Details for: GSK3B

Gene ID: 2932

Symbol: GSK3B

Ensembl ID: ENSG00000082701

Description: glycogen synthase kinase 3 beta

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.69
    Marker Score: 124,669
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.44
    Marker Score: 18,022
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.17
    Marker Score: 10,634
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.95
    Marker Score: 15,845
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.8
    Marker Score: 21,077
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.78
    Marker Score: 49,264
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.66
    Marker Score: 3,315
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.66
    Marker Score: 5,837
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.65
    Marker Score: 3,735
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.63
    Marker Score: 12,155
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.59
    Marker Score: 6,211
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.56
    Marker Score: 57,290
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.51
    Marker Score: 37,597
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.51
    Marker Score: 5,775
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.5
    Marker Score: 2,875
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.48
    Marker Score: 94,046
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.46
    Marker Score: 782
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.46
    Marker Score: 1,894
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.45
    Marker Score: 52,348
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.45
    Marker Score: 18,775
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.39
    Marker Score: 1,802
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.39
    Marker Score: 47,474
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.38
    Marker Score: 9,967
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.36
    Marker Score: 1,408
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.35
    Marker Score: 1,926
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.34
    Marker Score: 2,021
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.34
    Marker Score: 1,361
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.3
    Marker Score: 9,540
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.29
    Marker Score: 1,207
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.26
    Marker Score: 4,355
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.25
    Marker Score: 83,000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.23
    Marker Score: 1,108
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.19
    Marker Score: 916
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.18
    Marker Score: 1,076
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.17
    Marker Score: 8,398
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.17
    Marker Score: 2,627
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.17
    Marker Score: 1,258
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.16
    Marker Score: 9,025
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.15
    Marker Score: 2,898
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.14
    Marker Score: 1,026
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.13
    Marker Score: 2,354
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.11
    Marker Score: 616
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.05
    Marker Score: 2,326
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.04
    Marker Score: 19,178
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.02
    Marker Score: 1,131
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2
    Marker Score: 123,252
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.96
    Marker Score: 2,117
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.95
    Marker Score: 561
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.93
    Marker Score: 19,926
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.89
    Marker Score: 7,710
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.88
    Marker Score: 1,307
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.86
    Marker Score: 5,309
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.86
    Marker Score: 17,655
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.85
    Marker Score: 29,776
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.85
    Marker Score: 1,035
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.84
    Marker Score: 2,217
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.83
    Marker Score: 2,263
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.82
    Marker Score: 1,065
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.82
    Marker Score: 1,011
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,598
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8
    Marker Score: 693
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.8
    Marker Score: 3,023
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.75
    Marker Score: 3,560
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.75
    Marker Score: 552
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.74
    Marker Score: 1,658
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.72
    Marker Score: 888
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.72
    Marker Score: 1,522
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7
    Marker Score: 4,264
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.69
    Marker Score: 2,454
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.69
    Marker Score: 819
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.67
    Marker Score: 457
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.67
    Marker Score: 606
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.65
    Marker Score: 5,879
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.63
    Marker Score: 1,712
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.61
    Marker Score: 1,804
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.61
    Marker Score: 1,391
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.59
    Marker Score: 498
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.59
    Marker Score: 573
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.58
    Marker Score: 584
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,392
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.55
    Marker Score: 5,074
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.53
    Marker Score: 5,436
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.52
    Marker Score: 570
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.52
    Marker Score: 2,151
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.5
    Marker Score: 815
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.5
    Marker Score: 1,606
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.49
    Marker Score: 1,858
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.45
    Marker Score: 493
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.45
    Marker Score: 3,412
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.45
    Marker Score: 755
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.44
    Marker Score: 542
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.44
    Marker Score: 463
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.39
    Marker Score: 508
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.35
    Marker Score: 445
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.34
    Marker Score: 8,618
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.33
    Marker Score: 1,406
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.32
    Marker Score: 1,659
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,337
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.28
    Marker Score: 368
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.27
    Marker Score: 766

