GSK3B | ENSG00000082701 | NCBI 2932

Details for: GSK3B

Gene ID: 2932

Symbol: GSK3B

Ensembl ID: ENSG00000082701

Description: glycogen synthase kinase 3 beta

Associated with

Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Axon guidance
(R-HSA-422475)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to heat stress
(R-HSA-3371556)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Crmps in sema3a signaling
(R-HSA-399956)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Developmental biology
(R-HSA-1266738)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Epigenetic regulation of gene expression
(R-HSA-212165)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Hedgehog 'off' state
(R-HSA-5610787)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of nucleoprotein
(R-HSA-9694631)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nervous system development
(R-HSA-9675108)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Semaphorin interactions
(R-HSA-373755)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Transcriptional regulation by runx2
(R-HSA-8878166)
Translation of structural proteins
(R-HSA-9694635)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Beta-catenin binding
(GO:0008013)
Chromatin remodeling
(GO:0006338)
Dynactin binding
(GO:0034452)
Epithelial to mesenchymal transition
(GO:0001837)
Er overload response
(GO:0006983)
Glycogen metabolic process
(GO:0005977)
Histone h2as1 kinase activity
(GO:0044024)
Kinase activity
(GO:0016301)
Nf-kappab binding
(GO:0051059)
P53 binding
(GO:0002039)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 487.1895
Cell Significance Index: -75.7800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 295.8090
Cell Significance Index: -75.0300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 159.2587
Cell Significance Index: -64.7000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 143.0300
Cell Significance Index: -73.5700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 118.0140
Cell Significance Index: -79.1900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 68.0602
Cell Significance Index: -64.9800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 63.0598
Cell Significance Index: -77.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.3997
Cell Significance Index: -73.4000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.7316
Cell Significance Index: -49.7500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.1589
Cell Significance Index: -68.0600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.8135
Cell Significance Index: -78.1900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.6709
Cell Significance Index: 205.9900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.5017
Cell Significance Index: 83.9800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.9662
Cell Significance Index: 1063.9100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.9477
Cell Significance Index: 181.1800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.8769
Cell Significance Index: 73.9500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.7121
Cell Significance Index: 208.1200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6796
Cell Significance Index: 537.5200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4552
Cell Significance Index: 487.2500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9247
Cell Significance Index: 26.2600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.8978
Cell Significance Index: 27.3000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.8058
Cell Significance Index: 1248.9800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.7119
Cell Significance Index: 75.7200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6768
Cell Significance Index: 46.8600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6383
Cell Significance Index: 62.0400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.5581
Cell Significance Index: 104.7700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.3995
Cell Significance Index: 29.9200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.9998
Cell Significance Index: 28.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9341
Cell Significance Index: 101.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8741
Cell Significance Index: 25.1900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7148
Cell Significance Index: 13.9500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7059
Cell Significance Index: 127.2600
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.6750
Cell Significance Index: 14.7800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5683
Cell Significance Index: 69.8800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4829
Cell Significance Index: 12.9000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.4703
Cell Significance Index: 8.0600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4131
Cell Significance Index: 21.6900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3916
Cell Significance Index: 63.6900
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.3836
Cell Significance Index: 9.3600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3753
Cell Significance Index: 37.1300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3425
Cell Significance Index: 644.9000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3411
Cell Significance Index: 186.3100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2638
Cell Significance Index: 119.7500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2632
Cell Significance Index: 116.3800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2396
Cell Significance Index: 152.1600
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.2074
Cell Significance Index: 2.1600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2044
Cell Significance Index: 314.6700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1848
Cell Significance Index: 340.8500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1192
Cell Significance Index: 107.6200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1142
Cell Significance Index: 15.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0863
Cell Significance Index: 117.3200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0546
Cell Significance Index: 1.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0240
Cell Significance Index: 1.1200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0207
Cell Significance Index: -1.0800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0221
Cell Significance Index: -1.0000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0314
Cell Significance Index: -19.6100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0332
