Details for: NRBP1

Gene ID: 29959

Symbol: NRBP1

Ensembl ID: ENSG00000115216

Description: nuclear receptor binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 241.8589
    Cell Significance Index: -37.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.6192
    Cell Significance Index: -40.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 102.0709
    Cell Significance Index: -48.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.0260
    Cell Significance Index: -40.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.4466
    Cell Significance Index: -46.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.0841
    Cell Significance Index: -48.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.6816
    Cell Significance Index: -40.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4781
    Cell Significance Index: -42.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7256
    Cell Significance Index: -34.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3278
    Cell Significance Index: -44.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.7213
    Cell Significance Index: -32.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8185
    Cell Significance Index: -19.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0951
    Cell Significance Index: 360.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1841
    Cell Significance Index: 162.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1716
    Cell Significance Index: 232.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9551
    Cell Significance Index: 49.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9464
    Cell Significance Index: 25.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8952
    Cell Significance Index: 11.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7896
    Cell Significance Index: 35.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7824
    Cell Significance Index: 96.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7616
    Cell Significance Index: 20.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7582
    Cell Significance Index: 684.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7355
    Cell Significance Index: 132.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7315
    Cell Significance Index: 146.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7252
    Cell Significance Index: 20.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7067
    Cell Significance Index: 20.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7020
    Cell Significance Index: 33.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6642
    Cell Significance Index: 362.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6577
    Cell Significance Index: 16.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6345
    Cell Significance Index: 22.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6044
    Cell Significance Index: 267.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5830
    Cell Significance Index: 27.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5646
    Cell Significance Index: 36.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5066
    Cell Significance Index: 350.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4964
    Cell Significance Index: 14.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4453
    Cell Significance Index: 9.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4180
    Cell Significance Index: 67.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3554
    Cell Significance Index: 18.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3471
    Cell Significance Index: 9.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3212
    Cell Significance Index: 115.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3191
    Cell Significance Index: 60.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3118
    Cell Significance Index: 39.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3096
    Cell Significance Index: 8.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2562
    Cell Significance Index: 18.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2556
    Cell Significance Index: 33.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2214
    Cell Significance Index: 15.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2188
    Cell Significance Index: 37.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2011
    Cell Significance Index: 23.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1948
    Cell Significance Index: 19.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1818
    Cell Significance Index: 13.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1228
    Cell Significance Index: 7.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1006
    Cell Significance Index: 6.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0825
    Cell Significance Index: 4.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0454
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0173
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0169
    Cell Significance Index: 31.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0187
    Cell Significance Index: -11.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0196
    Cell Significance Index: -26.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0329
    Cell Significance Index: -24.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0348
    Cell Significance Index: -25.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0482
    Cell Significance Index: -21.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0549
    Cell Significance Index: -1.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0577
    Cell Significance Index: -32.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0731
    Cell Significance Index: -7.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0792
    Cell Significance Index: -6.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1204
    Cell Significance Index: -34.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1310
    Cell Significance Index: -2.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1329
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1332
    Cell Significance Index: -15.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1366
    Cell Significance Index: -28.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1666
    Cell Significance Index: -24.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1819
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2085
    Cell Significance Index: -23.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2097
    Cell Significance Index: -4.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2500
    Cell Significance Index: -4.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3031
    Cell Significance Index: -17.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3112
    Cell Significance Index: -7.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3356
    Cell Significance Index: -4.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3623
    Cell Significance Index: -24.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3650
    Cell Significance Index: -4.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3702
    Cell Significance Index: -2.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3989
    Cell Significance Index: -41.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4171
    Cell Significance Index: -2.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4939
    Cell Significance Index: -10.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5064
    Cell Significance Index: -40.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5292
    Cell Significance Index: -16.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5897
    Cell Significance Index: -10.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6274
    Cell Significance Index: -6.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6595
    Cell Significance Index: -7.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7268
    Cell Significance Index: -32.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7411
    Cell Significance Index: -19.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7595
    Cell Significance Index: -22.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7672
    Cell Significance Index: -47.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8582
    Cell Significance Index: -16.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8678
    Cell Significance Index: -32.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9061
    Cell Significance Index: -24.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NRBP1 is a protein-coding gene with an Ensembl ID of ENSG00000115216. It is significantly expressed in various cell types, including placental villous trophoblast, interstitial cells of the ovary, oogonial cells, granulosa cells, primordial germ cells, squamous epithelial cells, stromal cells of the ovary, epithelial cells of the esophagus, and blood cells. The gene is associated with several cellular processes, including protein binding, homodimerization, and kinase activity. **Pathways and Functions:** NRBP1 is involved in various cellular pathways, including: 1. **Gene Expression (Transcription):** NRBP1 regulates gene expression by interacting with nuclear receptors and modulating transcriptional activity. 2. **Protein Binding:** The protein binds to various proteins, influencing their activity and localization within the cell. 3. **Protein Homodimerization Activity:** NRBP1 facilitates the formation of homodimers between NRBP1 molecules, which is essential for its function. 4. **Protein Serine/Threonine Kinase Activity:** NRBP1 possesses kinase activity, which enables it to phosphorylate and regulate downstream targets. 5. **Endoplasmic Reticulum to Golgi Vesicle-Mediated Transport:** NRBP1 is involved in the transport of proteins between the endoplasmic reticulum and Golgi apparatus. **Clinical Significance:** NRBP1's role in regulating immune responses and maintaining cellular homeostasis has significant implications for various diseases. Alterations in NRBP1 expression or function may contribute to: 1. **Autoimmune Diseases:** Dysregulation of NRBP1 may lead to autoimmune responses, as it influences the balance between immune activation and tolerance. 2. **Cancer:** NRBP1's involvement in protein binding and kinase activity may contribute to the development and progression of cancer by modulating signaling pathways. 3. **Reproductive Health:** NRBP1's expression in placental villous trophoblast and granulosa cells suggests its potential role in reproductive health and embryonic development. 4. **Infectious Diseases:** NRBP1's involvement in immune regulation may also impact the body's response to infections, highlighting its importance in infectious disease management. In conclusion, NRBP1 is a multifunctional protein that plays a critical role in regulating immune responses, cellular homeostasis, and various cellular processes. Further research is necessary to elucidate the mechanisms underlying NRBP1's functions and its potential as a therapeutic target for various diseases.

