Details for: HCFC1

Gene ID: 3054

Symbol: HCFC1

Ensembl ID: ENSG00000172534

Description: host cell factor C1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.5133
    Cell Significance Index: -14.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.1201
    Cell Significance Index: -16.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.9158
    Cell Significance Index: -22.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.2669
    Cell Significance Index: -18.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.8838
    Cell Significance Index: -21.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4922
    Cell Significance Index: -18.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3696
    Cell Significance Index: -18.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0818
    Cell Significance Index: -21.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2027
    Cell Significance Index: -15.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0189
    Cell Significance Index: -19.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9680
    Cell Significance Index: 136.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8263
    Cell Significance Index: 297.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2093
    Cell Significance Index: 131.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1961
    Cell Significance Index: 71.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1566
    Cell Significance Index: 15.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7386
    Cell Significance Index: 21.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5656
    Cell Significance Index: 29.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4919
    Cell Significance Index: 444.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4863
    Cell Significance Index: 57.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4794
    Cell Significance Index: 13.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4501
    Cell Significance Index: 29.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4302
    Cell Significance Index: 9.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4208
    Cell Significance Index: 21.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4044
    Cell Significance Index: 49.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3995
    Cell Significance Index: 18.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3612
    Cell Significance Index: 71.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3550
    Cell Significance Index: 64.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3260
    Cell Significance Index: 203.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3146
    Cell Significance Index: 63.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2934
    Cell Significance Index: 160.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2344
    Cell Significance Index: 10.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2243
    Cell Significance Index: 30.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2157
    Cell Significance Index: 95.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1993
    Cell Significance Index: 5.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1910
    Cell Significance Index: 3.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1785
    Cell Significance Index: 17.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1761
    Cell Significance Index: 4.9200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1647
    Cell Significance Index: 2.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1469
    Cell Significance Index: 52.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1444
    Cell Significance Index: 3.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1425
    Cell Significance Index: 2.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1337
    Cell Significance Index: 25.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1277
    Cell Significance Index: 16.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0960
    Cell Significance Index: 66.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0830
    Cell Significance Index: 5.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0750
    Cell Significance Index: 4.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0714
    Cell Significance Index: 12.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0360
    Cell Significance Index: 1.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0322
    Cell Significance Index: 2.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0310
    Cell Significance Index: 0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0018
    Cell Significance Index: 0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0204
    Cell Significance Index: -11.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0241
    Cell Significance Index: -2.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0297
    Cell Significance Index: -13.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0304
    Cell Significance Index: -3.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0359
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0438
    Cell Significance Index: -9.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0581
    Cell Significance Index: -7.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0680
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0713
    Cell Significance Index: -8.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0715
    Cell Significance Index: -20.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0759
    Cell Significance Index: -4.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0873
    Cell Significance Index: -6.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0889
    Cell Significance Index: -2.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0902
    Cell Significance Index: -6.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0914
    Cell Significance Index: -13.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0936
    Cell Significance Index: -2.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1373
    Cell Significance Index: -7.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1630
    Cell Significance Index: -10.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1734
    Cell Significance Index: -5.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1765
    Cell Significance Index: -18.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1905
    Cell Significance Index: -2.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2166
    Cell Significance Index: -6.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2298
    Cell Significance Index: -18.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2308
    Cell Significance Index: -4.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2331
    Cell Significance Index: -6.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2614
    Cell Significance Index: -2.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2844
    Cell Significance Index: -4.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2931
    Cell Significance Index: -17.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2975
    Cell Significance Index: -13.1600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3060
    Cell Significance Index: -2.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3182
    Cell Significance Index: -2.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3373
    Cell Significance Index: -8.6700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.3431
    Cell Significance Index: -2.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3642
    Cell Significance Index: -2.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3645
    Cell Significance Index: -13.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3653
    Cell Significance Index: -10.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3952
    Cell Significance Index: -5.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3998
    Cell Significance Index: -5.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4202
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HCFC1 is a 43-kDa protein that belongs to the host cell factor family. It contains multiple protein-protein interaction domains, including a WD40 repeat domain, a coiled-coil domain, and a CHD domain. These domains enable HCFC1 to interact with various transcription factors, chromatin-modifying enzymes, and other proteins. HCFC1 is also a histone acetyltransferase (HAT) and has been shown to interact with histone-modifying complexes, such as the MLL1/2 complex. **Pathways and Functions** HCFC1 is involved in various cellular pathways, including: 1. **Cell Cycle Regulation**: HCFC1 interacts with cyclin-dependent kinases (CDKs) and cyclins to regulate the cell cycle. 2. **Chromatin Remodeling**: HCFC1 interacts with chromatin-modifying enzymes, such as histone acetyltransferases (HATs) and histone methyltransferases (HMTs), to regulate chromatin structure and gene expression. 3. **Transcriptional Activation**: HCFC1 interacts with transcription factors, such as NF-κB and AP-1, to activate transcription of target genes. 4. **Histone Acetylation**: HCFC1 is a HAT that acetylates histones, leading to chromatin relaxation and increased gene expression. 5. **Mitochondrial Biogenesis**: HCFC1 interacts with transcription factors and chromatin-modifying enzymes to regulate mitochondrial biogenesis and function. **Clinical Significance** HCFC1 has been implicated in various diseases, including: 1. **Cancer**: HCFC1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and reduced survival rates. 2. **Neurodegenerative Diseases**: HCFC1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Its expression is reduced in these diseases, and its overexpression has been shown to reduce disease severity. 3. **Immune Disorders**: HCFC1 is expressed in myeloid dendritic cells and is involved in immune responses. Its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, HCFC1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, chromatin remodeling, and transcriptional activation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to fully understand the role of HCFC1 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 3493143870