Cell Significance Index: -24.5600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0413
Cell Significance Index: -6.0000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0688
Cell Significance Index: -50.4800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0830
Cell Significance Index: -9.7900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0861
Cell Significance Index: -0.5200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0951
Cell Significance Index: -72.0200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1084
Cell Significance Index: -61.1500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1110
Cell Significance Index: -18.9500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1196
Cell Significance Index: -22.7700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1577
Cell Significance Index: -7.4100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2328
Cell Significance Index: -12.1000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2410
Cell Significance Index: -69.3300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2415
Cell Significance Index: -50.8700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2501
Cell Significance Index: -32.3100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2559
Cell Significance Index: -17.7000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2722
Cell Significance Index: -27.8100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.2779
Cell Significance Index: -35.6300
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3753
Cell Significance Index: -5.3900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3967
Cell Significance Index: -46.2300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4326
Cell Significance Index: -49.3800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4427
Cell Significance Index: -50.7200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4557
Cell Significance Index: -12.2100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4699
Cell Significance Index: -48.9300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5042
Cell Significance Index: -31.7800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5558
Cell Significance Index: -35.8600
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5937
Cell Significance Index: -8.7700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5939
Cell Significance Index: -44.2600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6378
Cell Significance Index: -13.2300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6464
Cell Significance Index: -8.0600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6875
Cell Significance Index: -48.6200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.8020
Cell Significance Index: -13.5100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8605
Cell Significance Index: -68.1600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9796
Cell Significance Index: -19.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0241
Cell Significance Index: -32.8000
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.0569
Cell Significance Index: -13.3400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0663
Cell Significance Index: -34.9100
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.1138
Cell Significance Index: -22.3600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1159
Cell Significance Index: -35.5400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.1460
Cell Significance Index: -9.3500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.1587
Cell Significance Index: -40.2700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1614
Cell Significance Index: -24.6500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.1834
Cell Significance Index: -32.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2496
Cell Significance Index: -76.6100
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.2940
Cell Significance Index: -19.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** GSK3B is a constitutively active enzyme that is primarily expressed in the brain and other tissues. Its activity is regulated by phosphorylation, which is crucial for its function in various signaling pathways. GSK3B is involved in the regulation of glycogen metabolism, cell cycle progression, and transcriptional regulation. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic disorders. **Pathways and Functions:** GSK3B is involved in multiple signaling pathways, including: 1. **Wnt/β-catenin signaling pathway:** GSK3B phosphorylates and stabilizes β-catenin, which is essential for the transcription of target genes involved in cell proliferation, differentiation, and survival. 2. **PI3K/Akt signaling pathway:** GSK3B phosphorylates and inactivates Akt, which is a key regulator of cell survival, proliferation, and metabolism. 3. **NF-κB signaling pathway:** GSK3B phosphorylates and inhibits NF-κB, which is a transcription factor involved in inflammation, immune responses, and cell survival. 4. **Glycogen metabolism:** GSK3B phosphorylates and inactivates glycogen synthase, which is essential for glycogen synthesis. 5. **Transcriptional regulation:** GSK3B phosphorylates and regulates the activity of various transcription factors, including NF-κB, Akt, and Runx2. **Clinical Significance:** GSK3B dysregulation has been implicated in various diseases, including: 1. **Cancer:** GSK3B is involved in the regulation of cell proliferation, survival, and metabolism. Its dysregulation has been implicated in several types of cancer, including colorectal, breast, and lung cancer. 2. **Neurodegenerative disorders:** GSK3B is involved in the regulation of glycogen metabolism and neuronal function. Its dysregulation has been implicated in diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Metabolic disorders:** GSK3B is involved in the regulation of glycogen metabolism and glucose homeostasis. Its dysregulation has been implicated in diseases such as diabetes and metabolic syndrome. 4. **Inflammatory disorders:** GSK3B is involved in the regulation of NF-κB signaling pathway, which is essential for the transcription of pro-inflammatory genes. Its dysregulation has been implicated in diseases such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. In conclusion, GSK3B is a multifunctional enzyme that plays a crucial role in various cellular processes, including glycogen metabolism, signaling pathways, and transcriptional regulation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, metabolic disorders, and inflammatory disorders. Further research is needed to understand the mechanisms of GSK3B dysregulation and to develop therapeutic strategies for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein kinase GSK3B

