NCKAP1L | ENSG00000123338 | NCBI 3071

Details for: NCKAP1L

Gene ID: 3071

Symbol: NCKAP1L

Ensembl ID: ENSG00000123338

Description: NCK associated protein 1 like

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Neutrophil degranulation
(R-HSA-6798695)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin polymerization-dependent cell motility
(GO:0070358)
B cell homeostasis
(GO:0001782)
B cell receptor signaling pathway
(GO:0050853)
Cell migration
(GO:0016477)
Cell morphogenesis
(GO:0000902)
Cell projection assembly
(GO:0030031)
Chemotaxis
(GO:0006935)
Cortical actin cytoskeleton organization
(GO:0030866)
Cytosol
(GO:0005829)
Erythrocyte development
(GO:0048821)
Erythrocyte homeostasis
(GO:0034101)
Extracellular exosome
(GO:0070062)
Ficolin-1-rich granule membrane
(GO:0101003)
Gtpase activator activity
(GO:0005096)
Maintenance of cell polarity
(GO:0030011)
Membrane
(GO:0016020)
Myeloid cell homeostasis
(GO:0002262)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cytotoxic t cell degranulation
(GO:0043318)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-17 production
(GO:0032700)
Neuron projection morphogenesis
(GO:0048812)
Neutrophil chemotaxis
(GO:0030593)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cd4-positive, alpha-beta t cell differentiation
(GO:0043372)
Positive regulation of cd8-positive, alpha-beta t cell differentiation
(GO:0043378)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of lymphocyte differentiation
(GO:0045621)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of neutrophil migration
(GO:1902624)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of torc2 signaling
(GO:1904515)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activator activity
(GO:0030295)
Response to xenobiotic stimulus
(GO:0009410)
Scar complex
(GO:0031209)
Secretory granule membrane
(GO:0030667)
T cell homeostasis
(GO:0043029)
Torc2 complex binding
(GO:1904841)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 78.8838
Cell Significance Index: -12.2700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 34.0212
Cell Significance Index: -17.5000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 19.1805
Cell Significance Index: -4.8700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.2518
Cell Significance Index: -12.6400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.9293
Cell Significance Index: -15.1400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.7670
Cell Significance Index: -12.7700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.3492
Cell Significance Index: -7.3300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.3350
Cell Significance Index: -13.1600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.9251
Cell Significance Index: 73.1200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.5110
Cell Significance Index: 46.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.0983
Cell Significance Index: 45.4600
Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.9487
Cell Significance Index: 12.4400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.7291
Cell Significance Index: 111.5600
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.7018
Cell Significance Index: 11.2900
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 1.6798
Cell Significance Index: 4.5000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.0351
Cell Significance Index: 30.4000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9540
Cell Significance Index: 112.5000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7308
Cell Significance Index: 139.0800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.6221
Cell Significance Index: 16.6400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4823
Cell Significance Index: 47.7100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3863
Cell Significance Index: 348.7900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2698
Cell Significance Index: 43.8800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2209
Cell Significance Index: 4.7100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2127
Cell Significance Index: 23.1400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0643
Cell Significance Index: 4.4500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0640
Cell Significance Index: 3.8400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0504
Cell Significance Index: 31.5000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.0226
Cell Significance Index: 0.3300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0043
Cell Significance Index: -0.1500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0051
Cell Significance Index: -0.1300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0055
Cell Significance Index: -10.3800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0070
Cell Significance Index: -1.3800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0075
Cell Significance Index: -4.2500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0076
Cell Significance Index: -14.0200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0080
Cell Significance Index: -12.2600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0102
Cell Significance Index: -13.9200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0161
Cell Significance Index: -12.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0172
Cell Significance Index: -3.4600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0217
Cell Significance Index: -11.8400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0233
Cell Significance Index: -8.3400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0240
Cell Significance Index: -17.5900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0240
Cell Significance Index: -5.0500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0256
Cell Significance Index: -16.2500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0330
Cell Significance Index: -9.4900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0331
Cell Significance Index: -15.0200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0363
Cell Significance Index: -6.2000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0381
Cell Significance Index: -1.7300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0525
Cell Significance Index: -6.0200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0529
Cell Significance Index: -5.4000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0668
Cell Significance Index: -12.0400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0727
Cell Significance Index: -9.9800
Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.0793
Cell Significance Index: -0.3300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0857
Cell Significance Index: -2.4700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0902
