Details for: GSTZ1

Gene ID: 2954

Symbol: GSTZ1

Ensembl ID: ENSG00000100577

Description: glutathione S-transferase zeta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.58
    Marker Score: 6192
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.51
    Marker Score: 3444
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.48
    Marker Score: 1235.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.36
    Marker Score: 2009
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.35
    Marker Score: 1697
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.29
    Marker Score: 44677
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.26
    Marker Score: 364
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.14
    Marker Score: 1398
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.09
    Marker Score: 9423
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.08
    Marker Score: 1798
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.08
    Marker Score: 404
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.03
    Marker Score: 4959
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.02
    Marker Score: 2147
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.01
    Marker Score: 293
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.01
    Marker Score: 1067.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.01
    Marker Score: 3727
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71747
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1890
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47970.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.99
    Marker Score: 1423
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15352
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.98
    Marker Score: 7295
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.96
    Marker Score: 2287
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.92
    Marker Score: 432
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.91
    Marker Score: 449
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.91
    Marker Score: 2230
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2716
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.87
    Marker Score: 2594
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.87
    Marker Score: 366
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.87
    Marker Score: 281
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5250
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4923
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.85
    Marker Score: 439
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 2003
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.84
    Marker Score: 834
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.82
    Marker Score: 1867
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8
    Marker Score: 537
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.8
    Marker Score: 508
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.79
    Marker Score: 877
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.78
    Marker Score: 432
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.78
    Marker Score: 938
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.78
    Marker Score: 3176
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.77
    Marker Score: 242
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.74
    Marker Score: 2868
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.74
    Marker Score: 368
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.74
    Marker Score: 363
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.73
    Marker Score: 5693.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.71
    Marker Score: 477
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.71
    Marker Score: 3057
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.71
    Marker Score: 749
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 762
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.7
    Marker Score: 2470
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.69
    Marker Score: 1228
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.69
    Marker Score: 918
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.69
    Marker Score: 2966
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2872.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.68
    Marker Score: 654
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.67
    Marker Score: 1401
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1364
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.66
    Marker Score: 382.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.65
    Marker Score: 444
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.65
    Marker Score: 1765
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.64
    Marker Score: 243
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.64
    Marker Score: 2016
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.64
    Marker Score: 1045.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4047
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.63
    Marker Score: 349
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.63
    Marker Score: 1018
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.63
    Marker Score: 179
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.63
    Marker Score: 251.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.63
    Marker Score: 969
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.62
    Marker Score: 1693
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.62
    Marker Score: 299
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.62
    Marker Score: 150
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 152
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.61
    Marker Score: 3982
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.6
    Marker Score: 1503
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 357
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.59
    Marker Score: 151
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.59
    Marker Score: 598.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.59
    Marker Score: 361
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 591
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.58
    Marker Score: 3736
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.58
    Marker Score: 546
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.58
    Marker Score: 6505
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.58
    Marker Score: 917
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.57
    Marker Score: 614
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.57
    Marker Score: 3087

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * The GSTZ1 gene is located on chromosome 15q26.1. * It is a large gene, with a length of approximately 31,000 nucleotides. * The GSTZ1 protein is a transmembrane protein that is expressed in a variety of cell types. * It is a key enzyme in the metabolism of glutathione. **Pathways and functions** * The GSTZ1 protein is involved in the detoxification of a variety of substances, including hydrogen peroxide, hydroxyl radicals, and carbon tetrachloride. * It is also involved in the regulation of redox balance. * The GSTZ1 protein is a key enzyme in the metabolism of glutathione. It is involved in the formation of glutathione S-transferase, which is an enzyme that catalyzes the transfer of glutathione between molecules. This reaction helps to protect cells from damage caused by reactive oxygen species. **Clinical significance** * Mutations in the GSTZ1 gene have been linked to a number of human diseases, including liver disease, kidney disease, and cancer. * In liver disease, mutations in the GSTZ1 gene can lead to the accumulation of glutathione in the liver, which can damage liver cells and lead to liver failure. * In kidney disease, mutations in the GSTZ1 gene can lead to the accumulation of glutathione in the kidneys, which can damage kidney cells and lead to kidney failure. * In cancer, mutations in the GSTZ1 gene can lead to the development of tumors that are resistant to chemotherapy. **Additional information** * The GSTZ1 gene is a member of the glutathione S-transferase family of proteins. * The GSTZ1 protein is a multi-functional protein that is involved in a variety of cellular processes. * The GSTZ1 protein is a highly conserved protein that is found in organisms from yeast to humans.

