Details for: GSK3B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 487.1895
Cell Significance Index: -75.7800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 295.8090
Cell Significance Index: -75.0300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 159.2587
Cell Significance Index: -64.7000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 143.0300
Cell Significance Index: -73.5700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 118.0140
Cell Significance Index: -79.1900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 68.0602
Cell Significance Index: -64.9800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 63.0598
Cell Significance Index: -77.7500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.3997
Cell Significance Index: -73.4000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.7316
Cell Significance Index: -49.7500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.1589
Cell Significance Index: -68.0600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.8135
Cell Significance Index: -78.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.6709
Cell Significance Index: 205.9900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.5017
Cell Significance Index: 83.9800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.9662
Cell Significance Index: 1063.9100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.9477
Cell Significance Index: 181.1800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.8769
Cell Significance Index: 73.9500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.7121
Cell Significance Index: 208.1200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6796
Cell Significance Index: 537.5200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4552
Cell Significance Index: 487.2500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9247
Cell Significance Index: 26.2600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.8978
Cell Significance Index: 27.3000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.8058
Cell Significance Index: 1248.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.7119
Cell Significance Index: 75.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6768
Cell Significance Index: 46.8600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6383
Cell Significance Index: 62.0400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.5581
Cell Significance Index: 104.7700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.3995
Cell Significance Index: 29.9200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.9998
Cell Significance Index: 28.5300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9341
Cell Significance Index: 101.6000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8741
Cell Significance Index: 25.1900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7148
Cell Significance Index: 13.9500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7059
Cell Significance Index: 127.2600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.6750
Cell Significance Index: 14.7800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5683
Cell Significance Index: 69.8800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4829
Cell Significance Index: 12.9000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.4703
Cell Significance Index: 8.0600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4131
Cell Significance Index: 21.6900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3916
Cell Significance Index: 63.6900 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.3836
Cell Significance Index: 9.3600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3753
Cell Significance Index: 37.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3425
Cell Significance Index: 644.9000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3411
Cell Significance Index: 186.3100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2638
Cell Significance Index: 119.7500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2632
Cell Significance Index: 116.3800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2396
Cell Significance Index: 152.1600 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.2074
Cell Significance Index: 2.1600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2044
Cell Significance Index: 314.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1848
Cell Significance Index: 340.8500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1192
Cell Significance Index: 107.6200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1142
Cell Significance Index: 15.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0863
Cell Significance Index: 117.3200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0546
Cell Significance Index: 1.9200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0240
Cell Significance Index: 1.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0207
Cell Significance Index: -1.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0221
Cell Significance Index: -1.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0314
Cell Significance Index: -19.6100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0332
Cell Significance Index: -24.5600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0413
Cell Significance Index: -6.0000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0688
Cell Significance Index: -50.4800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0830
Cell Significance Index: -9.7900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0861
Cell Significance Index: -0.5200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0951
Cell Significance Index: -72.0200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1084
Cell Significance Index: -61.1500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1110
Cell Significance Index: -18.9500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1196
Cell Significance Index: -22.7700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1577
Cell Significance Index: -7.4100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2328
Cell Significance Index: -12.1000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2410
Cell Significance Index: -69.3300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2415
Cell Significance Index: -50.8700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2501
Cell Significance Index: -32.3100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2559
Cell Significance Index: -17.7000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2722
Cell Significance Index: -27.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2779
Cell Significance Index: -35.6300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3753
Cell Significance Index: -5.3900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3967
Cell Significance Index: -46.2300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4326
Cell Significance Index: -49.3800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4427
Cell Significance Index: -50.7200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4557
Cell Significance Index: -12.2100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4699
Cell Significance Index: -48.9300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5042
Cell Significance Index: -31.7800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5558
Cell Significance Index: -35.8600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5937
Cell Significance Index: -8.7700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5939
Cell Significance Index: -44.2600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6378
Cell Significance Index: -13.2300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6464
Cell Significance Index: -8.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6875
Cell Significance Index: -48.6200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.8020
Cell Significance Index: -13.5100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8605
Cell Significance Index: -68.1600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9796
Cell Significance Index: -19.3700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0241
Cell Significance Index: -32.8000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.0569
Cell Significance Index: -13.3400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0663
Cell Significance Index: -34.9100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.1138
Cell Significance Index: -22.3600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1159
Cell Significance Index: -35.5400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.1460
Cell Significance Index: -9.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.1587
Cell Significance Index: -40.2700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1614
Cell Significance Index: -24.6500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.1834
Cell Significance Index: -32.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2496
Cell Significance Index: -76.6100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.2940
Cell Significance Index: -19.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3615212708
Symbol: GSK3B_HUMAN
Name: Serine/threonine-protein kinase GSK3B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7980435
Title: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
PubMed ID: 7980435
DOI: 10.1042/bj3030701
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10486203
Title: Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.
PubMed ID: 10486203
PubMed ID: 10523816
Title: Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.
