Gene GSK3B - ENSG00000082701 | NCBI Gene ID: 2932

Details for: GSK3B

Gene ID: 2932

Symbol: GSK3B

Ensembl ID: ENSG00000082701

Description: glycogen synthase kinase 3 beta

Associated with

Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Axon guidance
(R-HSA-422475)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to heat stress
(R-HSA-3371556)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Crmps in sema3a signaling
(R-HSA-399956)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Developmental biology
(R-HSA-1266738)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Epigenetic regulation of gene expression
(R-HSA-212165)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-HSA-9762114)
Hedgehog 'off' state
(R-HSA-5610787)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of nucleoprotein
(R-HSA-9694631)
Nervous system development
(R-HSA-9675108)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Semaphorin interactions
(R-HSA-373755)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx2
(R-HSA-8878166)
Translation of structural proteins
(R-HSA-9694635)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Beta-catenin binding
(GO:0008013)
Circadian rhythm
(GO:0007623)
Dopamine receptor signaling pathway
(GO:0007212)
Dynactin binding
(GO:0034452)
Epithelial to mesenchymal transition
(GO:0001837)
Er overload response
(GO:0006983)
Glycogen metabolic process
(GO:0005977)
Insulin receptor signaling pathway
(GO:0008286)
Kinase activity
(GO:0016301)
Nf-kappab binding
(GO:0051059)
P53 binding
(GO:0002039)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.69
Marker Score: 124668.5
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.44
Marker Score: 18022
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.17
Marker Score: 10634
Cell Name: stellate neuron (CL0000122)
Fold Change: 2.95
Marker Score: 15845
Cell Name: granule cell (CL0000120)
Fold Change: 2.8
Marker Score: 21076.5
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.78
Marker Score: 49264
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.66
Marker Score: 3315
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.66
Marker Score: 5837
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.65
Marker Score: 3735
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.63
Marker Score: 12155
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.59
Marker Score: 6211
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.56
Marker Score: 57290
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.51
Marker Score: 37596.5
Cell Name: macroglial cell (CL0000126)
Fold Change: 2.51
Marker Score: 5775
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.5
Marker Score: 2875
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.48
Marker Score: 94046
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.46
Marker Score: 782
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.46
Marker Score: 1894
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.45
Marker Score: 52347.5
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.45
Marker Score: 18775
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 2.39
Marker Score: 1802
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.39
Marker Score: 47473.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.38
Marker Score: 9966.5
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.36
Marker Score: 1407.5
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.35
Marker Score: 1926
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.34
Marker Score: 2021
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.34
Marker Score: 1361
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.3
Marker Score: 9540
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.29
Marker Score: 1207
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.26
Marker Score: 4355
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.25
Marker Score: 83000
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.23
Marker Score: 1108
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.19
Marker Score: 916
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.18
Marker Score: 1076
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.17
Marker Score: 8397.5
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.17
Marker Score: 2627
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.17
Marker Score: 1258
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.16
Marker Score: 9025
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.15
Marker Score: 2898
Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.14
Marker Score: 1026
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.13
Marker Score: 2354
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.11
Marker Score: 616
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.05
Marker Score: 2325.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.04
Marker Score: 19178
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.02
Marker Score: 1130.5
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2
Marker Score: 123251.5
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.96
Marker Score: 2117
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.95
Marker Score: 560.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.93
Marker Score: 19926
Cell Name: neuron (CL0000540)
Fold Change: 1.89
Marker Score: 7710
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.88
Marker Score: 1307
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.86
Marker Score: 5309
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.86
Marker Score: 17655
Cell Name: lactocyte (CL0002325)
Fold Change: 1.85
Marker Score: 29776
Cell Name: fat cell (CL0000136)
Fold Change: 1.85
Marker Score: 1035
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.84
Marker Score: 2217
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.83
Marker Score: 2263
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.82
Marker Score: 1065
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.82
Marker Score: 1011
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.82
Marker Score: 15597.5
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.8
Marker Score: 693
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.8
Marker Score: 3023
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.75
Marker Score: 3560
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.75
Marker Score: 552
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.74
Marker Score: 1658
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.72
Marker Score: 888
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.72
Marker Score: 1522
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.7
Marker Score: 4264
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.69
Marker Score: 2454
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.69
Marker Score: 819
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.67
Marker Score: 457
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.67
Marker Score: 606
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.65
Marker Score: 5879
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.63
Marker Score: 1712
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.61
Marker Score: 1804
Cell Name: astrocyte (CL0000127)
Fold Change: 1.61
Marker Score: 1391
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.59
Marker Score: 498
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.59
Marker Score: 573
Cell Name: podocyte (CL0000653)
Fold Change: 1.58
Marker Score: 584
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.55
Marker Score: 2392
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.55
Marker Score: 5074
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.53
Marker Score: 5435.5
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.52
Marker Score: 570
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.52
Marker Score: 2150.5
Cell Name: contractile cell (CL0000183)
Fold Change: 1.5
Marker Score: 815
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.5
Marker Score: 1606
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.49
Marker Score: 1858
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.45
Marker Score: 493
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.45
Marker Score: 3412
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.45
Marker Score: 755
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.44
Marker Score: 542
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.44
Marker Score: 463
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.39
Marker Score: 508
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.35
Marker Score: 445
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.34
Marker Score: 8618
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.33
Marker Score: 1406
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.32
Marker Score: 1659
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3
Marker Score: 20337
Cell Name: male germ cell (CL0000015)
Fold Change: 1.28
Marker Score: 368
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.27
Marker Score: 766

