Details for: TRHDE

Gene ID: 29953

Symbol: TRHDE

Ensembl ID: ENSG00000072657

Description: thyrotropin releasing hormone degrading enzyme

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.2482
    Cell Significance Index: -24.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2116
    Cell Significance Index: -24.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.5217
    Cell Significance Index: 128.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3101
    Cell Significance Index: -24.9000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 5.4939
    Cell Significance Index: 69.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2317
    Cell Significance Index: -11.4500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.7570
    Cell Significance Index: 37.9000
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 3.3931
    Cell Significance Index: 4.3900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.9750
    Cell Significance Index: 30.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.9565
    Cell Significance Index: 84.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3079
    Cell Significance Index: 439.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9470
    Cell Significance Index: 38.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8587
    Cell Significance Index: 372.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.4213
    Cell Significance Index: 9.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2550
    Cell Significance Index: 450.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1748
    Cell Significance Index: 1060.7900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.0667
    Cell Significance Index: 14.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8861
    Cell Significance Index: 612.8300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.7958
    Cell Significance Index: 8.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7307
    Cell Significance Index: 15.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7130
    Cell Significance Index: 40.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6890
    Cell Significance Index: 68.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6646
    Cell Significance Index: 72.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6387
    Cell Significance Index: 103.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6209
    Cell Significance Index: 15.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5379
    Cell Significance Index: 32.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5191
    Cell Significance Index: 14.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4562
    Cell Significance Index: 9.9900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.4457
    Cell Significance Index: 1.9400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4174
    Cell Significance Index: 6.2900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3609
    Cell Significance Index: 4.5000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.3478
    Cell Significance Index: 4.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2334
    Cell Significance Index: 8.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2118
    Cell Significance Index: 13.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1944
    Cell Significance Index: 8.8100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1854
    Cell Significance Index: 1.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0863
    Cell Significance Index: 14.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0824
    Cell Significance Index: 1.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0760
    Cell Significance Index: 1.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0558
    Cell Significance Index: 10.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0230
    Cell Significance Index: 0.2400
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: 0.0208
    Cell Significance Index: 0.2100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0052
    Cell Significance Index: -0.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0145
    Cell Significance Index: -22.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0161
    Cell Significance Index: -11.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0184
    Cell Significance Index: -11.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -25.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0238
    Cell Significance Index: -0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0254
    Cell Significance Index: -11.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0340
    Cell Significance Index: -25.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0353
    Cell Significance Index: -26.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0393
    Cell Significance Index: -21.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0405
    Cell Significance Index: -18.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0420
    Cell Significance Index: -26.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0475
    Cell Significance Index: -26.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0744
    Cell Significance Index: -21.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0828
    Cell Significance Index: -16.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1055
    Cell Significance Index: -14.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1136
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1291
    Cell Significance Index: -27.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1302
    Cell Significance Index: -16.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1351
    Cell Significance Index: -19.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1701
    Cell Significance Index: -17.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1921
    Cell Significance Index: -22.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1956
    Cell Significance Index: -22.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2028
    Cell Significance Index: -10.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2070
    Cell Significance Index: -26.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2077
    Cell Significance Index: -2.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2135
    Cell Significance Index: -5.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2219
    Cell Significance Index: -14.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2263
    Cell Significance Index: -23.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2408
    Cell Significance Index: -17.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2844
    Cell Significance Index: -4.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2871
    Cell Significance Index: -22.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2882
    Cell Significance Index: -14.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2895
    Cell Significance Index: -8.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3157
    Cell Significance Index: -24.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3647
    Cell Significance Index: -7.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3671
    Cell Significance Index: -7.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3762
    Cell Significance Index: -23.0700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3773
    Cell Significance Index: -3.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4070
    Cell Significance Index: -25.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4397
    Cell Significance Index: -4.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4675
    Cell Significance Index: -24.3500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4690
    Cell Significance Index: -3.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4862
    Cell Significance Index: -21.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4966
    Cell Significance Index: -18.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5005
    Cell Significance Index: -7.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5033
    Cell Significance Index: -23.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5206
    Cell Significance Index: -16.6800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.5235
    Cell Significance Index: -5.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5621
    Cell Significance Index: -19.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5721
    Cell Significance Index: -16.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6098
    Cell Significance Index: -5.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6136
    Cell Significance Index: -20.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6190
    Cell Significance Index: -5.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRHDE is a zinc-dependent metalloaminopeptidase that exhibits aminopeptidase and pyroglutamyl-peptidase activities. Its substrate specificity is characterized by the degradation of thyrotropin-releasing hormone (TRH), a peptide hormone involved in regulating thyroid function. The enzyme's activity is crucial in modulating the TRH/TH axis, which in turn affects thyroid hormone production and secretion. TRHDE's expression is observed in various cell types, including neurons, suggesting its involvement in neural signaling and neurotransmission. **Pathways and Functions:** TRHDE's enzymatic activity is linked to several cellular processes, including: 1. **Proteolysis:** TRHDE's ability to degrade TRH is essential in regulating the TRH/TH axis, which in turn affects thyroid hormone production and secretion. 2. **Signal Transduction:** As a metalloaminopeptidase, TRHDE can modulate signaling pathways involved in cell proliferation, differentiation, and survival. 3. **Cell-Cell Signaling:** TRHDE's expression in neurons suggests its involvement in neural signaling and neurotransmission. 4. **Extracellular Space:** TRHDE's presence in the extracellular space may facilitate the degradation of TRH in the bloodstream, regulating its availability for binding to its receptors. **Clinical Significance:** Dysregulation of the TRH/TH axis has been implicated in various thyroid-related disorders, including hypothyroidism and hyperthyroidism. TRHDE's role in modulating this axis has significant implications for the diagnosis and treatment of thyroid diseases. Furthermore, TRHDE's involvement in neural signaling and neurotransmission may have implications for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the Thyrotropin Releasing Hormone Degrading Enzyme (TRHDE) is a protein of significant interest in the realm of immunology, with implications for thyroid function, neural signaling, and neurotransmission. Further research is necessary to fully elucidate the function and clinical significance of TRHDE, but its discovery highlights the complexity and importance of the TRH/TH axis in regulating thyroid function and overall health.

