Gene GTF2F1 - ENSG00000125651 | NCBI Gene ID: 2962

Details for: GTF2F1

Gene ID: 2962

Symbol: GTF2F1

Ensembl ID: ENSG00000125651

Description: general transcription factor IIF subunit 1

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Cell junction
(GO:0030054)
Dna binding
(GO:0003677)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of protein binding
(GO:0032091)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatase activator activity
(GO:0019211)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Promoter-specific chromatin binding
(GO:1990841)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein phosphatase binding
(GO:0019903)
Response to virus
(GO:0009615)
Rna binding
(GO:0003723)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Tfiif-class transcription factor complex binding
(GO:0001096)
Transcription by rna polymerase ii
(GO:0006366)
Transcription elongation by rna polymerase ii
(GO:0006368)
Transcription factor tfiid complex
(GO:0005669)
Transcription factor tfiif complex
(GO:0005674)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney cell (CL1000497)
Fold Change: 1.5
Marker Score: 1001
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.48
Marker Score: 3092
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.41
Marker Score: 48981
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.4
Marker Score: 3809
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.4
Marker Score: 1476
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.38
Marker Score: 999
Cell Name: blood cell (CL0000081)
Fold Change: 1.38
Marker Score: 16025
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.37
Marker Score: 4705
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.37
Marker Score: 926
Cell Name: Unknown (CL0002371)
Fold Change: 1.35
Marker Score: 1436
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.33
Marker Score: 3026
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.32
Marker Score: 14912
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.3
Marker Score: 416
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.29
Marker Score: 2195
Cell Name: supporting cell (CL0000630)
Fold Change: 1.28
Marker Score: 2398
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.27
Marker Score: 1869
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.26
Marker Score: 8225
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.26
Marker Score: 695
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.25
Marker Score: 2058
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.23
Marker Score: 922
Cell Name: decidual cell (CL2000002)
Fold Change: 1.23
Marker Score: 5296
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.23
Marker Score: 4752
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.22
Marker Score: 7777
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.21
Marker Score: 12226.5
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.21
Marker Score: 1303
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.2
Marker Score: 1212
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.2
Marker Score: 282
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.18
Marker Score: 4363
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.18
Marker Score: 588
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.16
Marker Score: 15265
Cell Name: plasmablast (CL0000980)
Fold Change: 1.16
Marker Score: 1538
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.15
Marker Score: 771
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.15
Marker Score: 783
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.15
Marker Score: 2036
Cell Name: acinar cell (CL0000622)
Fold Change: 1.15
Marker Score: 809.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.13
Marker Score: 2381
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.12
Marker Score: 3050
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.12
Marker Score: 4674
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.12
Marker Score: 2627
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.11
Marker Score: 2172
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.11
Marker Score: 388
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1
Marker Score: 4328
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.1
Marker Score: 369
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.09
Marker Score: 746
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.09
Marker Score: 694
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.09
Marker Score: 1954
Cell Name: Unknown (CL0000548)
Fold Change: 1.09
Marker Score: 792
Cell Name: osteoclast (CL0000092)
Fold Change: 1.09
Marker Score: 541
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.08
Marker Score: 4426
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.08
Marker Score: 435
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.08
Marker Score: 844
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.07
Marker Score: 896
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.07
Marker Score: 1200
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.07
Marker Score: 1640.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.06
Marker Score: 253
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.06
Marker Score: 583
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.05
Marker Score: 9119
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.05
Marker Score: 1121
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.05
Marker Score: 552
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.04
Marker Score: 1477.5
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.04
Marker Score: 294
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.03
Marker Score: 2102
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.03
Marker Score: 7666
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.03
Marker Score: 683
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.02
Marker Score: 1782
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.02
Marker Score: 260
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.02
Marker Score: 1273
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.01
Marker Score: 1062.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.01
Marker Score: 53373
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1
Marker Score: 56015
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1
Marker Score: 1040
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1
Marker Score: 3143
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1
Marker Score: 2481.5
Cell Name: enterocyte (CL0000584)
Fold Change: 1
Marker Score: 4777.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71586
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47809
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Marker Score: 1976
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.98
Marker Score: 1412
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.98
Marker Score: 259.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30369
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.98
Marker Score: 192
Cell Name: memory B cell (CL0000787)
Fold Change: 0.98
Marker Score: 739
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.98
Marker Score: 476
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.97
Marker Score: 2717
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.97
Marker Score: 294
Cell Name: male germ cell (CL0000015)
Fold Change: 0.97
Marker Score: 279
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.97
Marker Score: 195
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.96
Marker Score: 684
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.96
Marker Score: 231
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.96
Marker Score: 9718
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.96
Marker Score: 297
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.96
Marker Score: 901
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.96
Marker Score: 627
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.95
Marker Score: 923
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.95
Marker Score: 508
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.95
Marker Score: 472
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.95
Marker Score: 899.5
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.95
Marker Score: 1145
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.95
Marker Score: 464
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.95
Marker Score: 594