Genular Protein ID: 643167687

Symbol: NRBP_HUMAN

Name: Nuclear receptor-binding protein

UniProtKB Accession Codes:

Q9UHY1 B3KV40 D6W558 Q53FZ5 Q96SU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10843813

Title: Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein.

PubMed ID: 10843813

DOI: 10.1006/geno.2000.6167

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11956649

Title: Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.

PubMed ID: 11956649

PubMed ID: 15084397

Title: The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure.

PubMed ID: 15084397

DOI: 10.1016/j.virusres.2004.01.025

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 535
  • Mass: 59845
  • Checksum: 398078661547EDD0
  • Sequence:
    • MSEGESQTVL SSGSDPKVES SSSAPGLTSV SPPVTSTTSA ASPEEEEESE DESEILEESP 
CGRWQKRREE VNQRNVPGID SAYLAMDTEE GVEVVWNEVQ FSERKNYKLQ EEKVRAVFDN 
LIQLEHLNIV KFHKYWADIK ENKARVIFIT EYMSSGSLKQ FLKKTKKNHK TMNEKAWKRW 
CTQILSALSY LHSCDPPIIH GNLTCDTIFI QHNGLIKIGS VAPDTINNHV KTCREEQKNL 
HFFAPEYGEV TNVTTAVDIY SFGMCALEMA VLEIQGNGES SYVPQEAISS AIQLLEDPLQ 
REFIQKCLQS EPARRPTARE LLFHPALFEV PSLKLLAAHC IVGHQHMIPE NALEEITKNM 
DTSAVLAEIP AGPGREPVQT LYSQSPALEL DKFLEDVRNG IYPLTAFGLP RPQQPQQEEV 
TSPVVPPSVK TPTPEPAEVE TRKVVLMQCN IESVEEGVKH HLTLLLKLED KLNRHLSCDL 
MPNENIPELA AELVQLGFIS EADQSRLTSL LEETLNKFNF ARNSTLNSAA VTVSS

Genular Protein ID: 2003009935

Symbol: F8W6G1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W6G1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 543
  • Mass: 60830
  • Checksum: 9AEED88B92AC83FC
  • Sequence:
    • MSEGESQTVL SSGSDPKVES SSSAPGLTSV SPPVTSTTSA ASPEEEEESE DESEILEESP 
CGRWQKRREE VNQRNVPGID SAYLAMDTEE GVEVVWNEVQ FSERKNYKLQ EEKVRAVFDN 
LIQLEHLNIV KFHKYWADIK ENKARVIFIT EYMSSGSLKQ FLKKTKKNHK TMNEKAWKRW 
CTQILSALSY LHSCDPPIIH GNLTCDTIFI QHNGLIKIGS VFHRIFANVA PDTINNHVKT 
CREEQKNLHF FAPEYGEVTN VTTAVDIYSF GMCALEMAVL EIQGNGESSY VPQEAISSAI 
QLLEDPLQRE FIQKCLQSEP ARRPTARELL FHPALFEVPS LKLLAAHCIV GHQHMIPENA 
LEEITKNMDT SAVLAEIPAG PGREPVQTLY SQSPALELDK FLEDVRNGIY PLTAFGLPRP 
QQPQQEEVTS PVVPPSVKTP TPEPAEVETR KVVLMQCNIE SVEEGVKHHL TLLLKLEDKL 
NRHLSCDLMP NENIPELAAE LVQLGFISEA DQSRLTSLLE ETLNKFNFAR NSTLNSAAVT 
VSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.