Details for: SNX12

Gene ID: 29934

Symbol: SNX12

Ensembl ID: ENSG00000147164

Description: sorting nexin 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 124.2082
    Cell Significance Index: -19.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.6718
    Cell Significance Index: -18.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.2499
    Cell Significance Index: -19.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.6947
    Cell Significance Index: -15.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7240
    Cell Significance Index: -20.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.5804
    Cell Significance Index: -15.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5196
    Cell Significance Index: -17.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3040
    Cell Significance Index: -20.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0685
    Cell Significance Index: 64.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9493
    Cell Significance Index: 857.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8415
    Cell Significance Index: 91.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7388
    Cell Significance Index: 19.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6343
    Cell Significance Index: 17.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6316
    Cell Significance Index: 32.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6201
    Cell Significance Index: 100.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4457
    Cell Significance Index: 30.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3866
    Cell Significance Index: 69.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3568
    Cell Significance Index: 43.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3434
    Cell Significance Index: 7.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3368
    Cell Significance Index: 67.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3131
    Cell Significance Index: 16.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2386
    Cell Significance Index: 12.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2297
    Cell Significance Index: 22.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2104
    Cell Significance Index: 93.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2059
    Cell Significance Index: 28.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1870
    Cell Significance Index: 13.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1765
    Cell Significance Index: 35.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1697
    Cell Significance Index: 7.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1650
    Cell Significance Index: 4.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1611
    Cell Significance Index: 1.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1395
    Cell Significance Index: 4.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1204
    Cell Significance Index: 15.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1172
    Cell Significance Index: 8.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1163
    Cell Significance Index: 5.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1112
    Cell Significance Index: 39.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1073
    Cell Significance Index: 58.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1060
    Cell Significance Index: 6.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1037
    Cell Significance Index: 17.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0976
    Cell Significance Index: 18.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0753
    Cell Significance Index: 9.6500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0723
    Cell Significance Index: 0.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0583
    Cell Significance Index: 6.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0545
    Cell Significance Index: 1.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0373
    Cell Significance Index: 1.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0239
    Cell Significance Index: 0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 1.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -21.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0137
    Cell Significance Index: -9.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0192
    Cell Significance Index: -26.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0381
    Cell Significance Index: -1.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0390
    Cell Significance Index: -17.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0484
    Cell Significance Index: -7.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0541
    Cell Significance Index: -15.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0548
    Cell Significance Index: -11.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0630
    Cell Significance Index: -7.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0926
    Cell Significance Index: -1.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0944
    Cell Significance Index: -11.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1086
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1102
    Cell Significance Index: -12.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1269
    Cell Significance Index: -8.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1343
    Cell Significance Index: -1.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1437
    Cell Significance Index: -8.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1527
    Cell Significance Index: -4.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1561
    Cell Significance Index: -2.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1595
    Cell Significance Index: -2.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1776
    Cell Significance Index: -1.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1857
    Cell Significance Index: -14.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1960
    Cell Significance Index: -20.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2121
    Cell Significance Index: -7.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2286
    Cell Significance Index: -5.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2290
    Cell Significance Index: -12.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2334
    Cell Significance Index: -17.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2539
    Cell Significance Index: -2.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2799
    Cell Significance Index: -12.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2880
    Cell Significance Index: -4.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2988
    Cell Significance Index: -7.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3004
    Cell Significance Index: -7.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3044
    Cell Significance Index: -6.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3252
    Cell Significance Index: -5.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3272
    Cell Significance Index: -12.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3296
    Cell Significance Index: -20.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3634
    Cell Significance Index: -10.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3660
    Cell Significance Index: -2.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4193
    Cell Significance Index: -12.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4367
    Cell Significance Index: -6.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4413
    Cell Significance Index: -12.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4442
    Cell Significance Index: -8.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4548
    Cell Significance Index: -16.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX12 is a small, membrane-associated protein that belongs to the sorting nexin family. It is characterized by its ability to bind to phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol (PI). SNX12 has been shown to interact with various proteins, including Rab GTPases, which are essential for regulating membrane trafficking and endocytosis. Its expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer. **Pathways and Functions:** SNX12 plays a crucial role in regulating various cellular processes, including: 1. **Endocytosis:** SNX12 is involved in the regulation of endocytic recycling, which is essential for maintaining cellular homeostasis. It binds to PI3P and PI, which are involved in the formation and regulation of endosomes. 2. **Protein Transport:** SNX12 regulates the transport of proteins between the endoplasmic reticulum (ER) and the Golgi apparatus, which is essential for protein processing and modification. 3. **Gene Expression:** SNX12 has been shown to negatively regulate gene expression by binding to specific mRNAs and preventing their translation. 4. **Protein Catabolism:** SNX12 regulates the degradation of proteins by binding to proteins and preventing their degradation by the proteasome. 5. **Retromer Complex:** SNX12 is a component of the retromer complex, which is involved in the regulation of endocytic recycling and protein transport. **Clinical Significance:** SNX12 has been implicated in various diseases, including cancer. Its dysregulation has been observed in various types of cancer, including breast, lung, and colon cancer. SNX12 has been shown to act as a tumor suppressor, and its loss is associated with cancer progression. Additionally, SNX12 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SNX12 is a crucial regulator of cellular homeostasis and cancer progression. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the mechanisms by which SNX12 regulates cellular processes and to explore its potential as a therapeutic target. **Implications for Cancer Therapy:** The dysregulation of SNX12 has been observed in various types of cancer, and its loss is associated with cancer progression. Therefore, targeting SNX12 could be a potential therapeutic strategy for cancer treatment. SNX12 inhibitors could be developed to restore its function and prevent cancer progression. Additionally, SNX12 could be used as a biomarker for cancer diagnosis and prognosis. **Implications for Neurological Disorders:** SNX12 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. Its dysregulation has been observed in the brains of patients with these diseases, and its loss is associated with disease progression. Therefore, targeting SNX12 could be a potential therapeutic strategy for treating these diseases. SNX12 inhibitors could be developed to restore its function and prevent disease progression. In summary, SNX12 is a crucial regulator of cellular homeostasis and cancer progression. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the mechanisms by which SNX12 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 1429562818

Symbol: SNX12_HUMAN

Name: Sorting nexin-12

UniProtKB Accession Codes:

Q9UMY4 F8W8K5 Q8WUG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 162
  • Mass: 18885
  • Checksum: 48CBC16A86AFDB08
  • Sequence:
    • MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI 
FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR 
QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKV RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.