Details for: GRSF1

Gene ID: 2926

Symbol: GRSF1

Ensembl ID: ENSG00000132463

Description: G-rich RNA sequence binding factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 254.3955
    Cell Significance Index: -39.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.8257
    Cell Significance Index: -37.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 114.2985
    Cell Significance Index: -47.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.7077
    Cell Significance Index: -46.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.0814
    Cell Significance Index: -39.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.1040
    Cell Significance Index: -44.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.5452
    Cell Significance Index: -39.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.7377
    Cell Significance Index: -42.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0246
    Cell Significance Index: -37.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1466
    Cell Significance Index: -43.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8353
    Cell Significance Index: -33.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1285
    Cell Significance Index: -17.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.5277
    Cell Significance Index: 243.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5261
    Cell Significance Index: 1377.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1129
    Cell Significance Index: 51.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0897
    Cell Significance Index: 29.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0612
    Cell Significance Index: 212.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9984
    Cell Significance Index: 545.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9710
    Cell Significance Index: 114.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9560
    Cell Significance Index: 49.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9539
    Cell Significance Index: 25.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9231
    Cell Significance Index: 166.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8410
    Cell Significance Index: 24.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7925
    Cell Significance Index: 97.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7872
    Cell Significance Index: 149.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7752
    Cell Significance Index: 20.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7254
    Cell Significance Index: 6.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6884
    Cell Significance Index: 18.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6647
    Cell Significance Index: 91.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6551
    Cell Significance Index: 42.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6385
    Cell Significance Index: 126.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6173
    Cell Significance Index: 100.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5442
    Cell Significance Index: 11.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5012
    Cell Significance Index: 35.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4661
    Cell Significance Index: 21.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4473
    Cell Significance Index: 197.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4362
    Cell Significance Index: 9.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4264
    Cell Significance Index: 152.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4106
    Cell Significance Index: 14.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3917
    Cell Significance Index: 30.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3442
    Cell Significance Index: 9.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3436
    Cell Significance Index: 44.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3242
    Cell Significance Index: 55.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3157
    Cell Significance Index: 34.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2899
    Cell Significance Index: 28.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2739
    Cell Significance Index: 20.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2381
    Cell Significance Index: 6.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2133
    Cell Significance Index: 27.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1760
    Cell Significance Index: 9.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1388
    Cell Significance Index: 7.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0741
    Cell Significance Index: 1.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0664
    Cell Significance Index: 7.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0609
    Cell Significance Index: 0.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0526
    Cell Significance Index: 36.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0451
    Cell Significance Index: 84.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0030
    Cell Significance Index: 4.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0079
    Cell Significance Index: -10.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0264
    Cell Significance Index: -2.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0394
    Cell Significance Index: -2.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0441
    Cell Significance Index: -6.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0512
    Cell Significance Index: -1.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0552
    Cell Significance Index: -31.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0646
    Cell Significance Index: -1.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0775
    Cell Significance Index: -1.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0827
    Cell Significance Index: -5.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0908
    Cell Significance Index: -19.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1021
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1238
    Cell Significance Index: -14.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1274
    Cell Significance Index: -2.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1278
    Cell Significance Index: -36.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1491
    Cell Significance Index: -9.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1814
    Cell Significance Index: -9.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1854
    Cell Significance Index: -21.2400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2023
    Cell Significance Index: -1.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2117
    Cell Significance Index: -6.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3247
    Cell Significance Index: -9.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3340
    Cell Significance Index: -15.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3376
    Cell Significance Index: -14.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3546
    Cell Significance Index: -5.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3751
    Cell Significance Index: -39.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4024
    Cell Significance Index: -5.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4373
    Cell Significance Index: -16.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4583
    Cell Significance Index: -36.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4595
    Cell Significance Index: -7.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4709
    Cell Significance Index: -10.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4855
    Cell Significance Index: -12.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4965
    Cell Significance Index: -29.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6174
    Cell Significance Index: -37.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6621
    Cell Significance Index: -4.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6686
    Cell Significance Index: -7.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7582
    Cell Significance Index: -21.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GRSF1 is a G-rich RNA sequence binding factor, characterized by its ability to bind to specific RNA sequences, thereby regulating various cellular processes. The protein is predominantly expressed in cells of the immune system, including T cells, B cells, and epithelial cells. Notably, GRSF1 is highly expressed in cells that undergo rapid proliferation, such as T cells and oogonial cells. The protein's expression is also elevated in response to viral infections, suggesting its involvement in the regulation of immune responses. **Pathways and Functions:** GRSF1 is involved in several cellular pathways, including: 1. **Mitochondrial RNA Catabolism:** GRSF1 plays a crucial role in the processing and degradation of mitochondrial RNA, which is essential for maintaining mitochondrial function and preventing mitochondrial dysfunction. 2. **Immune Regulation:** GRSF1 is involved in the regulation of immune cell development and function, particularly in the context of viral infections. The protein binds to specific RNA sequences, influencing the expression of genes involved in immune responses. 3. **RNA Splicing:** GRSF1 is also involved in the regulation of RNA splicing, which is essential for the production of mature messenger RNA. 4. **Viral Infection:** GRSF1 has been implicated in the regulation of viral RNA translation and replication, suggesting its involvement in the defense against viral infections. **Clinical Significance:** The clinical significance of GRSF1 is multifaceted: 1. **Viral Infections:** GRSF1's role in regulating viral RNA translation and replication makes it a potential target for the development of antiviral therapies. 2. **Autoimmune Diseases:** The protein's involvement in immune regulation and RNA splicing may also contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** GRSF1's expression in cancer cells may be indicative of its role in regulating cellular proliferation and apoptosis. 4. **Neurological Disorders:** The protein's involvement in mitochondrial RNA catabolism may also contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GRSF1 is a critical component in the regulation of mitochondrial RNA catabolism and immune response. Further studies are necessary to elucidate the protein's role in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 1279660415