PubMed ID: 10523816
PubMed ID: 1846781
Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
PubMed ID: 1846781
PubMed ID: 8397507
Title: Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.
PubMed ID: 8397507
DOI: 10.1042/bj2940625
PubMed ID: 8250835
Title: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
PubMed ID: 8250835
DOI: 10.1042/bj2960015
PubMed ID: 8524413
Title: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
PubMed ID: 8524413
DOI: 10.1038/378785a0
PubMed ID: 9072970
Title: Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
PubMed ID: 9072970
PubMed ID: 9731200
Title: Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.
PubMed ID: 9731200
PubMed ID: 9819408
Title: Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.
PubMed ID: 9819408
PubMed ID: 9736715
Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
PubMed ID: 9736715
PubMed ID: 11004522
Title: Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.
PubMed ID: 11004522
PubMed ID: 10868943
Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
PubMed ID: 10868943
PubMed ID: 11430833
Title: A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
PubMed ID: 11430833
PubMed ID: 12054501
Title: Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
PubMed ID: 12054501
PubMed ID: 14690523
Title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.
PubMed ID: 14690523
PubMed ID: 15448698
Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
PubMed ID: 15448698
DOI: 10.1038/ncb1173
PubMed ID: 15752768
Title: Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
PubMed ID: 15752768
PubMed ID: 15647282
Title: Wnt-dependent regulation of the E-cadherin repressor snail.
PubMed ID: 15647282
PubMed ID: 16981698
Title: GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.
PubMed ID: 16981698
DOI: 10.1021/bi061147r
PubMed ID: 16428445
Title: Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
PubMed ID: 16428445
PubMed ID: 16484495
Title: Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.
PubMed ID: 16484495
PubMed ID: 17050006
Title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.
PubMed ID: 17050006
PubMed ID: 17318175
Title: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
PubMed ID: 17318175
PubMed ID: 18846110
Title: Identification of an antiapoptotic protein complex at death receptors.
PubMed ID: 18846110
DOI: 10.1038/cdd.2008.124
PubMed ID: 18348280
Title: Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.
PubMed ID: 18348280
DOI: 10.1002/jcb.21737
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19493954
Title: Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.
PubMed ID: 19493954
DOI: 10.1093/cvr/cvp175
PubMed ID: 19946213
Title: A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.
PubMed ID: 19946213
PubMed ID: 19706605
Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
PubMed ID: 19706605
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20067585
Title: The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.
PubMed ID: 20067585
PubMed ID: 20932480
Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.
PubMed ID: 20932480
PubMed ID: 20080667
Title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.
PubMed ID: 20080667
PubMed ID: 20937854
Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
PubMed ID: 20937854
PubMed ID: 11749387
Title: Glycogen synthase kinase-3: properties, functions, and regulation.
PubMed ID: 11749387
DOI: 10.1021/cr000110o
PubMed ID: 17478001
Title: The role of GSK3 in glucose homeostasis and the development of insulin resistance.
PubMed ID: 17478001
PubMed ID: 19366350
Title: Glycogen synthase kinase 3: more than a namesake.
PubMed ID: 19366350
PubMed ID: 20007971
Title: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.
PubMed ID: 20007971
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21029237
Title: Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
PubMed ID: 21029237
PubMed ID: 22514281
Title: Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP).
PubMed ID: 22514281
PubMed ID: 22539723
Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
PubMed ID: 22539723
PubMed ID: 23332125
Title: ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation.
PubMed ID: 23332125
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24391509
Title: NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.
PubMed ID: 24391509
PubMed ID: 25169422
Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
PubMed ID: 25169422
DOI: 10.1002/jcb.24956
PubMed ID: 25920809
Title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.
PubMed ID: 25920809
PubMed ID: 25897075
Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
PubMed ID: 25897075
PubMed ID: 27484798
Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.
PubMed ID: 27484798
PubMed ID: 28829046
Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
PubMed ID: 28829046
DOI: 10.1038/cr.2017.107
PubMed ID: 28903391
Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
PubMed ID: 28903391
PubMed ID: 28992046
Title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.
PubMed ID: 28992046
DOI: 10.1093/jmcb/mjx034
PubMed ID: 25827072
Title: FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.
PubMed ID: 25827072
PubMed ID: 29059170
Title: SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis.
PubMed ID: 29059170
DOI: 10.1038/onc.2017.370
PubMed ID: 30704899
Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.
PubMed ID: 30704899
PubMed ID: 31073040
Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.
PubMed ID: 31073040
PubMed ID: 34058472
Title: A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.
PubMed ID: 34058472
PubMed ID: 35606353
Title: GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.
PubMed ID: 35606353
PubMed ID: 11440715
Title: Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.
PubMed ID: 11440715
PubMed ID: 11738041
Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
PubMed ID: 11738041
PubMed ID: 12554650
Title: Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.
PubMed ID: 12554650
DOI: 10.1093/emboj/cdg068
Sequence Information:
- Length: 420
- Mass: 46744
- Checksum: 4ACC24D00CDBB9C3
- Sequence:
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.