Gene H2AC7 - ENSG00000196866 | NCBI Gene ID: 3013

Details for: H2AC7

Gene ID: 3013

Symbol: H2AC7

Ensembl ID: ENSG00000196866

Description: H2A clustered histone 7

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)
Molecular_function
(GO:0003674)
Nucleosomal dna binding
(GO:0031492)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.99
Marker Score: 1998
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.86
Marker Score: 3843
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1175
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 860
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 489
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4826
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 505
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71840
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48065
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.84
Marker Score: 890
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.61
Marker Score: 466.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.61
Marker Score: 355
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.57
Marker Score: 343
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.56
Marker Score: 180
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.4
Marker Score: 140
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.38
Marker Score: 896
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.35
Marker Score: 185
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.34
Marker Score: 144
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.32
Marker Score: 232
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.32
Marker Score: 99
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.22
Marker Score: 71
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.22
Marker Score: 77
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.2
Marker Score: 206.5
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.19
Marker Score: 67
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.19
Marker Score: 103
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.18
Marker Score: 116
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 41
Cell Name: thymocyte (CL0000893)
Fold Change: 0.16
Marker Score: 170.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.16
Marker Score: 427
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.15
Marker Score: 372
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.15
Marker Score: 91
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.14
Marker Score: 210
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.14
Marker Score: 144
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.13
Marker Score: 52
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.12
Marker Score: 43
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.11
Marker Score: 77
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.1
Marker Score: 96
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.1
Marker Score: 25
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.09
Marker Score: 132
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.09
Marker Score: 45
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.08
Marker Score: 230
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.08
Marker Score: 38
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.08
Marker Score: 62
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.07
Marker Score: 40
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.07
Marker Score: 149
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.06
Marker Score: 38
Cell Name: plasmablast (CL0000980)
Fold Change: 0.06
Marker Score: 83
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.06
Marker Score: 101
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.06
Marker Score: 47
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.06
Marker Score: 146
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.06
Marker Score: 36
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.06
Marker Score: 15
Cell Name: microglial cell (CL0000129)
Fold Change: 0.05
Marker Score: 99.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.05
Marker Score: 13
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.05
Marker Score: 37
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.05
Marker Score: 17
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.05
Marker Score: 35.5
Cell Name: erythroblast (CL0000765)
Fold Change: 0.05
Marker Score: 32
Cell Name: B cell (CL0000236)
Fold Change: 0.04
Marker Score: 42
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.04
Marker Score: 54
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.04
Marker Score: 14
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.04
Marker Score: 30
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.04
Marker Score: 16
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.04
Marker Score: 53.5
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.03
Marker Score: 29
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.03
Marker Score: 35
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.03
Marker Score: 26
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.03
Marker Score: 20
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.03
Marker Score: 36
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.03
Marker Score: 10
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.03
Marker Score: 35
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.03
Marker Score: 41
Cell Name: plasma cell (CL0000786)
Fold Change: 0.03
Marker Score: 35
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.03
Marker Score: 9
Cell Name: granulocyte (CL0000094)
Fold Change: 0.03
Marker Score: 14
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.03
Marker Score: 43
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.03
Marker Score: 21
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.03
Marker Score: 21
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.03
Marker Score: 14
Cell Name: podocyte (CL0000653)
Fold Change: 0.03
Marker Score: 11
Cell Name: mast cell (CL0000097)
Fold Change: 0.03
Marker Score: 17
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.03
Marker Score: 26
Cell Name: astrocyte (CL0000127)
Fold Change: 0.03
Marker Score: 25
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.03
Marker Score: 9
Cell Name: eosinophil (CL0000771)
Fold Change: 0.03
Marker Score: 9
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.03
Marker Score: 32
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.03
Marker Score: 7
Cell Name: neutrophil (CL0000775)
Fold Change: 0.03
Marker Score: 16
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.03
Marker Score: 17
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.03
Marker Score: 8
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.03
Marker Score: 13

Hover over a box to see details here...

