Details for: GRHL1

Gene ID: 29841

Symbol: GRHL1

Ensembl ID: ENSG00000134317

Description: grainyhead like transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.5185
    Cell Significance Index: -9.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.3725
    Cell Significance Index: -10.7500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 13.3868
    Cell Significance Index: 17.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6053
    Cell Significance Index: -10.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 7.3322
    Cell Significance Index: 195.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.7675
    Cell Significance Index: 78.6900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 5.6844
    Cell Significance Index: 35.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.3887
    Cell Significance Index: 227.9800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 4.1418
    Cell Significance Index: 2.9600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.7526
    Cell Significance Index: 16.9400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.5220
    Cell Significance Index: 15.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9186
    Cell Significance Index: 61.4500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.7299
    Cell Significance Index: 3.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6799
    Cell Significance Index: 15.4700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0186
    Cell Significance Index: 14.5000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.0108
    Cell Significance Index: 6.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8685
    Cell Significance Index: 101.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8532
    Cell Significance Index: 40.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7860
    Cell Significance Index: 13.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7142
    Cell Significance Index: 19.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7140
    Cell Significance Index: 128.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6563
    Cell Significance Index: 10.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6320
    Cell Significance Index: 125.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6050
    Cell Significance Index: 28.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4672
    Cell Significance Index: 93.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4636
    Cell Significance Index: 204.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4594
    Cell Significance Index: 32.4900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4314
    Cell Significance Index: 4.4500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.4197
    Cell Significance Index: 4.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4087
    Cell Significance Index: 50.2500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3579
    Cell Significance Index: 4.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3472
    Cell Significance Index: 5.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3329
    Cell Significance Index: 24.8100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2783
    Cell Significance Index: 2.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2091
    Cell Significance Index: 39.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2000
    Cell Significance Index: 25.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1942
    Cell Significance Index: 13.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1872
    Cell Significance Index: 5.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1664
    Cell Significance Index: 59.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1435
    Cell Significance Index: 78.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1313
    Cell Significance Index: 12.9900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1305
    Cell Significance Index: 1.3500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.1218
    Cell Significance Index: 0.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0701
    Cell Significance Index: 2.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0689
    Cell Significance Index: 11.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0641
    Cell Significance Index: 1.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0605
    Cell Significance Index: 54.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0576
    Cell Significance Index: 6.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0511
    Cell Significance Index: 3.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0494
    Cell Significance Index: 1.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0437
    Cell Significance Index: 30.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0308
    Cell Significance Index: 0.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0240
    Cell Significance Index: 1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0205
    Cell Significance Index: 0.7200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0093
    Cell Significance Index: 0.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0022
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -7.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0068
    Cell Significance Index: -0.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0078
    Cell Significance Index: -1.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -5.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0149
    Cell Significance Index: -0.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0178
    Cell Significance Index: -11.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0179
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0192
    Cell Significance Index: -8.7300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0260
    Cell Significance Index: -7.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0306
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0318
    Cell Significance Index: -3.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0351
    Cell Significance Index: -0.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0402
    Cell Significance Index: -0.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0446
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0538
    Cell Significance Index: -11.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0562
    Cell Significance Index: -2.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0573
    Cell Significance Index: -5.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0577
    Cell Significance Index: -7.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0590
    Cell Significance Index: -4.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0678
    Cell Significance Index: -3.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0687
    Cell Significance Index: -9.4400
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0788
    Cell Significance Index: -0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0870
    Cell Significance Index: -10.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1043
    Cell Significance Index: -10.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1044
    Cell Significance Index: -6.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1062
    Cell Significance Index: -6.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1166
    Cell Significance Index: -1.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1218
    Cell Significance Index: -9.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1448
    Cell Significance Index: -3.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1503
    Cell Significance Index: -3.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1559
    Cell Significance Index: -10.0600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1605
    Cell Significance Index: -1.8400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1629
    Cell Significance Index: -1.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1681
    Cell Significance Index: -8.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GRHL1 is a transcription factor that belongs to the Grainyhead family, which is characterized by the presence of a grainyhead domain. This domain is a conserved motif that is essential for the interaction with other proteins and DNA sequences. GRHL1 is specifically expressed in epithelial tissues, including squamous epithelial cells, corneal epithelial cells, and stratified epithelial cells. Its expression is also observed in other cell types, such as rod bipolar cells, mural cells, and cardiac endothelial cells. **Pathways and Functions:** GRHL1 is involved in various cellular processes, including: 1. **Epithelial development:** GRHL1 regulates the expression of genes involved in epithelial development, including those involved in the establishment of the skin barrier and the development of epithelial tissues. 2. **Metabolism:** GRHL1 is involved in the regulation of lipid metabolism, particularly in the context of PPARα activation. 3. **Differentiation:** GRHL1 regulates the expression of genes involved in keratinocyte differentiation and lipid metabolism. 4. **Chromatin organization:** GRHL1 interacts with chromatin and regulates the expression of genes involved in chromatin organization and DNA replication. GRHL1's functions can be broadly categorized into three main areas: 1. **Transcriptional regulation:** GRHL1 regulates the expression of target genes by binding to specific DNA sequences and interacting with other transcription factors. 2. **Post-transcriptional regulation:** GRHL1 regulates the expression of target genes by influencing the stability and translation of mRNA. 3. **Cellular signaling:** GRHL1 interacts with other signaling molecules to regulate cellular processes, including metabolism and differentiation. **Clinical Significance:** GRHL1 has been implicated in various human diseases, including: 1. **Skin disorders:** GRHL1 is involved in the development of skin disorders, such as epidermolysis bullosa simplex. 2. **Cancer:** GRHL1 is overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Metabolic disorders:** GRHL1 is involved in the regulation of lipid metabolism and has been implicated in metabolic disorders, such as obesity and type 2 diabetes. In conclusion, GRHL1 is a critical transcription factor that plays a pivotal role in epithelial development, metabolism, and differentiation. Its dysregulation has been implicated in various human diseases, highlighting the importance of GRHL1 in maintaining epithelial homeostasis and overall health. Further research is needed to fully elucidate the mechanisms by which GRHL1 regulates cellular processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 4118408980

