Details for: GTF2H3

Gene ID: 2967

Symbol: GTF2H3

Ensembl ID: ENSG00000111358

Description: general transcription factor IIH subunit 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.41
    Marker Score: 1127
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.36
    Marker Score: 920
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.22
    Marker Score: 12640
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.21
    Marker Score: 10383
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1840
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.16
    Marker Score: 11059
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68239
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.11
    Marker Score: 10434
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.1
    Marker Score: 40602
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3767
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71719
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47944
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.99
    Marker Score: 3836
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.97
    Marker Score: 405
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3879
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.94
    Marker Score: 13991
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.92
    Marker Score: 18222
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.91
    Marker Score: 34546
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2708
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.89
    Marker Score: 18992
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.87
    Marker Score: 238
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.85
    Marker Score: 6539
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4851
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.83
    Marker Score: 826
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.83
    Marker Score: 620
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.82
    Marker Score: 3193
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1309
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.79
    Marker Score: 3286
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.76
    Marker Score: 26355
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.75
    Marker Score: 2950
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1086
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.73
    Marker Score: 530
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.72
    Marker Score: 906
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.72
    Marker Score: 1510
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.7
    Marker Score: 351
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10981
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2922.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 442
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.69
    Marker Score: 206
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.69
    Marker Score: 198
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.68
    Marker Score: 359
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 450
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 619
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.65
    Marker Score: 356
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.64
    Marker Score: 827
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 684
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.63
    Marker Score: 167
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.63
    Marker Score: 260
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.63
    Marker Score: 427
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.62
    Marker Score: 659
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 539
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.62
    Marker Score: 216
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 564
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.61
    Marker Score: 812
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6
    Marker Score: 171
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.6
    Marker Score: 376
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.6
    Marker Score: 289
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.6
    Marker Score: 1627
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.59
    Marker Score: 374
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.59
    Marker Score: 271
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 593
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.59
    Marker Score: 6603
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 640
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.58
    Marker Score: 608
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.57
    Marker Score: 577
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.57
    Marker Score: 391
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.57
    Marker Score: 1446
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.57
    Marker Score: 1540.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.57
    Marker Score: 275
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.57
    Marker Score: 6582
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.56
    Marker Score: 404
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.55
    Marker Score: 1328
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.55
    Marker Score: 406.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.55
    Marker Score: 577
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.55
    Marker Score: 585
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.55
    Marker Score: 4774
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.55
    Marker Score: 176
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.55
    Marker Score: 1345
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 228
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.54
    Marker Score: 778
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.54
    Marker Score: 883
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.54
    Marker Score: 289
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.54
    Marker Score: 480
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.54
    Marker Score: 1052
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.53
    Marker Score: 1116
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.53
    Marker Score: 3956
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.53
    Marker Score: 241
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.53
    Marker Score: 356
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.52
    Marker Score: 299

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GTF2H3 is a highly conserved protein with a predicted molecular weight of approximately 120 kDa. * It is expressed in a wide range of cell types, including pulmonary interstitial fibroblasts, proerythroblasts, dopaminergic neurons, and glial cells. * GTF2H3 is a key regulator of gene expression in response to various stimuli, including DNA damage, cytokines, and growth factors. **Pathways and functions:** * GTF2H3 is involved in multiple pathways and functions, including: * DNA repair: It is a key component of the DNA repair pathway in response to DNA damage, where it promotes the repair of double-strand breaks (DSBs) through the activation of DNA repair proteins. * Epigenetic regulation of gene expression: GTF2H3 modulates the expression of various genes involved in cellular development, differentiation, and tumor suppression. * Gene expression (transcription): It is a key factor in the regulation of gene expression through the initiation and elongation of RNA polymerase II-dependent transcription events. * Negative epigenetic regulation of rRNA expression: GTF2H3 suppresses the expression of rRNA genes, which are involved in ribosome assembly and protein synthesis. **Clinical significance:** * Mutations in GTF2H3 have been linked to several human diseases, including: * Cancer: GTF2H3 mutations are frequently observed in cancer cells, where they promote tumor growth, invasion, and metastasis. * Neurodevelopmental disorders: Mutations in GTF2H3 have been linked to intellectual disability, developmental abnormalities, and neurodegenerative diseases. **Additional notes:** * GTF2H3 is a highly versatile transcription factor that plays a critical role in maintaining homeostasis and preventing cancer development. * It is a potential therapeutic target for various diseases by modulating its expression or activity.

Genular Protein ID: 921879314

Symbol: TF2H3_HUMAN

Name: General transcription factor IIH subunit 3

UniProtKB Accession Codes:

Q13889 B2R819 B4DNZ6 Q7L0G0 Q96AT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 34 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 29 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8194529

Title: p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair.

PubMed ID: 8194529

DOI: 10.1002/j.1460-2075.1994.tb06523.x

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

Sequence Information:

  • Length: 308
  • Mass: 34378
  • Checksum: E739E2176CD6BAA5
  • Sequence:
    • MVSDEDELNL LVIVVDANPI WWGKQALKES QFTLSKCIDA VMVLGNSHLF MNRSNKLAVI 
ASHIQESRFL YPGKNGRLGD FFGDPGNPPE FNPSGSKDGK YELLTSANEV IVEEIKDLMT 
KSDIKGQHTE TLLAGSLAKA LCYIHRMNKE VKDNQEMKSR ILVIKAAEDS ALQYMNFMNV 
IFAAQKQNIL IDACVLDSDS GLLQQACDIT GGLYLKVPQM PSLLQYLLWV FLPDQDQRSQ 
LILPPPVHVD YRAACFCHRN LIEIGYVCSV CLSIFCNFSP ICTTCETAFK ISLPPVLKAK 
KKKLKVSA

Genular Protein ID: 1505869691

Symbol: A0A087WYD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYD5

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 2 RuleBase 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 162
  • Mass: 18218
  • Checksum: 16BD8643F24A6C8F
  • Sequence:
    • MNKEVKDNQE MKSRILVIKA AEDSALQYMN FMNVIFAAQK QNILIDACVL DSDSGLLQQA 
CDITGGLYLK VPQMPSLLQY LLWVFLPDQD QRSQLILPPP VHVDYRAACF CHRNLIEIGY 
VCSVCLSIFC NFSPICTTCE TAFKISLPPV LKAKKKKLKV SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.