Details for: HMGCS2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: ileal goblet cell (CL1000326)
Fold Change: 18.0918
Cell Significance Index: -12.1400 - Cell Name: precursor cell (CL0011115)
Fold Change: 13.7017
Cell Significance Index: 103.9000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 7.6933
Cell Significance Index: 348.7100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.5886
Cell Significance Index: -17.6500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 5.4319
Cell Significance Index: 282.1700 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 5.1084
Cell Significance Index: 19.5600 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 4.8257
Cell Significance Index: 12.7300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 4.6366
Cell Significance Index: 76.4100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.1444
Cell Significance Index: 90.6000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.1288
Cell Significance Index: 2825.0900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.7724
Cell Significance Index: 25.5300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.6730
Cell Significance Index: 57.9100 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 2.5337
Cell Significance Index: 8.7000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.4481
Cell Significance Index: 398.1600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.1530
Cell Significance Index: 32.2600 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.9801
Cell Significance Index: 21.4600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8208
Cell Significance Index: 361.3500 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1.7891
Cell Significance Index: 1.2800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.5291
Cell Significance Index: 105.7500 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.4577
Cell Significance Index: 16.9500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.4121
Cell Significance Index: 21.2800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.3811
Cell Significance Index: 23.2700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1988
Cell Significance Index: 216.1200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.1917
Cell Significance Index: 17.5900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8342
Cell Significance Index: 59.0000 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.7574
Cell Significance Index: 5.3300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6783
Cell Significance Index: 21.7300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5497
Cell Significance Index: 67.5900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3449
Cell Significance Index: 12.1200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3309
Cell Significance Index: 24.6600 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.3160
Cell Significance Index: 1.8200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2912
Cell Significance Index: 7.2800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2287
Cell Significance Index: 4.8700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2179
Cell Significance Index: 41.4700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1619
Cell Significance Index: 16.0200 - Cell Name: stem cell (CL0000034)
Fold Change: 0.1114
Cell Significance Index: 0.8100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1102
Cell Significance Index: 48.7100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0710
Cell Significance Index: 0.7400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0665
Cell Significance Index: 7.7500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0561
Cell Significance Index: 35.0100 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.0425
Cell Significance Index: 0.1600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0310
Cell Significance Index: 0.4800 - Cell Name: urothelial cell (CL0000731)
Fold Change: 0.0258
Cell Significance Index: 0.1800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0068
Cell Significance Index: 0.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0034
Cell Significance Index: 0.1000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0005
Cell Significance Index: -0.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0047
Cell Significance Index: -3.5000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0053
Cell Significance Index: -0.2200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0054
Cell Significance Index: -0.9200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0054
Cell Significance Index: -10.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0075
Cell Significance Index: -4.2200 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: -0.0097
Cell Significance Index: -0.0100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0130
Cell Significance Index: -0.6600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0134
Cell Significance Index: -10.1600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0134
Cell Significance Index: -24.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0163
Cell Significance Index: -25.0200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0185
Cell Significance Index: -25.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0188
Cell Significance Index: -10.2500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0215
Cell Significance Index: -15.7300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0215
Cell Significance Index: -4.5200 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0274
Cell Significance Index: -0.1700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0277
Cell Significance Index: -17.5700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0308
Cell Significance Index: -11.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0399
Cell Significance Index: -18.1300 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0431
Cell Significance Index: -0.7300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0548
Cell Significance Index: -10.9900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0579
Cell Significance Index: -16.6700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0596
Cell Significance Index: -8.6700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0610
Cell Significance Index: -6.9900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0642
Cell Significance Index: -7.3300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0906
Cell Significance Index: -1.8800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0916
Cell Significance Index: -12.5800 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0918
Cell Significance Index: -0.9500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0977
Cell Significance Index: -9.9900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1145
Cell Significance Index: -7.0200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1449
Cell Significance Index: -18.7200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1697
Cell Significance Index: -11.4100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1738
Cell Significance Index: -13.3400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1774
Cell Significance Index: -11.1800 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1825
Cell Significance Index: -1.9300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1828
Cell Significance Index: -4.8800 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: -0.1879
Cell Significance Index: -1.6400 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: -0.1976
Cell Significance Index: -1.1600 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.2096
Cell Significance Index: -2.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2222
Cell Significance Index: -4.6500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2269
Cell Significance Index: -17.9700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2306
Cell Significance Index: -4.5000 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2438
Cell Significance Index: -3.1600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2782
Cell Significance Index: -17.1000 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.2858
Cell Significance Index: -3.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2918
Cell Significance Index: -15.2000 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.2929
Cell Significance Index: -3.1300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2962
Cell Significance Index: -13.1000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2971
Cell Significance Index: -7.9600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2983
Cell Significance Index: -10.4500 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.2999
Cell Significance Index: -3.1200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3052
Cell Significance Index: -17.1300 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3144
Cell Significance Index: -4.3600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3294
Cell Significance Index: -15.3600 - Cell Name: group 3 innate lymphoid cell, human (CL0001078)
Fold Change: -0.3394
Cell Significance Index: -3.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2924371138
Symbol: HMCS2_HUMAN
Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7893153
Title: Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
PubMed ID: 7893153
PubMed ID: 9305755
Title: Cloning and characterization of the human mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase gene.
PubMed ID: 9305755
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7851882
Title: Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution.
PubMed ID: 7851882
PubMed ID: 21952825
Title: Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.
PubMed ID: 21952825
PubMed ID: 16940161
Title: Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
PubMed ID: 16940161
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 20346956
Title: Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
PubMed ID: 20346956
PubMed ID: 11479731
Title: Genetic basis of mitochondrial HMG-CoA synthase deficiency.
PubMed ID: 11479731
PubMed ID: 11228257
Title: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients.
PubMed ID: 11228257
PubMed ID: 12647205
Title: Mitochondrial HMG-CoA synthase deficiency: identification of two further patients carrying two novel mutations.
PubMed ID: 12647205
PubMed ID: 16601895
Title: Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
PubMed ID: 16601895
PubMed ID: 23751782
Title: New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations.
PubMed ID: 23751782
PubMed ID: 25511235
Title: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
PubMed ID: 25511235
PubMed ID: 29597274
Title: Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients.
PubMed ID: 29597274
DOI: 10.3390/ijms19041010
Sequence Information:
- Length: 508
- Mass: 56635
- Checksum: BD362D631F7C3C80
- Sequence:
MQRLLTPVKR ILQLTRAVQE TSLTPARLLP VAHQRFSTAS AVPLAKTDTW PKDVGILALE VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD FYKPNLASEY PIVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFGG LKLEDTYTNK DLDKALLKAS QDMFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF FSFRVSQDAA PGSPLDKLVS STSDLPKRLA SRKCVSPEEF TEIMNQREQF YHKVNFSPPG DTNSLFPGTW YLERVDEQHR RKYARRPV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.