Details for: HBD
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 161.6798
Cell Significance Index: 73.6300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 5.7653
Cell Significance Index: -2.3800 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 1.5703
Cell Significance Index: 25.2500 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.9877
Cell Significance Index: 7.1000 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.6899
Cell Significance Index: 1.8200 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.5670
Cell Significance Index: 2.3600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 0.5220
Cell Significance Index: -2.0600 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.3722
Cell Significance Index: 2.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 0.3548
Cell Significance Index: -0.0900 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.1403
Cell Significance Index: 2.3600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.1100
Cell Significance Index: 1.6700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0925
Cell Significance Index: 2.4800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0667
Cell Significance Index: 1.5400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0146
Cell Significance Index: 2.8900 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0135
Cell Significance Index: 1.3800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0097
Cell Significance Index: 0.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0003
Cell Significance Index: -0.2500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0005
Cell Significance Index: -0.2700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0008
Cell Significance Index: -1.5700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0015
Cell Significance Index: -2.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0019
Cell Significance Index: -2.9500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0024
Cell Significance Index: -0.2700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0032
Cell Significance Index: -0.1600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0034
Cell Significance Index: -2.5900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0039
Cell Significance Index: -2.4700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0048
Cell Significance Index: -2.1800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0055
Cell Significance Index: -0.1500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0064
Cell Significance Index: -1.8400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0065
Cell Significance Index: -0.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0070
Cell Significance Index: -2.5100 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0075
Cell Significance Index: -0.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0095
Cell Significance Index: -1.7200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0110
Cell Significance Index: -2.2000 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0113
Cell Significance Index: -0.1200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0139
Cell Significance Index: -0.2900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0146
Cell Significance Index: -0.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0152
Cell Significance Index: -2.0900 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0156
Cell Significance Index: -0.1900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0159
Cell Significance Index: -1.0000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0165
Cell Significance Index: -2.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0170
Cell Significance Index: -2.4700 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: -0.0192
Cell Significance Index: -0.2300 - Cell Name: deuterosomal cell (CL4033044)
Fold Change: -0.0222
Cell Significance Index: -0.1700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0230
Cell Significance Index: -0.3300 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0238
Cell Significance Index: -0.4100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0243
Cell Significance Index: -1.8700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0255
Cell Significance Index: -0.4300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0257
Cell Significance Index: -0.2900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0264
Cell Significance Index: -0.3900 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0281
Cell Significance Index: -0.4100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0284
Cell Significance Index: -0.7300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0284
Cell Significance Index: -0.4500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0302
Cell Significance Index: -0.9900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0311
Cell Significance Index: -1.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0311
Cell Significance Index: -1.4500 - Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.0339
Cell Significance Index: -0.2300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0340
Cell Significance Index: -1.1900 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0344
Cell Significance Index: -0.5000 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.0357
Cell Significance Index: -0.3300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0385
Cell Significance Index: -2.1600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0399
Cell Significance Index: -2.6800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0416
Cell Significance Index: -2.1600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0418
Cell Significance Index: -1.8500 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.0418
Cell Significance Index: -0.2900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0432
Cell Significance Index: -2.7900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0443
Cell Significance Index: -1.9300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0467
Cell Significance Index: -1.7700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0473
Cell Significance Index: -1.7400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0488
Cell Significance Index: -0.5300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0494
Cell Significance Index: -1.4600 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0498
Cell Significance Index: -1.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0512
Cell Significance Index: -2.4100 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.0513
Cell Significance Index: -0.3200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0515
Cell Significance Index: -1.2900 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0568
Cell Significance Index: -0.7200 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0569
Cell Significance Index: -0.5400 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.0575
Cell Significance Index: -0.5500 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0584
Cell Significance Index: -0.5600 - Cell Name: melanocyte (CL0000148)
Fold Change: -0.0651
Cell Significance Index: -0.6100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0652
Cell Significance Index: -1.5800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0653
Cell Significance Index: -2.0800 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0680
Cell Significance Index: -0.9600 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0732
Cell Significance Index: -1.1900 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0768
Cell Significance Index: -0.9500 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0777
Cell Significance Index: -0.8800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0825
Cell Significance Index: -2.0600 - Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.0834
Cell Significance Index: -0.9200 - Cell Name: peridermal cell (CL0000078)
Fold Change: -0.0850
Cell Significance Index: -0.5300 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0856
Cell Significance Index: -1.1200 - Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.0865
Cell Significance Index: -0.5300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0878
Cell Significance Index: -2.3100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0881
Cell Significance Index: -2.1500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0886
Cell Significance Index: -1.7300 - Cell Name: chondroblast (CL0000058)
Fold Change: -0.0886
Cell Significance Index: -0.5200 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0890
Cell Significance Index: -1.2200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0891
Cell Significance Index: -2.3800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0913
Cell Significance Index: -2.1900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0939
Cell Significance Index: -2.6800 - Cell Name: early promyelocyte (CL0002154)
Fold Change: -0.0940
Cell Significance Index: -0.6000 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0949
Cell Significance Index: -1.3300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 679129080
Symbol: HBD_HUMAN
Name: Hemoglobin subunit delta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7438204
Title: Complete nucleotide sequence of the human delta-globin gene.