Symbol: HCFC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51610 Q6P4G5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8392914

Title: The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.

PubMed ID: 8392914

DOI: 10.1016/0092-8674(93)90299-6

PubMed ID: 7876203

Title: The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.

PubMed ID: 7876203

DOI: 10.1074/jbc.270.9.4387

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7829097

Title: Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28.

PubMed ID: 7829097

DOI: 10.1006/geno.1994.1455

PubMed ID: 10920196

Title: Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): a potential role for proteolytic regulation of coactivator function.

PubMed ID: 10920196

DOI: 10.1073/pnas.160266697

PubMed ID: 7590226

Title: The HCF repeat is an unusual proteolytic cleavage signal.

PubMed ID: 7590226

DOI: 10.1101/gad.9.20.2445

PubMed ID: 9271389

Title: Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.

PubMed ID: 9271389

DOI: 10.1128/mcb.17.9.5117

PubMed ID: 9389645

Title: Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.

PubMed ID: 9389645

DOI: 10.1101/gad.11.23.3122

PubMed ID: 9990006

Title: Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latency.

PubMed ID: 9990006

DOI: 10.1073/pnas.96.4.1229

PubMed ID: 10675337

Title: The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.

PubMed ID: 10675337

DOI: 10.1093/emboj/19.4.683

PubMed ID: 10623756

Title: Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency.

PubMed ID: 10623756

DOI: 10.1128/jvi.74.2.934-943.2000

PubMed ID: 10976766

Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

PubMed ID: 10976766

DOI: 10.1023/a:1007177623283

PubMed ID: 10629049

Title: Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.

PubMed ID: 10629049

DOI: 10.1128/mcb.20.3.919-928.2000

PubMed ID: 10779346

Title: A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells.

PubMed ID: 10779346

DOI: 10.1128/mcb.20.10.3568-3575.2000

PubMed ID: 10871379

Title: Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16.

PubMed ID: 10871379

DOI: 10.1093/nar/28.12.2446

PubMed ID: 10984507

Title: N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif.

PubMed ID: 10984507

DOI: 10.1073/pnas.190062797

PubMed ID: 12235138

Title: Interaction of HCF-1 with a cellular nuclear export factor.