Cell Significance Index: -2.8900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0950
Cell Significance Index: -10.8400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0956
Cell Significance Index: -5.8600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1057
Cell Significance Index: -15.3700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1133
Cell Significance Index: -2.3500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1139
Cell Significance Index: -11.8600
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1145
Cell Significance Index: -1.9500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1180
Cell Significance Index: -14.5100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1243
Cell Significance Index: -16.0600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1286
Cell Significance Index: -14.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1294
Cell Significance Index: -9.9300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1405
Cell Significance Index: -1.7800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1410
Cell Significance Index: -18.0700
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1595
Cell Significance Index: -2.1200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1643
Cell Significance Index: -7.7200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1787
Cell Significance Index: -7.7700
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1876
Cell Significance Index: -1.5200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1959
Cell Significance Index: -9.9000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2017
Cell Significance Index: -10.4800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2049
Cell Significance Index: -13.7800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2055
Cell Significance Index: -9.0900
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2065
Cell Significance Index: -3.5600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2138
Cell Significance Index: -8.1000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2174
Cell Significance Index: -16.2000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2211
Cell Significance Index: -11.6100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2240
Cell Significance Index: -14.1200
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.2320
Cell Significance Index: -1.2700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2322
Cell Significance Index: -14.2700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2450
Cell Significance Index: -13.7500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2463
Cell Significance Index: -8.6300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2710
Cell Significance Index: -2.2100
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.2773
Cell Significance Index: -2.7800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2814
Cell Significance Index: -13.1200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2915
Cell Significance Index: -5.7000
Cell Name: microglial cell (CL0000129)
Fold Change: -0.2917
Cell Significance Index: -3.4300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2963
Cell Significance Index: -8.2800
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.2974
Cell Significance Index: -2.6200
Cell Name: liver dendritic cell (CL2000055)
Fold Change: -0.2976
Cell Significance Index: -0.7900
Cell Name: macrophage (CL0000235)
Fold Change: -0.3125
Cell Significance Index: -3.1900
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.3196
Cell Significance Index: -5.4900
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3226
Cell Significance Index: -3.9900
Cell Name: mature T cell (CL0002419)
Fold Change: -0.3335
Cell Significance Index: -2.4000
Cell Name: centroblast (CL0009112)
Fold Change: -0.3343
Cell Significance Index: -0.7800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3344
Cell Significance Index: -10.6500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3530
Cell Significance Index: -5.3200
Cell Name: mature microglial cell (CL0002629)
Fold Change: -0.3662
Cell Significance Index: -4.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structure**: NCKAP1L is a protein that belongs to the NCKAP family, which consists of three members: NCKAP1, NCKAP2, and NCKAP3. NCKAP1L shares high sequence homology with NCKAP1 and is believed to have similar functions. 2. **Expression**: NCKAP1L is highly expressed in immune cells, including macrophages, monocytes, and lymphocytes. It is also expressed in other cell types, such as neurons and epithelial cells. 3. **Function**: NCKAP1L regulates actin dynamics, cytoskeleton organization, and protein-protein interactions. It is involved in various cellular processes, including cell migration, adhesion, and signaling pathways. **Pathways and Functions** NCKAP1L is involved in several signaling pathways, including: 1. **Actin polymerization-dependent cell motility**: NCKAP1L regulates actin polymerization, which is essential for cell migration and adhesion. 2. **B cell homeostasis**: NCKAP1L is involved in regulating B cell development and differentiation. 3. **B cell receptor signaling pathway**: NCKAP1L is a component of the B cell receptor signaling complex, which regulates B cell activation and proliferation. 4. **Cell migration**: NCKAP1L regulates cell migration, which is essential for immune cell function and tissue repair. 5. **Cytoskeleton organization**: NCKAP1L regulates cytoskeleton organization, which is essential for cell shape, movement, and signaling. **Clinical Significance** NCKAP1L has been implicated in several immune-related disorders, including: 1. **Leishmania infection**: NCKAP1L has been shown to play a crucial role in regulating phagocytosis and immune response to Leishmania infection. 2. **Autoimmune diseases**: NCKAP1L has been implicated in several autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Cancer**: NCKAP1L has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 4. **Neurological disorders**: NCKAP1L has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In summary, NCKAP1L is a gene that plays a crucial role in regulating immune cell function, cell migration, and signaling pathways. Its dysregulation has been implicated in several immune-related disorders, including Leishmania infection, autoimmune diseases, cancer, and neurological disorders. Further research is needed to fully understand the role of NCKAP1L in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Membrane-associated protein HEM-1

Genular Protein ID: 4202610991

Symbol: NCKPL_HUMAN

Name: Membrane-associated protein HEM-1

UniProtKB Accession Codes:

P55160 B4DUT5 Q52LW0

Database IDs:

Citations:

PubMed ID: 1932118

Title: Hem-1, a potential membrane protein, with expression restricted to blood cells.