Genular Protein ID: 3773954204

Symbol: TRHDE_HUMAN

Name: Thyrotropin-releasing hormone-degrading ectoenzyme

UniProtKB Accession Codes:

Q9UKU6 A5PL19 H0YHU0 Q6UWJ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 10491199

Title: Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment.

PubMed ID: 10491199

DOI: 10.1046/j.1432-1327.1999.00753.x

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1069
  • Mass: 122133
  • Checksum: D83B6CC67230FFD9
  • Sequence:
    • MALDGELGEQ EEEKKKKKKK KRKKKKEEEE EEEGAEKSSS PFAAAMGEDD AALRAGSRGL 
SDPWADSVGV RPRTTERHIA VHKRLVLAFA VSLVALLAVT MLAVLLSLRF DECGASATPG 
ADGGPSGFPE RGGNGSLPGS ARRNHHAGGD SWQPEAGGVA SPGTTSAQPP SEEEREPWEP 
WTQLRLSGHL KPLHYNLMLT AFMENFTFSG EVNVEIACRN ATRYVVLHAS RVAVEKVQLA 
EDRAFGAVPV AGFFLYPQTQ VLVVVLNRTL DAQRNYNLKI IYNALIENEL LGFFRSSYVL 
HGERRFLGVT QFSPTHARKA FPCFDEPIYK ATFKISIKHQ ATYLSLSNMP VETSVFEEDG 
WVTDHFSQTP LMSTYYLAWA ICNFTYRETT TKSGVVVRLY ARPDAIRRGS GDYALHITKR 
LIEFYEDYFK VPYSLPKLDL LAVPKHPYAA MENWGLSIFV EQRILLDPSV SSISYLLDVT 
MVIVHEICHQ WFGDLVTPVW WEDVWLKEGF AHYFEFVGTD YLYPGWNMEK QRFLTDVLHE 
VMLLDGLASS HPVSQEVLQA TDIDRVFDWI AYKKGAALIR MLANFMGHSV FQRGLQDYLT 
IHKYGNAARN DLWNTLSEAL KRNGKYVNIQ EVMDQWTLQM GYPVITILGN TTAENRIIIT 
QQHFIYDISA KTKALKLQNN SYLWQIPLTI VVGNRSHVSS EAIIWVSNKS EHHRITYLDK 
GSWLLGNINQ TGYFRVNYDL RNWRLLIDQL IRNHEVLSVS NRAGLIDDAF SLARAGYLPQ 
NIPLEIIRYL SEEKDFLPWH AASRALYPLD KLLDRMENYN IFNEYILKQV ATTYIKLGWP 
KNNFNGSLVQ ASYQHEELRR EVIMLACSFG NKHCHQQAST LISDWISSNR NRIPLNVRDI 
VYCTGVSLLD EDVWEFIWMK FHSTTAVSEK KILLEALTCS DDRNLLNRLL NLSLNSEVVL 
DQDAIDVIIH VARNPHGRDL AWKFFRDKWK ILNTRYGEAL FMNSKLISGV TEFLNTEGEL 
KELKNFMKNY DGVAAASFSR AVETVEANVR WKMLYQDELF QWLGKALRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.