Details for: HBQ1

Gene ID: 3049

Symbol: HBQ1

Ensembl ID: ENSG00000086506

Description: hemoglobin subunit theta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 48.6379
    Cell Significance Index: 22.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.9817
    Cell Significance Index: -3.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 7.0764
    Cell Significance Index: -3.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.9937
    Cell Significance Index: -2.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.9880
    Cell Significance Index: 259.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.1108
    Cell Significance Index: -2.9700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.1951
    Cell Significance Index: 20.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0263
    Cell Significance Index: -4.0500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.5733
    Cell Significance Index: 6.4900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5178
    Cell Significance Index: 7.4200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4106
    Cell Significance Index: 3.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1420
    Cell Significance Index: 3.5400
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.1065
    Cell Significance Index: 0.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0274
    Cell Significance Index: 0.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0088
    Cell Significance Index: 3.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0085
    Cell Significance Index: 1.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0077
    Cell Significance Index: 2.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0059
    Cell Significance Index: 3.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0057
    Cell Significance Index: 0.3500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.0034
    Cell Significance Index: 0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0010
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0054
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0094
    Cell Significance Index: -1.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0107
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0279
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0291
    Cell Significance Index: -0.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0292
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0321
    Cell Significance Index: -3.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0334
    Cell Significance Index: -3.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0363
    Cell Significance Index: -0.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0395
    Cell Significance Index: -2.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0457
    Cell Significance Index: -0.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0487
    Cell Significance Index: -1.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0492
    Cell Significance Index: -6.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0492
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0501
    Cell Significance Index: -3.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0573
    Cell Significance Index: -6.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0605
    Cell Significance Index: -4.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0612
    Cell Significance Index: -1.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0612
    Cell Significance Index: -3.2200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0677
    Cell Significance Index: -0.9900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0694
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0731
    Cell Significance Index: -3.4100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0742
    Cell Significance Index: -0.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0763
    Cell Significance Index: -0.8300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0783
    Cell Significance Index: -0.8100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0794
    Cell Significance Index: -1.0800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0813
    Cell Significance Index: -1.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0823
    Cell Significance Index: -3.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0850
    Cell Significance Index: -4.7700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0856
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0875
    Cell Significance Index: -0.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0881
    Cell Significance Index: -3.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0887
    Cell Significance Index: -6.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0922
    Cell Significance Index: -2.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0926
    Cell Significance Index: -4.3500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0993
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1013
    Cell Significance Index: -2.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1013
    Cell Significance Index: -4.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1027
    Cell Significance Index: -2.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1040
    Cell Significance Index: -3.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1047
    Cell Significance Index: -4.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1076
    Cell Significance Index: -2.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1086
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1088
    Cell Significance Index: -1.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1126
    Cell Significance Index: -4.2700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1140
    Cell Significance Index: -1.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1151
    Cell Significance Index: -2.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1161
    Cell Significance Index: -3.8000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1190
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1203
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1221
    Cell Significance Index: -3.9100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1255
    Cell Significance Index: -1.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1263
    Cell Significance Index: -3.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1277
    Cell Significance Index: -2.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1307
    Cell Significance Index: -3.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1314
    Cell Significance Index: -4.1900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1365
    Cell Significance Index: -2.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1378
    Cell Significance Index: -2.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1424
    Cell Significance Index: -1.3500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1424
    Cell Significance Index: -1.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1441
    Cell Significance Index: -2.1000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1470
    Cell Significance Index: -0.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1523
    Cell Significance Index: -3.8900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1536
    Cell Significance Index: -2.4700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1547
    Cell Significance Index: -2.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1560
    Cell Significance Index: -2.1900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1584
    Cell Significance Index: -0.9700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1621
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1624
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1666
    Cell Significance Index: -2.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1674
    Cell Significance Index: -3.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1691
    Cell Significance Index: -2.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1701
    Cell Significance Index: -2.2600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1708
    Cell Significance Index: -4.2700
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1734
    Cell Significance Index: -2.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Composition:** HBQ1 is a subunit of the hemoglobin complex, composed of a heme group, a globin protein, and a histidine residue that binds to the heme. 2. **Oxygen Binding:** HBQ1 exhibits high affinity for oxygen, allowing for efficient oxygen transport and binding. 3. **Cellular Expression:** HBQ1 is expressed in various cell types, including type I pneumocytes, lung endothelial cells, and erythroid progenitor cells. 4. **Protein Binding:** HBQ1 interacts with other proteins, such as haptoglobin, to form a complex that facilitates the clearance of hemoglobin from the circulation. **Pathways and Functions:** 1. **Cellular Oxidant Detoxification:** HBQ1 participates in the detoxification of reactive oxygen species (ROS) by facilitating the reduction of hydrogen peroxide to water. 2. **Heme Binding:** HBQ1 binds to heme, which is essential for the formation of the hemoglobin complex. 3. **Oxygen Transport:** HBQ1 plays a critical role in oxygen transport and binding, facilitating the delivery of oxygen to tissues. 4. **Peroxidase Activity:** HBQ1 exhibits peroxidase activity, allowing it to reduce hydrogen peroxide to water. 5. **Protein Binding:** HBQ1 interacts with other proteins, such as haptoglobin, to form a complex that facilitates the clearance of hemoglobin from the circulation. **Clinical Significance:** HBQ1's involvement in oxygen transport, cellular oxidant detoxification, and protein binding makes it an essential component of the immune system. Abnormalities in HBQ1 expression or function have been implicated in various diseases, including: 1. **Anemia:** Alterations in HBQ1 expression have been linked to anemia, a condition characterized by reduced red blood cell count or hemoglobin levels. 2. **Oxygen Transport Disorders:** HBQ1 dysfunction has been implicated in disorders affecting oxygen transport, such as sickle cell disease and beta-thalassemia. 3. **Oxidative Stress:** HBQ1's role in cellular oxidant detoxification makes it a potential target for therapies aimed at mitigating oxidative stress in diseases such as cancer and neurodegenerative disorders. In conclusion, HBQ1 is a vital component of the hemoglobin complex, playing a critical role in oxygen transport, cellular oxidant detoxification, and protein binding. Its clinical significance is underscored by its involvement in various diseases, highlighting the importance of further research into the immunological mechanisms underlying HBQ1's functions.

Genular Protein ID: 122231094

Symbol: HBAT_HUMAN

Name: Hemoglobin subunit theta-1

UniProtKB Accession Codes:

P09105 Q13723 Q1W6G5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3422341

Title: Structure and expression of the human theta 1 globin gene.

PubMed ID: 3422341

DOI: 10.1038/331094a0

PubMed ID: 3408475

Title: Nucleotide sequence of the human theta 1-globin gene.

PubMed ID: 3408475

DOI: 10.1007/bf00561460

PubMed ID: 16728641

Title: A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

PubMed ID: 16728641

DOI: 10.1126/science.1126431

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2569721

Title: Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters.

PubMed ID: 2569721

DOI: 10.1093/nar/17.14.5687

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 142
  • Mass: 15508
  • Checksum: 9D4F103D758694D6
  • Sequence:
    • MALSAEDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KTYFSHLDLS PGSSQVRAHG 
QKVADALSLA VERLDDLPHA LSALSHLHAC QLRVDPASFQ LLGHCLLVTL ARHYPGDFSP 
ALQASLDKFL SHVISALVSE YR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.