Details for: TAX1BP3

Gene ID: 30851

Symbol: TAX1BP3

Ensembl ID: ENSG00000213977

Description: Tax1 binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 197.4988
    Cell Significance Index: -30.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.3875
    Cell Significance Index: -28.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.0723
    Cell Significance Index: -30.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.0171
    Cell Significance Index: -28.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.4381
    Cell Significance Index: -30.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.1834
    Cell Significance Index: -31.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1494
    Cell Significance Index: -24.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9117
    Cell Significance Index: -31.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3260
    Cell Significance Index: -19.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.8271
    Cell Significance Index: 562.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9836
    Cell Significance Index: 81.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.9278
    Cell Significance Index: 476.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.4384
    Cell Significance Index: 20.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2967
    Cell Significance Index: 21.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2664
    Cell Significance Index: 47.4400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.2414
    Cell Significance Index: 19.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9108
    Cell Significance Index: 234.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4823
    Cell Significance Index: 16.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4508
    Cell Significance Index: 261.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2847
    Cell Significance Index: 176.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2311
    Cell Significance Index: 63.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1389
    Cell Significance Index: 147.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0466
    Cell Significance Index: 74.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9909
    Cell Significance Index: 438.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9480
    Cell Significance Index: 70.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9363
    Cell Significance Index: 14.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8995
    Cell Significance Index: 15.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8756
    Cell Significance Index: 18.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8030
    Cell Significance Index: 8.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7753
    Cell Significance Index: 36.4400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6979
    Cell Significance Index: 4.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6514
    Cell Significance Index: 17.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6439
    Cell Significance Index: 16.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6326
    Cell Significance Index: 43.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6246
    Cell Significance Index: 18.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6074
    Cell Significance Index: 4.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5140
    Cell Significance Index: 50.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4858
    Cell Significance Index: 16.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4226
    Cell Significance Index: 230.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4171
    Cell Significance Index: 53.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3764
    Cell Significance Index: 24.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2679
    Cell Significance Index: 12.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2265
    Cell Significance Index: 6.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2142
    Cell Significance Index: 40.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1655
    Cell Significance Index: 2.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1613
    Cell Significance Index: 3.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1287
    Cell Significance Index: 116.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0935
    Cell Significance Index: 1.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0878
    Cell Significance Index: 66.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0705
    Cell Significance Index: 8.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0595
    Cell Significance Index: 1.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0441
    Cell Significance Index: 2.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0047
    Cell Significance Index: -0.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0099
    Cell Significance Index: -1.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0123
    Cell Significance Index: -23.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0146
    Cell Significance Index: -5.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0220
    Cell Significance Index: -40.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0239
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0241
    Cell Significance Index: -17.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0256
    Cell Significance Index: -5.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0263
    Cell Significance Index: -40.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0306
    Cell Significance Index: -41.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0395
    Cell Significance Index: -25.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0405
    Cell Significance Index: -28.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0414
    Cell Significance Index: -30.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0485
    Cell Significance Index: -4.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0506
    Cell Significance Index: -10.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0544
    Cell Significance Index: -30.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0571
    Cell Significance Index: -35.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0668
    Cell Significance Index: -30.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0771
    Cell Significance Index: -13.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0903
    Cell Significance Index: -25.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1008
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1109
    Cell Significance Index: -12.7100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1212
    Cell Significance Index: -1.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1273
    Cell Significance Index: -3.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1544
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1795
    Cell Significance Index: -37.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1877
    Cell Significance Index: -27.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2415
    Cell Significance Index: -5.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2654
    Cell Significance Index: -20.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3006
    Cell Significance Index: -7.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3007
    Cell Significance Index: -31.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3021
    Cell Significance Index: -3.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3023
    Cell Significance Index: -23.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3231
    Cell Significance Index: -9.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3739
    Cell Significance Index: -22.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4012
    Cell Significance Index: -24.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4243
    Cell Significance Index: -2.8800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4249
    Cell Significance Index: -2.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4398
    Cell Significance Index: -29.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4424
    Cell Significance Index: -26.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4526
    Cell Significance Index: -13.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4712
    Cell Significance Index: -29.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4978
    Cell Significance Index: -25.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5207
    Cell Significance Index: -29.2200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.5606
    Cell Significance Index: -2.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6020
    Cell Significance Index: -24.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6339
    Cell Significance Index: -23.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6420
    Cell Significance Index: -33.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Tax1BP3 is a cytosolic protein that interacts with various proteins, including Tax1, a protein involved in viral replication. It exhibits negative regulatory properties, modulating cell proliferation, protein localization, and signaling pathways. Tax1BP3 is highly expressed in different cell types, including pulmonary interstitial fibroblasts, stratified epithelial cells, and mesodermal cells. **Pathways and Functions:** Tax1BP3 is involved in several signaling pathways, including: 1. **Wnt signaling pathway**: Tax1BP3 negatively regulates Wnt signaling, which is crucial for cell proliferation, differentiation, and survival. 2. **Rho GTPase pathway**: Tax1BP3 interacts with Rho GTPases, modulating their activity and subsequent signaling. 3. **Actin cytoskeleton**: Tax1BP3 regulates actin cytoskeleton dynamics, affecting cell shape, movement, and adhesion. 4. **Negative regulation of cell population proliferation**: Tax1BP3 inhibits cell proliferation, which is essential for preventing uncontrolled cell growth and tumor formation. **Clinical Significance:** Tax1BP3's involvement in various diseases highlights its potential as a therapeutic target. Its role in: 1. **Cancer**: Tax1BP3's negative regulation of Wnt signaling and cell proliferation makes it a potential target for cancer therapy. 2. **Fibrosis**: Tax1BP3's expression in pulmonary interstitial fibroblasts suggests its involvement in fibrotic diseases, such as pulmonary fibrosis. 3. **Inflammatory diseases**: Tax1BP3's interaction with Rho GTPases may contribute to inflammatory responses, making it a potential target for inflammatory diseases. **Conclusion:** Tax1BP3 is a complex protein that plays a crucial role in various cellular processes, including signaling pathways and cell proliferation. Its clinical significance in different diseases highlights its potential as a therapeutic target. Further research is necessary to fully understand the mechanisms of Tax1BP3 and its potential applications in medicine. **Recommendations:** 1. **Investigate Tax1BP3's role in specific diseases**: Further studies are needed to elucidate Tax1BP3's involvement in various diseases, including cancer, fibrosis, and inflammatory diseases. 2. **Develop therapeutic strategies**: Targeting Tax1BP3 may provide new therapeutic avenues for treating diseases where it plays a crucial role. 3. **Explore Tax1BP3's interactions with other proteins**: Further research is necessary to understand the complex interactions between Tax1BP3 and other proteins, which may reveal new insights into its functions and potential applications.

