Details for: NME7

Gene ID: 29922

Symbol: NME7

Ensembl ID: ENSG00000143156

Description: NME/NM23 family member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 282.8759
    Cell Significance Index: -44.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.5716
    Cell Significance Index: -41.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.0855
    Cell Significance Index: -41.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.9028
    Cell Significance Index: -45.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.4754
    Cell Significance Index: -36.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.8741
    Cell Significance Index: -36.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.9600
    Cell Significance Index: -45.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1632
    Cell Significance Index: -40.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6724
    Cell Significance Index: -46.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.8354
    Cell Significance Index: 45.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7433
    Cell Significance Index: 550.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.0954
    Cell Significance Index: 44.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9602
    Cell Significance Index: 47.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8909
    Cell Significance Index: 53.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8871
    Cell Significance Index: 126.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8712
    Cell Significance Index: 115.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8623
    Cell Significance Index: 104.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7632
    Cell Significance Index: 77.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6993
    Cell Significance Index: 64.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6883
    Cell Significance Index: 605.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5454
    Cell Significance Index: 97.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3107
    Cell Significance Index: 906.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2353
    Cell Significance Index: 245.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9149
    Cell Significance Index: 106.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6021
    Cell Significance Index: 65.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5637
    Cell Significance Index: 43.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5553
    Cell Significance Index: 303.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4936
    Cell Significance Index: 80.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3971
    Cell Significance Index: 358.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3813
    Cell Significance Index: 19.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3637
    Cell Significance Index: 69.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2580
    Cell Significance Index: 3.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2413
    Cell Significance Index: 33.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2171
    Cell Significance Index: 26.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2143
    Cell Significance Index: 403.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2022
    Cell Significance Index: 5.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1998
    Cell Significance Index: 3.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1951
    Cell Significance Index: 35.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1682
    Cell Significance Index: 21.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1249
    Cell Significance Index: 3.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1238
    Cell Significance Index: 78.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1185
    Cell Significance Index: 182.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1033
    Cell Significance Index: 45.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0998
    Cell Significance Index: 184.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0976
    Cell Significance Index: 6.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0942
    Cell Significance Index: 2.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0694
    Cell Significance Index: 94.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0492
    Cell Significance Index: 1.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0449
    Cell Significance Index: 0.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0323
    Cell Significance Index: 3.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0175
    Cell Significance Index: 7.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0111
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0162
    Cell Significance Index: -11.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0362
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0452
    Cell Significance Index: -33.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0470
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0550
    Cell Significance Index: -41.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0681
    Cell Significance Index: -38.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0788
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0835
    Cell Significance Index: -52.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0982
    Cell Significance Index: -2.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1201
    Cell Significance Index: -5.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1351
    Cell Significance Index: -38.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1662
    Cell Significance Index: -28.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1667
    Cell Significance Index: -21.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1866
    Cell Significance Index: -19.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2280
    Cell Significance Index: -26.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2330
    Cell Significance Index: -49.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2361
    Cell Significance Index: -5.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2778
    Cell Significance Index: -20.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2844
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2891
    Cell Significance Index: -33.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3305