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**Key characteristics:** * GSK3B is a large protein with a molecular weight of approximately 120 kDa. * It is a serine/threonine kinase, meaning it phosphorylates serine and threonine residues in proteins. * GSK3B has a unique structure, with a catalytic domain that is responsible for phosphorylating specific substrates. * It is a key regulator of cell cycle progression, cell cycle checkpoints, and apoptosis. **Pathways and functions:** * GSK3B is involved in the regulation of cell cycle progression through phosphorylation of various targets. * It promotes cell cycle entry by phosphorylatingCDK4 and CDK6, which are inhibitors of cell cycle progression. * It also inhibits the cell cycle checkpoint protein p53, allowing cells to enter S phase. * In addition to its role in cell cycle regulation, GSK3B is involved in various cellular processes, including development, differentiation, and tissue homeostasis. * It is also a key regulator of apoptosis, promoting the death of cells that are no longer needed. **Clinical significance:** * Mutations in GSK3B have been linked to several human diseases, including cancer and neurodegenerative disorders. * The GSK3B inhibitor Bay 12 is a promising therapeutic for cancer, as it blocks the activity of GSK3B and inhibits cell growth. * Dysregulation of GSK3B signaling has been implicated in a variety of human diseases, including cancer, neurodegenerative disorders, and metabolic diseases. **Conclusion:** GSK3B is a critical regulator of cell cycle progression, cell cycle checkpoints, and various cellular processes. Its clinical significance lies in its role in cancer and neurodegenerative disorders, where its inhibition can provide therapeutic benefits.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein kinase GSK3B

Genular Protein ID: 3615212708

Symbol: GSK3B_HUMAN

Name: Serine/threonine-protein kinase GSK3B

UniProtKB Accession Codes:

P49841 D3DN89 Q9BWH3 Q9UL47

Database IDs:

Citations:

PubMed ID: 7980435

Title: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.

PubMed ID: 7980435

DOI: 10.1042/bj3030701

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10486203

Title: Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.

PubMed ID: 10486203

DOI: 10.1006/geno.1999.5875

PubMed ID: 10523816

Title: Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.

PubMed ID: 10523816

DOI: 10.1038/sj.mp.4000538

PubMed ID: 1846781

Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

PubMed ID: 1846781

DOI: 10.1016/0092-8674(91)90241-p

PubMed ID: 8397507

Title: Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

PubMed ID: 8397507

DOI: 10.1042/bj2940625

PubMed ID: 8250835

Title: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

PubMed ID: 8250835

DOI: 10.1042/bj2960015

PubMed ID: 8524413

Title: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.

