Details for: PNMA3

Gene ID: 29944

Symbol: PNMA3

Ensembl ID: ENSG00000183837

Description: PNMA family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.6465
    Cell Significance Index: -8.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.8664
    Cell Significance Index: -8.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9021
    Cell Significance Index: -8.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9446
    Cell Significance Index: 189.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5985
    Cell Significance Index: 17.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4773
    Cell Significance Index: 12.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4271
    Cell Significance Index: 5.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4157
    Cell Significance Index: 82.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4112
    Cell Significance Index: 147.5000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4041
    Cell Significance Index: 5.2400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3890
    Cell Significance Index: 4.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3739
    Cell Significance Index: 19.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2426
    Cell Significance Index: 16.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2242
    Cell Significance Index: 1.7900
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.1845
    Cell Significance Index: 1.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1406
    Cell Significance Index: 97.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1119
    Cell Significance Index: 3.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0740
    Cell Significance Index: 1.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0712
    Cell Significance Index: 0.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0635
    Cell Significance Index: 0.9100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0268
    Cell Significance Index: 0.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0195
    Cell Significance Index: 0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0188
    Cell Significance Index: 1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0034
    Cell Significance Index: 0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0028
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0024
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0046
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0063
    Cell Significance Index: -4.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0099
    Cell Significance Index: -4.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -7.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0144
    Cell Significance Index: -0.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0144
    Cell Significance Index: -7.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0198
    Cell Significance Index: -5.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0292
    Cell Significance Index: -0.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0300
    Cell Significance Index: -0.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0314
    Cell Significance Index: -0.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0331
    Cell Significance Index: -5.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0334
    Cell Significance Index: -0.8000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0351
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0379
    Cell Significance Index: -7.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0397
    Cell Significance Index: -5.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0407
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0440
    Cell Significance Index: -7.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0453
    Cell Significance Index: -4.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0462
    Cell Significance Index: -5.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0463
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0477
    Cell Significance Index: -5.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0477
    Cell Significance Index: -5.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0520
    Cell Significance Index: -6.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0525
    Cell Significance Index: -1.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0599
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0610
    Cell Significance Index: -6.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0670
    Cell Significance Index: -0.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0730
    Cell Significance Index: -5.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0736
    Cell Significance Index: -2.4100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0738
    Cell Significance Index: -0.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0758
    Cell Significance Index: -1.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0776
    Cell Significance Index: -2.1700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0778
    Cell Significance Index: -0.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0842
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0860
    Cell Significance Index: -6.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0875
    Cell Significance Index: -3.0400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0939
    Cell Significance Index: -0.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0962
    Cell Significance Index: -3.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0989
    Cell Significance Index: -6.3800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1002
    Cell Significance Index: -1.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1011
    Cell Significance Index: -7.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1188
    Cell Significance Index: -1.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1217
    Cell Significance Index: -6.3400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1239
    Cell Significance Index: -1.6200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1260
    Cell Significance Index: -1.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1263
    Cell Significance Index: -1.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1360
    Cell Significance Index: -6.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1368
    Cell Significance Index: -7.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1482
    Cell Significance Index: -6.9700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1484
    Cell Significance Index: -2.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1613
    Cell Significance Index: -2.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1626
    Cell Significance Index: -7.3700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1636
    Cell Significance Index: -3.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1877
    Cell Significance Index: -6.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2001
    Cell Significance Index: -7.0300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2169
    Cell Significance Index: -5.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2191
    Cell Significance Index: -6.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2209
    Cell Significance Index: -3.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2212
    Cell Significance Index: -3.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2227
    Cell Significance Index: -4.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2232
    Cell Significance Index: -3.8600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2348
    Cell Significance Index: -3.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2408
    Cell Significance Index: -4.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2419
    Cell Significance Index: -6.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2520
    Cell Significance Index: -7.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Nucleic Acid Binding**: PNMA3 is a nucleic acid-binding protein, which implies its involvement in regulating gene expression, DNA repair, and other nucleic acid-related processes. 2. **Apoptotic Regulation**: The gene is positively regulated in the context of apoptosis, suggesting its role in modulating programmed cell death. 3. **Zinc Ion Binding**: PNMA3 exhibits zinc ion binding capabilities, which may contribute to its nucleic acid-binding properties or modulate its interactions with other proteins. 4. **Protein Interaction**: PNMA3 interacts with various proteins, including those involved in nucleolus organization and apoptosis. **Pathways and Functions** 1. **Nucleolus Organization**: PNMA3 is involved in the regulation of nucleolus formation and maintenance, which is crucial for ribosome biogenesis and cellular growth. 2. **Apoptotic Process**: The gene's positive regulation of apoptosis suggests its role in modulating programmed cell death, which is essential for tissue homeostasis and development. 3. **Protein Binding and Regulation**: PNMA3 interacts with various proteins, including those involved in protein degradation, transport, and signaling, to regulate cellular processes. 4. **Zinc Ion Homeostasis**: The gene's zinc ion binding capabilities contribute to maintaining zinc ion homeostasis, which is essential for numerous cellular processes, including protein function and DNA repair. **Clinical Significance** 1. **Cancer Association**: PNMA3 has been identified as a paraneoplastic antigen, which implies its involvement in cancer-related processes, including tumor growth and metastasis. 2. **Neurological Disorders**: The gene's expression in neuronal populations suggests its involvement in neurological disorders, such as neurodegenerative diseases and cancer-related neurological complications. 3. **Immunological Relevance**: PNMA3's interaction with various proteins and its involvement in apoptosis and nucleolus organization make it a potential target for immunotherapeutic interventions. 4. **Diagnostic Potential**: The gene's expression patterns in various tissues and its association with cancer and neurological disorders make it a promising candidate for diagnostic biomarkers. In conclusion, the PNMA3 gene is a complex and multifaceted molecule that plays a crucial role in various cellular processes, including apoptosis, nucleolus organization, and protein binding. Its widespread expression and involvement in disease-related processes make it an attractive target for further research and potential therapeutic applications.