    Cell Significance Index: -17.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3368
    Cell Significance Index: -35.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3419
    Cell Significance Index: -24.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3456
    Cell Significance Index: -22.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3462
    Cell Significance Index: -16.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3514
    Cell Significance Index: -9.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3515
    Cell Significance Index: -6.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3755
    Cell Significance Index: -6.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4275
    Cell Significance Index: -22.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4722
    Cell Significance Index: -9.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4739
    Cell Significance Index: -37.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4961
    Cell Significance Index: -15.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5168
    Cell Significance Index: -16.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5715
    Cell Significance Index: -35.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6110
    Cell Significance Index: -12.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6301
    Cell Significance Index: -13.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6393
    Cell Significance Index: -20.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6777
    Cell Significance Index: -9.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6909
    Cell Significance Index: -10.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7063
    Cell Significance Index: -10.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7190
    Cell Significance Index: -15.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7430
    Cell Significance Index: -18.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7546
    Cell Significance Index: -20.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7646
    Cell Significance Index: -10.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8382
    Cell Significance Index: -10.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8578
    Cell Significance Index: -30.0500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8645
    Cell Significance Index: -10.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NME7 is a member of the NME/NM23 family, which consists of a group of small, highly conserved genes that play critical roles in various cellular processes. The key characteristics of NME7 include: 1. **3'-5' Exonuclease Activity**: NME7 possesses 3'-5' exonuclease activity, which is essential for regulating the degradation of nucleic acids and maintaining genome stability. 2. **Nucleoside Diphosphate Kinase Activity**: NME7 exhibits nucleoside diphosphate kinase activity, which is involved in the regulation of nucleotide metabolism and energy homeostasis. 3. **Protein Kinase Activity**: NME7 displays protein kinase activity, which is essential for regulating protein-protein interactions and signaling pathways. 4. **Cell Cycle Regulation**: NME7 plays a critical role in regulating the cell cycle, particularly during the G2/M transition. 5. **Microtubule Nucleation**: NME7 is involved in regulating microtubule nucleation, which is essential for maintaining microtubule dynamics and cellular structure. **Pathways and Functions:** NME7 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation**: NME7 regulates the G2/M transition, ensuring proper cell cycle progression and preventing aberrant cell proliferation. 2. **Microtubule Nucleation**: NME7 promotes microtubule nucleation, which is essential for maintaining microtubule dynamics and cellular structure. 3. **Centrosome Maturation**: NME7 is involved in regulating centrosome maturation, ensuring proper centrosome function and cellular organization. 4. **GTP Biosynthetic Process**: NME7 regulates GTP biosynthesis, which is essential for regulating protein-protein interactions and signaling pathways. 5. **Metal Ion Binding**: NME7 exhibits metal ion binding activity, which is involved in regulating protein-protein interactions and signaling pathways. **Clinical Significance:** The clinical significance of NME7 is underscored by its involvement in regulating neuronal function and its potential role in neurological disorders. NME7 is significantly expressed in GABAergic cortical interneurons, which are critical for regulating neuronal excitability and synaptic transmission. Dysregulation of NME7 has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. Further investigation into the role of NME7 in these disorders may provide valuable insights into the development of novel therapeutic strategies. In conclusion, NME7 is a critical regulator of cellular processes, including cell cycle regulation, microtubule nucleation, and centrosome maturation. Its significant expression in GABAergic cortical interneurons and potential role in neurological disorders underscore its clinical significance. Further research into the function and regulation of NME7 is essential for understanding its role in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3195583775

Symbol: NDK7_HUMAN

Name: Nucleoside diphosphate kinase homolog 7

UniProtKB Accession Codes:

Q9Y5B8 A8K3T6 A8MY09 B3KSW9 Q5TGZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16313181

Title: Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.

PubMed ID: 16313181

DOI: 10.1021/bi0515974

PubMed ID: 24807905

Title: NME7 is a functional component of the gamma-tubulin ring complex.

PubMed ID: 24807905

DOI: 10.1091/mbc.e13-06-0339

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

PubMed ID: 37258679

Title: Axonemal structures reveal mechanoregulatory and disease mechanisms.

PubMed ID: 37258679

DOI: 10.1038/s41586-023-06140-2

Sequence Information:

  • Length: 376
  • Mass: 42492
  • Checksum: 67C121D6C36E7012
  • Sequence:
    • MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYDNLHLEDL 
FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP DAISKAGEII EIINKAGFTI 
TKLKMMMLSR KEALDFHVDH QSRPFFNELI QFITTGPIIA MEILRDDAIC EWKRLLGPAN 
SGVARTDASE SIRALFGTDG IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT 
CCIVKPHAVS EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 
EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI QNAVHCTDLP 
EDGLLEVQYF FKILDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.