Genular Protein ID: 874419888

Symbol: MAAI_HUMAN

Name: Maleylacetoacetate isomerase

UniProtKB Accession Codes:

O43708 A6NED0 A6NNB8 A8MWD7 B2RCK3 O15308 O75430 Q6IB17 Q7Z610 Q9BV63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 4 EMBL 25 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 2 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9417084

Title: Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue.

PubMed ID: 9417084

DOI: 10.1074/jbc.273.1.329

PubMed ID: 9396740

Title: Zeta, a novel class of glutathione transferases in a range of species from plants to humans.

PubMed ID: 9396740

DOI: 10.1042/bj3280929

PubMed ID: 9925947

Title: Characterization and chromosome location of the gene GSTZ1 encoding the human zeta class glutathione transferase and maleylacetoacetate isomerase.

PubMed ID: 9925947

DOI: 10.1159/000015145

PubMed ID: 10373324

Title: Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.

PubMed ID: 10373324

DOI: 10.1006/geno.1999.5832

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9531472

Title: Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid.

PubMed ID: 9531472

DOI: 10.1042/bj3310371

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27876694

Title: Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency.

PubMed ID: 27876694

DOI: 10.1136/jmedgenet-2016-104289

PubMed ID: 10739172

Title: Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

PubMed ID: 10739172

DOI: 10.1097/00008571-200002000-00007

PubMed ID: 11327815

Title: Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.

PubMed ID: 11327815

DOI: 10.1021/bi002249z

Sequence Information:

  • Length: 216
  • Mass: 24212
  • Checksum: 2B3112B8AE6B55E0
  • Sequence:
    • MQAGKPILYS YFRSSCSWRV RIALALKGID YKTVPINLIK DRGQQFSKDF QALNPMKQVP 
TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK 
QVGEEMQLTW AQNAITCGFN ALEQILQSTA GIYCVGDEVT MADLCLVPQV ANAERFKVDL 
TPYPTISSIN KRLLVLEAFQ VSHPCRQPDT PTELRA

Genular Protein ID: 2757845087

Symbol: A0A0C4DFM0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFM0

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 1 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 9 KEGG 1 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 2 Proteomes 2 RefSeq 1 Rhea 1 SFLD 2 SUPFAM 2 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 216
  • Mass: 24114
  • Checksum: C2A0B18A22F55E44
  • Sequence:
    • MQAGKPILYS YFRSSCSWRV RIALALKGID YETVPINLIK DGGQQFSKDF QALNPMKQVP 
TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK 
QVGEEMQLTW AQNAITCGFN ALEQILQSTA GIYCVGDEVT MADLCLVPQV ANAERFKVDL 
TPYPTISSIN KRLLVLEAFQ VSHPCRQPDT PTELRA

Genular Protein ID: 2446110476

Symbol: A0A0A0MR33_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR33

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 174
  • Mass: 19373
  • Checksum: 784686C97916162B
  • Sequence:
    • MQAGKPILYS YFRSSCSWRV RIALALKGID YETVPINLIK DGGQQFSKDF QALNPMKQVP 
TLKIDGITIH QSNLSVLKQV GEEMQLTWAQ NAITCGFNAL EQILQSTAGI YCVGDEVTMA 
DLCLVPQVAN AERFKVDLTP YPTISSINKR LLVLEAFQVS HPCRQPDTPT ELRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.