Genular Protein ID: 2763681799

Symbol: TX1B3_HUMAN

Name: Tax1-binding protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9482110

Title: The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.

PubMed ID: 9482110

DOI: 10.1038/sj.onc.1201567

PubMed ID: 10673275

Title: The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.

PubMed ID: 10673275

DOI: 10.1101/gr.10.2.165

PubMed ID: 11163757

Title: The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.

PubMed ID: 11163757

DOI: 10.1016/s0014-5793(00)02373-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10940294

Title: The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.

PubMed ID: 10940294

DOI: 10.1074/jbc.m000465200

PubMed ID: 16855024

Title: TIP-1 has PDZ scaffold antagonist activity.

PubMed ID: 16855024

DOI: 10.1091/mbc.e06-02-0129

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21139582

Title: The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.

PubMed ID: 21139582

DOI: 10.1038/sj.bjc.6606026

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19685007

Title: Solution structure of the human Tax-interacting protein-1.

PubMed ID: 19685007

DOI: 10.1007/s10858-009-9361-8

PubMed ID: 19635485

Title: Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.

PubMed ID: 19635485

DOI: 10.1016/j.jmb.2009.07.060

PubMed ID: 21417405

Title: Promiscuous binding at the crossroads of numerous cancer pathways: insight from the binding of glutaminase interacting protein with glutaminase L.

PubMed ID: 21417405

DOI: 10.1021/bi102055y

PubMed ID: 21787750

Title: Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.

PubMed ID: 21787750

DOI: 10.1016/j.bbrc.2011.07.029

PubMed ID: 25645515

Title: Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia.

PubMed ID: 25645515

DOI: 10.1002/humu.22759

Sequence Information:

  • Length: 124
  • Mass: 13735
  • Checksum: FF0BCDF475F682CD
  • Sequence:
  • MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV 
    SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ 
    SMLS

Genular Protein ID: 1537479462

Symbol: A0A087X282_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 98
  • Mass: 11050
  • Checksum: C58A4ECC5F0E1EC1
  • Sequence:
  • MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKVNGWDMT 
    MVTHDQARKR LTKRSEEVVR LLVTRQSLQK AVQQSMLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.