PubMed ID: 7438204
PubMed ID: 16370491
Title: The IVS-II-1(G>A) betao-thalassemia mutation in cis with HbA2-Troodos [Delta 116 (G18) Arg>Cys (CGC>TGC)] causes a complex prenatal diagnosis in an Iranian family.
PubMed ID: 16370491
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 680638
Title: Hemoglobins, XXIII. Note on the sequence of the delta-chains of human hemoglobin.
PubMed ID: 680638
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 15449937
Title: Crystal structures of HbA2 and HbE and modeling of hemoglobin delta 4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb.
PubMed ID: 15449937
DOI: 10.1021/bi048903i
PubMed ID: 5956309
Title: Haemoglobin A2: alpha-2-delta-2-16 glycine-->arginine.
PubMed ID: 5956309
DOI: 10.1038/2091217a0
PubMed ID: 5678016
Title: Haemoglobin Babinga (delta 136 glycine-aspartic acid): a new delta chain variant.
PubMed ID: 5678016
DOI: 10.1038/2191360a0
PubMed ID: 5824070
Title: Hemoglobin NYU, a delta chain variant, alpha 2 delta 2 Lys.
PubMed ID: 5824070
DOI: 10.1172/jci106171
PubMed ID: 4995018
Title: Hemoglobin A2-Indonesia or alpha 2 delta 2 69(E13) Gly-->Arg.
PubMed ID: 4995018
PubMed ID: 4850239
Title: A new delta chain variant, haemoglobin-A2-Melbourne or alpha2 delta2 43Glu-Lys(CD2).
PubMed ID: 4850239
PubMed ID: 1148221
Title: Hemoglobin-A2-Coburg or alpha2delta2116Arg leads to His (G18).
PubMed ID: 1148221
PubMed ID: 952968
Title: Hemoglobin A2-Roosevelt: alpha 2 delta 2 20Val replaced by Glu.
PubMed ID: 952968
PubMed ID: 7129931
Title: Hb A2-Canada or alpha 2 delta 2 99(G1) Asp replaced by Asn, a newly discovered delta chain variant with increased oxygen affinity occurring in cis to beta-thalassemia.
PubMed ID: 7129931
PubMed ID: 6629825
Title: Hb A2-Manzanares or alpha 2 delta 2 121 (GH4) Glu replaced by Val, an unstable delta chain variant observed in a Spanish family.
PubMed ID: 6629825
PubMed ID: 6629826
Title: Hb A2-Zagreb or alpha 2 delta 2(125)(H3)Gln replaced by Glu, a new delta chain variant in association with delta beta-thalassemia.
PubMed ID: 6629826
PubMed ID: 6469695
Title: HbA2 Victoria delta 24 (B6) Gly-->Asp. A new delta chain variant occurring with beta-thalassemia.
PubMed ID: 6469695
PubMed ID: 6548205
Title: Hemoglobin A2 Fitzroy delta 142 Ala-->Asp: a new delta-chain variant.
PubMed ID: 6548205
PubMed ID: 2869009
Title: Hemoglobin A2 Honai (alpha 2 delta 2(90)(F6)Glu-->Val): a new delta chain variant.