PubMed ID: 8524413

DOI: 10.1038/378785a0

PubMed ID: 9072970

Title: Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.

PubMed ID: 9072970

DOI: 10.1126/science.275.5308.1930

PubMed ID: 9731200

Title: Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.

PubMed ID: 9731200

DOI: 10.1006/bbrc.1998.9253

PubMed ID: 9819408

Title: Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.

PubMed ID: 9819408

DOI: 10.1128/mcb.18.12.7216

PubMed ID: 9736715

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

PubMed ID: 9736715

DOI: 10.1073/pnas.95.19.11211

PubMed ID: 11004522

Title: Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.

PubMed ID: 11004522

DOI: 10.1016/s0167-4781(00)00127-5

PubMed ID: 10868943

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

PubMed ID: 10868943

DOI: 10.2337/diabetes.49.2.263

PubMed ID: 11430833

Title: A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.

PubMed ID: 11430833

DOI: 10.1016/s1097-2765(01)00253-2

PubMed ID: 12054501

Title: Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.

PubMed ID: 12054501

DOI: 10.1016/s0006-291x(02)00349-2

PubMed ID: 14690523

Title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.

PubMed ID: 14690523

DOI: 10.1111/j.1471-4159.2004.02155.x

PubMed ID: 15448698

Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

PubMed ID: 15448698

DOI: 10.1038/ncb1173

PubMed ID: 15752768

Title: Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.

PubMed ID: 15752768

DOI: 10.1016/j.bbrc.2005.02.089

PubMed ID: 15647282

Title: Wnt-dependent regulation of the E-cadherin repressor snail.

PubMed ID: 15647282

DOI: 10.1074/jbc.m413878200

PubMed ID: 16981698

Title: GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.

PubMed ID: 16981698

DOI: 10.1021/bi061147r

PubMed ID: 16428445

Title: Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.

PubMed ID: 16428445

DOI: 10.1128/mcb.26.3.898-911.2006

PubMed ID: 16484495

Title: Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.

PubMed ID: 16484495

DOI: 10.1126/science.1121613

PubMed ID: 17050006

Title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.

PubMed ID: 17050006

DOI: 10.1016/j.bbamcr.2006.09.015

PubMed ID: 17318175

Title: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

PubMed ID: 17318175

DOI: 10.1038/sj.emboj.7601607

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18348280

Title: Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.

PubMed ID: 18348280

DOI: 10.1002/jcb.21737

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19493954

Title: Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.

PubMed ID: 19493954

DOI: 10.1093/cvr/cvp175

PubMed ID: 19946213

Title: A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.

PubMed ID: 19946213

DOI: 10.4161/cc.8.24.10273

PubMed ID: 19706605

Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

PubMed ID: 19706605

DOI: 10.1074/jbc.m109.002659

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20067585

Title: The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.

PubMed ID: 20067585

DOI: 10.1111/j.1471-4159.2010.06581.x

PubMed ID: 20932480

Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

PubMed ID: 20932480

DOI: 10.1016/j.molcel.2010.09.013

PubMed ID: 20080667

Title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.

PubMed ID: 20080667

DOI: 10.1073/pnas.0908133107

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 11749387

Title: Glycogen synthase kinase-3: properties, functions, and regulation.

PubMed ID: 11749387

DOI: 10.1021/cr000110o

PubMed ID: 17478001

Title: The role of GSK3 in glucose homeostasis and the development of insulin resistance.

PubMed ID: 17478001

DOI: 10.1016/j.diabres.2007.01.033

PubMed ID: 19366350

Title: Glycogen synthase kinase 3: more than a namesake.

PubMed ID: 19366350

DOI: 10.1111/j.1476-5381.2008.00085.x

PubMed ID: 20007971

Title: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.

PubMed ID: 20007971

DOI: 10.1074/jbc.m109.047944

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21029237

Title: Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.

PubMed ID: 21029237

DOI: 10.1111/j.1750-3639.2010.00437.x

PubMed ID: 22514281

Title: Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP).