PubMed ID: 1932118

DOI: 10.1016/0167-4781(91)90109-y

PubMed ID: 7643388

Title: The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis.

PubMed ID: 7643388

DOI: 10.1006/jmbi.1995.0414

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 17696648

Title: An actin-based wave generator organizes cell motility.

PubMed ID: 17696648

DOI: 10.1371/journal.pbio.0050221

PubMed ID: 20969869

Title: Hem-1: putting the 'WAVE' into actin polymerization during an immune response.

PubMed ID: 20969869

DOI: 10.1016/j.febslet.2010.10.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32647003

Title: HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.

PubMed ID: 32647003

DOI: 10.1126/science.aay5663

Sequence Information:

Length: 1127
Mass: 128153
Checksum: 9389BAB163BAEA45
Sequence:

MSLTSAYQHK LAEKLTILND RGQGVLIRMY NIKKTCSDPK SKPPFLLEKS MEPSLKYINK 
KFPNIDVRNS TQHLGPVHRE KAEIIRFLTN YYQSFVDVME FRDHVYELLN TIDACQCHFD 
INLNFDFTRS YLDLIVTYTS VILLLSRIED RRILIGMYNC AHEMLHGHGD PSFARLGQMV 
LEYDHPLKKL TEEFGPHTKA VSGALLSLHF LFVRRNQGAE QWRSAQLLSL ISNPPAMINP 
ANSDTMACEY LSVEVMERWI IIGFLLCHGC LNSNSQCQKL WKLCLQGSLY ITLIREDVLQ 
VHKVTEDLFS SLKGYGKRVA DIKESKEHVI ANSGQFHCQR RQFLRMAVKE LETVLADEPG 
LLGPKALFAF MALSFIRDEV TWLVRHTENV TKTKTPEDYA DSSIAELLFL LEGIRSLVRR 
HIKVIQQYHL QYLARFDALV LSDIIQNLSV CPEEESIIMS SFVSILSSLN LKQVDNGEKF 
EFSGLRLDWF RLQAYTSVAK APLHLHENPD LAKVMNLIVF HSRMLDSVEK LLVETSDLST 
FCFHLRIFEK MFAMTLEESA MLRYAIAFPL ICAHFVHCTH EMCPEEYPHL KNHGLHHCNS 
FLEELAKQTS NCVLEICAEQ RNLSEQLLPK HCATTISKAK NKKTRKQRQT PRKGEPERDK 
PGAESHRKNR SIVTNMDKLH LNLTELALTM NHVYSFSVFE HTIFPSEYLS SHLEARLNRA 
IVWLAGYNAT TQEIVRPSEL LAGVKAYIGF IQSLAQFLGA DASRVIRNAL LQQTQPLDSC 
GEQTITTLYT NWYLESLLRQ ASSGTIILSP AMQAFVSLPR EGEQNFSAEE FSDISEMRAL 
AELLGPYGMK FLSENLMWHV TSQIVELKKL VVENMDILVQ IRSNFSKPDL MASLLPQLTG 
AENVLKRMTI IGVILSFRAM AQEGLREVFS SHCPFLMGPI ECLKEFVTPD TDIKVTLSIF 
ELASAAGVGC DIDPALVAAI ANLKADTSSP EEEYKVACLL LIFLAVSLPL LATDPSSFYS 
IEKDGYNNNI HCLTKAIIQV SAALFTLYNK NIETHLKEFL VVASVSLLQL GQETDKLKTR 
NRESISLLMR LVVEESSFLT LDMLESCFPY VLLRNAYREV SRAFHLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NCKAP1L

Associated with

Cells (max top 100)

Other Information

Hem-1, a potential membrane protein, with expression restricted to blood cells. PubMed ID: 1932118

The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis. PubMed ID: 7643388

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PubMed ID: 16417406

An actin-based wave generator organizes cell motility. PubMed ID: 17696648

Hem-1: putting the 'WAVE' into actin polymerization during an immune response. PubMed ID: 20969869

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. PubMed ID: 32647003