Details for: NT5C

Gene ID: 30833

Symbol: NT5C

Ensembl ID: ENSG00000125458

Description: 5', 3'-nucleotidase, cytosolic

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 238.9016
    Cell Significance Index: -37.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 134.4801
    Cell Significance Index: -34.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.8323
    Cell Significance Index: -36.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.6801
    Cell Significance Index: -42.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.5731
    Cell Significance Index: -41.9600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.2468
    Cell Significance Index: -42.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.1624
    Cell Significance Index: -37.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.8236
    Cell Significance Index: -40.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4302
    Cell Significance Index: -30.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7247
    Cell Significance Index: -42.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6795
    Cell Significance Index: -29.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8759
    Cell Significance Index: -12.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.8016
    Cell Significance Index: 455.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0235
    Cell Significance Index: 220.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6931
    Cell Significance Index: 23.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6413
    Cell Significance Index: 37.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5491
    Cell Significance Index: 14.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4788
    Cell Significance Index: 76.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4745
    Cell Significance Index: 40.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4667
    Cell Significance Index: 66.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4182
    Cell Significance Index: 41.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3839
    Cell Significance Index: 89.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3295
    Cell Significance Index: 182.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2980
    Cell Significance Index: 159.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1834
    Cell Significance Index: 213.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1608
    Cell Significance Index: 33.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1557
    Cell Significance Index: 631.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0051
    Cell Significance Index: 28.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9550
    Cell Significance Index: 67.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9391
    Cell Significance Index: 110.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9390
    Cell Significance Index: 44.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8734
    Cell Significance Index: 386.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7912
    Cell Significance Index: 101.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7243
    Cell Significance Index: 25.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6927
    Cell Significance Index: 10.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6635
    Cell Significance Index: 41.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6581
    Cell Significance Index: 130.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6497
    Cell Significance Index: 48.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5573
    Cell Significance Index: 4.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5265
    Cell Significance Index: 24.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4495
    Cell Significance Index: 11.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4160
    Cell Significance Index: 21.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4023
    Cell Significance Index: 51.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3877
    Cell Significance Index: 38.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3297
    Cell Significance Index: 9.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2718
    Cell Significance Index: 5.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2424
    Cell Significance Index: 167.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2134
    Cell Significance Index: 7.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2059
    Cell Significance Index: 39.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1619
    Cell Significance Index: 1.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0603
    Cell Significance Index: 12.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0377
    Cell Significance Index: 0.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0323
    Cell Significance Index: 0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0219
    Cell Significance Index: 16.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0193
    Cell Significance Index: 0.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0160
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0137
    Cell Significance Index: 25.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0102
    Cell Significance Index: 7.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0039
    Cell Significance Index: 7.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0084
    Cell Significance Index: -0.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0178
    Cell Significance Index: -24.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0258
    Cell Significance Index: -4.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0268
    Cell Significance Index: -17.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0293
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0501
    Cell Significance Index: -37.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0549
    Cell Significance Index: -24.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0664
    Cell Significance Index: -37.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0732
    Cell Significance Index: -45.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0741
    Cell Significance Index: -1.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0795
    Cell Significance Index: -22.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0815
    Cell Significance Index: -4.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1036
    Cell Significance Index: -7.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1466
    Cell Significance Index: -17.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1499
    Cell Significance Index: -4.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1538
    Cell Significance Index: -3.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1628
    Cell Significance Index: -23.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1763
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1768
    Cell Significance Index: -20.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1950
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2089
    Cell Significance Index: -44.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2935
    Cell Significance Index: -6.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3008
    Cell Significance Index: -8.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3046
    Cell Significance Index: -17.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3661
    Cell Significance Index: -9.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3679
    Cell Significance Index: -22.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3705
    Cell Significance Index: -29.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3719
    Cell Significance Index: -2.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3825
    Cell Significance Index: -39.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3916
    Cell Significance Index: -9.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4132
    Cell Significance Index: -6.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4213
    Cell Significance Index: -21.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5053
    Cell Significance Index: -5.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6399
    Cell Significance Index: -43.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6758
    Cell Significance Index: -41.4300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6934
    Cell Significance Index: -5.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6936
    Cell Significance Index: -12.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7334
    Cell Significance Index: -6.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7415
    Cell Significance Index: -4.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme specificity:** NT5C is a cytosolic 5',3'-nucleotidase, which is a type of enzyme that catalyzes the hydrolysis of nucleotides, resulting in the production of nucleosides and nucleobases. 2. **Expression pattern:** The NT5C gene is significantly expressed in various cell types, including colon epithelial cells, basal cells of the trachea epithelium, class-switched memory B cells, enterocytes, and renal cells. 3. **Protein structure:** The NT5C protein is a homodimeric enzyme, consisting of two identical subunits. **Pathways and Functions:** 1. **Nucleotide metabolism:** NT5C plays a crucial role in the metabolism of nucleotides, including the hydrolysis of nucleoside triphosphates (NTPs) and nucleoside diphosphates (NDPs) to produce nucleosides and nucleobases. 2. **Purine and pyrimidine catabolism:** NT5C is involved in the catabolism of purines and pyrimidines, including the breakdown of adenine, guanine, cytosine, and thymine. 3. **Immune function:** NT5C has been implicated in immune function, particularly in the regulation of B cell development and differentiation. The enzyme is also involved in the production of cytokines and chemokines, which are essential for immune responses. 4. **Regulation of cell growth and differentiation:** NT5C may also play a role in regulating cell growth and differentiation, particularly in epithelial cells and immune cells. **Clinical Significance:** 1. **Immunodeficiency disorders:** Mutations in the NT5C gene have been associated with immunodeficiency disorders, such as X-linked adrenoleukodystrophy (ALD) and other forms of immunodeficiency. 2. **Cancer:** Aberrant expression of NT5C has been observed in various types of cancer, including colon, breast, and lung cancer. 3. **Neurological disorders:** NT5C has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Diagnostic markers:** NT5C may serve as a diagnostic marker for certain diseases, including cancer and immunodeficiency disorders. In conclusion, the NT5C gene plays a crucial role in various cellular processes, including nucleotide metabolism, purine and pyrimidine catabolism, and immune function. Further research is needed to fully understand the mechanisms by which NT5C regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2510646699

Symbol: NT5C_HUMAN

Name: 5'(3')-deoxyribonucleotidase, cytosolic type

UniProtKB Accession Codes:

Q8TCD5 Q96HS6 Q9NP82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10681516

Title: Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells.

PubMed ID: 10681516

DOI: 10.1074/jbc.275.8.5409

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12234672

Title: Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs.

PubMed ID: 12234672

DOI: 10.1016/s0378-1119(02)00651-0

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17985935

Title: Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues.

PubMed ID: 17985935

DOI: 10.1021/bi7014794

Sequence Information:

  • Length: 201
  • Mass: 23383
  • Checksum: C4C289BBDEC0FA89
  • Sequence:
    • MARSVRVLVD MDGVLADFEA GLLRGFRRRF PEEPHVPLEQ RRGFLAREQY RALRPDLADK 
VASVYEAPGF FLDLEPIPGA LDAVREMNDL PDTQVFICTS PLLKYHHCVG EKYRWVEQHL 
GPQFVERIIL TRDKTVVLGD LLIDDKDTVR GQEETPSWEH ILFTCCHNRH LVLPPTRRRL 
LSWSDNWREI LDSKRGAAQR E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.