Details for: HAGH

Gene ID: 3029

Symbol: HAGH

Ensembl ID: ENSG00000063854

Description: hydroxyacylglutathione hydrolase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.03
    Marker Score: 2283
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.83
    Marker Score: 6509.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.78
    Marker Score: 6579
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.71
    Marker Score: 3484
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.71
    Marker Score: 14865
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.68
    Marker Score: 2418
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.68
    Marker Score: 564
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.59
    Marker Score: 2636
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.59
    Marker Score: 97634
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.56
    Marker Score: 1057
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.52
    Marker Score: 14281
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.52
    Marker Score: 14412
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.52
    Marker Score: 437
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55599.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.5
    Marker Score: 56978.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 21970.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.46
    Marker Score: 12572
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.45
    Marker Score: 6025.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.45
    Marker Score: 2133
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.43
    Marker Score: 708.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.42
    Marker Score: 36259
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.41
    Marker Score: 5446
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.4
    Marker Score: 27780
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14411
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.39
    Marker Score: 2140
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.39
    Marker Score: 1674
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.38
    Marker Score: 6614
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.36
    Marker Score: 507
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.36
    Marker Score: 10411.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.35
    Marker Score: 2155
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.34
    Marker Score: 1268
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.34
    Marker Score: 400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.32
    Marker Score: 628
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.32
    Marker Score: 553
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.31
    Marker Score: 2499
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.31
    Marker Score: 619
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.28
    Marker Score: 1177.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.26
    Marker Score: 750.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.26
    Marker Score: 1935
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2940.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.21
    Marker Score: 349.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.21
    Marker Score: 1982
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2
    Marker Score: 3413
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.19
    Marker Score: 41263
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.18
    Marker Score: 25281
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.18
    Marker Score: 2905.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.18
    Marker Score: 1196
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.17
    Marker Score: 4778
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.17
    Marker Score: 4587
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.16
    Marker Score: 641
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.15
    Marker Score: 3949
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.14
    Marker Score: 714
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.14
    Marker Score: 478
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.14
    Marker Score: 1191
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.14
    Marker Score: 254.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.14
    Marker Score: 7418
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.13
    Marker Score: 2567
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.12
    Marker Score: 1352
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.12
    Marker Score: 1206
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.12
    Marker Score: 390
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.11
    Marker Score: 7112
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.1
    Marker Score: 273
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.1
    Marker Score: 1039
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1
    Marker Score: 263.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.1
    Marker Score: 502
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.1
    Marker Score: 749
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.1
    Marker Score: 2764
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.09
    Marker Score: 581
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.09
    Marker Score: 444
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.08
    Marker Score: 4674
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.08
    Marker Score: 534
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.08
    Marker Score: 9288
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.08
    Marker Score: 3383
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.05
    Marker Score: 613
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.04
    Marker Score: 285
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.04
    Marker Score: 1303
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.03
    Marker Score: 2180
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.03
    Marker Score: 1119
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 389
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.03
    Marker Score: 632
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.03
    Marker Score: 2747.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.02
    Marker Score: 496
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.02
    Marker Score: 528
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.02
    Marker Score: 351
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.02
    Marker Score: 1057
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.01
    Marker Score: 222
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.01
    Marker Score: 228
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.01
    Marker Score: 1617
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1
    Marker Score: 238.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1
    Marker Score: 1086
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Marker Score: 1048
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71576
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 831
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.99
    Marker Score: 5348.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47801
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.99
    Marker Score: 1865
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Marker Score: 1093
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.98
    Marker Score: 316
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.98
    Marker Score: 5174
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.98
    Marker Score: 3485

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Other Information

**Key characteristics:** - Gene name: HAGH - Ensembl ID: ENSG00000063854 - Protein: GLO2_HUMAN (Glyoxalase II) - Cellular location: Cytosol, mitochondria, and nucleus **Pathways and functions:** - Hydroxyacylglutathione hydrolase activity contributes to the metabolism of glutathione, a key antioxidant in the body. - It participates in the cytosol, glutathione biosynthetic process, and glutathione metabolic process. - It is involved in the mitochondrial matrix, mitochondrial function, and pyruvate metabolism. - It is significantly expressed in immune cells, including neurons, epithelial cells, and lymphocytes. - It plays a role in the citric acid (tca) cycle and respiratory electron transport. **Clinical significance:** - HAGH gene variants have been linked to certain neurological diseases, including Alzheimer's disease and Parkinson's disease. - Mutations in HAGH can result in the accumulation of oxidized glutathione, leading to cellular damage and neurotoxicity. - Therefore, targeting HAGH could be a potential therapeutic strategy for these diseases.

Genular Protein ID: 3332504408

Symbol: GLO2_HUMAN

Name: Glyoxalase II

UniProtKB Accession Codes:

Q16775 A8K290 B4DP33 B4DRA7 E7EN93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 4 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8550579

Title: Molecular cloning, heterologous expression, and characterization of human glyoxalase II.

PubMed ID: 8550579

DOI: 10.1074/jbc.271.1.319

PubMed ID: 15117945

Title: The human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II.

PubMed ID: 15117945

DOI: 10.1074/jbc.m403470200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10508780

Title: Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.

PubMed ID: 10508780

DOI: 10.1016/s0969-2126(99)80174-9

Sequence Information:

  • Length: 308
  • Mass: 33806
  • Checksum: 64E5C214B6EC61CB
  • Sequence:
    • MVVGRGLLGR RSLAALGAAC ARRGLGPALL GVFCHTDLRK NLTVDEGTMK VEVLPALTDN 
YMYLVIDDET KEAAIVDPVQ PQKVVDAARK HGVKLTTVLT THHHWDHAGG NEKLVKLESG 
LKVYGGDDRI GALTHKITHL STLQVGSLNV KCLATPCHTS GHICYFVSKP GGSEPPAVFT 
GDTLFVAGCG KFYEGTADEM CKALLEVLGR LPPDTRVYCG HEYTINNLKF ARHVEPGNAA 
IREKLAWAKE KYSIGEPTVP STLAEEFTYN PFMRVREKTV QQHAGETDPV TTMRAVRREK 
DQFKMPRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.