Details for: NCAPH2

Gene ID: 29781

Symbol: NCAPH2

Ensembl ID: ENSG00000025770

Description: non-SMC condensin II complex subunit H2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 76.0872
    Cell Significance Index: -11.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.4642
    Cell Significance Index: -15.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.2271
    Cell Significance Index: -18.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.5378
    Cell Significance Index: -15.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 27.7450
    Cell Significance Index: -18.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.0776
    Cell Significance Index: -15.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9948
    Cell Significance Index: -17.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5247
    Cell Significance Index: -14.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5527
    Cell Significance Index: -17.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4772
    Cell Significance Index: -10.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.3803
    Cell Significance Index: 22.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9675
    Cell Significance Index: 13.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7451
    Cell Significance Index: 81.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7294
    Cell Significance Index: 118.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7058
    Cell Significance Index: 42.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6849
    Cell Significance Index: 618.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6077
    Cell Significance Index: 17.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4739
    Cell Significance Index: 12.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4346
    Cell Significance Index: 11.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4263
    Cell Significance Index: 42.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4207
    Cell Significance Index: 49.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3601
    Cell Significance Index: 16.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3073
    Cell Significance Index: 21.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2961
    Cell Significance Index: 4.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2567
    Cell Significance Index: 11.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2456
    Cell Significance Index: 12.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2449
    Cell Significance Index: 169.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2372
    Cell Significance Index: 104.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2349
    Cell Significance Index: 32.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2284
    Cell Significance Index: 45.8200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2114
    Cell Significance Index: 3.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2020
    Cell Significance Index: 25.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1885
    Cell Significance Index: 37.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1854
    Cell Significance Index: 5.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1767
    Cell Significance Index: 6.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1720
    Cell Significance Index: 10.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1659
    Cell Significance Index: 8.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1649
    Cell Significance Index: 21.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1390
    Cell Significance Index: 2.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1315
    Cell Significance Index: 4.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1306
    Cell Significance Index: 46.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1241
    Cell Significance Index: 67.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1199
    Cell Significance Index: 14.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1159
    Cell Significance Index: 1.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1118
    Cell Significance Index: 7.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1030
    Cell Significance Index: 7.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0521
    Cell Significance Index: 0.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0479
    Cell Significance Index: 2.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0446
    Cell Significance Index: 0.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0409
    Cell Significance Index: 7.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0265
    Cell Significance Index: 5.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0200
    Cell Significance Index: 3.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0155
    Cell Significance Index: 0.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0131
    Cell Significance Index: 0.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0033
    Cell Significance Index: 0.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0212
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0253
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0266
    Cell Significance Index: -12.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0296
    Cell Significance Index: -16.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0331
    Cell Significance Index: -20.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0521
    Cell Significance Index: -15.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0614
    Cell Significance Index: -8.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0667
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0863
    Cell Significance Index: -9.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0874
    Cell Significance Index: -10.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0902
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0984
    Cell Significance Index: -20.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1006
    Cell Significance Index: -2.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1169
    Cell Significance Index: -1.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1267
    Cell Significance Index: -7.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1438
    Cell Significance Index: -11.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1633
    Cell Significance Index: -4.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1676
    Cell Significance Index: -17.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1965
    Cell Significance Index: -13.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1972
    Cell Significance Index: -15.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2286
    Cell Significance Index: -6.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2328
    Cell Significance Index: -14.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2338
    Cell Significance Index: -6.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2654
    Cell Significance Index: -3.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2738
    Cell Significance Index: -3.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2850
    Cell Significance Index: -4.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2996
    Cell Significance Index: -7.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3260
    Cell Significance Index: -14.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3296
    Cell Significance Index: -9.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3814
    Cell Significance Index: -14.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3881
    Cell Significance Index: -8.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3912
    Cell Significance Index: -14.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3942
    Cell Significance Index: -11.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3955
    Cell Significance Index: -8.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3965
    Cell Significance Index: -13.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of the non-SMC condensin II complex**: NCAPH2 is a subunit of the NSMC2, a protein complex that assembles on chromosomes during prophase and condenses chromatin, leading to the formation of compact chromosomes. 2. **Essential for chromosome condensation and segregation**: NCAPH2 is required for the proper condensation of chromosomes and the subsequent segregation of chromosomes during mitosis and meiosis. 3. **Regulated by cell cycle checkpoints**: The expression and function of NCAPH2 are tightly regulated by cell cycle checkpoints, ensuring that chromosomes are properly condensed and segregated at the correct times during the cell cycle. 4. **Implicated in human diseases**: Alterations in NCAPH2 have been linked to various human diseases, including cancer, developmental disorders, and neurodegenerative diseases. **Pathways and Functions:** 1. **Cell cycle regulation**: NCAPH2 plays a critical role in regulating the cell cycle, ensuring that chromosomes are properly condensed and segregated during mitosis and meiosis. 2. **Chromosome condensation**: NCAPH2 is involved in the condensation of prophase chromosomes, leading to the formation of compact chromosomes. 3. **Condensin complex formation**: NCAPH2 assembles with other subunits to form the NSMC2, which is essential for chromosome condensation and segregation. 4. **Chromosome segregation**: NCAPH2 is required for the proper segregation of chromosomes during mitosis and meiosis, ensuring that sister chromatids are separated correctly. **Clinical Significance:** 1. **Cancer**: Alterations in NCAPH2 have been linked to various types of cancer, including breast cancer and leukemia. 2. **Developmental disorders**: NCAPH2 mutations have been associated with developmental disorders, such as intellectual disability and autism spectrum disorder. 3. **Neurodegenerative diseases**: NCAPH2 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Genetic instability**: NCAPH2 mutations can lead to genetic instability, increasing the risk of cancer and other diseases. In conclusion, the NCAPH2 gene plays a critical role in maintaining genome stability and regulating the cell cycle. Its dysregulation has been linked to various human diseases, highlighting the importance of understanding its function and regulation. Further research is needed to elucidate the mechanisms by which NCAPH2 functions and its implications in human health and disease.

Genular Protein ID: 591842280

Symbol: CNDH2_HUMAN

Name: Condensin-2 complex subunit H2

UniProtKB Accession Codes:

Q6IBW4 B7WPH1 O43788 Q13391 Q96C14 Q96GJ0 Q9BQ71 Q9BUT3 Q9BVD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14532007

Title: Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.

PubMed ID: 14532007

DOI: 10.1016/s0092-8674(03)00724-4

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 605
  • Mass: 68227
  • Checksum: 2C8A1070C27B4547
  • Sequence:
    • MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI 
QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS 
LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR 
MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS 
QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER 
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ 
DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA 
EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA 
TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL 
VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP 
SMAQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.