Details for: OLA1

Gene ID: 29789

Symbol: OLA1

Ensembl ID: ENSG00000138430

Description: Obg like ATPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 436.9147
    Cell Significance Index: -67.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 238.0902
    Cell Significance Index: -60.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 173.9056
    Cell Significance Index: -71.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 169.5958
    Cell Significance Index: -80.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 161.4249
    Cell Significance Index: -65.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 143.2584
    Cell Significance Index: -73.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 119.5490
    Cell Significance Index: -80.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 68.8458
    Cell Significance Index: -65.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.6786
    Cell Significance Index: -77.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.7676
    Cell Significance Index: -63.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.1049
    Cell Significance Index: -79.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.0036
    Cell Significance Index: -61.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5828
    Cell Significance Index: -25.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.1387
    Cell Significance Index: 176.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1107
    Cell Significance Index: 617.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4875
    Cell Significance Index: 499.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0248
    Cell Significance Index: 726.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8603
    Cell Significance Index: 51.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5632
    Cell Significance Index: 96.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5120
    Cell Significance Index: 825.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4872
    Cell Significance Index: 39.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3153
    Cell Significance Index: 237.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2435
    Cell Significance Index: 152.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2382
    Cell Significance Index: 54.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1361
    Cell Significance Index: 785.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1011
    Cell Significance Index: 11.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0670
    Cell Significance Index: 79.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0424
    Cell Significance Index: 73.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0037
    Cell Significance Index: 47.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9899
    Cell Significance Index: 23.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9802
    Cell Significance Index: 65.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9643
    Cell Significance Index: 124.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9391
    Cell Significance Index: 110.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9142
    Cell Significance Index: 404.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9098
    Cell Significance Index: 58.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9082
    Cell Significance Index: 34.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7696
    Cell Significance Index: 59.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7260
    Cell Significance Index: 99.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7194
    Cell Significance Index: 122.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6885
    Cell Significance Index: 23.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5896
    Cell Significance Index: 30.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4762
    Cell Significance Index: 429.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3910
    Cell Significance Index: 20.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3870
    Cell Significance Index: 8.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3023
    Cell Significance Index: 7.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2835
    Cell Significance Index: 12.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2737
    Cell Significance Index: 5.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2262
    Cell Significance Index: 29.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2146
    Cell Significance Index: 34.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2086
    Cell Significance Index: 392.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2007
    Cell Significance Index: 91.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1733
    Cell Significance Index: 2.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1702
    Cell Significance Index: 108.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1608
    Cell Significance Index: 247.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1401
    Cell Significance Index: 258.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0880
    Cell Significance Index: 16.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0795
    Cell Significance Index: 2.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0727
    Cell Significance Index: 3.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0517
    Cell Significance Index: 70.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0110
    Cell Significance Index: 1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0196
    Cell Significance Index: -14.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0304
    Cell Significance Index: -22.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0403
    Cell Significance Index: -30.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0475
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0606
    Cell Significance Index: -37.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0972
    Cell Significance Index: -9.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1015
    Cell Significance Index: -57.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1553
    Cell Significance Index: -4.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2010
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2155
    Cell Significance Index: -45.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2372
    Cell Significance Index: -68.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2393
    Cell Significance Index: -15.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3059
    Cell Significance Index: -8.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3482
    Cell Significance Index: -3.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3616
    Cell Significance Index: -4.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3754
    Cell Significance Index: -43.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3824
    Cell Significance Index: -43.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3991
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5580
    Cell Significance Index: -63.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5679
    Cell Significance Index: -59.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6193
    Cell Significance Index: -13.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6701
    Cell Significance Index: -17.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6773
    Cell Significance Index: -14.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6907
    Cell Significance Index: -6.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6939
    Cell Significance Index: -5.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7180
    Cell Significance Index: -25.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7347
    Cell Significance Index: -58.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7585
    Cell Significance Index: -20.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8286
    Cell Significance Index: -26.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8451
    Cell Significance Index: -11.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8766
    Cell Significance Index: -45.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9694
    Cell Significance Index: -25.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0031
    Cell Significance Index: -21.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0832
    Cell Significance Index: -31.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2577
    Cell Significance Index: -77.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3696
    Cell Significance Index: -44.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3766
    Cell Significance Index: -31.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3823
    Cell Significance Index: -44.0300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.4064
    Cell Significance Index: -8.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4085
    Cell Significance Index: -8.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OLA1 is a member of the OB-fold protein family, characterized by its unique structure and ATPase activity. The protein exhibits a high degree of sequence homology with other OB-fold proteins, suggesting a conserved evolutionary origin. OLA1 is predominantly expressed in neurons, including GABAergic interneurons, and has also been detected in other cell types, such as epithelial cells and platelets. **Pathways and Functions:** OLA1 is involved in several cellular pathways, including: 1. **ATP hydrolysis and metabolic process**: OLA1 catalyzes the hydrolysis of ATP, which is essential for various cellular processes, such as energy transfer, membrane trafficking, and cytoskeletal regulation. 2. **GTP binding and signaling**: OLA1 interacts with GTP-binding proteins, influencing signaling pathways involved in cell proliferation, differentiation, and survival. 3. **Cadherin binding and cell adhesion**: OLA1 interacts with cadherins, which are essential for cell-cell adhesion and tissue organization. 4. **Centrosome and cytoskeleton organization**: OLA1 regulates the formation and function of centrosomes, which are critical for maintaining cytoskeletal organization and cell polarity. 5. **Platelet activation and aggregation**: OLA1 is specifically expressed in platelets and plays a role in regulating platelet activation, aggregation, and degranulation. **Clinical Significance:** OLA1 has been implicated in various disease states, including: 1. **Neurological disorders**: Mutations in OLA1 have been associated with neurological disorders, such as epilepsy and schizophrenia. 2. **Cancer**: OLA1 is overexpressed in certain types of cancer, including breast and lung cancer. 3. **Platelet disorders**: Abnormalities in OLA1 expression have been linked to platelet-related disorders, such as thrombocytopenia and bleeding tendencies. In conclusion, OLA1 is a multifaceted gene involved in various cellular processes, including signaling, membrane trafficking, and cytoskeletal regulation. Its dysregulation has been implicated in various disease states, highlighting the importance of OLA1 in maintaining cellular homeostasis and overall health.