Symbol: GRHL1_HUMAN

Name: Mammalian grainyhead

UniProtKB Accession Codes:

Q9NZI5 A6NLA4 B2R7E4 B5MEC2 Q53T93 Q6NWN7 Q6NWN8 Q6NWN9 Q8NI33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644752

Title: Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.

PubMed ID: 10644752

DOI: 10.1074/jbc.275.4.2852

PubMed ID: 12175488

Title: A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.

PubMed ID: 12175488

DOI: 10.1016/s0925-4773(02)00046-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12549979

Title: The identification and characterization of human sister-of-mammalian grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.

PubMed ID: 12549979

DOI: 10.1042/bj20021476

PubMed ID: 18288204

Title: Perturbed desmosomal cadherin expression in grainy head-like 1-null mice.

PubMed ID: 18288204

DOI: 10.1038/emboj.2008.24

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35013237

Title: Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.

PubMed ID: 35013237

DOI: 10.1038/s41467-021-27732-4

PubMed ID: 29309642

Title: Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.

PubMed ID: 29309642

DOI: 10.1093/nar/gkx1299

Sequence Information:

  • Length: 618
  • Mass: 70113
  • Checksum: 449587B17F4A8A44
  • Sequence:
    • MTQEYDNKRP VLVLQNEALY PQRRSYTSED EAWKSFLENP LTAATKAMMS INGDEDSAAA 
LGLLYDYYKV PRERRSSTAK PEVEHPEPDH SKRNSIPIVT EQPLISAGEN RVQVLKNVPF 
NIVLPHGNQL GIDKRGHLTA PDTTVTVSIA TMPTHSIKTE TQPHGFAVGI PPAVYHPEPT 
ERVVVFDRNL NTDQFSSGAQ APNAQRRTPD STFSETFKEG VQEVFFPSDL SLRMPGMNSE 
DYVFDSVSGN NFEYTLEASK SLRQKPGDST MTYLNKGQFY PITLKEVSSS EGIHHPISKV 
RSVIMVVFAE DKSREDQLRH WKYWHSRQHT AKQRCIDIAD YKESFNTISN IEEIAYNAIS 
FTWDINDEAK VFISVNCLST DFSSQKGVKG LPLNIQVDTY SYNNRSNKPV HRAYCQIKVF 
CDKGAERKIR DEERKQSKRK VSDVKVPLLP SHKRMDITVF KPFIDLDTQP VLFIPDVHFA 
NLQRGTHVLP IASEELEGEG SVLKRGPYGT EDDFAVPPST KLARIEEPKR VLLYVRKESE 
EVFDALMLKT PSLKGLMEAI SDKYDVPHDK IGKIFKKCKK GILVNMDDNI VKHYSNEDTF 
QLQIEEAGGS YKLTLTEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.