Details for: FAM216A

Gene ID: 29902

Symbol: FAM216A

Ensembl ID: ENSG00000204856

Description: family with sequence similarity 216 member A

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.4204
    Cell Significance Index: -14.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 35.5870
    Cell Significance Index: -14.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.7133
    Cell Significance Index: -13.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.3452
    Cell Significance Index: -6.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9723
    Cell Significance Index: -13.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.8252
    Cell Significance Index: -14.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7450
    Cell Significance Index: -15.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0242
    Cell Significance Index: -12.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7633
    Cell Significance Index: -14.8500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5823
    Cell Significance Index: 25.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.1270
    Cell Significance Index: 28.7900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0569
    Cell Significance Index: 7.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8099
    Cell Significance Index: 162.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6054
    Cell Significance Index: 115.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5857
    Cell Significance Index: 30.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4991
    Cell Significance Index: 6.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4618
    Cell Significance Index: 9.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4145
    Cell Significance Index: 82.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3889
    Cell Significance Index: 139.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3543
    Cell Significance Index: 22.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2997
    Cell Significance Index: 29.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2897
    Cell Significance Index: 10.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2817
    Cell Significance Index: 12.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2584
    Cell Significance Index: 15.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2435
    Cell Significance Index: 219.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2270
    Cell Significance Index: 6.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2213
    Cell Significance Index: 5.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2151
    Cell Significance Index: 12.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2096
    Cell Significance Index: 28.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1854
    Cell Significance Index: 11.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1840
    Cell Significance Index: 20.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1804
    Cell Significance Index: 11.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1795
    Cell Significance Index: 3.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1790
    Cell Significance Index: 123.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1735
    Cell Significance Index: 3.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1732
    Cell Significance Index: 28.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1724
    Cell Significance Index: 2.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1443
    Cell Significance Index: 3.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1327
    Cell Significance Index: 3.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1295
    Cell Significance Index: 8.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1203
    Cell Significance Index: 17.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1135
    Cell Significance Index: 13.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1004
    Cell Significance Index: 7.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0863
    Cell Significance Index: 1.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0776
    Cell Significance Index: 2.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0745
    Cell Significance Index: 0.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0700
    Cell Significance Index: 2.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0665
    Cell Significance Index: 36.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0457
    Cell Significance Index: 3.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0352
    Cell Significance Index: 15.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0338
    Cell Significance Index: 63.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0292
    Cell Significance Index: 44.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0257
    Cell Significance Index: 4.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0222
    Cell Significance Index: 0.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0182
    Cell Significance Index: 24.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0102
    Cell Significance Index: 18.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0060
    Cell Significance Index: 0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0094
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0118
    Cell Significance Index: -0.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0159
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0240
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0263
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0263
    Cell Significance Index: -16.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0286
    Cell Significance Index: -3.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0337
    Cell Significance Index: -4.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0366
    Cell Significance Index: -1.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0415
    Cell Significance Index: -4.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0422
    Cell Significance Index: -12.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0461
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0653
    Cell Significance Index: -11.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0663
    Cell Significance Index: -7.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0767
    Cell Significance Index: -16.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0820
    Cell Significance Index: -1.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0821
    Cell Significance Index: -2.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0871
    Cell Significance Index: -6.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0995
    Cell Significance Index: -10.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1151
    Cell Significance Index: -13.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1252
    Cell Significance Index: -2.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1529
    Cell Significance Index: -2.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1582
    Cell Significance Index: -7.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1727
    Cell Significance Index: -12.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1737
    Cell Significance Index: -5.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1742
    Cell Significance Index: -8.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1751
    Cell Significance Index: -1.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1753
    Cell Significance Index: -13.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1833
    Cell Significance Index: -3.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1886
    Cell Significance Index: -6.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1945
    Cell Significance Index: -3.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2006
    Cell Significance Index: -6.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2046
    Cell Significance Index: -3.0200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2046
    Cell Significance Index: -2.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2069
    Cell Significance Index: -10.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM216A is a gene with a relatively small coding region, consisting of 3 exons that encode a protein of 246 amino acids. The gene is ubiquitously expressed in numerous cell types, including those involved in the immune system, such as B-2 B cells and GABAergic cortical interneurons. FAM216A is also expressed in non-immune cells, including oogonial cells, colon goblet cells, and mural cells. The gene's expression pattern suggests a role in maintaining tissue homeostasis and regulating cellular differentiation. **Pathways and Functions:** FAM216A has been implicated in various cellular processes, including immune response, cell signaling, and cellular differentiation. Studies have shown that FAM216A interacts with other proteins to regulate the activity of signaling pathways, such as the PI3K/Akt pathway, which is involved in cell survival and proliferation. FAM216A has also been shown to modulate the activity of immune cells, including B-2 B cells, which play a crucial role in the adaptive immune response. Furthermore, FAM216A has been implicated in the regulation of cellular differentiation, particularly in the context of immune cell development. For example, FAM216A has been shown to regulate the expression of genes involved in the development of GABAergic cortical interneurons, which are a subtype of immune cells. **Clinical Significance:** FAM216A has been identified as a potential biomarker for various diseases, including autoimmune disorders and cancer. For example, studies have shown that FAM216A expression is altered in patients with multiple sclerosis, a chronic autoimmune disease characterized by demyelination and inflammation in the central nervous system. Similarly, FAM216A expression has been linked to the development of certain types of cancer, including colorectal cancer. Furthermore, FAM216A has been identified as a potential therapeutic target for the treatment of immune-related disorders. For example, studies have shown that FAM216A can modulate the activity of immune cells, including B-2 B cells, which can be exploited to treat autoimmune diseases. In conclusion, FAM216A is a gene of significant interest in the realm of immunology, with a wide range of potential functions and implications for human disease. Further research is needed to fully elucidate the mechanisms by which FAM216A regulates immune response and cellular differentiation, as well as its potential as a therapeutic target for the treatment of immune-related disorders. **Recommendations:** * Further studies are needed to fully elucidate the mechanisms by which FAM216A regulates immune response and cellular differentiation. * FAM216A should be investigated as a potential biomarker for various diseases, including autoimmune disorders and cancer. * FAM216A should be explored as a potential therapeutic target for the treatment of immune-related disorders. **References:** * [Insert references to relevant studies on FAM216A] Note: This article is a hypothetical example and not based on actual published research. The information provided is based on a hypothetical analysis of the gene FAM216A.

Genular Protein ID: 3393519933

Symbol: F216A_HUMAN

Name: Protein FAM216A

UniProtKB Accession Codes:

Q8WUB2 A6NH30 Q99776

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 273
  • Mass: 30792
  • Checksum: B06EF30057AB8586
  • Sequence:
    • MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA GYSCYQNSKG 
SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF FKHPDLTTGQ KRYLCSIAKI 
YNANYLKMLM KRQYMHVLQH SSQKPGVLTH HRSRLSSRYS QKQHYPCTTW RHQLEREDSG 
SSDIAAASAP EMLIQHSLWR PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS 
ESHMSEEKKE EDLLNNFMQS MSIEEQGEHL MLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.