PubMed ID: 22514281

DOI: 10.1074/jbc.m111.306373

PubMed ID: 22539723

Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PubMed ID: 22539723

DOI: 10.1126/science.1217032

PubMed ID: 23332125

Title: ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation.

PubMed ID: 23332125

DOI: 10.1186/1478-811x-11-5

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24391509

Title: NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.

PubMed ID: 24391509

DOI: 10.1371/journal.pgen.1003996

PubMed ID: 25169422

Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.

PubMed ID: 25169422

DOI: 10.1002/jcb.24956

PubMed ID: 25920809

Title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.

PubMed ID: 25920809

DOI: 10.1016/j.bbamcr.2015.04.013

PubMed ID: 25897075

Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

PubMed ID: 25897075

DOI: 10.1074/jbc.m114.633057

PubMed ID: 27484798

Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.

PubMed ID: 27484798

DOI: 10.1074/jbc.m116.738047

PubMed ID: 28829046

Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.

PubMed ID: 28829046

DOI: 10.1038/cr.2017.107

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 28992046

Title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

PubMed ID: 28992046

DOI: 10.1093/jmcb/mjx034

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 11440715

Title: Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

PubMed ID: 11440715

DOI: 10.1016/s0092-8674(01)00374-9

PubMed ID: 11738041

Title: The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

PubMed ID: 11738041

DOI: 10.1016/s0969-2126(01)00679-7

PubMed ID: 12554650

Title: Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

PubMed ID: 12554650

DOI: 10.1093/emboj/cdg068

Sequence Information:

Length: 420
Mass: 46744
Checksum: 4ACC24D00CDBB9C3
Sequence:

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 
NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GSK3B

Associated with

Cells (max top 100)

Other Information

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. PubMed ID: 7980435

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter. PubMed ID: 10486203

Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway. PubMed ID: 10523816

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. PubMed ID: 1846781

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. PubMed ID: 8397507

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. PubMed ID: 8250835

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. PubMed ID: 8524413

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. PubMed ID: 9072970

Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. PubMed ID: 9731200

Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. PubMed ID: 9819408

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. PubMed ID: 9736715

Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta. PubMed ID: 11004522

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. PubMed ID: 10868943

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. PubMed ID: 11430833

Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction. PubMed ID: 12054501

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules. PubMed ID: 14690523

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. PubMed ID: 15448698

Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain. PubMed ID: 15752768

Wnt-dependent regulation of the E-cadherin repressor snail. PubMed ID: 15647282

GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. PubMed ID: 16981698

Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. PubMed ID: 16428445

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. PubMed ID: 16484495

Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. PubMed ID: 17050006

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. PubMed ID: 17318175

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. PubMed ID: 18348280

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts. PubMed ID: 19493954

A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation. PubMed ID: 19946213

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. PubMed ID: 19706605

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. PubMed ID: 20067585

Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. PubMed ID: 20932480

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. PubMed ID: 20080667

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. PubMed ID: 20937854

Glycogen synthase kinase-3: properties, functions, and regulation. PubMed ID: 11749387

The role of GSK3 in glucose homeostasis and the development of insulin resistance. PubMed ID: 17478001

Glycogen synthase kinase 3: more than a namesake. PubMed ID: 19366350

Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. PubMed ID: 20007971

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. PubMed ID: 21029237

Glycogen synthase kinase 3? (GSK3?) modulates antiviral activity of zinc-finger antiviral protein (ZAP). PubMed ID: 22514281

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. PubMed ID: 22539723

ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation. PubMed ID: 23332125

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas. PubMed ID: 24391509

HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells. PubMed ID: 25169422

GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation. PubMed ID: 25920809

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. PubMed ID: 25897075

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta. PubMed ID: 27484798

Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. PubMed ID: 28829046

Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. PubMed ID: 28903391

Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells. PubMed ID: 28992046

Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. PubMed ID: 30704899

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. PubMed ID: 11440715

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. PubMed ID: 11738041

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. PubMed ID: 12554650