Symbol: GRSF1_HUMAN

Name: G-rich sequence factor 1

UniProtKB Accession Codes:

Q12849 B3KPW0 Q4W5S5 Q6ZST3 Q8IWD6 Q8NBD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8036161

Title: GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.

PubMed ID: 8036161

DOI: 10.1093/nar/22.12.2334

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23473033

Title: The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.

PubMed ID: 23473033

DOI: 10.1016/j.cmet.2013.02.006

PubMed ID: 23473034

Title: GRSF1 regulates RNA processing in mitochondrial RNA granules.

PubMed ID: 23473034

DOI: 10.1016/j.cmet.2013.02.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25683715

Title: Mitochondrial RNA granules are centers for post-transcriptional RNA processing and ribosome biogenesis.

PubMed ID: 25683715

DOI: 10.1016/j.celrep.2015.01.030

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29967381

Title: Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.

PubMed ID: 29967381

DOI: 10.1038/s41467-018-05007-9

Sequence Information:

  • Length: 480
  • Mass: 53126
  • Checksum: E09EE4E70212A70F
  • Sequence:
    • MAGTRWVLGA LLRGCGCNCS SCRRTGAACL PFYSAAGSIP SGVSGRRRLL LLLGAAAAAA 
SQTRGLQTGP VPPGRLAGPP AVATSAAAAA AASYSALRAS LLPQSLAAAA AVPTRSYSQE 
SKTTYLEDLP PPPEYELAPS KLEEEVDDVF LIRAQGLPWS CTMEDVLNFF SDCRIRNGEN 
GIHFLLNRDG KRRGDALIEM ESEQDVQKAL EKHRMYMGQR YVEVYEINNE DVDALMKSLQ 
VKSSPVVNDG VVRLRGLPYS CNEKDIVDFF AGLNIVDITF VMDYRGRRKT GEAYVQFEEP 
EMANQALLKH REEIGNRYIE IFPSRRNEVR THVGSYKGKK IASFPTAKYI TEPEMVFEEH 
EVNEDIQPMT AFESEKEIEL PKEVPEKLPE AADFGTTSSL HFVHMRGLPF QANAQDIINF 
FAPLKPVRIT MEYSSSGKAT GEADVHFETH EDAVAAMLKD RSHVHHRYIE LFLNSCPKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.