Genular Protein ID: 1814720947

Symbol: PNMA3_HUMAN

Name: Paraneoplastic antigen Ma3

UniProtKB Accession Codes:

Q9UL41 D3DWT7 Q9H0A4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11558790

Title: Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

PubMed ID: 11558790

DOI: 10.1002/ana.1288.abs

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16214224

Title: The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease.

PubMed ID: 16214224

DOI: 10.1016/j.jneuroim.2005.08.019

PubMed ID: 19366867

Title: Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner.

PubMed ID: 19366867

DOI: 10.1093/cercor/bhp062

Sequence Information:

  • Length: 463
  • Mass: 52376
  • Checksum: 0843EF6601D8557C
  • Sequence:
    • MPLTLLQDWC RGEHLNTRRC MLILGIPEDC GEDEFEETLQ EACRHLGRYR VIGRMFRREE 
NAQAILLELA QDIDYALLPR EIPGKGGPWE VIVKPRNSDG EFLNRLNRFL EEERRTVSDM 
NRVLGSDTNC SAPRVTISPE FWTWAQTLGA AVQPLLEQML YRELRVFSGN TISIPGALAF 
DAWLEHTTEM LQMWQVPEGE KRRRLMECLR GPALQVVSGL RASNASITVE ECLAALQQVF 
GPVESHKIAQ VKLCKAYQEA GEKVSSFVLR LEPLLQRAVE NNVVSRRNVN QTRLKRVLSG 
ATLPDKLRDK LKLMKQRRKP PGFLALVKLL REEEEWEATL GPDRESLEGL EVAPRPPARI 
TGVGAVPLPA SGNSFDARPS QGYRRRRGRG QHRRGGVARA GSRGSRKRKR HTFCYSCGED 
GHIRVQCINP SNLLLVKQKK QAAVESGNGN WAWDKSHPKS KAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.