Details for: ZNF354C

Gene ID: 30832

Symbol: ZNF354C

Ensembl ID: ENSG00000177932

Description: zinc finger protein 354C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.4332
    Cell Significance Index: -10.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.9487
    Cell Significance Index: -10.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.8587
    Cell Significance Index: -10.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.1333
    Cell Significance Index: -8.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8000
    Cell Significance Index: -10.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7521
    Cell Significance Index: -10.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0104
    Cell Significance Index: -4.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6944
    Cell Significance Index: 132.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6278
    Cell Significance Index: 13.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5618
    Cell Significance Index: 35.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4817
    Cell Significance Index: 47.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4256
    Cell Significance Index: 9.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3501
    Cell Significance Index: 21.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3368
    Cell Significance Index: 66.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3037
    Cell Significance Index: 17.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2965
    Cell Significance Index: 32.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2891
    Cell Significance Index: 17.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2793
    Cell Significance Index: 252.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2391
    Cell Significance Index: 38.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2388
    Cell Significance Index: 4.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2098
    Cell Significance Index: 42.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1700
    Cell Significance Index: 19.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1335
    Cell Significance Index: 2.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1209
    Cell Significance Index: 8.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0936
    Cell Significance Index: 7.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0816
    Cell Significance Index: 3.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0812
    Cell Significance Index: 11.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0725
    Cell Significance Index: 26.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0620
    Cell Significance Index: 1.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0610
    Cell Significance Index: 93.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0605
    Cell Significance Index: 1.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0572
    Cell Significance Index: 1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0440
    Cell Significance Index: 7.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0387
    Cell Significance Index: 0.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0348
    Cell Significance Index: 19.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0303
    Cell Significance Index: 0.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0297
    Cell Significance Index: 55.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0285
    Cell Significance Index: 1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0232
    Cell Significance Index: 10.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0191
    Cell Significance Index: 35.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0189
    Cell Significance Index: 12.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0167
    Cell Significance Index: 0.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0100
    Cell Significance Index: 4.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0078
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0063
    Cell Significance Index: 8.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0018
    Cell Significance Index: 0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0076
    Cell Significance Index: -1.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0110
    Cell Significance Index: -0.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0113
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0190
    Cell Significance Index: -0.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0271
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0278
    Cell Significance Index: -4.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0290
    Cell Significance Index: -1.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0322
    Cell Significance Index: -9.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0336
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0424
    Cell Significance Index: -4.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0432
    Cell Significance Index: -0.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0521
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0536
    Cell Significance Index: -11.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0542
    Cell Significance Index: -1.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0641
    Cell Significance Index: -3.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0647
    Cell Significance Index: -3.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0747
    Cell Significance Index: -9.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0773
    Cell Significance Index: -2.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0791
    Cell Significance Index: -1.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0814
    Cell Significance Index: -8.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0826
    Cell Significance Index: -8.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0876
    Cell Significance Index: -2.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1001
    Cell Significance Index: -7.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1131
    Cell Significance Index: -3.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1155
    Cell Significance Index: -9.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1202
    Cell Significance Index: -6.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1239
    Cell Significance Index: -3.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1253
    Cell Significance Index: -5.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1263
    Cell Significance Index: -1.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1267
    Cell Significance Index: -9.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1509
    Cell Significance Index: -4.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1525
    Cell Significance Index: -9.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1540
    Cell Significance Index: -4.0500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1816
    Cell Significance Index: -2.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1854
    Cell Significance Index: -3.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1931
    Cell Significance Index: -6.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2118
    Cell Significance Index: -6.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2144
    Cell Significance Index: -5.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2153
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2154
    Cell Significance Index: -7.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2160
    Cell Significance Index: -3.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2342
    Cell Significance Index: -1.9100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2351
    Cell Significance Index: -3.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2397
    Cell Significance Index: -3.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2425
    Cell Significance Index: -3.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2425
    Cell Significance Index: -6.9200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2460
    Cell Significance Index: -1.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2468
    Cell Significance Index: -7.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2579
    Cell Significance Index: -7.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor:** ZNF354C is a transcription factor that binds to specific DNA sequences, regulating gene expression. 2. **Zinc Finger Domain:** The gene contains a zinc finger domain, which is essential for DNA binding and transcriptional regulation. 3. **Cellular Expression:** ZNF354C is significantly expressed in cells of the immune system, including goblet cells, enterocytes, and GABAergic interneurons. 4. **Pathway Involvement:** ZNF354C is involved in negative regulation of sprouting angiogenesis and transcription by RNA polymerase II. **Pathways and Functions:** 1. **Gene Expression (Transcription):** ZNF354C regulates gene expression by binding to specific DNA sequences, influencing the transcription of target genes. 2. **Cytoplasm:** ZNF354C interacts with RNA polymerase II in the cytoplasm, regulating transcriptional activity. 3. **Nuclear Membrane:** ZNF354C is localized to the nuclear membrane, where it regulates gene expression and transcription. 4. **Metal Ion Binding:** The zinc finger domain of ZNF354C binds metal ions, which is essential for DNA binding and transcriptional regulation. 5. **Regulation of Transcription by RNA Polymerase II:** ZNF354C negatively regulates transcription by RNA polymerase II, influencing the expression of target genes. **Clinical Significance:** 1. **Immune-Related Diseases:** ZNF354C has been implicated in immune-related diseases, such as inflammatory bowel disease (IBD) and multiple sclerosis (MS). 2. **Angiogenesis:** ZNF354C's role in negative regulation of sprouting angiogenesis makes it a potential target for therapies aimed at preventing or treating angiogenesis-related diseases. 3. **Gene Therapy:** ZNF354C's involvement in gene regulation and transcription makes it a potential target for gene therapy approaches aimed at modulating immune responses. 4. **Cancer:** ZNF354C's role in regulating gene expression and transcription makes it a potential target for cancer therapies aimed at modulating immune responses and inhibiting tumor growth. In conclusion, ZNF354C is a transcription factor that plays a crucial role in regulating gene expression in immune cells. Its involvement in negative regulation of sprouting angiogenesis and transcription by RNA polymerase II highlights its importance in immune cell development and function. Further research is needed to fully understand the clinical significance of ZNF354C in immune-related diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 4041413990

