Details for: SAC3D1

Gene ID: 29901

Symbol: SAC3D1

Ensembl ID: ENSG00000168061

Description: SAC3 domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.0252
    Cell Significance Index: -8.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.1204
    Cell Significance Index: -13.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.5164
    Cell Significance Index: -13.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.9581
    Cell Significance Index: -15.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9305
    Cell Significance Index: -13.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5819
    Cell Significance Index: -14.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9163
    Cell Significance Index: -13.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8266
    Cell Significance Index: -15.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.7707
    Cell Significance Index: -8.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0884
    Cell Significance Index: 65.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9205
    Cell Significance Index: 149.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8527
    Cell Significance Index: 769.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8289
    Cell Significance Index: 28.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6921
    Cell Significance Index: 80.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5409
    Cell Significance Index: 5.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5198
    Cell Significance Index: 10.8800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4529
    Cell Significance Index: 3.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3992
    Cell Significance Index: 39.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3737
    Cell Significance Index: 6.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3699
    Cell Significance Index: 73.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3684
    Cell Significance Index: 9.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3524
    Cell Significance Index: 24.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3520
    Cell Significance Index: 24.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3464
    Cell Significance Index: 189.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3451
    Cell Significance Index: 16.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3375
    Cell Significance Index: 39.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3186
    Cell Significance Index: 14.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3141
    Cell Significance Index: 138.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3097
    Cell Significance Index: 9.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3033
    Cell Significance Index: 41.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2522
    Cell Significance Index: 7.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2373
    Cell Significance Index: 15.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2363
    Cell Significance Index: 5.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2080
    Cell Significance Index: 5.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1948
    Cell Significance Index: 10.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1869
    Cell Significance Index: 2.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1837
    Cell Significance Index: 11.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1810
    Cell Significance Index: 2.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1236
    Cell Significance Index: 15.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1037
    Cell Significance Index: 20.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1010
    Cell Significance Index: 2.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0764
    Cell Significance Index: 2.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0562
    Cell Significance Index: 10.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0512
    Cell Significance Index: 6.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0449
    Cell Significance Index: 8.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0415
    Cell Significance Index: 1.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0396
    Cell Significance Index: 1.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0332
    Cell Significance Index: 11.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0150
    Cell Significance Index: 0.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0072
    Cell Significance Index: 0.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0060
    Cell Significance Index: 0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0006
    Cell Significance Index: 0.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -11.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0101
    Cell Significance Index: -18.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0109
    Cell Significance Index: -1.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0132
    Cell Significance Index: -17.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0149
    Cell Significance Index: -10.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0162
    Cell Significance Index: -0.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0198
    Cell Significance Index: -12.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0213
    Cell Significance Index: -2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0268
    Cell Significance Index: -16.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0330
    Cell Significance Index: -14.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0346
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0362
    Cell Significance Index: -6.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0401
    Cell Significance Index: -0.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0552
    Cell Significance Index: -1.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0625
    Cell Significance Index: -0.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0688
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0826
    Cell Significance Index: -17.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0851
    Cell Significance Index: -9.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0878
    Cell Significance Index: -12.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1016
    Cell Significance Index: -7.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1126
    Cell Significance Index: -6.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1280
    Cell Significance Index: -3.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1308
    Cell Significance Index: -8.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1443
    Cell Significance Index: -15.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1494
    Cell Significance Index: -2.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1634
    Cell Significance Index: -12.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1758
    Cell Significance Index: -11.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1813
    Cell Significance Index: -13.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1843
    Cell Significance Index: -2.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2147
    Cell Significance Index: -4.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2564
    Cell Significance Index: -6.5900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2896
    Cell Significance Index: -4.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3011
    Cell Significance Index: -13.3200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3024
    Cell Significance Index: -2.5700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3398
    Cell Significance Index: -2.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3528
    Cell Significance Index: -12.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3635
    Cell Significance Index: -13.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3684
    Cell Significance Index: -12.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3815
    Cell Significance Index: -12.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3919
    Cell Significance Index: -14.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4081
    Cell Significance Index: -12.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4090
    Cell Significance Index: -11.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SAC3D1 is a gene that encodes a protein containing a SAC3 domain, a conserved motif involved in centrosome duplication and spindle assembly. The SAC3 domain is characterized by a conserved sequence of amino acids that interacts with other proteins to regulate cell cycle progression. SAC3D1 is also expressed in various cell types, including those involved in the development of the nervous system and reproductive organs. **Pathways and Functions:** SAC3D1 is implicated in several cellular pathways, including: 1. **Cell Division:** SAC3D1 regulates the G2/M checkpoint, ensuring that cells enter mitosis only after proper chromosome alignment and segregation. 2. **Centrosome Duplication:** SAC3D1 is involved in the regulation of centrosome duplication, ensuring that the correct number of centrosomes is produced during cell division. 3. **Spindle Assembly:** SAC3D1 interacts with other proteins to regulate spindle assembly, ensuring that chromosomes are properly aligned and segregated during mitosis. 4. **Protein Binding:** SAC3D1 interacts with various proteins, including those involved in cell cycle regulation, to modulate its activity. **Clinical Significance:** The dysregulation of SAC3D1 has been implicated in several diseases, including: 1. **Cancer:** SAC3D1's role in regulating cell cycle progression and centrosome duplication makes it a potential target for cancer therapy. 2. **Neurodevelopmental Disorders:** SAC3D1's expression in cerebral cortex GABAergic interneurons suggests that it may play a role in neurodevelopmental disorders, such as autism spectrum disorder. 3. **Reproductive Disorders:** SAC3D1's expression in primordial germ cells and ovarian surface epithelial cells suggests that it may play a role in reproductive disorders, such as infertility. In conclusion, SAC3D1 is a critical regulator of cell division, centrosome duplication, and spindle assembly. Its dysregulation has been implicated in several diseases, highlighting its potential as a therapeutic target for the treatment of these disorders. Further research is necessary to fully elucidate SAC3D1's role in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 3811538402

Symbol: F8WC89_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8WC89

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 3 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 358
  • Mass: 38580
  • Checksum: 22E575D47942D5ED
  • Sequence:
    • MPGCELPVGT CPDMCPAAER AQREREHRLH RLEVVPGCRQ DPPRADPQRA VKEYSRPAAG 
KPRPPPSQLR PPSVLLATVR YLAGEVAESA DIARAEVASF VADRLRAVLL DLALQGAGDA 
EAAVVLEAAL ATLLTVVARL GPDAARGPAD PVLLQAQVQE GFGSLRRCYA RGAGPHPRQP 
AFQGLFLLYN LGSVEALHEV LQLPAALRAC PPLRKALAVD AAFREGNAAR LFRLLQTLPY 
LPSCAVQCHV GHARREALAR FARAFSTPKG QTLPLGFMVN LLALDGLREA RDLCQAHGLP 
LDGEERVVFL RGRYVEEGLP PASTCKVLVE SKLRGRTLEE VVMAEEEDEG TDRPGSPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.