Genular Protein ID: 3615212708

Symbol: GSK3B_HUMAN

Name: Serine/threonine-protein kinase GSK3B

UniProtKB Accession Codes:

P49841 D3DN89 Q9BWH3 Q9UL47

Database IDs:

Citations:

PubMed ID: 7980435

Title: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.

PubMed ID: 7980435

DOI: 10.1042/bj3030701

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10486203

Title: Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.

PubMed ID: 10486203

DOI: 10.1006/geno.1999.5875

PubMed ID: 10523816

Title: Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.

PubMed ID: 10523816

DOI: 10.1038/sj.mp.4000538

PubMed ID: 1846781

Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

PubMed ID: 1846781

DOI: 10.1016/0092-8674(91)90241-p

PubMed ID: 8397507

Title: Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

PubMed ID: 8397507

DOI: 10.1042/bj2940625

PubMed ID: 8250835

Title: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

PubMed ID: 8250835

DOI: 10.1042/bj2960015

PubMed ID: 8524413

Title: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

PubMed ID: 8524413

DOI: 10.1038/378785a0

PubMed ID: 9072970

Title: Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.

PubMed ID: 9072970

DOI: 10.1126/science.275.5308.1930

PubMed ID: 9731200

Title: Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.

PubMed ID: 9731200

DOI: 10.1006/bbrc.1998.9253

PubMed ID: 9819408

Title: Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.

PubMed ID: 9819408

DOI: 10.1128/mcb.18.12.7216

PubMed ID: 9736715

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

PubMed ID: 9736715

DOI: 10.1073/pnas.95.19.11211

PubMed ID: 11004522

Title: Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.

PubMed ID: 11004522

DOI: 10.1016/s0167-4781(00)00127-5

PubMed ID: 10868943

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

PubMed ID: 10868943

DOI: 10.2337/diabetes.49.2.263

PubMed ID: 11430833

Title: A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.

PubMed ID: 11430833

DOI: 10.1016/s1097-2765(01)00253-2

PubMed ID: 12054501

Title: Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.

PubMed ID: 12054501

DOI: 10.1016/s0006-291x(02)00349-2

PubMed ID: 14690523

Title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.

PubMed ID: 14690523

DOI: 10.1111/j.1471-4159.2004.02155.x

PubMed ID: 15448698

Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

PubMed ID: 15448698

DOI: 10.1038/ncb1173

PubMed ID: 15752768

Title: Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.

PubMed ID: 15752768

DOI: 10.1016/j.bbrc.2005.02.089

PubMed ID: 15647282

Title: Wnt-dependent regulation of the E-cadherin repressor snail.

PubMed ID: 15647282

DOI: 10.1074/jbc.m413878200

PubMed ID: 16981698

Title: GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.

PubMed ID: 16981698

DOI: 10.1021/bi061147r

PubMed ID: 16428445

Title: Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.

PubMed ID: 16428445

DOI: 10.1128/mcb.26.3.898-911.2006

PubMed ID: 16484495

Title: Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.

PubMed ID: 16484495

DOI: 10.1126/science.1121613

PubMed ID: 17050006

Title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.

PubMed ID: 17050006

DOI: 10.1016/j.bbamcr.2006.09.015

PubMed ID: 17318175

Title: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

PubMed ID: 17318175

DOI: 10.1038/sj.emboj.7601607

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18348280

Title: Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.

PubMed ID: 18348280

DOI: 10.1002/jcb.21737

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19493954

Title: Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.

PubMed ID: 19493954

DOI: 10.1093/cvr/cvp175

PubMed ID: 19946213

Title: A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.

PubMed ID: 19946213

DOI: 10.4161/cc.8.24.10273

PubMed ID: 19706605

Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

PubMed ID: 19706605

DOI: 10.1074/jbc.m109.002659

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20067585

Title: The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.

PubMed ID: 20067585

DOI: 10.1111/j.1471-4159.2010.06581.x

PubMed ID: 20932480

Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

PubMed ID: 20932480

DOI: 10.1016/j.molcel.2010.09.013

PubMed ID: 20080667

Title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.

PubMed ID: 20080667

DOI: 10.1073/pnas.0908133107

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 11749387

Title: Glycogen synthase kinase-3: properties, functions, and regulation.

PubMed ID: 11749387

DOI: 10.1021/cr000110o

PubMed ID: 17478001

Title: The role of GSK3 in glucose homeostasis and the development of insulin resistance.

PubMed ID: 17478001

DOI: 10.1016/j.diabres.2007.01.033

PubMed ID: 19366350

Title: Glycogen synthase kinase 3: more than a namesake.

PubMed ID: 19366350

DOI: 10.1111/j.1476-5381.2008.00085.x

PubMed ID: 20007971

Title: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.

PubMed ID: 20007971

DOI: 10.1074/jbc.m109.047944

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21029237

Title: Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.

PubMed ID: 21029237

DOI: 10.1111/j.1750-3639.2010.00437.x

PubMed ID: 22514281

Title: Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP).