**Key characteristics:** - H2A7 is a large gene cluster with 13 members. - The cluster is divided into two subgroups: H2A1 and H2A7. - H2A1 is involved in various cellular processes, including cell cycle regulation, developmental biology, and disease. - H2A7 is involved in chromatin remodeling and gene expression. **Pathways and functions:** - H2A7 proteins are involved in the regulation of hox gene expression during differentiation. - They are also involved in cell cycle regulation, developmental biology, and disease. - H2A7 proteins interact with other histone proteins to form chromatin remodeling complexes that regulate gene expression. **Clinical significance:** - Mutations in H2A7 genes have been linked to various diseases, including cancer and developmental disorders. - H2A7 mutations can lead to the activation of hox genes, which can result in the formation of tumors. - H2A7 mutations can also lead to the inactivation of tumor suppressor genes, which can lead to cancer development. - Therefore, H2A7 genes are a promising target for cancer immunotherapy. **Additional information:** - H2A7 is a highly conserved gene family. - The H2A7 proteins are expressed in all eukaryotic cells. - H2A7 is a highly important gene in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2A type 1-D
B2R5B6_HUMAN

Genular Protein ID: 4289289202

Symbol: H2A1D_HUMAN

Name: Histone H2A type 1-D

UniProtKB Accession Codes:

P20671 A0PK91 P57754 Q6FGY6

Database IDs:

Citations:

PubMed ID: 2587222

Title: Nucleotide sequences of mouse histone genes H2A and H3.1.

PubMed ID: 2587222

DOI: 10.1093/nar/17.21.8861

PubMed ID: 9119399

Title: Human histone gene organization: nonregular arrangement within a large cluster.

PubMed ID: 9119399

DOI: 10.1006/geno.1996.4592

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15078818

Title: Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

PubMed ID: 15078818

DOI: 10.1101/gad.1184604

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 15823041

Title: Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.

PubMed ID: 15823041

DOI: 10.1021/bi047505c

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16702407

Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

PubMed ID: 16702407

DOI: 10.1101/gad.373706

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22713238

Title: A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

PubMed ID: 22713238

DOI: 10.4161/cc.20919

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24140421

Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.

PubMed ID: 24140421

DOI: 10.1016/j.molcel.2013.09.017

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 25470042

Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

PubMed ID: 25470042

DOI: 10.1038/nature13955

PubMed ID: 27083998

Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

PubMed ID: 27083998

DOI: 10.1101/gad.271841.115

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

Sequence Information:

Length: 130
Mass: 14107
Checksum: 48CE6184B2CC9164
Sequence:

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 
TESHHKAKGK

Genular Protein ID: 2920351554

Symbol: B2R5B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R5B6

Database IDs:

Sequence Information:

Length: 130
Mass: 14138
Checksum: 48CE75D5F7CC9164
Sequence:

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTITQGGVLP NIQAVLLPKK 
TESHHKAKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: H2AC7

Associated with

Cells (max top 100)

Other Information

Nucleotide sequences of mouse histone genes H2A and H3.1. PubMed ID: 2587222

Human histone gene organization: nonregular arrangement within a large cluster. PubMed ID: 9119399

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. PubMed ID: 15078818

Phosphorylation of histone H2A inhibits transcription on chromatin templates. PubMed ID: 15010469

Role of histone H2A ubiquitination in Polycomb silencing. PubMed ID: 15386022

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. PubMed ID: 15823041

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. PubMed ID: 16359901

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. PubMed ID: 16702407

Precise characterization of human histones in the H2A gene family by top down mass spectrometry. PubMed ID: 16457589

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. PubMed ID: 18001824

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. PubMed ID: 18001825

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. PubMed ID: 19203578

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. PubMed ID: 19203579

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. PubMed ID: 22980979

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. PubMed ID: 22713238

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. PubMed ID: 24140421

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. PubMed ID: 24352239

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. PubMed ID: 25470042

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. PubMed ID: 27083998

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297