Symbol: Z354C_HUMAN

Name: Zinc finger protein 354C

UniProtKB Accession Codes:

Q86Y25 Q6P4P9 Q8NFX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15555547

Title: Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library.

PubMed ID: 15555547

DOI: 10.1016/j.bbrc.2004.10.158

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33154469

Title: ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.

PubMed ID: 33154469

DOI: 10.1038/s41598-020-76193-0

Sequence Information:

  • Length: 554
  • Mass: 64847
  • Checksum: 3B95DED46CCECFFC
  • Sequence:
    • MAVDLLSAQE PVTFRDVAVF FSQDEWLHLD SAQRALYREV MLENYSSLVS LGIPFSMPKL 
IHQLQQGEDP CMVEREVPSD TRLGFKTWLE TEALPHRQDI FIEETSQGMV KKESIKDGHW 
DINFEEAVEF ESEIEEEQEK KPLRQMIDSH EKTISEDGNH TSLELGKSLF TNTALVTQQS 
VPIERIPNMY YTFGKDFKQN FDLMKCFQIY PGGKPHICNE CGKSFKQNLH LIEHQRIHTG 
EKPYKCNECE KTFSHRSSLL SHQRIHTGEK PYKCNECEKA FSNSSTLIKH LRVHTGEKPY 
RCRECGKAFS QCSTLTVHQR IHTGEKLYKC GECEKAFNCR AKLHRHQRIH TGEKPYKCSE 
CGKGYSQFTS LAEHQRFHTG EQLYTCLECG RTFTRIVTLI EHQRIHTGQK PYQCNECEKA 
FNQYSSFNEH RKIHTGEKLY TCEECGKAFG CKSNLYRHQR IHTGEKPYQC NQCGKAFSQY 
SFLTEHERIH TGEKLYKCME CGKAYSYRSN LCRHKKVHTK EKLYKWKEYG KPFICSSSLT 
QYQRFFKGDK AYEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.