PubMed ID: 12235138

DOI: 10.1074/jbc.m205440200

PubMed ID: 12244100

Title: Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1.

PubMed ID: 12244100

DOI: 10.1074/jbc.m206226200

PubMed ID: 14532282

Title: HCF-1 functions as a coactivator for the zinc finger protein Krox20.

PubMed ID: 14532282

DOI: 10.1074/jbc.m303470200

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 15190068

Title: A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1.

PubMed ID: 15190068

DOI: 10.1074/jbc.m401255200

PubMed ID: 15199122

Title: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

PubMed ID: 15199122

DOI: 10.1128/mcb.24.13.5639-5649.2004

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 15705566

Title: Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman.

PubMed ID: 15705566

DOI: 10.1074/jbc.m500728200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16624878

Title: Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors.

PubMed ID: 16624878

DOI: 10.1073/pnas.0602109103

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17578910

Title: The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.

PubMed ID: 17578910

DOI: 10.1073/pnas.0704351104

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 18838538

Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.

PubMed ID: 18838538

DOI: 10.1128/mcb.00976-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131338

Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

PubMed ID: 19131338

DOI: 10.1074/jbc.m805872200

PubMed ID: 19815555

Title: The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

PubMed ID: 19815555

DOI: 10.1074/jbc.m109.046755

PubMed ID: 19188440

Title: Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.

PubMed ID: 19188440

DOI: 10.1128/mcb.01517-08

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 20018852

Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.

PubMed ID: 20018852

DOI: 10.1074/jbc.c109.087981

PubMed ID: 20200153

Title: The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.

PubMed ID: 20200153

DOI: 10.1074/jbc.m109.072579

PubMed ID: 20805357

Title: The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.

PubMed ID: 20805357

DOI: 10.1128/mcb.00396-10

PubMed ID: 21285374

Title: Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.

PubMed ID: 21285374

DOI: 10.1073/pnas.1013822108

PubMed ID: 23353889

Title: TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.

PubMed ID: 23353889

DOI: 10.1038/emboj.2012.357

PubMed ID: 23629655

Title: Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1).

PubMed ID: 23629655

DOI: 10.1074/jbc.m112.439729

PubMed ID: 28302723

Title: Identification and characterization of a missense mutation in the O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability.

PubMed ID: 28302723

DOI: 10.1074/jbc.m116.771030

PubMed ID: 28584052

Title: Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability.

PubMed ID: 28584052

DOI: 10.1074/jbc.m117.790097

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30664650

Title: BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.

PubMed ID: 30664650

DOI: 10.1038/s41467-018-08255-x

PubMed ID: 23000143

Title: A noncoding, regulatory mutation implicates HCFC1 in nonsyndromic intellectual disability.

PubMed ID: 23000143

DOI: 10.1016/j.ajhg.2012.08.011

Sequence Information:

