Details for: SNX12

Gene ID: 29934

Symbol: SNX12

Ensembl ID: ENSG00000147164

Description: sorting nexin 12

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Marker Score: 3,946
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,741
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,966
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.97
    Marker Score: 1,395
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,250
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,908
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.84
    Marker Score: 1,054
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.83
    Marker Score: 1,679
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.82
    Marker Score: 886
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.81
    Marker Score: 676
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 691
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11,409
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.72
    Marker Score: 1,065
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.72
    Marker Score: 677
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.71
    Marker Score: 353
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 637
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.69
    Marker Score: 2,962
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.67
    Marker Score: 324
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,811
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.67
    Marker Score: 367
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.65
    Marker Score: 187
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.64
    Marker Score: 5,516
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.63
    Marker Score: 424
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.63
    Marker Score: 3,002
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.62
    Marker Score: 663
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.6
    Marker Score: 200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.58
    Marker Score: 543
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.57
    Marker Score: 1,350
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.57
    Marker Score: 4,447
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.57
    Marker Score: 140
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.56
    Marker Score: 677
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1,117
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.55
    Marker Score: 518
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.55
    Marker Score: 846
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.54
    Marker Score: 257
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.53
    Marker Score: 874
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.53
    Marker Score: 264
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.52
    Marker Score: 552
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.51
    Marker Score: 542
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.51
    Marker Score: 283
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.51
    Marker Score: 1,975
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.51
    Marker Score: 144
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 207
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.5
    Marker Score: 268
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.5
    Marker Score: 4,318
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5
    Marker Score: 489
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.5
    Marker Score: 374
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.5
    Marker Score: 315
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.49
    Marker Score: 30,286
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.49
    Marker Score: 4,277
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.48
    Marker Score: 3,064
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.48
    Marker Score: 2,910
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 316
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.48
    Marker Score: 3,538
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.47
    Marker Score: 493
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.47
    Marker Score: 321
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.47
    Marker Score: 254
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.47
    Marker Score: 314
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.47
    Marker Score: 4,469
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.47
    Marker Score: 229
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.47
    Marker Score: 826
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.46
    Marker Score: 292
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.46
    Marker Score: 5,226
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.46
    Marker Score: 1,049
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.46
    Marker Score: 708
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.46
    Marker Score: 1,091
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.46
    Marker Score: 241
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2,749
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.46
    Marker Score: 6,030
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.46
    Marker Score: 412
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.45
    Marker Score: 402
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.45
    Marker Score: 105
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.44
    Marker Score: 1,151
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.44
    Marker Score: 683
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.44
    Marker Score: 1,389
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 424
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.44
    Marker Score: 441
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.43
    Marker Score: 85
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.43
    Marker Score: 98
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.43
    Marker Score: 691
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.43
    Marker Score: 11,007
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 425
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.43
    Marker Score: 967
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.42
    Marker Score: 309
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.42
    Marker Score: 4,929

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX12 is a small, membrane-associated protein that belongs to the sorting nexin family. It is characterized by its ability to bind to phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol (PI). SNX12 has been shown to interact with various proteins, including Rab GTPases, which are essential for regulating membrane trafficking and endocytosis. Its expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer. **Pathways and Functions:** SNX12 plays a crucial role in regulating various cellular processes, including: 1. **Endocytosis:** SNX12 is involved in the regulation of endocytic recycling, which is essential for maintaining cellular homeostasis. It binds to PI3P and PI, which are involved in the formation and regulation of endosomes. 2. **Protein Transport:** SNX12 regulates the transport of proteins between the endoplasmic reticulum (ER) and the Golgi apparatus, which is essential for protein processing and modification. 3. **Gene Expression:** SNX12 has been shown to negatively regulate gene expression by binding to specific mRNAs and preventing their translation. 4. **Protein Catabolism:** SNX12 regulates the degradation of proteins by binding to proteins and preventing their degradation by the proteasome. 5. **Retromer Complex:** SNX12 is a component of the retromer complex, which is involved in the regulation of endocytic recycling and protein transport. **Clinical Significance:** SNX12 has been implicated in various diseases, including cancer. Its dysregulation has been observed in various types of cancer, including breast, lung, and colon cancer. SNX12 has been shown to act as a tumor suppressor, and its loss is associated with cancer progression. Additionally, SNX12 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SNX12 is a crucial regulator of cellular homeostasis and cancer progression. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the mechanisms by which SNX12 regulates cellular processes and to explore its potential as a therapeutic target. **Implications for Cancer Therapy:** The dysregulation of SNX12 has been observed in various types of cancer, and its loss is associated with cancer progression. Therefore, targeting SNX12 could be a potential therapeutic strategy for cancer treatment. SNX12 inhibitors could be developed to restore its function and prevent cancer progression. Additionally, SNX12 could be used as a biomarker for cancer diagnosis and prognosis. **Implications for Neurological Disorders:** SNX12 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. Its dysregulation has been observed in the brains of patients with these diseases, and its loss is associated with disease progression. Therefore, targeting SNX12 could be a potential therapeutic strategy for treating these diseases. SNX12 inhibitors could be developed to restore its function and prevent disease progression. In summary, SNX12 is a crucial regulator of cellular homeostasis and cancer progression. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the mechanisms by which SNX12 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 1429562818

Symbol: SNX12_HUMAN

Name: Sorting nexin-12

UniProtKB Accession Codes:

Q9UMY4 F8W8K5 Q8WUG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 162
  • Mass: 18885
  • Checksum: 48CBC16A86AFDB08
  • Sequence:
    • MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI 
FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR 
QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKV RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.