H2AC7 | ENSG00000196866 | NCBI 3013

Details for: H2AC7

Gene ID: 3013

Symbol: H2AC7

Ensembl ID: ENSG00000196866

Description: H2A clustered histone 7

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 14.5938
Cell Significance Index: -2.2700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 9.1861
Cell Significance Index: -2.3300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 5.5641
Cell Significance Index: 178.2100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.9060
Cell Significance Index: -2.3500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.3898
Cell Significance Index: 28.8300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3794
Cell Significance Index: 8.0800
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.3591
Cell Significance Index: 5.0400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3490
Cell Significance Index: 20.9600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2697
Cell Significance Index: 3.6800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2647
Cell Significance Index: 3.7900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2616
Cell Significance Index: 49.7800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1966
Cell Significance Index: 21.3900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0855
Cell Significance Index: 5.9200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0780
Cell Significance Index: 12.6900
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.0481
Cell Significance Index: 0.3500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0426
Cell Significance Index: 7.6900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0413
Cell Significance Index: 1.1900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0405
Cell Significance Index: 0.6100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0373
Cell Significance Index: 1.6900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0152
Cell Significance Index: 1.5100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0151
Cell Significance Index: 0.5300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0136
Cell Significance Index: 12.2700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0116
Cell Significance Index: 0.2900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0097
Cell Significance Index: 0.2100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0070
Cell Significance Index: 0.9000
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0028
Cell Significance Index: 0.0300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0027
Cell Significance Index: 0.1500
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0005
Cell Significance Index: -0.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0006
Cell Significance Index: -0.3400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0012
Cell Significance Index: -0.0600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0021
Cell Significance Index: -0.3600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0033
Cell Significance Index: -0.1300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0036
Cell Significance Index: -1.9400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0053
Cell Significance Index: -1.9100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0086
Cell Significance Index: -0.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0090
Cell Significance Index: -1.2400
Cell Name: respiratory suprabasal cell (CL4033048)
Fold Change: -0.0094
Cell Significance Index: -0.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0095
Cell Significance Index: -1.0900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0096
Cell Significance Index: -1.9400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0099
Cell Significance Index: -0.6400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0110
Cell Significance Index: -1.3500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0118
Cell Significance Index: -0.5500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0187
Cell Significance Index: -1.9100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0206
Cell Significance Index: -0.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0224
Cell Significance Index: -2.6400
Cell Name: renal principal cell (CL0005009)
Fold Change: -0.0227
Cell Significance Index: -0.2400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0258
Cell Significance Index: -0.5400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0260
Cell Significance Index: -1.2200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0280
Cell Significance Index: -2.1500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0308
Cell Significance Index: -0.3500
Cell Name: Langerhans cell (CL0000453)
Fold Change: -0.0345
Cell Significance Index: -0.3300
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0372
Cell Significance Index: -0.4700
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0408
Cell Significance Index: -0.5800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0418
Cell Significance Index: -0.5800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0432
Cell Significance Index: -0.4700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0436
Cell Significance Index: -2.2900
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0464
Cell Significance Index: -0.6700
Cell Name: ionocyte (CL0005006)
Fold Change: -0.0469
Cell Significance Index: -0.4900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0517
Cell Significance Index: -2.2900
Cell Name: osteoblast (CL0000062)
Fold Change: -0.0526
Cell Significance Index: -0.5100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0544
Cell Significance Index: -0.7900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0547
Cell Significance Index: -1.4600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0568
Cell Significance Index: -1.8600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0610
Cell Significance Index: -2.3100
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0635
Cell Significance Index: -0.8300
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0654
Cell Significance Index: -0.7000
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0671
Cell Significance Index: -1.3700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0675
Cell Significance Index: -2.1500
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0675
Cell Significance Index: -0.7000
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.0690
Cell Significance Index: -0.5300
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: -0.0692
Cell Significance Index: -0.5500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0693
Cell Significance Index: -1.7700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0705
Cell Significance Index: -1.8900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0716
Cell Significance Index: -2.5100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0730
Cell Significance Index: -2.1500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0734
Cell Significance Index: -0.9300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0740
Cell Significance Index: -2.7200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0799
Cell Significance Index: -2.0400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0804
Cell Significance Index: -2.3600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0821
Cell Significance Index: -1.6100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0835
Cell Significance Index: -2.4000
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0836
Cell Significance Index: -0.8700
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.0882
Cell Significance Index: -0.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0898
Cell Significance Index: -2.3600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0905
Cell Significance Index: -0.5600
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0908
Cell Significance Index: -0.9400
Cell Name: peg cell (CL4033014)
Fold Change: -0.0909
Cell Significance Index: -2.1000
Cell Name: erythroblast (CL0000765)
Fold Change: -0.0927
Cell Significance Index: -1.1100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0927
Cell Significance Index: -1.8100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0941
Cell Significance Index: -2.3500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0953
Cell Significance Index: -2.0600
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0958
Cell Significance Index: -2.3900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0962
Cell Significance Index: -2.3300
Cell Name: chondroblast (CL0000058)
Fold Change: -0.0971
Cell Significance Index: -0.5700
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0994
Cell Significance Index: -1.1800
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1004
Cell Significance Index: -1.6100
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.1059
Cell Significance Index: -1.8100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1061
Cell Significance Index: -1.5900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1062
Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H2AC7 exhibits several key characteristics that distinguish it from other histones: 1. **Acetylation and methylation**: H2AC7 is acetylated and methylated by various enzymes, such as Hat1, Hcmv early events, and Rmts, which regulate its activity and interaction with other histones and chromatin proteins. 2. **Chromatin organization**: H2AC7 is involved in the assembly of nucleosomes, which are the basic units of chromatin, and regulates chromatin organization during development, cell cycle, and senescence. 3. **Transcriptional regulation**: H2AC7 is involved in the regulation of gene expression, particularly in the transcription of androgen receptor-regulated genes and anterior Hox genes in hindbrain development. 4. **Cell cycle and senescence**: H2AC7 is also involved in the regulation of the cell cycle, particularly in mitosis, and senescence, particularly in oxidative stress-induced senescence. **Pathways and Functions** H2AC7 is involved in various cellular pathways and functions, including: 1. **Transcriptional regulation**: H2AC7 regulates the transcription of genes involved in development, cell cycle, and senescence. 2. **DNA replication and repair**: H2AC7 is involved in the regulation of DNA replication and repair, particularly in the assembly of the pre-replicative complex. 3. **Chromatin modifications**: H2AC7 is involved in the regulation of chromatin modifications, such as acetylation and methylation, which regulate gene expression. 4. **Cell cycle and senescence**: H2AC7 regulates the cell cycle, particularly in mitosis, and senescence, particularly in oxidative stress-induced senescence. **Clinical Significance** The dysregulation of H2AC7 has been implicated in various diseases, including: 1. **Cancer**: H2AC7 is often overexpressed in cancer cells, leading to the deregulation of gene expression and the promotion of tumorigenesis. 2. **Neurological disorders**: H2AC7 has been implicated in the regulation of gene expression in the brain, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Aging and senescence**: H2AC7 is involved in the regulation of senescence, and its dysregulation has been linked to aging and age-related diseases. In conclusion, H2AC7 is a critical component of the histone H2A family, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of H2AC7 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2A type 1-D
B2R5B6_HUMAN

