Details for: DPP7

Gene ID: 29952

Symbol: DPP7

Ensembl ID: ENSG00000176978

Description: dipeptidyl peptidase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 346.2658
    Cell Significance Index: -53.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 176.5471
    Cell Significance Index: -44.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 132.1823
    Cell Significance Index: -53.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 128.4836
    Cell Significance Index: -60.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.1581
    Cell Significance Index: -59.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 90.6080
    Cell Significance Index: -60.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.2560
    Cell Significance Index: -53.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.3983
    Cell Significance Index: -58.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.2822
    Cell Significance Index: -50.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3242
    Cell Significance Index: -60.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2976
    Cell Significance Index: -40.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2029
    Cell Significance Index: -22.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.9694
    Cell Significance Index: 278.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.1245
    Cell Significance Index: 364.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9160
    Cell Significance Index: 56.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3383
    Cell Significance Index: 62.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3086
    Cell Significance Index: 35.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2856
    Cell Significance Index: 67.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2646
    Cell Significance Index: 81.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1839
    Cell Significance Index: 61.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0888
    Cell Significance Index: 140.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0115
    Cell Significance Index: 75.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9987
    Cell Significance Index: 200.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8642
    Cell Significance Index: 101.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8295
    Cell Significance Index: 149.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8035
    Cell Significance Index: 103.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7622
    Cell Significance Index: 93.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7438
    Cell Significance Index: 328.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5776
    Cell Significance Index: 79.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5720
    Cell Significance Index: 15.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5514
    Cell Significance Index: 39.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5457
    Cell Significance Index: 37.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5284
    Cell Significance Index: 288.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5262
    Cell Significance Index: 188.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4571
    Cell Significance Index: 12.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4419
    Cell Significance Index: 399.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4004
    Cell Significance Index: 9.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3208
    Cell Significance Index: 6.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3041
    Cell Significance Index: 5.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3025
    Cell Significance Index: 209.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2846
    Cell Significance Index: 46.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2114
    Cell Significance Index: 6.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1863
    Cell Significance Index: 35.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1231
    Cell Significance Index: 5.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1092
    Cell Significance Index: 10.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0447
    Cell Significance Index: 32.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0275
    Cell Significance Index: 4.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0213
    Cell Significance Index: 16.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0078
    Cell Significance Index: 14.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0011
    Cell Significance Index: 0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0413
    Cell Significance Index: -56.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0436
    Cell Significance Index: -27.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0546
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0577
    Cell Significance Index: -42.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0673
    Cell Significance Index: -30.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0825
    Cell Significance Index: -9.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0970
    Cell Significance Index: -54.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1082
    Cell Significance Index: -67.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1266
    Cell Significance Index: -3.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1475
    Cell Significance Index: -7.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1699
    Cell Significance Index: -10.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1773
    Cell Significance Index: -35.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1864
    Cell Significance Index: -53.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2785
    Cell Significance Index: -40.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2919
    Cell Significance Index: -61.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3085
    Cell Significance Index: -23.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3432
    Cell Significance Index: -3.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4352
    Cell Significance Index: -29.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4438
    Cell Significance Index: -11.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5325
    Cell Significance Index: -6.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5327
    Cell Significance Index: -13.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5476
    Cell Significance Index: -57.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5533
    Cell Significance Index: -14.8300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6171
    Cell Significance Index: -12.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6525
    Cell Significance Index: -51.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6996
    Cell Significance Index: -8.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7396
    Cell Significance Index: -32.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7412
    Cell Significance Index: -45.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8279
    Cell Significance Index: -50.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8671
    Cell Significance Index: -11.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9178
    Cell Significance Index: -51.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9364
    Cell Significance Index: -35.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0591
    Cell Significance Index: -18.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1224
    Cell Significance Index: -32.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1619
    Cell Significance Index: -20.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2505
    Cell Significance Index: -15.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2589
    Cell Significance Index: -40.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2861
    Cell Significance Index: -52.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2980
    Cell Significance Index: -45.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2991
    Cell Significance Index: -19.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3250
    Cell Significance Index: -48.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3632
    Cell Significance Index: -43.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4157
    Cell Significance Index: -14.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.4284
    Cell Significance Index: -22.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4357
    Cell Significance Index: -72.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4634
    Cell Significance Index: -36.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4716
    Cell Significance Index: -48.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine-type peptidase**: DPP7 belongs to the serine-type peptidase family, which is characterized by the presence of a serine residue at the active site. 2. **Multifunctional**: DPP7 is involved in multiple cellular processes, including proteolysis, immune system regulation, and vesicular trafficking. 3. **Cellular localization**: DPP7 is expressed in various cell types, including acinar cells of the salivary gland, pancreatic acinar cells, Kupffer cells, and immune cells such as T cells and plasma cells. 4. **Protein specificity**: DPP7 is known to cleave specific peptides, including dipeptides and tripeptides. **Pathways and Functions:** 1. **Proteolysis**: DPP7 participates in the degradation of various proteins, including peptides and proteins, through its serine-type peptidase activity. 2. **Immune system regulation**: DPP7 plays a role in modulating the immune response, particularly in the context of neutrophil degranulation and the innate immune system. 3. **Vesicular trafficking**: DPP7 is involved in the regulation of vesicular trafficking, including the formation and degradation of vesicles, which is essential for cellular communication and signaling. 4. **Extracellular exosome**: DPP7 is also expressed in the extracellular exosome, a membrane-bound organelle involved in the transport and secretion of proteins and lipids. **Clinical Significance:** 1. **Disease association**: DPP7 has been associated with various diseases, including inflammatory bowel disease, autoimmune disorders, and cancer. 2. **Immunotherapy**: DPP7 may serve as a target for immunotherapeutic interventions, particularly in the context of cancer and autoimmune diseases. 3. **Protein engineering**: The understanding of DPP7's structure and function may lead to the development of novel protein engineering strategies for the treatment of diseases. 4. **Cancer therapy**: DPP7 has been implicated in cancer progression, and its inhibition may provide a therapeutic strategy for cancer treatment. In conclusion, DPP7 is a multifunctional serine-type peptidase that plays a crucial role in various cellular processes, including proteolysis, immune system regulation, and vesicular trafficking. Its clinical significance is underscored by its association with various diseases, including inflammatory bowel disease, autoimmune disorders, and cancer. Further research is needed to fully elucidate the mechanisms of DPP7 and its potential therapeutic applications.