PubMed ID: 22514281

DOI: 10.1074/jbc.m111.306373

PubMed ID: 22539723

Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PubMed ID: 22539723

DOI: 10.1126/science.1217032

PubMed ID: 23332125

Title: ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation.

PubMed ID: 23332125

DOI: 10.1186/1478-811x-11-5

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24391509

Title: NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.

PubMed ID: 24391509

DOI: 10.1371/journal.pgen.1003996

PubMed ID: 25169422

Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.

PubMed ID: 25169422

DOI: 10.1002/jcb.24956

PubMed ID: 25920809

Title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.

PubMed ID: 25920809

DOI: 10.1016/j.bbamcr.2015.04.013

PubMed ID: 25897075

Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

PubMed ID: 25897075

DOI: 10.1074/jbc.m114.633057

PubMed ID: 27484798

Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.

PubMed ID: 27484798

DOI: 10.1074/jbc.m116.738047

PubMed ID: 28829046

Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.

PubMed ID: 28829046

DOI: 10.1038/cr.2017.107

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 28992046

Title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

PubMed ID: 28992046

DOI: 10.1093/jmcb/mjx034

PubMed ID: 25827072

Title: FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.

PubMed ID: 25827072

DOI: 10.1016/j.canlet.2015.03.037

PubMed ID: 29059170

Title: SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis.

PubMed ID: 29059170

DOI: 10.1038/onc.2017.370

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 34058472

Title: A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.

PubMed ID: 34058472

DOI: 10.1016/j.bbrc.2021.05.043

PubMed ID: 35606353

Title: GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.

PubMed ID: 35606353

DOI: 10.1038/s41389-022-00402-w

PubMed ID: 11440715

Title: Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

PubMed ID: 11440715

DOI: 10.1016/s0092-8674(01)00374-9

PubMed ID: 11738041

Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

PubMed ID: 11738041

DOI: 10.1016/s0969-2126(01)00679-7

PubMed ID: 12554650

Title: Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

PubMed ID: 12554650

DOI: 10.1093/emboj/cdg068

Sequence Information:

Length: 420
Mass: 46744
Checksum: 4ACC24D00CDBB9C3
Sequence:

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 
NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GSK3B

Associated with

Cells (max top 100)

Other Information

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. PubMed ID: 7980435

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter. PubMed ID: 10486203

Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway. PubMed ID: 10523816

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. PubMed ID: 1846781

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. PubMed ID: 8397507

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. PubMed ID: 8250835

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. PubMed ID: 8524413

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. PubMed ID: 9072970

Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. PubMed ID: 9731200

Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. PubMed ID: 9819408

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. PubMed ID: 9736715

Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta. PubMed ID: 11004522

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. PubMed ID: 10868943

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. PubMed ID: 11430833

Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction. PubMed ID: 12054501

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules. PubMed ID: 14690523

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. PubMed ID: 15448698

Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain. PubMed ID: 15752768

Wnt-dependent regulation of the E-cadherin repressor snail. PubMed ID: 15647282

GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. PubMed ID: 16981698

Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. PubMed ID: 16428445

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. PubMed ID: 16484495

Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. PubMed ID: 17050006

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. PubMed ID: 17318175

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. PubMed ID: 18348280

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts. PubMed ID: 19493954

A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation. PubMed ID: 19946213

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. PubMed ID: 19706605

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. PubMed ID: 20067585

Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. PubMed ID: 20932480

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. PubMed ID: 20080667

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. PubMed ID: 20937854

Glycogen synthase kinase-3: properties, functions, and regulation. PubMed ID: 11749387

The role of GSK3 in glucose homeostasis and the development of insulin resistance. PubMed ID: 17478001

Glycogen synthase kinase 3: more than a namesake. PubMed ID: 19366350

Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. PubMed ID: 20007971

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. PubMed ID: 21029237

Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP). PubMed ID: 22514281

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. PubMed ID: 22539723

ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation. PubMed ID: 23332125

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas. PubMed ID: 24391509

HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells. PubMed ID: 25169422

GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation. PubMed ID: 25920809

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. PubMed ID: 25897075

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta. PubMed ID: 27484798

Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. PubMed ID: 28829046

Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. PubMed ID: 28903391

Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells. PubMed ID: 28992046

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. PubMed ID: 25827072

SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis. PubMed ID: 29059170

Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. PubMed ID: 30704899

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals. PubMed ID: 34058472

GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis. PubMed ID: 35606353

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. PubMed ID: 11440715

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. PubMed ID: 11738041

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. PubMed ID: 12554650