Details for: NRBF2

Gene ID: 29982

Symbol: NRBF2

Ensembl ID: ENSG00000148572

Description: nuclear receptor binding factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.8904
    Cell Significance Index: -27.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.8035
    Cell Significance Index: -27.0900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 74.1356
    Cell Significance Index: -30.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.7623
    Cell Significance Index: -31.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.9743
    Cell Significance Index: -25.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.6537
    Cell Significance Index: -30.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.0327
    Cell Significance Index: -31.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.8190
    Cell Significance Index: -26.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.7356
    Cell Significance Index: -29.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1312
    Cell Significance Index: -27.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5823
    Cell Significance Index: -29.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5474
    Cell Significance Index: -20.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8879
    Cell Significance Index: 50.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5024
    Cell Significance Index: 90.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3795
    Cell Significance Index: 1245.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2205
    Cell Significance Index: 132.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7680
    Cell Significance Index: 36.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6445
    Cell Significance Index: 44.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6303
    Cell Significance Index: 8.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5930
    Cell Significance Index: 81.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5692
    Cell Significance Index: 69.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5512
    Cell Significance Index: 25.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5287
    Cell Significance Index: 14.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4833
    Cell Significance Index: 34.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4800
    Cell Significance Index: 212.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4584
    Cell Significance Index: 82.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4558
    Cell Significance Index: 248.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4343
    Cell Significance Index: 22.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4234
    Cell Significance Index: 12.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3782
    Cell Significance Index: 44.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3755
    Cell Significance Index: 6.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3480
    Cell Significance Index: 69.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3347
    Cell Significance Index: 42.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3041
    Cell Significance Index: 30.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2773
    Cell Significance Index: 12.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2550
    Cell Significance Index: 50.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1848
    Cell Significance Index: 35.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1841
    Cell Significance Index: 23.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1766
    Cell Significance Index: 9.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1245
    Cell Significance Index: 8.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1185
    Cell Significance Index: 81.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1082
    Cell Significance Index: 8.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0965
    Cell Significance Index: 34.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0889
    Cell Significance Index: 1.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0590
    Cell Significance Index: 10.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0481
    Cell Significance Index: 0.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0384
    Cell Significance Index: 1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0174
    Cell Significance Index: 0.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0061
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0170
    Cell Significance Index: -31.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0208
    Cell Significance Index: -31.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0252
    Cell Significance Index: -34.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0289
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0298
    Cell Significance Index: -16.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0309
    Cell Significance Index: -19.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0314
    Cell Significance Index: -3.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0375
    Cell Significance Index: -17.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0381
    Cell Significance Index: -2.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0405
    Cell Significance Index: -0.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0574
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0670
    Cell Significance Index: -14.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0681
    Cell Significance Index: -1.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0682
    Cell Significance Index: -19.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0813
    Cell Significance Index: -9.3100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0885
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0905
    Cell Significance Index: -13.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1069
    Cell Significance Index: -2.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1070
    Cell Significance Index: -12.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1315
    Cell Significance Index: -8.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1381
    Cell Significance Index: -10.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1819
    Cell Significance Index: -6.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1920
    Cell Significance Index: -4.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2387
    Cell Significance Index: -14.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2472
    Cell Significance Index: -6.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2482
    Cell Significance Index: -6.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2523
    Cell Significance Index: -28.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2560
    Cell Significance Index: -6.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2781
    Cell Significance Index: -28.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2792
    Cell Significance Index: -6.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2830
    Cell Significance Index: -14.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2998
    Cell Significance Index: -20.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3068
    Cell Significance Index: -17.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3199
    Cell Significance Index: -25.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3237
    Cell Significance Index: -9.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3322
    Cell Significance Index: -2.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3562
    Cell Significance Index: -8.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3567
    Cell Significance Index: -3.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4437
    Cell Significance Index: -9.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4525
    Cell Significance Index: -20.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4630
    Cell Significance Index: -5.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4922
    Cell Significance Index: -5.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5112
    Cell Significance Index: -31.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5335
    Cell Significance Index: -15.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5552
    Cell Significance Index: -14.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5670
    Cell Significance Index: -21.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NRBF2 is a nuclear receptor-binding factor that interacts with various nuclear receptors, influencing gene expression and transcription. Its protein structure consists of a nuclear receptor-binding domain, which allows it to interact with specific nuclear receptors, thereby modulating their activity. The gene is highly expressed in neural progenitor cells, male germ cells, and other cell types involved in immune responses. Its expression patterns suggest a multifaceted role in maintaining cellular homeostasis. **Pathways and Functions:** NRBF2 is implicated in several cellular pathways, including: 1. **Autophagy**: NRBF2 plays a crucial role in regulating autophagy, a process by which cells recycle damaged or dysfunctional components. Autophagy is essential for maintaining cellular homeostasis and preventing disease. 2. **Gene Expression (Transcription)**: NRBF2 interacts with nuclear receptors, modulating their activity and influencing gene expression. This interaction is critical for regulating cellular processes, including development, differentiation, and immune responses. 3. **Nuclear Receptor Transcription Pathway**: NRBF2 is a key component of the nuclear receptor transcription pathway, which regulates gene expression in response to various signals, including hormones and growth factors. 4. **Phosphatidylinositol 3-kinase Complex**: NRBF2 interacts with the phosphatidylinositol 3-kinase complex, a signaling pathway involved in cell growth, survival, and immune responses. **Clinical Significance:** The clinical significance of NRBF2 is multifaceted, with implications for various diseases and disorders. Some potential clinical applications of NRBF2 include: 1. **Autophagy-related disorders**: NRBF2 dysregulation may contribute to autophagy-related disorders, such as neurodegenerative diseases, cancer, and metabolic disorders. 2. **Immune system disorders**: NRBF2's role in regulating immune responses makes it a potential target for treating immune-related disorders, such as autoimmune diseases and cancer. 3. **Cancer therapy**: NRBF2's involvement in gene expression and autophagy suggests that it may be a useful target for cancer therapy, particularly in combination with other treatments. In conclusion, NRBF2 is a complex gene with a wide range of cellular expressions and functions. Its involvement in autophagy, gene expression, and immune responses underscores its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of NRBF2 and its potential applications in disease treatment and prevention.

Genular Protein ID: 2378897502

Symbol: NRBF2_HUMAN

Name: Nuclear receptor-binding factor 2

UniProtKB Accession Codes:

Q96F24 A6PW36 B4DWS0 Q86UR2 Q96NP6 Q9H0S9 Q9H2I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15610520

Title: Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator.

PubMed ID: 15610520

DOI: 10.1111/j.0022-202x.2004.23424.x

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18619852

Title: Nuclear receptor binding protein 2 is induced during neural progenitor differentiation and affects cell survival.

PubMed ID: 18619852

DOI: 10.1016/j.mcn.2008.05.013

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24785657

Title: NRBF2 regulates macroautophagy as a component of Vps34 Complex I.

PubMed ID: 24785657

DOI: 10.1042/bj20140515

PubMed ID: 25086043

Title: Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.

PubMed ID: 25086043

DOI: 10.1074/jbc.m114.561134

Sequence Information:

  • Length: 287
  • Mass: 32378
  • Checksum: 91EC0407F5108806
  • Sequence:
    • MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ 
RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS 
PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR 
HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS 
STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.