Gene NCKAP1L - ENSG00000123338 | NCBI Gene ID: 3071

Details for: NCKAP1L

Gene ID: 3071

Symbol: NCKAP1L

Ensembl ID: ENSG00000123338

Description: NCK associated protein 1 like

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Neutrophil degranulation
(R-HSA-6798695)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin polymerization-dependent cell motility
(GO:0070358)
B cell homeostasis
(GO:0001782)
B cell receptor signaling pathway
(GO:0050853)
Cell migration
(GO:0016477)
Cell morphogenesis
(GO:0000902)
Cell projection assembly
(GO:0030031)
Chemotaxis
(GO:0006935)
Cortical actin cytoskeleton organization
(GO:0030866)
Cytosol
(GO:0005829)
Erythrocyte development
(GO:0048821)
Erythrocyte homeostasis
(GO:0034101)
Extracellular exosome
(GO:0070062)
Ficolin-1-rich granule membrane
(GO:0101003)
Gtpase activator activity
(GO:0005096)
Maintenance of cell polarity
(GO:0030011)
Membrane
(GO:0016020)
Myeloid cell homeostasis
(GO:0002262)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cytotoxic t cell degranulation
(GO:0043318)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of myosin-light-chain-phosphatase activity
(GO:0035509)
Neuron projection morphogenesis
(GO:0048812)
Neutrophil chemotaxis
(GO:0030593)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cd4-positive, alpha-beta t cell differentiation
(GO:0043372)
Positive regulation of cd8-positive, alpha-beta t cell differentiation
(GO:0043378)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of lymphocyte differentiation
(GO:0045621)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of neutrophil migration
(GO:1902624)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of torc2 signaling
(GO:1904515)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activator activity
(GO:0030295)
Response to xenobiotic stimulus
(GO:0009410)
Scar complex
(GO:0031209)
Secretory granule membrane
(GO:0030667)
T cell homeostasis
(GO:0043029)
Torc2 complex binding
(GO:1904841)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.02
Marker Score: 1004
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.94
Marker Score: 108430
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.85
Marker Score: 2111
Cell Name: blood cell (CL0000081)
Fold Change: 1.83
Marker Score: 21327
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.73
Marker Score: 4307
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.71
Marker Score: 43818
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.69
Marker Score: 930
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.58
Marker Score: 3084
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.56
Marker Score: 1133
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.54
Marker Score: 15641
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.54
Marker Score: 2681
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.53
Marker Score: 3691
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.46
Marker Score: 1475
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167948
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.45
Marker Score: 594
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.41
Marker Score: 610
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.39
Marker Score: 1385.5
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.36
Marker Score: 1634
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.35
Marker Score: 5540
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.31
Marker Score: 472
Cell Name: mature T cell (CL0002419)
Fold Change: 1.29
Marker Score: 12822
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.27
Marker Score: 865
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.25
Marker Score: 1229
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.22
Marker Score: 828
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.2
Marker Score: 423
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.19
Marker Score: 3525
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.19
Marker Score: 581
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.18
Marker Score: 708
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.17
Marker Score: 270
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.17
Marker Score: 3686
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.16
Marker Score: 797
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.15
Marker Score: 7017
Cell Name: memory B cell (CL0000787)
Fold Change: 1.15
Marker Score: 872
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.15
Marker Score: 1631
Cell Name: naive B cell (CL0000788)
Fold Change: 1.15
Marker Score: 1027
Cell Name: microglial cell (CL0000129)
Fold Change: 1.14
Marker Score: 2079
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.14
Marker Score: 824
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.13
Marker Score: 2936
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.13
Marker Score: 4747
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.11
Marker Score: 703
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.11
Marker Score: 387
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.11
Marker Score: 1039
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.1
Marker Score: 2992
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.09
Marker Score: 1054
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.06
Marker Score: 2072
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.05
Marker Score: 6739
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.04
Marker Score: 509
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.04
Marker Score: 433
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.03
Marker Score: 2902
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.01
Marker Score: 1191
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.01
Marker Score: 883
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1
Marker Score: 934
Cell Name: osteoclast (CL0000092)
Fold Change: 1
Marker Score: 497
Cell Name: Unknown (CL0000548)
Fold Change: 1
Marker Score: 727
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71735
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47961
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Marker Score: 52565
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.99
Marker Score: 746
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.98
Marker Score: 1003
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.98
Marker Score: 1447
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30400
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.98
Marker Score: 314
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.98
Marker Score: 245
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.97
Marker Score: 2676
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.96
Marker Score: 477
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493
Cell Name: macrophage (CL0000235)
Fold Change: 0.95
Marker Score: 1059
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.95
Marker Score: 1308
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.95
Marker Score: 629
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.93
Marker Score: 568
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.92
Marker Score: 3825
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.91
Marker Score: 315
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.91
Marker Score: 455
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.91
Marker Score: 470
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2721
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5165
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 362
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.9
Marker Score: 2202
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.9
Marker Score: 1884
Cell Name: centroblast (CL0009112)
Fold Change: 0.89
Marker Score: 439
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.89
Marker Score: 2583
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: immature B cell (CL0000816)
Fold Change: 0.88
Marker Score: 580
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.87
Marker Score: 660
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.87
Marker Score: 682
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5259
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.86
Marker Score: 628
Cell Name: plasmablast (CL0000980)
Fold Change: 0.86
Marker Score: 1138
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.85
Marker Score: 585
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.83
Marker Score: 436
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.83
Marker Score: 256
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.82
Marker Score: 700
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.82
Marker Score: 1473
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.82
Marker Score: 271
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.82
Marker Score: 284
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.82
Marker Score: 686
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.8
Marker Score: 460
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 604.5

Hover over a box to see details here...

