Details for: HDC

Gene ID: 3067

Symbol: HDC

Ensembl ID: ENSG00000140287

Description: histidine decarboxylase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 2.64
    Marker Score: 1254
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7454
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251814
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.01
    Marker Score: 524
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2549
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.89
    Marker Score: 400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.68
    Marker Score: 353
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.64
    Marker Score: 1841
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.62
    Marker Score: 1252
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.61
    Marker Score: 353
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.43
    Marker Score: 191
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.41
    Marker Score: 133
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 843
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 676
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.33
    Marker Score: 248
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.32
    Marker Score: 552
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 154
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3691
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.23
    Marker Score: 153
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.21
    Marker Score: 129
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 404
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 43.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.16
    Marker Score: 297.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.14
    Marker Score: 108
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 90
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 397
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 152
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 102
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.12
    Marker Score: 141
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 104.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.11
    Marker Score: 269
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.1
    Marker Score: 100
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.1
    Marker Score: 129
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.1
    Marker Score: 141
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 122
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 29.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 88.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.09
    Marker Score: 301
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.08
    Marker Score: 100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.08
    Marker Score: 227
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 308
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 95
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.06
    Marker Score: 91
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 15

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Other Information

**Key characteristics:** - HDC is a protein of the cytochrome P450 family. - It is expressed in a variety of cell types, including basophils, goblet cells, and epithelial cells. - It is a highly regulated enzyme that is stimulated by histamine and other inflammatory mediators. **Pathways and functions:** - HDC is involved in the catabolism of histidine, which is a precursor to histamine. - It also plays a role in the biosynthesis of other compounds involved in inflammation, such as prostaglandins and leukotrienes. - HDC is involved in the regulation of inflammation by controlling the release of histamine from immune cells. **Clinical significance:** - Mutations in HDC genes have been linked to a number of inflammatory diseases, including asthma, allergies, and inflammatory bowel disease. - HDC inhibitors are being investigated as potential treatments for these diseases. **Additional information:** - HDC is a conserved enzyme that is found in organisms from yeast to humans. - It is a highly active enzyme that requires a coenzyme, histidine, for its activity. - HDC is a well-studied enzyme that has been extensively characterized in both biochemical and pharmacological studies.

Genular Protein ID: 3688287387

Symbol: DCHS_HUMAN

Name: Histidine decarboxylase

UniProtKB Accession Codes:

P19113 A1L4G0 B7ZM01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 CarbonylDB 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2216786

Title: Nucleotide sequence of the cDNA encoding L-histidine decarboxylase derived from human basophilic leukemia cell line, KU-812-F.

PubMed ID: 2216786

DOI: 10.1093/nar/18.19.5891

PubMed ID: 1768863

Title: Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15.

PubMed ID: 1768863

DOI: 10.3109/10425179109020795

PubMed ID: 1425659

Title: Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells.

PubMed ID: 1425659

DOI: 10.1111/j.1432-1033.1992.tb17317.x

PubMed ID: 8288622

Title: Structure of the L-histidine decarboxylase gene.

PubMed ID: 8288622

DOI: 10.1016/s0021-9258(17)42292-7

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22767596

Title: Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase.

PubMed ID: 22767596

DOI: 10.1074/jbc.m112.381897

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 662
  • Mass: 74141
  • Checksum: D7611CFAAD60F469
  • Sequence:
    • MMEPEEYRER GREMVDYICQ YLSTVRERRV TPDVQPGYLR AQLPESAPED PDSWDSIFGD 
IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN CLGFTWASSP ACTELEMNVM 
DWLAKMLGLP EHFLHHHPSS QGGGVLQSTV SESTLIALLA ARKNKILEMK TSEPDADESC 
LNARLVAYAS DQAHSSVEKA GLISLVKMKF LPVDDNFSLR GEALQKAIEE DKQRGLVPVF 
VCATLGTTGV CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT 
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GVATDFMHWQ IPLSRRFRSV 
KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPSFEI PAKRHLGLVV FRLKGPNCLT 
ENVLKEIAKA GRLFLIPATI QDKLIIRFTV TSQFTTRDDI LRDWNLIRDA ATLILSQHCT 
SQPSPRVGNL ISQIRGARAW ACGTSLQSVS GAGDDPVQAR KIIKQPQRVG AGPMKRENGL 
HLETLLDPVD DCFSEEAPDA TKHKLSSFLF SYLSVQTKKK TVRSLSCNSV PVSAQKPLPT 
EASVKNGGSS RVRIFSRFPE DMMMLKKSAF KKLIKFYSVP SFPECSSQCG LQLPCCPLQA 
MV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.