in the genomes of viruses and regulating their expression. - It is involved in influenza infection by binding to G-quadruplex rna molecules in the genomes of influenza viruses and regulating their transcription and replication. - It is involved in influenza viral rna transcription and replication by binding to G-quadruplex rna molecules in the genomes of influenza viruses and facilitating their transcription and replication. - It is involved in the metabolism of rna by binding to G-quadruplex rna molecules and facilitating their degradation. - It is involved in mitochondrial rna catabolic process by binding to G-quadruplex rna molecules in the mitochondrial genome and facilitating their degradation. - It is involved in mitochondrial rna degradation by binding to G-quadruplex rna molecules in the mitochondrial genome and facilitating their degradation. - It is involved in morphogenesis of embryonic epithelium by binding to G-quadruplex rna molecules in the genomes of epithelial cells and regulating their proliferation and differentiation. - It is involved in mrna binding by binding to mrna molecules and facilitating their polyadenylation. - It is involved in positive regulation of mitochondrial rna catabolic process by binding to G-quadruplex rna molecules in the mitochondrial genome and facilitating their degradation. - It is involved in protein binding by binding to proteins and facilitating their interaction with other proteins. - It is involved in rna binding by binding to rna molecules and facilitating their binding to other rna molecules. - It is involved in trna processing by binding to trna molecules and facilitating their processing into mature ribosomes. - It is involved in viral infection pathways by binding to viral mRNA molecules and facilitating their translation into viral proteins. - It is involved in viral mrna translation by binding to viral mRNA molecules and facilitating their translation into viral proteins.

Genular Protein ID: 1279660415

Symbol: GRSF1_HUMAN

Name: G-rich sequence factor 1

UniProtKB Accession Codes:

Q12849 B3KPW0 Q4W5S5 Q6ZST3 Q8IWD6 Q8NBD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8036161

Title: GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.

PubMed ID: 8036161

DOI: 10.1093/nar/22.12.2334

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23473033

Title: The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.

PubMed ID: 23473033

DOI: 10.1016/j.cmet.2013.02.006

PubMed ID: 23473034

Title: GRSF1 regulates RNA processing in mitochondrial RNA granules.

PubMed ID: 23473034

DOI: 10.1016/j.cmet.2013.02.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25683715

Title: Mitochondrial RNA granules are centers for post-transcriptional RNA processing and ribosome biogenesis.

PubMed ID: 25683715

DOI: 10.1016/j.celrep.2015.01.030

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29967381

Title: Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.

PubMed ID: 29967381

DOI: 10.1038/s41467-018-05007-9

Sequence Information:

  • Length: 480
  • Mass: 53126
  • Checksum: E09EE4E70212A70F
  • Sequence:
    • MAGTRWVLGA LLRGCGCNCS SCRRTGAACL PFYSAAGSIP SGVSGRRRLL LLLGAAAAAA 
SQTRGLQTGP VPPGRLAGPP AVATSAAAAA AASYSALRAS LLPQSLAAAA AVPTRSYSQE 
SKTTYLEDLP PPPEYELAPS KLEEEVDDVF LIRAQGLPWS CTMEDVLNFF SDCRIRNGEN 
GIHFLLNRDG KRRGDALIEM ESEQDVQKAL EKHRMYMGQR YVEVYEINNE DVDALMKSLQ 
VKSSPVVNDG VVRLRGLPYS CNEKDIVDFF AGLNIVDITF VMDYRGRRKT GEAYVQFEEP 
EMANQALLKH REEIGNRYIE IFPSRRNEVR THVGSYKGKK IASFPTAKYI TEPEMVFEEH 
EVNEDIQPMT AFESEKEIEL PKEVPEKLPE AADFGTTSSL HFVHMRGLPF QANAQDIINF 
FAPLKPVRIT MEYSSSGKAT GEADVHFETH EDAVAAMLKD RSHVHHRYIE LFLNSCPKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.