**Key characteristics:** * NCKAP1L is a transmembrane protein that is localized to the cell surface. * It is a member of the NCKAP family of proteins, which are involved in the regulation of phagocytosis. * NCKAP1L is a key regulator of phagocytosis, and its expression is often upregulated in diseases such as cancer and inflammation. **Pathways and functions:** * NCKAP1L is involved in the regulation of phagocytosis by binding to the Fcgamma receptor (fcgr) on the surface of macrophages and dendritic cells. * When NCKAP1L binds to fcgr, it recruits the adapter protein AP-2 to the cell surface. * AP-2 then recruits the phagocytic complex to the cell surface, which leads to the internalization of foreign particles. * NCKAP1L also plays a role in the regulation of the Rac1 gtpase cycle, which is a signaling pathway that is involved in the regulation of phagocytosis. **Clinical significance:** NCKAP1L is a key regulator of phagocytosis, and its expression is often upregulated in diseases such as cancer and inflammation. Mutations in NCKAP1L have been linked to a number of human diseases, including cancer, chronic inflammatory diseases, and autoimmune disorders. **Additional information:** * NCKAP1L is a highly conserved protein, with a similar protein found in other mammals. * It is a promising target for the treatment of cancer and inflammation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Membrane-associated protein HEM-1

Genular Protein ID: 4202610991

Symbol: NCKPL_HUMAN

Name: Membrane-associated protein HEM-1

UniProtKB Accession Codes:

P55160 B4DUT5 Q52LW0

Database IDs:

Citations:

PubMed ID: 1932118

Title: Hem-1, a potential membrane protein, with expression restricted to blood cells.

PubMed ID: 1932118

DOI: 10.1016/0167-4781(91)90109-y

PubMed ID: 7643388

Title: The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis.

PubMed ID: 7643388

DOI: 10.1006/jmbi.1995.0414

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 17696648

Title: An actin-based wave generator organizes cell motility.

PubMed ID: 17696648

DOI: 10.1371/journal.pbio.0050221

PubMed ID: 20969869

Title: Hem-1: putting the 'WAVE' into actin polymerization during an immune response.

PubMed ID: 20969869

DOI: 10.1016/j.febslet.2010.10.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32647003

Title: HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.

PubMed ID: 32647003

DOI: 10.1126/science.aay5663

Sequence Information:

Length: 1127
Mass: 128153
Checksum: 9389BAB163BAEA45
Sequence:

MSLTSAYQHK LAEKLTILND RGQGVLIRMY NIKKTCSDPK SKPPFLLEKS MEPSLKYINK 
KFPNIDVRNS TQHLGPVHRE KAEIIRFLTN YYQSFVDVME FRDHVYELLN TIDACQCHFD 
INLNFDFTRS YLDLIVTYTS VILLLSRIED RRILIGMYNC AHEMLHGHGD PSFARLGQMV 
LEYDHPLKKL TEEFGPHTKA VSGALLSLHF LFVRRNQGAE QWRSAQLLSL ISNPPAMINP 
ANSDTMACEY LSVEVMERWI IIGFLLCHGC LNSNSQCQKL WKLCLQGSLY ITLIREDVLQ 
VHKVTEDLFS SLKGYGKRVA DIKESKEHVI ANSGQFHCQR RQFLRMAVKE LETVLADEPG 
LLGPKALFAF MALSFIRDEV TWLVRHTENV TKTKTPEDYA DSSIAELLFL LEGIRSLVRR 
HIKVIQQYHL QYLARFDALV LSDIIQNLSV CPEEESIIMS SFVSILSSLN LKQVDNGEKF 
EFSGLRLDWF RLQAYTSVAK APLHLHENPD LAKVMNLIVF HSRMLDSVEK LLVETSDLST 
FCFHLRIFEK MFAMTLEESA MLRYAIAFPL ICAHFVHCTH EMCPEEYPHL KNHGLHHCNS 
FLEELAKQTS NCVLEICAEQ RNLSEQLLPK HCATTISKAK NKKTRKQRQT PRKGEPERDK 
PGAESHRKNR SIVTNMDKLH LNLTELALTM NHVYSFSVFE HTIFPSEYLS SHLEARLNRA 
IVWLAGYNAT TQEIVRPSEL LAGVKAYIGF IQSLAQFLGA DASRVIRNAL LQQTQPLDSC 
GEQTITTLYT NWYLESLLRQ ASSGTIILSP AMQAFVSLPR EGEQNFSAEE FSDISEMRAL 
AELLGPYGMK FLSENLMWHV TSQIVELKKL VVENMDILVQ IRSNFSKPDL MASLLPQLTG 
AENVLKRMTI IGVILSFRAM AQEGLREVFS SHCPFLMGPI ECLKEFVTPD TDIKVTLSIF 
ELASAAGVGC DIDPALVAAI ANLKADTSSP EEEYKVACLL LIFLAVSLPL LATDPSSFYS 
IEKDGYNNNI HCLTKAIIQV SAALFTLYNK NIETHLKEFL VVASVSLLQL GQETDKLKTR 
NRESISLLMR LVVEESSFLT LDMLESCFPY VLLRNAYREV SRAFHLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: NCKAP1L

Associated with

Cells (max top 100)

Other Information

Hem-1, a potential membrane protein, with expression restricted to blood cells. PubMed ID: 1932118

The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis. PubMed ID: 7643388

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PubMed ID: 16417406

An actin-based wave generator organizes cell motility. PubMed ID: 17696648

Hem-1: putting the 'WAVE' into actin polymerization during an immune response. PubMed ID: 20969869

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. PubMed ID: 32647003