Genular Protein ID: 3380038855

Symbol: DPP2_HUMAN

Name: Dipeptidyl peptidase 2

UniProtKB Accession Codes:

Q9UHL4 A8K7U7 Q5VSF1 Q969X4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 5 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567372

Title: Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase.

PubMed ID: 10567372

DOI: 10.1074/jbc.274.48.34053

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11067927

Title: Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase.

PubMed ID: 11067927

DOI: 10.4049/jimmunol.165.10.5695

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15487984

Title: Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7).

PubMed ID: 15487984

DOI: 10.1042/bj20041156

Sequence Information:

  • Length: 492
  • Mass: 54341
  • Checksum: 6C3EDECA90FA7583
  • Sequence:
    • MGSAPWAPVL LLALGLRGLQ AGARRAPDPG FQERFFQQRL DHFNFERFGN KTFPQRFLVS 
DRFWVRGEGP IFFYTGNEGD VWAFANNSAF VAELAAERGA LLVFAEHRYY GKSLPFGAQS 
TQRGHTELLT VEQALADFAE LLRALRRDLG AQDAPAIAFG GSYGGMLSAY LRMKYPHLVA 
GALAASAPVL AVAGLGDSNQ FFRDVTADFE GQSPKCTQGV REAFRQIKDL FLQGAYDTVR 
WEFGTCQPLS DEKDLTQLFM FARNAFTVLA MMDYPYPTDF LGPLPANPVK VGCDRLLSEA 
QRITGLRALA GLVYNASGSE HCYDIYRLYH SCADPTGCGT GPDARAWDYQ ACTEINLTFA 
SNNVTDMFPD LPFTDELRQR YCLDTWGVWP RPDWLLTSFW GGDLRAASNI IFSNGNLDPW 
AGGGIRRNLS ASVIAVTIQG GAHHLDLRAS HPEDPASVVE ARKLEATIIG EWVKAARREQ 
QPALRGGPRL SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.