Genular Protein ID: 4289289202

Symbol: H2A1D_HUMAN

Name: Histone H2A type 1-D

UniProtKB Accession Codes:

P20671 A0PK91 P57754 Q6FGY6

Database IDs:

Citations:

PubMed ID: 2587222

Title: Nucleotide sequences of mouse histone genes H2A and H3.1.

PubMed ID: 2587222

DOI: 10.1093/nar/17.21.8861

PubMed ID: 9119399

Title: Human histone gene organization: nonregular arrangement within a large cluster.

PubMed ID: 9119399

DOI: 10.1006/geno.1996.4592

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15078818

Title: Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

PubMed ID: 15078818

DOI: 10.1101/gad.1184604

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 15823041

Title: Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.

PubMed ID: 15823041

DOI: 10.1021/bi047505c

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16702407

Title: DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

PubMed ID: 16702407

DOI: 10.1101/gad.373706

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 22713238

Title: A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

PubMed ID: 22713238

DOI: 10.4161/cc.20919

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24140421

Title: VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription.

PubMed ID: 24140421

DOI: 10.1016/j.molcel.2013.09.017

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 25470042

Title: TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

PubMed ID: 25470042

DOI: 10.1038/nature13955

PubMed ID: 27083998

Title: USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

PubMed ID: 27083998

DOI: 10.1101/gad.271841.115

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

Sequence Information:

Length: 130
Mass: 14107
Checksum: 48CE6184B2CC9164
Sequence:

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 
TESHHKAKGK

Genular Protein ID: 2920351554

Symbol: B2R5B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R5B6

Database IDs:

Sequence Information:

Length: 130
Mass: 14138
Checksum: 48CE75D5F7CC9164
Sequence:

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTITQGGVLP NIQAVLLPKK 
TESHHKAKGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2AC7

Associated with

Cells (max top 100)

Other Information

Nucleotide sequences of mouse histone genes H2A and H3.1. PubMed ID: 2587222

Human histone gene organization: nonregular arrangement within a large cluster. PubMed ID: 9119399

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. PubMed ID: 15078818

Phosphorylation of histone H2A inhibits transcription on chromatin templates. PubMed ID: 15010469

Role of histone H2A ubiquitination in Polycomb silencing. PubMed ID: 15386022

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. PubMed ID: 15823041

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. PubMed ID: 16359901

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. PubMed ID: 16702407

Precise characterization of human histones in the H2A gene family by top down mass spectrometry. PubMed ID: 16457589

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. PubMed ID: 18001824

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. PubMed ID: 18001825

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. PubMed ID: 19203578

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. PubMed ID: 19203579

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. PubMed ID: 22980979

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. PubMed ID: 22713238

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. PubMed ID: 24140421

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. PubMed ID: 24352239

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. PubMed ID: 25470042

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. PubMed ID: 27083998

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297