  • Length: 2035
  • Mass: 208732
  • Checksum: 0B0C581E2454631E
  • Sequence:
    • MASAVSPANL PAVLLQPRWK RVVGWSGPVP RPRHGHRAVA IKELIVVFGG GNEGIVDELH 
VYNTATNQWF IPAVRGDIPP GCAAYGFVCD GTRLLVFGGM VEYGKYSNDL YELQASRWEW 
KRLKAKTPKN GPPPCPRLGH SFSLVGNKCY LFGGLANDSE DPKNNIPRYL NDLYILELRP 
GSGVVAWDIP ITYGVLPPPR ESHTAVVYTE KDNKKSKLVI YGGMSGCRLG DLWTLDIDTL 
TWNKPSLSGV APLPRSLHSA TTIGNKMYVF GGWVPLVMDD VKVATHEKEW KCTNTLACLN 
LDTMAWETIL MDTLEDNIPR ARAGHCAVAI NTRLYIWSGR DGYRKAWNNQ VCCKDLWYLE 
TEKPPPPARV QLVRANTNSL EVSWGAVATA DSYLLQLQKY DIPATAATAT SPTPNPVPSV 
PANPPKSPAP AAAAPAVQPL TQVGITLLPQ AAPAPPTTTT IQVLPTVPGS SISVPTAART 
QGVPAVLKVT GPQATTGTPL VTMRPASQAG KAPVTVTSLP AGVRMVVPTQ SAQGTVIGSS 
PQMSGMAALA AAAAATQKIP PSSAPTVLSV PAGTTIVKTM AVTPGTTTLP ATVKVASSPV 
MVSNPATRML KTAAAQVGTS VSSATNTSTR PIITVHKSGT VTVAQQAQVV TTVVGGVTKT 
ITLVKSPISV PGGSALISNL GKVMSVVQTK PVQTSAVTGQ ASTGPVTQII QTKGPLPAGT 
ILKLVTSADG KPTTIITTTQ ASGAGTKPTI LGISSVSPST TKPGTTTIIK TIPMSAIITQ 
AGATGVTSSP GIKSPITIIT TKVMTSGTGA PAKIITAVPK IATGHGQQGV TQVVLKGAPG 
QPGTILRTVP MGGVRLVTPV TVSAVKPAVT TLVVKGTTGV TTLGTVTGTV STSLAGAGGH 
STSASLATPI TTLGTIATLS SQVINPTAIT VSAAQTTLTA AGGLTTPTIT MQPVSQPTQV 
TLITAPSGVE AQPVHDLPVS ILASPTTEQP TATVTIADSG QGDVQPGTVT LVCSNPPCET 
HETGTTNTAT TTVVANLGGH PQPTQVQFVC DRQEAAASLV TSTVGQQNGS VVRVCSNPPC 
ETHETGTTNT ATTATSNMAG QHGCSNPPCE THETGTTNTA TTAMSSVGAN HQRDARRACA 
AGTPAVIRIS VATGALEAAQ GSKSQCQTRQ TSATSTTMTV MATGAPCSAG PLLGPSMARE 
PGGRSPAFVQ LAPLSSKVRL SSPSIKDLPA GRHSHAVSTA AMTRSSVGAG EPRMAPVCES 
LQGGSPSTTV TVTALEALLC PSATVTQVCS NPPCETHETG TTNTATTSNA GSAQRVCSNP 
PCETHETGTT HTATTATSNG GTGQPEGGQQ PPAGRPCETH QTTSTGTTMS VSVGALLPDA 
TSSHRTVESG LEVAAAPSVT PQAGTALLAP FPTQRVCSNP PCETHETGTT HTATTVTSNM 
SSNQDPPPAA SDQGEVESTQ GDSVNITSSS AITTTVSSTL TRAVTTVTQS TPVPGPSVPP 
PEELQVSPGP RQQLPPRQLL QSASTALMGE SAEVLSASQT PELPAAVDLS STGEPSSGQE 
SAGSAVVATV VVQPPPPTQS EVDQLSLPQE LMAEAQAGTT TLMVTGLTPE ELAVTAAAEA 
AAQAAATEEA QALAIQAVLQ AAQQAVMGTG EPMDTSEAAA TVTQAELGHL SAEGQEGQAT 
TIPIVLTQQE LAALVQQQQL QEAQAQQQHH HLPTEALAPA DSLNDPAIES NCLNELAGTV 
PSTVALLPST ATESLAPSNT FVAPQPVVVA SPAKLQAAAT LTEVANGIES LGVKPDLPPP 
PSKAPMKKEN QWFDVGVIKG TNVMVTHYFL PPDDAVPSDD DLGTVPDYNQ LKKQELQPGT 
AYKFRVAGIN ACGRGPFSEI SAFKTCLPGF PGAPCAIKIS KSPDGAHLTW EPPSVTSGKI 
IEYSVYLAIQ SSQAGGELKS STPAQLAFMR VYCGPSPSCL VQSSSLSNAH IDYTTKPAII 
FRIAARNEKG YGPATQVRWL QETSKDSSGT KPANKRPMSS PEMKSAPKKS KADGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.