Details for: SLC39A3

Gene ID: 29985

Symbol: SLC39A3

Ensembl ID: ENSG00000141873

Description: solute carrier family 39 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.5243
    Cell Significance Index: -6.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.9261
    Cell Significance Index: -18.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.1876
    Cell Significance Index: -18.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.3275
    Cell Significance Index: -4.4000
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 13.2848
    Cell Significance Index: 6.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.0986
    Cell Significance Index: -16.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5098
    Cell Significance Index: -14.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5970
    Cell Significance Index: -18.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2618
    Cell Significance Index: -13.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.9376
    Cell Significance Index: 51.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7571
    Cell Significance Index: 285.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2362
    Cell Significance Index: 134.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8298
    Cell Significance Index: 43.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7730
    Cell Significance Index: 90.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7071
    Cell Significance Index: 32.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6964
    Cell Significance Index: 628.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6449
    Cell Significance Index: 44.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5760
    Cell Significance Index: 15.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5283
    Cell Significance Index: 33.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4155
    Cell Significance Index: 226.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3990
    Cell Significance Index: 75.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3953
    Cell Significance Index: 27.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3605
    Cell Significance Index: 26.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3600
    Cell Significance Index: 64.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3549
    Cell Significance Index: 16.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3539
    Cell Significance Index: 22.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3180
    Cell Significance Index: 6.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3126
    Cell Significance Index: 138.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3050
    Cell Significance Index: 41.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2922
    Cell Significance Index: 6.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2896
    Cell Significance Index: 3.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2755
    Cell Significance Index: 33.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2563
    Cell Significance Index: 32.8600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2202
    Cell Significance Index: 1.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2075
    Cell Significance Index: 20.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1899
    Cell Significance Index: 9.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1835
    Cell Significance Index: 1.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1665
    Cell Significance Index: 21.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1607
    Cell Significance Index: 32.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1603
    Cell Significance Index: 5.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1106
    Cell Significance Index: 18.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0902
    Cell Significance Index: 2.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0661
    Cell Significance Index: 23.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0653
    Cell Significance Index: 2.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0163
    Cell Significance Index: 12.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0144
    Cell Significance Index: 9.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0048
    Cell Significance Index: 3.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0042
    Cell Significance Index: -0.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0051
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0096
    Cell Significance Index: -18.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0269
    Cell Significance Index: -17.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0287
    Cell Significance Index: -1.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0291
    Cell Significance Index: -0.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0313
    Cell Significance Index: -0.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0366
    Cell Significance Index: -0.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0375
    Cell Significance Index: -4.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0392
    Cell Significance Index: -17.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0406
    Cell Significance Index: -1.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0500
    Cell Significance Index: -14.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0607
    Cell Significance Index: -1.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0625
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0663
    Cell Significance Index: -7.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0946
    Cell Significance Index: -18.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0991
    Cell Significance Index: -20.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1039
    Cell Significance Index: -3.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1119
    Cell Significance Index: -6.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1278
    Cell Significance Index: -18.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1451
    Cell Significance Index: -4.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1614
    Cell Significance Index: -9.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1882
    Cell Significance Index: -4.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1905
    Cell Significance Index: -5.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1937
    Cell Significance Index: -15.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1976
    Cell Significance Index: -15.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2259
    Cell Significance Index: -13.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3017
    Cell Significance Index: -15.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3306
    Cell Significance Index: -9.7100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3409
    Cell Significance Index: -4.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3640
    Cell Significance Index: -10.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3724
    Cell Significance Index: -16.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3965
    Cell Significance Index: -12.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4020
    Cell Significance Index: -7.4300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4025
    Cell Significance Index: -3.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4065
    Cell Significance Index: -14.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4297
    Cell Significance Index: -16.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4380
    Cell Significance Index: -16.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4441
    Cell Significance Index: -14.1500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4571
    Cell Significance Index: -2.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4584
    Cell Significance Index: -6.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4813
    Cell Significance Index: -12.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5009
    Cell Significance Index: -7.1300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5068
    Cell Significance Index: -8.0400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5135
    Cell Significance Index: -9.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5362
    Cell Significance Index: -11.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Transporter:** SLC39A3, also known as ZIP3, is a zinc influx transporter that facilitates the uptake of zinc ions into cells. 2. **Cellular Expression:** ZIP3 is significantly expressed in various cell types, including pancreatic A cells, erythroid progenitor cells, pro-T cells, and myeloid dendritic cells. 3. **Tissue Distribution:** ZIP3 is widely distributed in tissues, including the pancreas, liver, kidney, and hematopoietic tissues. 4. **Evolutionary Conservation:** ZIP3 is highly conserved across species, suggesting its essential role in maintaining zinc homeostasis. **Pathways and Functions:** 1. **Zinc Homeostasis:** ZIP3 plays a critical role in maintaining cellular zinc homeostasis by facilitating the uptake of zinc ions into cells. 2. **Cell Morphogenesis:** ZIP3 has been implicated in regulating cell shape and morphology, particularly in the development of the embryonic cranial skeleton. 3. **Embryonic Development:** ZIP3 is essential for normal embryonic development, including in utero embryonic development and limb development. 4. **T Cell Homeostasis:** ZIP3 has been shown to regulate T cell homeostasis, which is critical for maintaining immune function. 5. **Metal Ion Transport:** ZIP3 is involved in the transport of other metal ions, including copper and manganese, in addition to zinc. 6. **Bile Salt and Organic Acid Transport:** ZIP3 has been implicated in the transport of bile salts and organic acids, which is essential for maintaining liver function. **Clinical Significance:** 1. **Zinc Deficiency:** ZIP3 mutations or dysregulation have been associated with zinc deficiency, which can lead to impaired immune function, growth retardation, and increased susceptibility to infections. 2. **Immunodeficiency:** ZIP3 deficiency has been linked to immunodeficiency disorders, including impaired T cell function and increased risk of infections. 3. **Neurological Disorders:** ZIP3 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where zinc dysregulation is a contributing factor. 4. **Cancer:** ZIP3 has been shown to play a role in cancer development and progression, particularly in the context of zinc dysregulation. In conclusion, SLC39A3, or ZIP3, is a critical gene involved in maintaining cellular zinc homeostasis and regulating various cellular pathways, including cell morphogenesis, embryonic development, and T cell homeostasis. Its dysregulation has been implicated in several clinical disorders, highlighting the importance of ZIP3 in maintaining human health.

Genular Protein ID: 3280232120

Symbol: S39A3_HUMAN

Name: Zinc transporter ZIP3

UniProtKB Accession Codes:

Q9BRY0 B3KMJ3 Q8WUG1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 314
  • Mass: 33601
  • Checksum: 572ADE958735D2CE
  • Sequence:
    • MVKLLVAKIL CMVGVFFFML LGSLLPVKII ETDFEKAHRS KKILSLCNTF GGGVFLATCF 
NALLPAVREK LQKVLSLGHI STDYPLAETI LLLGFFMTVF LEQLILTFRK EKPSFIDLET 
FNAGSDVGSD SEYESPFMGG ARGHALYVEP HGHGPSLSVQ GLSRASPVRL LSLAFALSAH 
SVFEGLALGL QEEGEKVVSL FVGVAVHETL VAVALGISMA RSAMPLRDAA KLAVTVSAMI 
PLGIGLGLGI ESAQGVPGSV ASVLLQGLAG GTFLFITFLE ILAKELEEKS DRLLKVLFLV 
LGYTVLAGMV FLKW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.