NME7 | ENSG00000143156 | NCBI 29922

Details for: NME7

Gene ID: 29922

Symbol: NME7

Ensembl ID: ENSG00000143156

Description: NME/NM23 family member 7

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Centrosome maturation
(R-HSA-380287)
G2/m transition
(R-HSA-69275)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
3'-5' exonuclease activity
(GO:0008408)
Atp binding
(GO:0005524)
Axonemal microtubule
(GO:0005879)
Centrosome
(GO:0005813)
Ctp biosynthetic process
(GO:0006241)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gamma-tubulin ring complex
(GO:0000931)
Gtp biosynthetic process
(GO:0006183)
Metal ion binding
(GO:0046872)
Nucleoside diphosphate kinase activity
(GO:0004550)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Regulation of microtubule nucleation
(GO:0010968)
Utp biosynthetic process
(GO:0006228)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.13
Marker Score: 16,335
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.13
Marker Score: 1,010
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.11
Marker Score: 41,938
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.07
Marker Score: 78,796
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.98
Marker Score: 29,677
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.92
Marker Score: 70,945
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.9
Marker Score: 17,839
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.87
Marker Score: 5,343
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.85
Marker Score: 7,155
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.85
Marker Score: 7,670
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.82
Marker Score: 112,207
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.8
Marker Score: 15,616
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.79
Marker Score: 3,001
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.79
Marker Score: 16,964
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.76
Marker Score: 7,387
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.75
Marker Score: 8,095
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.74
Marker Score: 14,951
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.74
Marker Score: 17,954
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.72
Marker Score: 1,297
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.67
Marker Score: 1,289
Cell Name: neuron (CL0000540)
Fold Change: 1.67
Marker Score: 6,786
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.59
Marker Score: 3,986
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.58
Marker Score: 33,715
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.57
Marker Score: 2,427
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.56
Marker Score: 914
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.48
Marker Score: 1,797
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,943
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.46
Marker Score: 610
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.44
Marker Score: 2,731
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.4
Marker Score: 1,886
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.35
Marker Score: 394
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.29
Marker Score: 43,687
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.29
Marker Score: 3,042
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.26
Marker Score: 1,358
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.21
Marker Score: 678
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.21
Marker Score: 4,145
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.2
Marker Score: 1,376
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.19
Marker Score: 1,206
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 1.18
Marker Score: 422
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.18
Marker Score: 2,263
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.17
Marker Score: 425
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.16
Marker Score: 574
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.13
Marker Score: 337
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.13
Marker Score: 655
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.12
Marker Score: 2,342
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.12
Marker Score: 17,489
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.11
Marker Score: 1,171
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.1
Marker Score: 4,580
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.09
Marker Score: 498
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.08
Marker Score: 296
Cell Name: podocyte (CL0000653)
Fold Change: 1.08
Marker Score: 398
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.06
Marker Score: 1,799
Cell Name: astrocyte (CL0000127)
Fold Change: 1.06
Marker Score: 917
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.05
Marker Score: 553
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.03
Marker Score: 1,287
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.01
Marker Score: 321
Cell Name: kidney cell (CL1000497)
Fold Change: 1
Marker Score: 668
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1
Marker Score: 2,395
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,712
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,937
Cell Name: proerythroblast (CL0000547)
Fold Change: 1
Marker Score: 675
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.99
Marker Score: 579
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.99
Marker Score: 875
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,394
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.97
Marker Score: 676
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.95
Marker Score: 367
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.95
Marker Score: 645
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.95
Marker Score: 21,278
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.95
Marker Score: 32,825
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.94
Marker Score: 3,167
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,399
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 485
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.94
Marker Score: 2,057
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.94
Marker Score: 2,673
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.93
Marker Score: 1,319
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 440
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.93
Marker Score: 802
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.93
Marker Score: 1,147
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.93
Marker Score: 882
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.92
Marker Score: 296
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.92
Marker Score: 312
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.9
Marker Score: 568
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,709
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.88
Marker Score: 943
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.87
Marker Score: 524
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.87
Marker Score: 904
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.87
Marker Score: 287
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.87
Marker Score: 4,664
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 310
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.86
Marker Score: 321
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.86
Marker Score: 807
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.85
Marker Score: 3,029
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4,867
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.85
Marker Score: 269
Cell Name: decidual cell (CL2000002)
Fold Change: 0.82
Marker Score: 3,555
Cell Name: lactocyte (CL0002325)
Fold Change: 0.82
Marker Score: 13,186
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.82
Marker Score: 539
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.82
Marker Score: 450
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.81
Marker Score: 2,892