Genular Protein ID: 2755155281

Symbol: OLA1_HUMAN

Name: DNA damage-regulated overexpressed in cancer 45

UniProtKB Accession Codes:

Q9NTK5 D7EHM2 Q5BJD7 Q8NCI8 Q96CU1 Q96SV2 Q9P1D3 Q9UNY9 Q9Y6G4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 20053727

Title: DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies.

PubMed ID: 20053727

DOI: 10.1158/1541-7786.mcr-09-0278

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17430889

Title: Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins.

PubMed ID: 17430889

DOI: 10.1074/jbc.m700541200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 396
  • Mass: 44744
  • Checksum: 4C7629BFC27CBEB2
  • Sequence:
    • MPPKKGGDGI KPPPIIGRFG TSLKIGIVGL PNVGKSTFFN VLTNSQASAE NFPFCTIDPN 
ESRVPVPDER FDFLCQYHKP ASKIPAFLNV VDIAGLVKGA HNGQGLGNAF LSHISACDGI 
FHLTRAFEDD DITHVEGSVD PIRDIEIIHE ELQLKDEEMI GPIIDKLEKV AVRGGDKKLK 
PEYDIMCKVK SWVIDQKKPV RFYHDWNDKE IEVLNKHLFL TSKPMVYLVN LSEKDYIRKK 
NKWLIKIKEW VDKYDPGALV IPFSGALELK LQELSAEERQ KYLEANMTQS ALPKIIKAGF 
AALQLEYFFT AGPDEVRAWT IRKGTKAPQA AGKIHTDFEK GFIMAEVMKY EDFKEEGSEN 
AVKAAGKYRQ QGRNYIVEDG DIIFFKFNTP QQPKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.