PubMed ID: 2869009
PubMed ID: 3841531
Title: Hb A2 Yokoshima, alpha(2)delta(2)25(B7)Gly-->Asp, a new delta chain variant found in a Japanese family.
PubMed ID: 3841531
PubMed ID: 2477064
Title: Hb A2-Wrens or alpha 2 delta 2 98(FG5) Val-->Met, an unstable delta chain variant identified by sequence analysis of amplified DNA.
PubMed ID: 2477064
PubMed ID: 1742490
Title: Identification of four novel delta-globin gene mutations in Greek Cypriots using polymerase chain reaction and automated fluorescence-based DNA sequence analysis.
PubMed ID: 1742490
PubMed ID: 1787103
Title: Hb A2-Niigata [delta 1(NA1)Val-->Ala]: a new delta chain variant found in the Japanese population.
PubMed ID: 1787103
PubMed ID: 1802883
Title: Hb A2-Parkville or delta 47(CD6)Asp-->Val, a new delta chain variant.
PubMed ID: 1802883
PubMed ID: 2066116
Title: A new delta chain variant hemoglobin A2-Corfu or alpha 2 delta 2 116 Arg-->Cys (G18), detected by delta-globin gene analysis in a Greek family.
PubMed ID: 2066116
DOI: 10.1007/bf00204193
PubMed ID: 8364213
Title: Analysis of delta-globin gene mutations in Greek cypriots.
PubMed ID: 8364213
PubMed ID: 8330984
Title: Hb A2-Grovetown or alpha 2 delta (2)75(E19)Leu-->Val.
PubMed ID: 8330984
PubMed ID: 8401543
Title: A new delta-chain variant hemoglobin A2-Puglia or alpha 2 delta 2 26 Glu-->Asp (B8), detected by DNA analysis in a family of southern Italian origin.
PubMed ID: 8401543
PubMed ID: 7713748
Title: Hb A2-Sant' Antioco alpha 2 delta (2)93(F9)Cys-->Gly: a new delta chain variant identified by sequencing of amplified DNA.
PubMed ID: 7713748
PubMed ID: 8537235
Title: Hb A2-Agrinio [delta 43(CD2)Glu-->Gly(GAG-->GGG)]: a new delta chain variant detected in a Greek family.
PubMed ID: 8537235
PubMed ID: 9101295
Title: Delta-thalassemic phenotype due to two 'novel' delta-globin gene mutations: CD11[GTC-->GGC (A8)-HbA2-Pylos] and CD 85[TTT-->TCT(F1)-HbA2-Etolia].
PubMed ID: 9101295
DOI: 10.1002/(sici)1098-1004(1997)9:4<344::aid-humu7>3.0.co;2-5
PubMed ID: 11939506
Title: Hb A2-Monreale delta146(HC3)His-->Arg, a novel delta chain variant detected in west Sicily.
PubMed ID: 11939506
PubMed ID: 12402333
Title: Epidemiology of the delta globin alleles in southern Italy shows complex molecular, genetic, and phenotypic features.
PubMed ID: 12402333
DOI: 10.1002/humu.10132
PubMed ID: 15921167
Title: Two new delta-globin mutations: Hb A2-Ninive [delta133(H11)Val-Ala] and a delta(+)-thalassemia mutation [-31 (A-->G)] in the TATA box of the delta-globin gene.
PubMed ID: 15921167
DOI: 10.1081/hem-58593
PubMed ID: 16370490
Title: Identification of a new delta chain hemoglobin variant in a beta-thalassemia carrier: Hb A2-mumc [delta13(a10)Ala-->Asp].
PubMed ID: 16370490
PubMed ID: 17145605
Title: Analysis of delta-globin gene alleles in the Sicilian population: identification of five new mutations.
PubMed ID: 17145605
Sequence Information:
- Length: 147
- Mass: 16055
- Checksum: F86BA4A09A57BB05
- Sequence:
MVHLTPEEKT AVNALWGKVN VDAVGGEALG RLLVVYPWTQ RFFESFGDLS SPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFSQLS ELHCDKLHVD PENFRLLGNV LVCVLARNFG KEFTPQMQAA YQKVVAGVAN ALAHKYH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.