Details for: TMOD2

Gene ID: 29767

Symbol: TMOD2

Ensembl ID: ENSG00000128872

Description: tropomodulin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 224.4363
    Cell Significance Index: -34.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.1754
    Cell Significance Index: -34.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.3945
    Cell Significance Index: -35.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.3060
    Cell Significance Index: -34.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8671
    Cell Significance Index: -34.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3968
    Cell Significance Index: -14.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4665
    Cell Significance Index: 494.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8862
    Cell Significance Index: 126.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8117
    Cell Significance Index: 51.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4538
    Cell Significance Index: 55.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4342
    Cell Significance Index: 63.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4115
    Cell Significance Index: 506.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2210
    Cell Significance Index: 75.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1166
    Cell Significance Index: 110.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9613
    Cell Significance Index: 21.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9007
    Cell Significance Index: 21.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7381
    Cell Significance Index: 9.1600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5937
    Cell Significance Index: 7.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5806
    Cell Significance Index: 94.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5094
    Cell Significance Index: 352.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4296
    Cell Significance Index: 46.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3889
    Cell Significance Index: 7.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2410
    Cell Significance Index: 4.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2016
    Cell Significance Index: 13.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1807
    Cell Significance Index: 9.4900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1750
    Cell Significance Index: 2.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0575
    Cell Significance Index: 3.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0433
    Cell Significance Index: 2.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0348
    Cell Significance Index: 1.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -6.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0134
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0299
    Cell Significance Index: -18.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0308
    Cell Significance Index: -17.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0352
    Cell Significance Index: -25.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0353
    Cell Significance Index: -6.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0360
    Cell Significance Index: -19.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0480
    Cell Significance Index: -36.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0485
    Cell Significance Index: -1.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0563
    Cell Significance Index: -1.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0680
    Cell Significance Index: -1.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0684
    Cell Significance Index: -3.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0832
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0834
    Cell Significance Index: -17.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0843
    Cell Significance Index: -14.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1001
    Cell Significance Index: -13.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1039
    Cell Significance Index: -29.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1225
    Cell Significance Index: -17.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1370
    Cell Significance Index: -27.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1409
    Cell Significance Index: -17.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1430
    Cell Significance Index: -3.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1617
    Cell Significance Index: -4.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1747
    Cell Significance Index: -17.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1747
    Cell Significance Index: -22.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2033
    Cell Significance Index: -4.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2096
    Cell Significance Index: -27.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2187
    Cell Significance Index: -4.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2293
    Cell Significance Index: -26.2700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2550
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2571
    Cell Significance Index: -29.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2650
    Cell Significance Index: -5.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2715
    Cell Significance Index: -8.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2716
    Cell Significance Index: -8.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2858
    Cell Significance Index: -21.9400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2920
    Cell Significance Index: -4.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2993
    Cell Significance Index: -34.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3045
    Cell Significance Index: -9.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3234
    Cell Significance Index: -33.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3577
    Cell Significance Index: -23.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3664
    Cell Significance Index: -29.0200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3726
    Cell Significance Index: -5.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3855
    Cell Significance Index: -28.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3890
    Cell Significance Index: -27.5100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4046
    Cell Significance Index: -3.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4187
    Cell Significance Index: -19.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4377
    Cell Significance Index: -20.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4383
    Cell Significance Index: -9.4700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4423
    Cell Significance Index: -5.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4430
    Cell Significance Index: -7.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4572
    Cell Significance Index: -23.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4940
    Cell Significance Index: -25.7300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5250
    Cell Significance Index: -5.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5308
    Cell Significance Index: -32.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5556
    Cell Significance Index: -13.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6006
    Cell Significance Index: -21.0400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6446
    Cell Significance Index: -7.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6950
    Cell Significance Index: -9.9800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.7006
    Cell Significance Index: -7.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7250
    Cell Significance Index: -8.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7407
    Cell Significance Index: -6.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7870
    Cell Significance Index: -11.2700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8016
    Cell Significance Index: -8.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8026
    Cell Significance Index: -16.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8198
    Cell Significance Index: -35.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMOD2 is a tropomyosin-binding protein that regulates the dynamics of actin filaments, which are essential components of the cytoskeleton. The protein exhibits high affinity for tropomyosin, a key regulator of muscle contraction, and acts as a positive regulator of the positive regulation of G protein-coupled receptor signaling pathway. TMOD2 also interacts with other actin-binding proteins, such as actin-associated proteins (AAPPs) and actin-modulating proteins (AMPs), to modulate actin filament organization and dynamics. **Pathways and Functions:** TMOD2 is involved in various cellular processes, including: 1. **Actin filament organization**: TMOD2 regulates the dynamics of actin filaments by interacting with tropomyosin and other actin-binding proteins, maintaining the structural integrity of the cytoskeleton. 2. **Muscle contraction**: TMOD2 binds to tropomyosin, which is essential for muscle contraction, and regulates the interaction between actin filaments and myosin heads. 3. **Neuron-neuron synaptic transmission**: TMOD2 interacts with AAPPs and AMPs to modulate actin filament organization and dynamics, which is essential for synaptic transmission and plasticity. 4. **Nervous system development**: TMOD2 is involved in the development and organization of the nervous system, including the formation of synapses and axons. 5. **Pointed-end actin filament capping**: TMOD2 regulates the capping of pointed-end actin filaments, which is essential for maintaining the structural integrity of the cytoskeleton. **Clinical Significance:** Dysregulation of TMOD2 has been implicated in various neurological and muscular disorders, including: 1. **Neurodegenerative diseases**: TMOD2 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Muscle disorders**: TMOD2 mutations have been linked to muscle disorders, such as muscular dystrophy and myopathy. 3. **Neurodevelopmental disorders**: TMOD2 dysregulation has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, TMOD2 is a critical protein that plays a pivotal role in maintaining the structural integrity and dynamics of the actin cytoskeleton. Its dysregulation has been implicated in various neurological and muscular disorders, highlighting the importance of further research into the functions and mechanisms of TMOD2.

Genular Protein ID: 3939168361

Symbol: TMOD2_HUMAN

Name: Tropomodulin-2

UniProtKB Accession Codes:

Q9NZR1 B4DEW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662549

Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

PubMed ID: 10662549

DOI: 10.1006/geno.1999.6061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 39595
  • Checksum: 547004595FCD6385
  • Sequence:
    • MALPFQKELE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESAMLPAGF RQKDQTQKAA 
TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPIETRKE EKVTLDPELE 
EALASASDTE LYDLAAVLGV HNLLNNPKFD EETANNKGGK GPVRNVVKGE KVKPVFEEPP 
NPTNVEISLQ QMKANDPSLQ EVNLNNIKNI PIPTLREFAK ALETNTHVKK FSLAATRSND 
PVAIAFADML KVNKTLTSLN IESNFITGTG ILALVEALKE NDTLTEIKID NQRQQLGTAV 
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEADR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.