Details for: TMOD2

Gene ID: 29767

Symbol: TMOD2

Ensembl ID: ENSG00000128872

Description: tropomodulin 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.85
    Marker Score: 16,051
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.28
    Marker Score: 2,837
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.13
    Marker Score: 3,003
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.05
    Marker Score: 30,721
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.96
    Marker Score: 41,822
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.96
    Marker Score: 38,920
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119,395
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.93
    Marker Score: 73,140
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17,777
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.86
    Marker Score: 68,514
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.83
    Marker Score: 17,368
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18,697
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,281
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,859
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.76
    Marker Score: 13,458
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.68
    Marker Score: 6,979
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.59
    Marker Score: 2,453
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.58
    Marker Score: 660
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1,142
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6,046
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.42
    Marker Score: 6,575
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.42
    Marker Score: 4,037
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.34
    Marker Score: 45,090
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.31
    Marker Score: 6,867
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.3
    Marker Score: 355
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.23
    Marker Score: 1,376
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.19
    Marker Score: 2,852
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.16
    Marker Score: 571
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.11
    Marker Score: 374
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.05
    Marker Score: 2,125
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.02
    Marker Score: 1,708
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,002
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1
    Marker Score: 1,232
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.96
    Marker Score: 371
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.95
    Marker Score: 231
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.93
    Marker Score: 214
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.92
    Marker Score: 605
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,108
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.89
    Marker Score: 282
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.88
    Marker Score: 597
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.85
    Marker Score: 738
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.84
    Marker Score: 6,334
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8
    Marker Score: 1,406
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.8
    Marker Score: 467
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.8
    Marker Score: 1,760
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,239
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.74
    Marker Score: 857
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.74
    Marker Score: 268
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,506
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,100
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.72
    Marker Score: 339
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 652
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.71
    Marker Score: 783
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.71
    Marker Score: 352
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.7
    Marker Score: 162
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.65
    Marker Score: 385
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.62
    Marker Score: 1,422
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9,524
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.6
    Marker Score: 339
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.59
    Marker Score: 145
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.59
    Marker Score: 343
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.57
    Marker Score: 212
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.56
    Marker Score: 671
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.55
    Marker Score: 131
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.54
    Marker Score: 262
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.54
    Marker Score: 1,335
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.53
    Marker Score: 1,781
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.53
    Marker Score: 196
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 240
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.51
    Marker Score: 264
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.5
    Marker Score: 473
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.49
    Marker Score: 898
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.49
    Marker Score: 198
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2,899
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.48
    Marker Score: 691
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.46
    Marker Score: 292
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.46
    Marker Score: 134
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.46
    Marker Score: 1,291
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.45
    Marker Score: 158
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.45
    Marker Score: 557
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 195
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.44
    Marker Score: 237
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.44
    Marker Score: 144

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMOD2 is a tropomyosin-binding protein that regulates the dynamics of actin filaments, which are essential components of the cytoskeleton. The protein exhibits high affinity for tropomyosin, a key regulator of muscle contraction, and acts as a positive regulator of the positive regulation of G protein-coupled receptor signaling pathway. TMOD2 also interacts with other actin-binding proteins, such as actin-associated proteins (AAPPs) and actin-modulating proteins (AMPs), to modulate actin filament organization and dynamics. **Pathways and Functions:** TMOD2 is involved in various cellular processes, including: 1. **Actin filament organization**: TMOD2 regulates the dynamics of actin filaments by interacting with tropomyosin and other actin-binding proteins, maintaining the structural integrity of the cytoskeleton. 2. **Muscle contraction**: TMOD2 binds to tropomyosin, which is essential for muscle contraction, and regulates the interaction between actin filaments and myosin heads. 3. **Neuron-neuron synaptic transmission**: TMOD2 interacts with AAPPs and AMPs to modulate actin filament organization and dynamics, which is essential for synaptic transmission and plasticity. 4. **Nervous system development**: TMOD2 is involved in the development and organization of the nervous system, including the formation of synapses and axons. 5. **Pointed-end actin filament capping**: TMOD2 regulates the capping of pointed-end actin filaments, which is essential for maintaining the structural integrity of the cytoskeleton. **Clinical Significance:** Dysregulation of TMOD2 has been implicated in various neurological and muscular disorders, including: 1. **Neurodegenerative diseases**: TMOD2 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Muscle disorders**: TMOD2 mutations have been linked to muscle disorders, such as muscular dystrophy and myopathy. 3. **Neurodevelopmental disorders**: TMOD2 dysregulation has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, TMOD2 is a critical protein that plays a pivotal role in maintaining the structural integrity and dynamics of the actin cytoskeleton. Its dysregulation has been implicated in various neurological and muscular disorders, highlighting the importance of further research into the functions and mechanisms of TMOD2.

Genular Protein ID: 3939168361

Symbol: TMOD2_HUMAN

Name: Tropomodulin-2

UniProtKB Accession Codes:

Q9NZR1 B4DEW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662549

Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.

PubMed ID: 10662549

DOI: 10.1006/geno.1999.6061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 39595
  • Checksum: 547004595FCD6385
  • Sequence:
    • MALPFQKELE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESAMLPAGF RQKDQTQKAA 
TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPIETRKE EKVTLDPELE 
EALASASDTE LYDLAAVLGV HNLLNNPKFD EETANNKGGK GPVRNVVKGE KVKPVFEEPP 
NPTNVEISLQ QMKANDPSLQ EVNLNNIKNI PIPTLREFAK ALETNTHVKK FSLAATRSND 
PVAIAFADML KVNKTLTSLN IESNFITGTG ILALVEALKE NDTLTEIKID NQRQQLGTAV 
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEADR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.