Details for: HMGCS2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 4
Marker Score: 13,107 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.58
Marker Score: 6,515 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.53
Marker Score: 7,952 - Cell Name: stem cell (CL0000034)
Fold Change: 2.36
Marker Score: 5,602 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.16
Marker Score: 11,617 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 2.06
Marker Score: 5,809 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.82
Marker Score: 7,836 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.76
Marker Score: 11,288 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.67
Marker Score: 1,604 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.56
Marker Score: 1,553 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.55
Marker Score: 3,512 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.52
Marker Score: 1,309 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.47
Marker Score: 2,160 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.45
Marker Score: 2,058 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.43
Marker Score: 1,104 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.42
Marker Score: 535 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.38
Marker Score: 6,617 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.35
Marker Score: 8,604 - Cell Name: precursor cell (CL0011115)
Fold Change: 1.27
Marker Score: 308 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.26
Marker Score: 247 - Cell Name: peptic cell (CL0000155)
Fold Change: 1.05
Marker Score: 441 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,798 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.01
Marker Score: 687 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,815 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,040 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.96
Marker Score: 277 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.96
Marker Score: 1,590 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.95
Marker Score: 1,548 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,353 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,738 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.88
Marker Score: 942 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.87
Marker Score: 249 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 315 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.78
Marker Score: 565 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.76
Marker Score: 3,183 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.75
Marker Score: 151 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.75
Marker Score: 185 - Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 676 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469 - Cell Name: mast cell (CL0000097)
Fold Change: 0.68
Marker Score: 397 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.64
Marker Score: 242 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.59
Marker Score: 9,170 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.56
Marker Score: 174 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.56
Marker Score: 147 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.54
Marker Score: 7,243 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.54
Marker Score: 317 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.51
Marker Score: 236 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.51
Marker Score: 340 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.49
Marker Score: 185 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.49
Marker Score: 205 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.49
Marker Score: 107 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.49
Marker Score: 134 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.49
Marker Score: 487 - Cell Name: paneth cell (CL0000510)
Fold Change: 0.46
Marker Score: 322 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 276 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.45
Marker Score: 1,721 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.44
Marker Score: 684 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.43
Marker Score: 113 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.43
Marker Score: 210 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.42
Marker Score: 181 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.41
Marker Score: 362 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.4
Marker Score: 951 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.4
Marker Score: 426 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.4
Marker Score: 757 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.39
Marker Score: 434 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.37
Marker Score: 199 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.37
Marker Score: 101 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.37
Marker Score: 110 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.36
Marker Score: 96 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.36
Marker Score: 186 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.36
Marker Score: 84 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.34
Marker Score: 210 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.33
Marker Score: 661 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.32
Marker Score: 93 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.3
Marker Score: 324 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.3
Marker Score: 234 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.29
Marker Score: 536 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.28
Marker Score: 282 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.27
Marker Score: 67 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 90 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.24
Marker Score: 76 - Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.24
Marker Score: 338 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.21
Marker Score: 54 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.21
Marker Score: 1,406 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.2
Marker Score: 362 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.2
Marker Score: 4,560 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.2
Marker Score: 103 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.19
Marker Score: 209 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.19
Marker Score: 304 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.19
Marker Score: 41 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.18
Marker Score: 183
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2924371138
Symbol: HMCS2_HUMAN
Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7893153
Title: Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.
PubMed ID: 7893153
PubMed ID: 9305755
Title: Cloning and characterization of the human mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase gene.
PubMed ID: 9305755
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7851882
Title: Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution.
PubMed ID: 7851882
PubMed ID: 21952825
Title: Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.
PubMed ID: 21952825
PubMed ID: 16940161
Title: Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer.
PubMed ID: 16940161
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 20346956
Title: Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
PubMed ID: 20346956
PubMed ID: 11479731
Title: Genetic basis of mitochondrial HMG-CoA synthase deficiency.
PubMed ID: 11479731
PubMed ID: 11228257
Title: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients.
PubMed ID: 11228257
PubMed ID: 12647205
Title: Mitochondrial HMG-CoA synthase deficiency: identification of two further patients carrying two novel mutations.
PubMed ID: 12647205
PubMed ID: 16601895
Title: Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency.
PubMed ID: 16601895
PubMed ID: 23751782
Title: New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations.
PubMed ID: 23751782
PubMed ID: 25511235
Title: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
PubMed ID: 25511235
PubMed ID: 29597274
Title: Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients.
PubMed ID: 29597274
DOI: 10.3390/ijms19041010
Sequence Information:
- Length: 508
- Mass: 56635
- Checksum: BD362D631F7C3C80
- Sequence:
MQRLLTPVKR ILQLTRAVQE TSLTPARLLP VAHQRFSTAS AVPLAKTDTW PKDVGILALE VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD FYKPNLASEY PIVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFGG LKLEDTYTNK DLDKALLKAS QDMFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF FSFRVSQDAA PGSPLDKLVS STSDLPKRLA SRKCVSPEEF TEIMNQREQF YHKVNFSPPG DTNSLFPGTW YLERVDEQHR RKYARRPV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.