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** NME7 is a member of the NME/NM23 family, which consists of a group of small, highly conserved genes that play critical roles in various cellular processes. The key characteristics of NME7 include: 1. **3'-5' Exonuclease Activity**: NME7 possesses 3'-5' exonuclease activity, which is essential for regulating the degradation of nucleic acids and maintaining genome stability. 2. **Nucleoside Diphosphate Kinase Activity**: NME7 exhibits nucleoside diphosphate kinase activity, which is involved in the regulation of nucleotide metabolism and energy homeostasis. 3. **Protein Kinase Activity**: NME7 displays protein kinase activity, which is essential for regulating protein-protein interactions and signaling pathways. 4. **Cell Cycle Regulation**: NME7 plays a critical role in regulating the cell cycle, particularly during the G2/M transition. 5. **Microtubule Nucleation**: NME7 is involved in regulating microtubule nucleation, which is essential for maintaining microtubule dynamics and cellular structure. **Pathways and Functions:** NME7 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation**: NME7 regulates the G2/M transition, ensuring proper cell cycle progression and preventing aberrant cell proliferation. 2. **Microtubule Nucleation**: NME7 promotes microtubule nucleation, which is essential for maintaining microtubule dynamics and cellular structure. 3. **Centrosome Maturation**: NME7 is involved in regulating centrosome maturation, ensuring proper centrosome function and cellular organization. 4. **GTP Biosynthetic Process**: NME7 regulates GTP biosynthesis, which is essential for regulating protein-protein interactions and signaling pathways. 5. **Metal Ion Binding**: NME7 exhibits metal ion binding activity, which is involved in regulating protein-protein interactions and signaling pathways. **Clinical Significance:** The clinical significance of NME7 is underscored by its involvement in regulating neuronal function and its potential role in neurological disorders. NME7 is significantly expressed in GABAergic cortical interneurons, which are critical for regulating neuronal excitability and synaptic transmission. Dysregulation of NME7 has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. Further investigation into the role of NME7 in these disorders may provide valuable insights into the development of novel therapeutic strategies. In conclusion, NME7 is a critical regulator of cellular processes, including cell cycle regulation, microtubule nucleation, and centrosome maturation. Its significant expression in GABAergic cortical interneurons and potential role in neurological disorders underscore its clinical significance. Further research into the function and regulation of NME7 is essential for understanding its role in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nucleoside diphosphate kinase 7

Genular Protein ID: 3195583775

Symbol: NDK7_HUMAN

Name: Nucleoside diphosphate kinase 7

UniProtKB Accession Codes:

Q9Y5B8 A8K3T6 A8MY09 B3KSW9 Q5TGZ4

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

Sequence Information:

Length: 376
Mass: 42492
Checksum: 67C121D6C36E7012
Sequence:

MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYDNLHLEDL 
FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP DAISKAGEII EIINKAGFTI 
TKLKMMMLSR KEALDFHVDH QSRPFFNELI QFITTGPIIA MEILRDDAIC EWKRLLGPAN 
SGVARTDASE SIRALFGTDG IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT 
CCIVKPHAVS EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 
EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI QNAVHCTDLP 
EDGLLEVQYF FKILDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NME7

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Initial characterization of the human central proteome. PubMed ID: 21269460