Details for: PYCR2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.56
Marker Score: 6,135 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 1.52
Marker Score: 921 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.49
Marker Score: 6,114 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.46
Marker Score: 1,526 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.34
Marker Score: 908 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.32
Marker Score: 956 - Cell Name: germ cell (CL0000586)
Fold Change: 1.27
Marker Score: 2,225 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.27
Marker Score: 11,056 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.21
Marker Score: 5,200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.19
Marker Score: 1,232 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.18
Marker Score: 836 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.13
Marker Score: 364 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.07
Marker Score: 1,571 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,678 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,903 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.98
Marker Score: 1,871 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.98
Marker Score: 1,579 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,391 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.98
Marker Score: 286 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.97
Marker Score: 288 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.95
Marker Score: 530 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,389 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 476 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 433 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,687 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5,024 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.87
Marker Score: 252 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.87
Marker Score: 8,830 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.87
Marker Score: 920 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.87
Marker Score: 1,813 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.86
Marker Score: 2,123 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5,226 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.86
Marker Score: 2,096 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 306 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.85
Marker Score: 851 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.84
Marker Score: 710 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.82
Marker Score: 20,949 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.81
Marker Score: 1,369 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.79
Marker Score: 27,459 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 316 - Cell Name: mature T cell (CL0002419)
Fold Change: 0.78
Marker Score: 7,733 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.78
Marker Score: 356 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,262 - Cell Name: Unknown (CL0000548)
Fold Change: 0.78
Marker Score: 566 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.77
Marker Score: 1,110 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.77
Marker Score: 1,227 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.77
Marker Score: 2,086 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.77
Marker Score: 189 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.76
Marker Score: 2,136 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.76
Marker Score: 153 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.75
Marker Score: 279 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.75
Marker Score: 355 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.75
Marker Score: 2,133 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 571 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.74
Marker Score: 2,158 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.74
Marker Score: 2,031 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.73
Marker Score: 402 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 372 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.72
Marker Score: 792 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.72
Marker Score: 8,054 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.71
Marker Score: 158 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.7
Marker Score: 2,584 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.7
Marker Score: 348 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.7
Marker Score: 706 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.69
Marker Score: 237 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.68
Marker Score: 457 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.68
Marker Score: 351 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.68
Marker Score: 714 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.68
Marker Score: 390 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.67
Marker Score: 3,521 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.67
Marker Score: 160 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.67
Marker Score: 1,336 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.67
Marker Score: 4,359 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.67
Marker Score: 456 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.67
Marker Score: 2,795 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.67
Marker Score: 743 - Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 605 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.66
Marker Score: 210 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.66
Marker Score: 174 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.66
Marker Score: 437 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.66
Marker Score: 1,203 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.66
Marker Score: 872 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.65
Marker Score: 666 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.65
Marker Score: 681 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.64
Marker Score: 2,746 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.64
Marker Score: 163 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.64
Marker Score: 230 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.64
Marker Score: 260 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.64
Marker Score: 169 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.64
Marker Score: 330 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.64
Marker Score: 1,056 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.64
Marker Score: 220 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.64
Marker Score: 568 - Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.64
Marker Score: 158 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.63
Marker Score: 222 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.63
Marker Score: 315 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.63
Marker Score: 497 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.63
Marker Score: 166 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.63
Marker Score: 145
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3818514575
Symbol: P5CR2_HUMAN
Name: Pyrroline-5-carboxylate reductase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 6894153
Title: Pyrroline-5-carboxylate reductase in human erythrocytes.
PubMed ID: 6894153
DOI: 10.1172/jci110115
PubMed ID: 2722838
Title: Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.
PubMed ID: 2722838
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23024808
Title: Functional specialization in proline biosynthesis of melanoma.
PubMed ID: 23024808
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24930674
Title: Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
PubMed ID: 24930674
PubMed ID: 25865492
Title: Mutations in PYCR2, encoding pyrroline-5-carboxylate reductase 2, cause microcephaly and hypomyelination.
PubMed ID: 25865492
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 320
- Mass: 33637
- Checksum: 9348455A64CCE722
- Sequence:
MSVGFIGAGQ LAYALARGFT AAGILSAHKI IASSPEMNLP TVSALRKMGV NLTRSNKETV KHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC MTNTPVVVQE GATVYATGTH ALVEDGQLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY AFMALDALAD GGVKMGLPRR LAIQLGAQAL LGAAKMLLDS EQHPCQLKDN VCSPGGATIH ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKISPA ALKKTLLDRV KLESPTVSTL TPSSPGKLLT RSLALGGKKD
Genular Protein ID: 2412144807
Symbol: A0A087WTV6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 246
- Mass: 25868
- Checksum: F7B8C99BC92FFA85
- Sequence:
MSVGFIGAGQ LAYALARGFT AAGILSAHKI IASSPEMNLP TVSALRKMGV NLTRSNKETV KHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT ISSVEKAFMA LDALADGGVK MGLPRRLAIQ LGAQALLGAA KMLLDSEQHP CQLKDNVCSP GGATIHALHF LESGGFRSLL INAVEASCIR TRELQSMADQ EKISPAALKK TLLDRVKLES PTVSTLTPSS PGKLLTRSLA LGGKKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.