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSK3B is a constitutively active enzyme that is primarily expressed in the brain and other tissues. Its activity is regulated by phosphorylation, which is crucial for its function in various signaling pathways. GSK3B is involved in the regulation of glycogen metabolism, cell cycle progression, and transcriptional regulation. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic disorders. **Pathways and Functions:** GSK3B is involved in multiple signaling pathways, including: 1. **Wnt/β-catenin signaling pathway:** GSK3B phosphorylates and stabilizes β-catenin, which is essential for the transcription of target genes involved in cell proliferation, differentiation, and survival. 2. **PI3K/Akt signaling pathway:** GSK3B phosphorylates and inactivates Akt, which is a key regulator of cell survival, proliferation, and metabolism. 3. **NF-κB signaling pathway:** GSK3B phosphorylates and inhibits NF-κB, which is a transcription factor involved in inflammation, immune responses, and cell survival. 4. **Glycogen metabolism:** GSK3B phosphorylates and inactivates glycogen synthase, which is essential for glycogen synthesis. 5. **Transcriptional regulation:** GSK3B phosphorylates and regulates the activity of various transcription factors, including NF-κB, Akt, and Runx2. **Clinical Significance:** GSK3B dysregulation has been implicated in various diseases, including: 1. **Cancer:** GSK3B is involved in the regulation of cell proliferation, survival, and metabolism. Its dysregulation has been implicated in several types of cancer, including colorectal, breast, and lung cancer. 2. **Neurodegenerative disorders:** GSK3B is involved in the regulation of glycogen metabolism and neuronal function. Its dysregulation has been implicated in diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Metabolic disorders:** GSK3B is involved in the regulation of glycogen metabolism and glucose homeostasis. Its dysregulation has been implicated in diseases such as diabetes and metabolic syndrome. 4. **Inflammatory disorders:** GSK3B is involved in the regulation of NF-κB signaling pathway, which is essential for the transcription of pro-inflammatory genes. Its dysregulation has been implicated in diseases such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. In conclusion, GSK3B is a multifunctional enzyme that plays a crucial role in various cellular processes, including glycogen metabolism, signaling pathways, and transcriptional regulation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, metabolic disorders, and inflammatory disorders. Further research is needed to understand the mechanisms of GSK3B dysregulation and to develop therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 3615212708

Symbol: GSK3B_HUMAN

Name: Serine/threonine-protein kinase GSK3B

UniProtKB Accession Codes:

P49841 D3DN89 Q9BWH3 Q9UL47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 14 CPTC 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 24 DrugCentral 1 EC 4 ELM 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 23 RefSeq 2 Rhea 12 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7980435

Title: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.

PubMed ID: 7980435

DOI: 10.1042/bj3030701

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10486203

Title: Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.

PubMed ID: 10486203

DOI: 10.1006/geno.1999.5875

PubMed ID: 10523816

Title: Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.

PubMed ID: 10523816

DOI: 10.1038/sj.mp.4000538

PubMed ID: 1846781

Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

PubMed ID: 1846781

DOI: 10.1016/0092-8674(91)90241-p

PubMed ID: 8397507

Title: Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

PubMed ID: 8397507

DOI: 10.1042/bj2940625

PubMed ID: 8250835

Title: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

PubMed ID: 8250835

DOI: 10.1042/bj2960015

PubMed ID: 8524413

Title: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

PubMed ID: 8524413

DOI: 10.1038/378785a0

PubMed ID: 9072970

Title: Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.

PubMed ID: 9072970

DOI: 10.1126/science.275.5308.1930

PubMed ID: 9731200

Title: Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.

PubMed ID: 9731200

DOI: 10.1006/bbrc.1998.9253

PubMed ID: 9819408

Title: Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.

PubMed ID: 9819408

DOI: 10.1128/mcb.18.12.7216

PubMed ID: 9736715

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

PubMed ID: 9736715

DOI: 10.1073/pnas.95.19.11211

PubMed ID: 11004522

Title: Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.

PubMed ID: 11004522

DOI: 10.1016/s0167-4781(00)00127-5

PubMed ID: 10868943

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

PubMed ID: 10868943

DOI: 10.2337/diabetes.49.2.263

PubMed ID: 11430833

Title: A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.

PubMed ID: 11430833

DOI: 10.1016/s1097-2765(01)00253-2

PubMed ID: 12054501

Title: Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.

PubMed ID: 12054501

DOI: 10.1016/s0006-291x(02)00349-2

PubMed ID: 14690523

Title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.

PubMed ID: 14690523

DOI: 10.1111/j.1471-4159.2004.02155.x

PubMed ID: 15448698

Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

PubMed ID: 15448698

DOI: 10.1038/ncb1173

PubMed ID: 15752768

Title: Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.