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## Summary GTF2F1 is a general transcription factor (GTF) that plays a crucial role in the regulation of gene expression in various cell types. It is involved in a wide range of cellular processes, including embryonic development, cell differentiation, proliferation, and apoptosis. ## Key characteristics * GTF2F1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the GTF2 family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression by interacting with specific DNA sequences. * GTF2F1 is a key regulator of the expression of genes involved in cell cycle regulation, cell growth, and differentiation. * It is also involved in the regulation of apoptosis and inflammation. ## Pathways and functions * GTF2F1 is involved in the regulation of cell cycle progression by binding to the promoters of genes involved in cell cycle checkpoints, such as p21 and p53. * It also regulates the expression of genes involved in cell growth and differentiation, such as those encoding growth factors, cytokines, and differentiation markers. * GTF2F1 is also involved in the regulation of inflammation by binding to DNA sequences in inflammatory genes and promoting their expression. * It also plays a role in the regulation of apoptosis by binding to DNA sequences in pro-apoptotic genes and inhibiting their expression. ## Clinical significance * Mutations in GTF2F1 have been linked to several human diseases, including cancer and cardiovascular disease. * GTF2F1 inhibitors are being investigated as potential therapeutics for these diseases, as they could be used to block the activity of this protein and inhibit cancer growth. **Additional notes:** * GTF2F1 is a highly conserved protein, with a similar gene product found in mammals, birds, and fish. * It is a well-studied protein, with a wealth of literature available on its structure, function, and regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

General transcription factor IIF subunit 1

Genular Protein ID: 2475394114

Symbol: T2FA_HUMAN

Name: General transcription factor IIF subunit 1

UniProtKB Accession Codes:

P35269 B2RCS0 Q9BWN0

Database IDs:

Citations:

PubMed ID: 1734283

Title: Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF.

PubMed ID: 1734283

DOI: 10.1038/355461a0

PubMed ID: 1734284

Title: A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II.

PubMed ID: 1734284

DOI: 10.1038/355464a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7667268

Title: Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.

PubMed ID: 7667268

DOI: 10.1073/pnas.92.18.8195

PubMed ID: 8625415

Title: TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74.

PubMed ID: 8625415

DOI: 10.1016/s0092-8674(00)81055-7

PubMed ID: 8662660

Title: RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.

PubMed ID: 8662660

DOI: 10.1074/jbc.271.20.11703

PubMed ID: 10428810

Title: Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor.

PubMed ID: 10428810

DOI: 10.1074/jbc.274.32.22387

PubMed ID: 12737519

Title: Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP).

PubMed ID: 12737519

DOI: 10.1038/sj.cr.7290155

PubMed ID: 12931194

Title: Transcription factor IIB acetylates itself to regulate transcription.

PubMed ID: 12931194

DOI: 10.1038/nature01899

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11183778

Title: Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution.

PubMed ID: 11183778

DOI: 10.1006/jmbi.2000.4110

PubMed ID: 11248041

Title: Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF.

PubMed ID: 11248041

DOI: 10.1073/pnas.051631098

PubMed ID: 12591941

Title: Molecular mechanism of recruitment of TFIIF-associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF.

PubMed ID: 12591941

DOI: 10.1073/pnas.262798199

PubMed ID: 12578358

Title: Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB.

PubMed ID: 12578358

DOI: 10.1021/bi0265473

PubMed ID: 12732728

Title: NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1.

PubMed ID: 12732728

DOI: 10.1073/pnas.1031524100

Sequence Information:

Length: 517
Mass: 58240
Checksum: 1032B04A36BDC24F
Sequence:

MAALGPSSQN VTEYVVRVPK NTTKKYNIMA FNAADKVNFA TWNQARLERD LSNKKIYQEE 
EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL RVNGKSGRKF KGIKKGGVTE 
NTSYYIFTQC PDGAFEAFPV HNWYNFTPLA RHRTLTAEEA EEEWERRNKV LNHFSIMQQR 
RLKDQDQDED EEEKEKRGRR KASELRIHDL EDDLEMSSDA SDASGEEGGR VPKAKKKAPL 
AKGGRKKKKK KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SQEEPESKAK APQQEEGPKG 
VDEQSDSSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSEESDSSEE SDIDSEASSA 
LFMAKKKTPP KRERKPSGGS SRGNSRPGTP SAEGGSTSST LRAAASKLEQ GKRVSEMPAA 
KRLRLDTGPQ SLSGKSTPQP PSGKTTPNSG DVQVTEDAVR RYLTRKPMTT KDLLKKFQTK 
KTGLSSEQTV NVLAQILKRL NPERKMINDK MHFSLKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GTF2F1

Associated with

Cells (max top 100)

Other Information

Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF. PubMed ID: 1734283

A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. PubMed ID: 1734284

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. PubMed ID: 7667268

TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. PubMed ID: 8625415

RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding. PubMed ID: 8662660

Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor. PubMed ID: 10428810

Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). PubMed ID: 12737519

Transcription factor IIB acetylates itself to regulate transcription. PubMed ID: 12931194

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution. PubMed ID: 11183778

Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF. PubMed ID: 11248041

Molecular mechanism of recruitment of TFIIF-associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF. PubMed ID: 12591941

Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. PubMed ID: 12578358

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. PubMed ID: 12732728