PubMed ID: 15752768

DOI: 10.1016/j.bbrc.2005.02.089

PubMed ID: 15647282

Title: Wnt-dependent regulation of the E-cadherin repressor snail.

PubMed ID: 15647282

DOI: 10.1074/jbc.m413878200

PubMed ID: 16981698

Title: GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.

PubMed ID: 16981698

DOI: 10.1021/bi061147r

PubMed ID: 16428445

Title: Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.

PubMed ID: 16428445

DOI: 10.1128/mcb.26.3.898-911.2006

PubMed ID: 16484495

Title: Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.

PubMed ID: 16484495

DOI: 10.1126/science.1121613

PubMed ID: 17050006

Title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.

PubMed ID: 17050006

DOI: 10.1016/j.bbamcr.2006.09.015

PubMed ID: 17318175

Title: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

PubMed ID: 17318175

DOI: 10.1038/sj.emboj.7601607

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18348280

Title: Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.

PubMed ID: 18348280

DOI: 10.1002/jcb.21737

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19493954

Title: Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.

PubMed ID: 19493954

DOI: 10.1093/cvr/cvp175

PubMed ID: 19946213

Title: A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.

PubMed ID: 19946213

DOI: 10.4161/cc.8.24.10273

PubMed ID: 19706605

Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

PubMed ID: 19706605

DOI: 10.1074/jbc.m109.002659

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20067585

Title: The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.

PubMed ID: 20067585

DOI: 10.1111/j.1471-4159.2010.06581.x

PubMed ID: 20932480

Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

PubMed ID: 20932480

DOI: 10.1016/j.molcel.2010.09.013

PubMed ID: 20080667

Title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.

PubMed ID: 20080667

DOI: 10.1073/pnas.0908133107

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 11749387

Title: Glycogen synthase kinase-3: properties, functions, and regulation.

PubMed ID: 11749387

DOI: 10.1021/cr000110o

PubMed ID: 17478001

Title: The role of GSK3 in glucose homeostasis and the development of insulin resistance.

PubMed ID: 17478001

DOI: 10.1016/j.diabres.2007.01.033

PubMed ID: 19366350

Title: Glycogen synthase kinase 3: more than a namesake.

PubMed ID: 19366350

DOI: 10.1111/j.1476-5381.2008.00085.x

PubMed ID: 20007971

Title: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.

PubMed ID: 20007971

DOI: 10.1074/jbc.m109.047944

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21029237

Title: Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.

PubMed ID: 21029237

DOI: 10.1111/j.1750-3639.2010.00437.x

PubMed ID: 22514281

Title: Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP).

PubMed ID: 22514281

DOI: 10.1074/jbc.m111.306373

PubMed ID: 22539723

Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PubMed ID: 22539723

DOI: 10.1126/science.1217032

PubMed ID: 23332125

Title: ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation.

PubMed ID: 23332125

DOI: 10.1186/1478-811x-11-5

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24391509

Title: NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.

PubMed ID: 24391509

DOI: 10.1371/journal.pgen.1003996

PubMed ID: 25169422

Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.

PubMed ID: 25169422

DOI: 10.1002/jcb.24956

PubMed ID: 25920809

Title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.

PubMed ID: 25920809

DOI: 10.1016/j.bbamcr.2015.04.013

PubMed ID: 25897075

Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

PubMed ID: 25897075

DOI: 10.1074/jbc.m114.633057

PubMed ID: 27484798

Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.

PubMed ID: 27484798

DOI: 10.1074/jbc.m116.738047

PubMed ID: 28829046

Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.

PubMed ID: 28829046

DOI: 10.1038/cr.2017.107

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 28992046

Title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

PubMed ID: 28992046

DOI: 10.1093/jmcb/mjx034

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 11440715

Title: Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

PubMed ID: 11440715

DOI: 10.1016/s0092-8674(01)00374-9

PubMed ID: 11738041

Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

PubMed ID: 11738041

DOI: 10.1016/s0969-2126(01)00679-7

PubMed ID: 12554650

Title: Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

PubMed ID: 12554650

DOI: 10.1093/emboj/cdg068

Sequence Information:

  • Length: 420
  • Mass: 46744
  • Checksum: 4ACC24D00CDBB9C3
  • Sequence:
    • MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 
NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.